AM3506
Inhibitor of FAAH (not alpha/beta hydrolase) IC50 2.4 nM; but not so bad MGLL inhibitor IC50 236nM
General
Type : FAAH inhibitor,Sulfur Compound,Sulfonyl
Chemical_Nomenclature : 5-(4-hydroxyphenyl)pentane-1-sulfonyl fluoride
Canonical SMILES : C1=CC(=CC=C1CCCCCS(=O)(=O)F)O
InChI : InChI=1S\/C11H15FO3S\/c12-16(14,15)9-3-1-2-4-10-5-7-11(13)8-6-10\/h5-8,13H,1-4,9H2
InChIKey : VCCAJGFVUCFGSD-UHFFFAOYSA-N
Other name(s) : CHEMBL2180821,5-(4-Hydroxyphenyl)Pentanesulfonyl Fluoride,AM-3506,SCHEMBL1171639,BDBM50399280
MW : 246.30
Formula : C11H15FO3S
CAS_number :
PubChem : 25017608
UniChem : VCCAJGFVUCFGSD-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : AM3506 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture :
Protein :
References (1)
| Title : Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats - Panlilio_2016_Psychopharmacology.(Berl)_233_1879 |
| Author(s) : Panlilio LV , Thorndike EB , Nikas SP , Alapafuja SO , Bandiera T , Cravatt BF , Makriyannis A , Piomelli D , Goldberg SR , Justinova Z |
| Ref : Psychopharmacology (Berl) , 233 :1879 , 2016 |
| Abstract : Panlilio_2016_Psychopharmacology.(Berl)_233_1879 |
| ESTHER : Panlilio_2016_Psychopharmacology.(Berl)_233_1879 |
| PubMedSearch : Panlilio_2016_Psychopharmacology.(Berl)_233_1879 |
| PubMedID: 26558620 |