Type : Pyrimidine,Morpholine
Chemical_Nomenclature : [6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl]-morpholin-4-ylmethanone
Canonical SMILES : CC1=NC2=NC(=CN2C(=C1CN)C3=C(C=C(C=C3)Cl)Cl)C(=O)N4CCOCC4
InChI : InChI=1S\/C19H19Cl2N5O2\/c1-11-14(9-22)17(13-3-2-12(20)8-15(13)21)26-10-16(24-19(26)23-11)18(27)25-4-6-28-7-5-25\/h2-3,8,10H,4-7,9,22H2,1H3
InChIKey : MNRQGIJBOGTUFQ-UHFFFAOYSA-N || MNRQGIJBOGTUFQ-UHFFFAOYSA-O
Other name(s) : SCHEMBL1408062,BDBM50324517,(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone,6A5,Compound 24c [PMID: 20684603]
MW : 420.29
Formula : C19H19Cl2N5O2
CAS_number :
PubChem : 11546261, 46840176, 72200262
UniChem : MNRQGIJBOGTUFQ-UHFFFAOYSA-N || MNRQGIJBOGTUFQ-UHFFFAOYSA-O
IUPHAR :
Wikipedia :
Families : CHEMBL1214943 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 3NOX Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone
Protein : human-DPP4 || human-DPP8
Title : Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors - Meng_2010_J.Med.Chem_53_5620 |
Author(s) : Meng W , Brigance RP , Chao HJ , Fura A , Harrity T , Marcinkeviciene J , O'Connor SP , Tamura JK , Xie D , Zhang Y , Klei HE , Kish K , Weigelt CA , Turdi H , Wang A , Zahler R , Kirby MS , Hamann LG |
Ref : Journal of Medicinal Chemistry , 53 :5620 , 2010 |
Abstract : Meng_2010_J.Med.Chem_53_5620 |
ESTHER : Meng_2010_J.Med.Chem_53_5620 |
PubMedSearch : Meng_2010_J.Med.Chem_53_5620 |
PubMedID: 20684603 |
Gene_locus related to this paper: human-DPP4 |