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Inhibitor Report for: 9-Aminoacridine

Tricyclic amine-containing compound. Fluorescent dye used as a topical antiseptic


General
Type Acridine
Chemical_Nomenclature 9-Acridinamine
Canonical SMILES C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N
InChI InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
InChIKey XJGFWWJLMVZSIG-UHFFFAOYSA-N
Other name(s) Monacrin ; Aminacrine ; 9-Aminoacridine hemihydrate ; 9AA ; 5-aminoacridine ; aminoacridine ; 10-amino-5-azaanthracene ; aminacrin ; izoacridina ; 9-Acridinamine hemihydrate
________________________________________________________________________________________________
MW|194.2
Formula|C13H10N2
CAS_number|90-45-9
PubChem|7019
UniChem|XJGFWWJLMVZSIG-UHFFFAOYSA-N
IUPHAR|
Wikipedia|9-Aminoacridine

Target
Families | 9-Aminoacridine ligand of proteins in family: ACHE
Stucture | 1 structure: 6O4X: Binary complex of native hAChE with 9-aminoacridine

References:
Search PubMed for references concerning: 9-Aminoacridine
    Title: Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
    Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P
    Ref: Biochemistry, 32:12074, 1993 : PubMed

            

    Title: Morphological alterations in erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine and 9-aminoacridine
    Palmieri DA, Jacob RJ, Butterfield DA
    Ref: Biochemical & Biophysical Research Communications, 163:1351, 1989 : PubMed

            


mouse-ACHE
MutationKiKsiIc50SubstrateConditionPaper
WT 40 & 10 nM 110 & 30 nM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074
Y337A 2.3 & 0.7 nM 5.9 & 1.0 nM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074
Y337F 171 & 55 nM 710 & 150 nM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074

mouse-BCHE
MutationKiKsiIc50SubstrateConditionPaper
WT 22 & 10 nM 34 & 13 nM - Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074

WT Kinetics
Kinetic parametersKiKsiIc50SubstrateConditionsPapers
mouse-ACHE40 & 10 nM110 & 30 nM- Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074
mouse-BCHE22 & 10 nM34 & 13 nM- Acetylthiocholine 100mM NaP pH7.0 T22C Radic_1993_Biochemistry_32_12074