CHEMBL238787
inhibitor of Hormone-sensitive_lipase_like (Ebdrup et al. 2007) but also CES1 and ABHD6 (Iglesias et al. 2016)
General
Type : Trifluoro,Carbamate,Piperidine
Chemical_Nomenclature : [4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl] 4-(hydroxymethyl)piperidine-1-carboxylate
Canonical SMILES : C1CN(CCC1CO)C(=O)OC2=CC=C(C=C2)OC3=NC=C(C=C3)C(F)(F)F
InChI : InChI=1S\/C19H19F3N2O4\/c20-19(21,22)14-1-6-17(23-11-14)27-15-2-4-16(5-3-15)28-18(26)24-9-7-13(12-25)8-10-24\/h1-6,11,13,25H,7-10,12H2
InChIKey : SEUFQIJDZTWDLJ-UHFFFAOYSA-N
Other name(s) : compound 13f,SCHEMBL5650843,SEUFQIJDZTWDLJ-UHFFFAOYSA-N,BDBM50224169,4-Hydroxymethyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester,4-hydroxymethyl-piperidine-1-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester
MW : 396.36
Formula : C19H19F3N2O4
CAS_number :
PubChem : 23636024
UniChem : SEUFQIJDZTWDLJ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : CHEMBL238787 ligand of proteins in family: Hormone-sensitive_lipase_like || Carb_B_Chordata || ABHD6-Lip
Stucture :
Protein :
References (2)
| Title : Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors - Iglesias_2016_J.Lipid.Res_57_131 |
| Author(s) : Iglesias J , Lamontagne J , Erb H , Gezzar S , Zhao S , Joly E , Truong VL , Skorey K , Crane S , Madiraju SR , Prentki M |
| Ref : J Lipid Res , 57 :131 , 2016 |
| Abstract : Iglesias_2016_J.Lipid.Res_57_131 |
| ESTHER : Iglesias_2016_J.Lipid.Res_57_131 |
| PubMedSearch : Iglesias_2016_J.Lipid.Res_57_131 |
| PubMedID: 26423520 |
| Title : Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects - Ebdrup_2007_J.Med.Chem_50_5449 |
| Author(s) : Ebdrup S , Refsgaard HH , Fledelius C , Jacobsen P |
| Ref : Journal of Medicinal Chemistry , 50 :5449 , 2007 |
| Abstract : Ebdrup_2007_J.Med.Chem_50_5449 |
| ESTHER : Ebdrup_2007_J.Med.Chem_50_5449 |
| PubMedSearch : Ebdrup_2007_J.Med.Chem_50_5449 |
| PubMedID: 17918819 |