Anagliptin
Anagliptin is an orally available, potent, selective inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Compared to vildagliptin, anagliptin caused longer lasting inhibition of DPP-4 activity
General
Type : Drug,Cyanide,Pyrrolidine,Gliptin,Pyrimidine,Carboxamide,Pyrazole
Chemical_Nomenclature : N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
Canonical SMILES : CC1=NN2C=C(C=NC2=C1)C(=O)NCC(C)(C)NCC(=O)N3CCCC3C#N
InChI : InChI=1S\/C19H25N7O2\/c1-13-7-16-21-9-14(11-26(16)24-13)18(28)22-12-19(2,3)23-10-17(27)25-6-4-5-15(25)8-20\/h7,9,11,15,23H,4-6,10,12H2,1-3H3,(H,22,28)\/t15-\/m0\/s1
InChIKey : LDXYBEHACFJIEL-HNNXBMFYSA-N
Other name(s) : Suiny,UNII-K726J96838,CHEMBL1929396,CHEMBL1929387,Anagliptin HCl
MW : 383.45
Formula : C19H25N7O2
CAS_number : 739366-20-2
PubChem : 44513473
UniChem : LDXYBEHACFJIEL-HNNXBMFYSA-N
IUPHAR :
Wikipedia :
Target
Families : Anagliptin ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 3WQH Crystal Structure of human DPP-IV in complex with Anagliptin
Protein : human-DPP4
References (2)
| Title : Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions - Watanabe_2015_J.Enzyme.Inhib.Med.Chem_30_981 |
| Author(s) : Watanabe YS , Yasuda Y , Kojima Y , Okada S , Motoyama T , Takahashi R , Oka M |
| Ref : J Enzyme Inhib Med Chem , 30 :981 , 2015 |
| Abstract : Watanabe_2015_J.Enzyme.Inhib.Med.Chem_30_981 |
| ESTHER : Watanabe_2015_J.Enzyme.Inhib.Med.Chem_30_981 |
| PubMedSearch : Watanabe_2015_J.Enzyme.Inhib.Med.Chem_30_981 |
| PubMedID: 26147347 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methyl pyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor - Kato_2011_Bioorg.Med.Chem_19_7221 |
| Author(s) : Kato N , Oka M , Murase T , Yoshida M , Sakairi M , Yamashita S , Yasuda Y , Yoshikawa A , Hayashi Y , Makino M , Takeda M , Mirensha Y , Kakigami T |
| Ref : Bioorganic & Medicinal Chemistry , 19 :7221 , 2011 |
| Abstract : Kato_2011_Bioorg.Med.Chem_19_7221 |
| ESTHER : Kato_2011_Bioorg.Med.Chem_19_7221 |
| PubMedSearch : Kato_2011_Bioorg.Med.Chem_19_7221 |
| PubMedID: 22019046 |