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Inhibitor Report for: CHEMBL4079247

Leaves the adduct Methyl dimethylcarbamate on the active serine


General
Type Carbamate
Chemical_Nomenclature [(1R,3R)-3-(4-methoxyanilino)cyclohexyl] N,N-dimethylcarbamate
Canonical SMILES CN(C)C(=O)OC1CCCC(C1)NC2=CC=C(C=C2)OC
InChI InChI=1S/C16H24N2O3/c1-18(2)16(19)21-15-6-4-5-13(11-15)17-12-7-9-14(20-3)10-8-12/h7-10,13,15,17H,4-6,11H2,1-3H3/t13-,15-/m1/s1
InChIKey DJUUOKKQPMZYKO-UKRRQHHQSA-N
Other name(s) BDBM50245735 ; CHEMBL4080162 ; BDBM50245729 ; trans-3-(4-Methoxyphenylamino)cyclohexyl N,N-dimethylcarbamate hydrochloride ; 6c' ; 5c'
________________________________________________________________________________________________
MW|292.37
Formula|C16H24N2O3"
CAS_number|
PubChem|137651291
UniChem|DJUUOKKQPMZYKO-UKRRQHHQSA-N
IUPHAR|
Wikipedia|

Target
Families | CHEMBL4079247 ligand of proteins in family: BCHE
Protein | human-BCHE

References:
Search PubMed for references concerning: CHEMBL4079247
    Title: Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease
    Li Q, Yang H, Chen Y, Sun H
    Ref: Eur Journal of Medicinal Chemistry, 132:294, 2017 : PubMed

            

    Title: Cholinesterases Inhibition by Novel cis- and trans-3-Arylaminocyclohexyl N, N-Dimethylcarbamates: Biological Evaluation and Molecular Modeling
    Yamazaki DA, Candido AA, Bagatin MC, Machinski M, Jr., Mossini SAG, Pontes RM, Rosa FA, Bassoa EA, Gauze GF
    Ref: J Braz Chem Soc, 27:1616, 2016 : PubMed