CHEMBL1938516
Compound (S)-6e inhibits humanPrCP at IC50 values of 1.5 nM
General
Type : Piperidine
Chemical_Nomenclature : N-[(1S)-1-(4-chlorophenyl)-2-methylpropyl]-3-(4-phenylpiperidin-1-yl)propanamide
Canonical SMILES : CC(C)C(C1=CC=C(C=C1)Cl)NC(=O)CCN2CCC(CC2)C3=CC=CC=C3
InChI : InChI=1S\/C24H31ClN2O\/c1-18(2)24(21-8-10-22(25)11-9-21)26-23(28)14-17-27-15-12-20(13-16-27)19-6-4-3-5-7-19\/h3-11,18,20,24H,12-17H2,1-2H3,(H,26,28)\/t24-\/m0\/s1
InChIKey : LFLXJKHBKXYLAD-DEOSSOPVSA-N
Other name(s) : CHEMBL1938516,BDBM50361780,(S)-6e,compound (S)-6e
MW : 399.0
Formula : C24H31ClN2O
CAS_number :
PubChem : 56835036
UniChem : LFLXJKHBKXYLAD-DEOSSOPVSA-N
IUPHAR :
Wikipedia :
Target
Families : CHEMBL1938516 ligand of proteins in family: Prolylcarboxypeptidase
Stucture :
Protein : human-PRCP
References (1)
| Title : The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors - Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| Author(s) : Graham TH , Shen HC , Liu W , Xiong Y , Verras A , Bleasby K , Bhatt UR , Chabin RM , Chen D , Chen Q , Garcia-Calvo M , Geissler WM , He H , Lassman ME , Shen Z , Tong X , Tung EC , Xie D , Xu S , Colletti SL , Tata JR , Hale JJ , Pinto S , Shen DM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :658 , 2012 |
| Abstract : Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| ESTHER : Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| PubMedSearch : Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| PubMedID: 22079761 |
| Gene_locus related to this paper: human-PRCP |