Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Bambuterol

Hydrolysis of Bambuterol 81732-65-2 by butyrylcholinesterase produce terbutaline 23031-25-6 which is a broncho-dilatator. Bambuterol is a BChE inhibitor and a weak substrate. There are derivatives of Bambuterol: Bambuterol methyl boronate CAS 325837-05-6, Bambuterol, trimethylsilyl ether, 325836-76-8 ; Bambuterol, N-trifluoroacetyl-O-trimethylsilyl deriv., 325836-96-2. Nb-Agonists are synthetic molecules used for the treatment of pulmonary disorders as well as tocolytic agents in human and veterinary medicine. Apart from their clinical use and therapeutic value, Nb-agonists are compounds with a high potential for misuse, both in sport and zootechnics, due to the stimulation on the central nervous system and promotion of certain anabolic effects when higher doses are administered A derivatization step is mandatory to convert the target analytes into compounds suitable for gas chromatography analysis


General
Type Carbamate, Drug, tert-Butyl, Not A/B H target, Pro-Drug
Chemical_Nomenclature [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
Canonical SMILES CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O.Cl
InChI InChI=1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H
InChIKey LBARATORRVNNQM-UHFFFAOYSA-N
Other name(s) bis-dimethyl-carbamate of terbutaline ; Bambec ; Bambuterolum ; Oxeol ; 81732-65-2 ; Prestwick0_000361 ; Prestwick1_000361 ; SPBio_002402
________________________________________________________________________________________________
MW|367.4
Formula|C18H29N3O5
CAS_number|81732-65-2
PubChem|54766, 54765
UniChem|LBARATORRVNNQM-UHFFFAOYSA-N
IUPHAR|6601
Wikipedia|Bambuterol

Target
Families | Bambuterol ligand of proteins in family: BCHE

References:
Search PubMed for references concerning: Bambuterol

18 more
    Title: Pharmacokinetics of bambuterol in subjects homozygous for the atypical gene for plasma cholinesterase
    Bang U, Nyberg L, Rosenborg J, Viby-Mogensen J
    Ref: British Journal of Clinical Pharmacology, 45:479, 1998 : PubMed

            

    Title: The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium-induced neuromuscular blockade in genotypically normal patients
    Bang U, Viby-Mogensen J, Wiren JE, Skovgaard LT
    Ref: Acta Anaesthesiologica Scandinavica, 34:596, 1990 : PubMed

            

    Title: The effect of bambuterol on plasma cholinesterase activity and suxamethonium-induced neuromuscular blockade in subjects heterozygous for abnormal plasma cholinesterase
    Bang U, Viby-Mogensen J, Wiren JE
    Ref: Acta Anaesthesiologica Scandinavica, 34:600, 1990 : PubMed

            


human-ACHE
MutationKiKsiIc50SubstrateConditionPaper
WT - - 41000 & 5000 nM Acetylthiocholine 50mM KP pH8 T37C Tunek_1988_Drug.Metab.Dispos_16_759

human-BCHE
MutationKiKsiIc50SubstrateConditionPaper
WT - - 17 & 3 nM Butyrylthiocholine 50mM KP pH8 T37C Tunek_1988_Drug.Metab.Dispos_16_759

WT Kinetics
Kinetic parametersKiKsiIc50SubstrateConditionsPapers
human-ACHE--41000 & 5000 nM Acetylthiocholine 50mM KP pH8 T37C Tunek_1988_Drug.Metab.Dispos_16_759
human-BCHE--17 & 3 nM Butyrylthiocholine 50mM KP pH8 T37C Tunek_1988_Drug.Metab.Dispos_16_759