Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Acridine

Tricyclic amine-containing compound


General
Type Acridine, Quinoline
Chemical_Nomenclature Acridine, Dibenzo[b,e]pyridine;10azaantracene
Canonical SMILES C1=CC=C2C(=C1)C=C3C=CC=CC3=N2
InChI InChI=1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H
InChIKey DZBUGLKDJFMEHC-UHFFFAOYSA-N
Other name(s) 9-Azaanthracene ; 10-Azaanthracene ; Benzo[b]quinoline ; 2,3-Benzoquinoline ; Dibenzo(b,e)pyridine ; Dibenzo[b,e]pyridine ; 2,3,5,6-dibenzopyridine
________________________________________________________________________________________________
MW|179.2
Formula|C13H9N
CAS_number|260-94-6
PubChem|9215
UniChem|DZBUGLKDJFMEHC-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Acridine

Target
Families | Acridine ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Acridine
    Title: Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
    Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P
    Ref: Biochemistry, 32:12074, 1993 : PubMed

            


mouse-ACHE
MutationKiKsiIc50SubstrateConditionPaper
WT 6.1 & 2.2 uM 26 & 7 uM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074
Y337A 0.87 & 0.15 uM 3.4 & 0.8 uM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074
Y337F 20 & 4 uM 210 & 22 uM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074

mouse-BCHE
MutationKiKsiIc50SubstrateConditionPaper
WT 1.6 & 0.9 uM 5.4 & 3.6 uM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074

WT Kinetics
Kinetic parametersKiKsiIc50SubstrateConditionsPapers
mouse-ACHE6.1 & 2.2 uM26 & 7 uM- Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074
mouse-BCHE1.6 & 0.9 uM5.4 & 3.6 uM- Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074