Hydrolysis of Bambuterol 81732-65-2 by butyrylcholinesterase produce terbutaline 23031-25-6 which is a broncho-dilatator. Bambuterol is a BChE inhibitor and a weak substrate. There are derivatives of Bambuterol: Bambuterol methyl boronate CAS 325837-05-6, Bambuterol, trimethylsilyl ether, 325836-76-8 ; Bambuterol, N-trifluoroacetyl-O-trimethylsilyl deriv., 325836-96-2. Nb-Agonists are synthetic molecules used for the treatment of pulmonary disorders as well as tocolytic agents in human and veterinary medicine. Apart from their clinical use and therapeutic value, Nb-agonists are compounds with a high potential for misuse, both in sport and zootechnics, due to the stimulation on the central nervous system and promotion of certain anabolic effects when higher doses are administered A derivatization step is mandatory to convert the target analytes into compounds suitable for gas chromatography analysis
Type : Carbamate,Drug,tert-Butyl,Not A\/B H target,Pro-Drug
Chemical_Nomenclature : [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
Canonical SMILES : CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O.Cl
InChI : InChI=1S\/C18H29N3O5.ClH\/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7\;\/h8-10,15,19,22H,11H2,1-7H3\;1H
InChIKey : LBARATORRVNNQM-UHFFFAOYSA-N
Other name(s) : bis-dimethyl-carbamate of terbutaline,Bambec,Bambuterolum,Oxeol,81732-65-2,Prestwick0_000361,Prestwick1_000361,SPBio_002402
MW : 367.4
Formula : C18H29N3O5
CAS_number : 81732-65-2
UniChem : LBARATORRVNNQM-UHFFFAOYSA-N
IUPHAR : 6601
Wikipedia : Bambuterol
Title : Exploring the Active Sites of Cholinesterases by Inhibition with Bambuterol and Haloxon - Kovarik_2003_Croatica.Chem.Acta_76_63 |
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Ref : Croatica Chemica Acta , 76 :63 , 2003 |
Abstract : Kovarik_2003_Croatica.Chem.Acta_76_63 |
ESTHER : Kovarik_2003_Croatica.Chem.Acta_76_63 |
PubMedSearch : Kovarik_2003_Croatica.Chem.Acta_76_63 |
PubMedID: |
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Author(s) : Xie W , Stribley JA , Chatonnet A , Wilder PJ , Rizzino A , McComb RD , Taylor P , Hinrichs SH , Lockridge O |
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Title : Amino acid residues involved in the interaction of acetylcholinesterase and butyrylcholinesterase with the carbamates Ro 02-0683 and bambuterol, and with terbutaline - Kovarik_1999_Biochim.Biophys.Acta_1433_261 |
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Author(s) : D'Alonzo GE , Smolensky MH , Feldman S , Gnosspelius Y , Karlsson K |
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Author(s) : Layer PG , Weikert T , Alber R |
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Author(s) : Loewenstein Y , Gnatt A , Neville LF , Soreq H |
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Author(s) : Loewenstein Y , Gnatt A , Neville LF , Zakut H , Soreq H |
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