4-Oxo-beta-Lactam-A272-closed
In the structure the beta-lactam ring is described as open
General
Type : Piperazine,beta-Lactam,Naphthalen
Chemical_Nomenclature :
Canonical SMILES : C1=CC(=C2C(=C1)C=CC=C2)CN3CCN(CC3)CC4=CC(=CC=C4)N5C(C(C5=O)(CC)CC)=O
InChI : InChI=1S\/C29H33N3O2\/c1-3-29(4-2)27(33)32(28(29)34)25-13-7-9-22(19-25)20-30-15-17-31(18-16-30)21-24-12-8-11-23-10-5-6-14-26(23)24\/h5-14,19H,3-4,15-18,20-21H2,1-2H3
InChIKey : LHQXMLDWDMQPLM-UHFFFAOYSA-N
Other name(s) :
Target
Families : 4-Oxo-beta-Lactam-A272-closed ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 7A3J Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor A272
Protein : human-DPP8
References (1)
| Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R |
| Ref : Angew Chem Int Ed Engl , : , 2022 |
| Abstract : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| ESTHER : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| PubMedSearch : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| PubMedID: 36089535 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |