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Inhibitor Report for: Aricept~Donepezil~E2020

Treatment of Alzheimer Disease, trademark is Aricept Reversible inhibitor of AChE but not of BChE


General
Type Derivative of Donepezil, Piperidine, Drug, Inden
Chemical_Nomenclature 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
Canonical SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChI InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
InChIKey XWAIAVWHZJNZQQ-UHFFFAOYSA-N
Other name(s) Donepezil hydrochloride ; DPZ ; Donepezilo ; Donepezilum ; 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine ; (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one ; Donepezil ; E2020 ; Aricept
________________________________________________________________________________________________
MW|415.953
Formula|C24H30ClNO3
CAS_number|120011-70-3, 120014-06-4
PubChem|5741, 3152
UniChem|XWAIAVWHZJNZQQ-UHFFFAOYSA-N
IUPHAR|6599
Wikipedia|Donepezil

Target
Families | Aricept~Donepezil~E2020 ligand of proteins in family: ACHE
Stucture | 4 structures (e.g. : 1EVE, 7E3H, 6O4W... more)
Protein | torca-ACHE, human-ACHE

References:
Search PubMed for references concerning: Aricept~Donepezil~E2020

51 more
    Title: Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients
    Zhang N, Gordon ML
    Ref: Clin Interv Aging, 13:1963, 2018 : PubMed

            

    Title: Use of donepezil in elderly patients with Alzheimer's disease--a Hawaii based study
    Alagiakrishnan K, Wong W, Blanchette PL
    Ref: Hawaii Med J, 59:57, 2000 : PubMed

            

    Title: Huperzine-A in capsules and tablets for treating patients with Alzheimer disease
    Xu SS, Cai ZY, Qu ZW, Yang RM, Cai YL, Wang GQ, Su XQ, Zhong XS, Cheng RY and Feng B <2 more author(s)>
    Ref: Zhongguo Yao Li Xue Bao, 20:486, 1999 : PubMed