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Inhibitor Report for: AS2586144

IC50 = 5.9 nM for rat sEH = 16nM for human sEH


General
Type Piperidine, Benzoate, Cyclopropyl
Chemical_Nomenclature 3-cyclopropyl-4-{4-[2-({[(1S,2R,5S)-6,6-dimethylbicyclo[3,1,1]heptan-2-yl]methyl}amino)-2-oxoethyl]piperidin-1-yl}benzoic acid monohydrochloride
Canonical SMILES CC1([C@@H]2CC[C@@H]([C@H]1C2)CNC(=O)CC3CCN(CC3)C4=C(C=C(C=C4)C(=O)O)C5CC5)C
InChI InChI=1S/C27H38N2O3/c1-27(2)21-7-5-20(23(27)15-21)16-28-25(30)13-17-9-11-29(12-10-17)24-8-6-19(26(31)32)14-22(24)18-3-4-18/h6,8,14,17-18,20-21,23H,3-5,7,9-13,15-16H2,1-2H3,(H,28,30)(H,31,32)/t20-,21-,23-/m1/s1
InChIKey TZTAAXZTTVCUFV-MQSCRBSSSA-N
Other name(s)
________________________________________________________________________________________________
MW|438.60
Formula|C27H38N2O3
CAS_number|
PubChem|
UniChem|TZTAAXZTTVCUFV-MQSCRBSSSA-N
IUPHAR|
Wikipedia|

Target
Families | AS2586144 ligand of proteins in family: Epoxide_hydrolase
Protein | human-EPHX2

References:
Search PubMed for references concerning: AS2586144
    Title: Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation
    Kodani SD, Morisseau C
    Ref: Biochimie, 159:59, 2019 : PubMed

            

    Title: Single administration of soluble epoxide hydrolase inhibitor suppresses neuroinflammation and improves neuronal damage after cardiac arrest in mice
    Taguchi N, Nakayama S, Tanaka M
    Ref: Neurosci Res, 111:56, 2016 : PubMed