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Inhibitor Report for: 4-Oxo-beta-Lactam-A272

In the structure the beta-lactam ring is described as open


General
Type Piperazine, beta-Lactam, Naphthalen
Chemical_Nomenclature 2-ethyl-2-methanoyl-~{N}-[3-[[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methyl]phenyl]butanamide
Canonical SMILES CCC(CC)(C=O)C(=O)Nc1cccc(c1)CN2CCN(CC2)Cc3cccc4c3cccc4
InChI InChI=1S/C29H35N3O2/c1-3-29(4-2,22-33)28(34)30-26-13-7-9-23(19-26)20-31-15-17-32(18-16-31)21-25-12-8-11-24-10-5-6-14-27(24)25/h5-14,19,22H,3-4,15-18,20-21H2,1-2H3,(H,30,34)
InChIKey AGJXNYANCJMTSI-UHFFFAOYSA-N
Other name(s) QXK
________________________________________________________________________________________________
MW|457.61
Formula|C29H35N3O2
CAS_number|
PubChem|156022753
UniChem|AGJXNYANCJMTSI-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | 4-Oxo-beta-Lactam-A272 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture | 1 structure: 7A3J: Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor A272
Protein | human-DPP8

References:
Search PubMed for references concerning: 4-Oxo-beta-Lactam-A272
    Title: Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    Carvalho LAR, Ross B, Fehr L, Bolgi O, Wohrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R and Moreira R <8 more author(s)>
    Ref: Angew Chem Int Ed Engl, :, 2022 : PubMed