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Inhibitor Report for: Aromatic-tertiary-amine-17c

IC50 eqBChE 0.22 +/- 0.018 microM, IC50 human-BCHE 0.016 +/- 0.006 microM


General
Type Naphthalen, Carboxamide
Chemical_Nomenclature N-(2-methylphenyl)-2-[2-methylpropyl(naphthalen-2-ylmethyl)amino]acetamide
Canonical SMILES CC1=CC=CC=C1NC(=O)CN(CC2=CC3=CC=CC=C3C=C2)CC(C)C
InChI InChI=1S/C24H28N2O/c1-18(2)15-26(17-24(27)25-23-11-7-4-8-19(23)3)16-20-12-13-21-9-5-6-10-22(21)14-20/h4-14,18H,15-17H2,1-3H3,(H,25,27)
InChIKey ULIOAMNTKXKLNZ-UHFFFAOYSA-N
Other name(s) 2-(isobutyl (naphthalen-2-ylmethyl)amino)-N-(o-tolyl)acetamide, 17c
________________________________________________________________________________________________
MW|360.5
Formula|C24H28N2O
CAS_number|
PubChem|156786229
UniChem|ULIOAMNTKXKLNZ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Aromatic-tertiary-amine-17c ligand of proteins in family: BCHE
Protein | human-BCHE

References:
Search PubMed for references concerning: Aromatic-tertiary-amine-17c
    Title: Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease
    Lu X, Qin N, Liu Y, Du C, Feng F, Liu W, Chen Y, Sun H
    Ref: Eur Journal of Medicinal Chemistry, 243:114729, 2022 : PubMed