C12-myristoyl-MAG-like-phosphonate
mimics the Monoacylglycerol MAG of identical size (here the 1-myristoylglycerol Monomyristin (C14:0)). The adduct on the active serine lacks the leaving group 4-nitrophenol
General
Type : Organophosphate,pNP,Analogue of substrate,Lipase inhibitor,Azido
Chemical_Nomenclature : 3-[dodecoxy(hydroxy)phosphoryl]propylimino-iminoazanium
Canonical SMILES : CCCCCCCCCCCCOP(=O)(CCCN=[N+]=N)O
InChI : InChI=1S\/C15H32N3O3P\/c1-2-3-4-5-6-7-8-9-10-11-14-21-22(19,20)15-12-13-17-18-16\/h16H,2-15H2,1H3\/p+1
InChIKey : BEUWZXAEJRVUSA-UHFFFAOYSA-O
Other name(s) : dodecyl 4-nitrophenyl (3-azidopropyl)phosphonate,Dodecyl Hydrogen (S)-(3-Azidopropyl)phosphonate,1QX
MW : 334.42 || 454,50
Formula : C15H33N3O3P+ || C21H35N4O5P
CAS_number :
PubChem : 71710907
UniChem : BEUWZXAEJRVUSA-UHFFFAOYSA-O
IUPHAR :
Wikipedia :
Target
Families : C12-myristoyl-MAG-like-phosphonate ligand of proteins in family: CarbLipBact_2
Stucture : 4KE7 Crystal structure of monoacylglycerol lipase from Bacillus sp. H257 in complex with an 1-myristoyl glycerol analogue
Protein : bac25-mglp
References (1)
| Title : Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase - Rengachari_2013_J.Biol.Chem_288_31093 |
| Author(s) : Rengachari S , Aschauer P , Schittmayer M , Mayer N , Gruber K , Breinbauer R , Birner-Gruenberger R , Dreveny I , Oberer M |
| Ref : Journal of Biological Chemistry , 288 :31093 , 2013 |
| Abstract : Rengachari_2013_J.Biol.Chem_288_31093 |
| ESTHER : Rengachari_2013_J.Biol.Chem_288_31093 |
| PubMedSearch : Rengachari_2013_J.Biol.Chem_288_31093 |
| PubMedID: 24014019 |
| Gene_locus related to this paper: bac25-mglp |