Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: BemPPOX

General
Type Oxadiazol, Phenoxyphenyl
Chemical_Nomenclature 3-(3-phenoxyphenyl)-5-(2-phenylmethoxyethoxy)-1,3,4-oxadiazol-2-one
Canonical SMILES C1=CC=C(C=C1)COCCOC2=NN(C(=O)O2)C3=CC(=CC=C3)OC4=CC=CC=C4
InChI InChI=1S/C23H20N2O5/c26-23-25(19-10-7-13-21(16-19)29-20-11-5-2-6-12-20)24-22(30-23)28-15-14-27-17-18-8-3-1-4-9-18/h1-13,16H,14-15,17H2
InChIKey MNELGUVPZVFXCB-UHFFFAOYSA-N
Other name(s) 5-(2-(Benzyloxy)ethoxy)-3-(3-PhenoxyPhenyl)-1,3,4-Oxadiazol-2(3H)-one ; CHEMBL4756536 ; AKOS040747939
________________________________________________________________________________________________
MW|404.4
Formula|C23H20N2O5
CAS_number|1998101-23-7
PubChem|132838385
UniChem|MNELGUVPZVFXCB-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | BemPPOX ligand of proteins in family: Acidic_Lipase
Protein | canfa-1lipg, human-LIPF

References:
Search PubMed for references concerning: BemPPOX
    Title: Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus
    Madani A, Mallick I, Guy A, Crauste C, Durand T, Fourquet P, Audebert S, Camoin L, Canaan S, Cavalier JF
    Ref: PLoS ONE, 15:e0238178, 2020 : PubMed

            

    Title: Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration
    Lemarie F, Cavalier JF, Garcia C, Boissel F, Point V, Catheline D, Legrand P, Carriere F, Rioux V
    Ref: Biochimica & Biophysica Acta, 1861:1111, 2016 : PubMed

            

    Title: Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis
    Point V, Benarouche A, Zarrillo J, Guy A, Magnez R, Fonseca L, Raux B, Leclaire J, Buono G and Cavalier JF <5 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 123:834, 2016 : PubMed