ArisugacinA
Mycotoxin purified from culture of fungus Penicillium sp. FO-4259 growing on rice related to Territeme B
General
Type : Natural,Meroterpenoid
Chemical_Nomenclature : (4aR,6aR,12aS,12bS)-9-(4-methoxyphenyl)-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-4a,6,6a,12,12a,12b-hexahydro-4H,11H-benzo[f]pyrano[4,3-b]chromene-1,11(5H)-dione
Canonical SMILES : CC1(C=CC(=O)C2(C1(CCC3(C2(CC4=C(O3)C=C(OC4=O)C5=CC(=C(C=C5)OC)OC)O)C)O)C)C
InChI : InChI=1S\/C28H32O8\/c1-24(2)10-9-22(29)26(4)27(24,31)12-11-25(3)28(26,32)15-17-20(36-25)14-19(35-23(17)30)16-7-8-18(33-5)21(13-16)34-6\/h7-10,13-14,31-32H,11-12,15H2,1-6H3\/t25-,26+,27-,28-\/m1\/s1
InChIKey : MIHBCQWIBJDVPX-JUDWXZBOSA-N
Other name(s) :
MW : 492.20
Formula : C28H32O8
CAS_number :
PubChem : 10255275
UniChem : MIHBCQWIBJDVPX-JUDWXZBOSA-N
IUPHAR :
Wikipedia :
Target
References (5)
| Title : Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin - Degen_1999_Bioorg.Med.Chem.Lett_9_973 |
| Author(s) : Degen SJ , Mueller KL , Shen HC , Mulder JA , Golding GM , Wei LL , Zificsak CA , Neeno-Eckwall A , Hsung RP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 9 :973 , 1999 |
| Abstract : Degen_1999_Bioorg.Med.Chem.Lett_9_973 |
| ESTHER : Degen_1999_Bioorg.Med.Chem.Lett_9_973 |
| PubMedSearch : Degen_1999_Bioorg.Med.Chem.Lett_9_973 |
| PubMedID: 10230623 |
| Title : Arisugacins, selective acetylcholinesterase inhibitors of microbial origin - Otoguro_1997_Pharmacol.Ther_76_45 |
| Author(s) : Otoguro K , Kuno F , Omura S |
| Ref : Pharmacol Ther , 76 :45 , 1997 |
| Abstract : Otoguro_1997_Pharmacol.Ther_76_45 |
| ESTHER : Otoguro_1997_Pharmacol.Ther_76_45 |
| PubMedSearch : Otoguro_1997_Pharmacol.Ther_76_45 |
| PubMedID: 9535168 |
| Title : Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity - Kuno_1996_J.Antibiotics_49_742 |
| Author(s) : Kuno F , Otoguro K , Shiomi K , Iwai Y , Omura S |
| Ref : Journal of Antibiotics , 49 :742 , 1996 |
| Abstract : Kuno_1996_J.Antibiotics_49_742 |
| ESTHER : Kuno_1996_J.Antibiotics_49_742 |
| PubMedSearch : Kuno_1996_J.Antibiotics_49_742 |
| PubMedID: 882350 |
| Title : Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation - Kuno_1996_J.Antibiotics_49_748 |
| Author(s) : Kuno F , Shiomi K , Otoguro K , Sunazuka T , Omura S |
| Ref : Journal of Antibiotics , 49 :748 , 1996 |
| Abstract : Kuno_1996_J.Antibiotics_49_748 |
| ESTHER : Kuno_1996_J.Antibiotics_49_748 |
| PubMedSearch : Kuno_1996_J.Antibiotics_49_748 |
| PubMedID: 8823505 |