Type : Pyrimidine,Carboxamide
Chemical_Nomenclature : 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-(2-pyridin-2-ylethyl)imidazo[1,2-a]pyrimidine-2-carboxamide
Canonical SMILES : CC1=NC2=NC(=CN2C(=C1CN)C3=C(C=C(C=C3)Cl)Cl)C(=O)NCCC4=CC=CC=N4
InChI : InChI=1S\/C22H20Cl2N6O\/c1-13-17(11-25)20(16-6-5-14(23)10-18(16)24)30-12-19(29-22(30)28-13)21(31)27-9-7-15-4-2-3-8-26-15\/h2-6,8,10,12H,7,9,11,25H2,1H3,(H,27,31)
InChIKey : JGJABGSOYWQCSC-UHFFFAOYSA-N
Other name(s) : GTPL8550,SCHEMBL8254631,BDBM50324512,Compound 24dd [PMID: 20684603]
MW : 455.33
Formula : C22H20Cl2N6O
CAS_number :
PubChem : 46900258
UniChem : JGJABGSOYWQCSC-UHFFFAOYSA-N
IUPHAR : 8550
Wikipedia :
Families : CHEMBL1215376 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture :
Protein : human-DPP4 || human-DPP8
Title : Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors - Meng_2010_J.Med.Chem_53_5620 |
Author(s) : Meng W , Brigance RP , Chao HJ , Fura A , Harrity T , Marcinkeviciene J , O'Connor SP , Tamura JK , Xie D , Zhang Y , Klei HE , Kish K , Weigelt CA , Turdi H , Wang A , Zahler R , Kirby MS , Hamann LG |
Ref : Journal of Medicinal Chemistry , 53 :5620 , 2010 |
Abstract : Meng_2010_J.Med.Chem_53_5620 |
ESTHER : Meng_2010_J.Med.Chem_53_5620 |
PubMedSearch : Meng_2010_J.Med.Chem_53_5620 |
PubMedID: 20684603 |
Gene_locus related to this paper: human-DPP4 |