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Inhibitor Report for: ACHE-GSK-3-27g

AChE: IC50 = 51.1 nM; GSK-3beta: IC50 = 89.3 nM


General
Type GSK-3 kinase inhibitor, Derivative of Tacrine, Multitarget
Chemical_Nomenclature 2-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptylamino]-6-(3-fluoropyridin-4-yl)-3-methylpyrimidin-4-one
Canonical SMILES CN1C(=O)C=C(N=C1NCCCCCCCNC2=C3CCCCC3=NC4=C2C=CC(=C4)Cl)C5=C(C=NC=C5)F
InChI InChI=1S/C30H34ClFN6O/c1-38-28(39)18-27(21-13-16-33-19-24(21)32)37-30(38)35-15-8-4-2-3-7-14-34-29-22-9-5-6-10-25(22)36-26-17-20(31)11-12-23(26)29/h11-13,16-19H,2-10,14-15H2,1H3,(H,34,36)(H,35,37)
InChIKey LLNZCYJMOMQYIU-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|549.1
Formula|C30H34ClFN6O
CAS_number|
PubChem|154632938
UniChem|LLNZCYJMOMQYIU-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | ACHE-GSK-3-27g ligand of proteins in family: ACHE
Protein | human-ACHE

References:
Search PubMed for references concerning: ACHE-GSK-3-27g
    Title: Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease
    Yao H, Uras G, Zhang P, Xu S, Yin Y, Liu J, Qin S, Li X, Allen S and Xu J <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, :, 2021 : PubMed