Sarin

The organophosphate nerve agents tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF) are among the most toxic chemical warfare agents known. The G-series nerve agents are named because German scientists led by Dr Gerhard Schraderfirst synthesized them during World War II, beginning with GA in 1936. GB was discovered next in 1938, followed by GD in 1944 and finally GF in 1949. The only other known nerve agent, O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX), V-series - VE, VG, VM, Russian VX). G-series nerve agents share a number of common physical and chemical properties. At room temperature, the G-series nerve agents are volatile liquids, making them a serious risk for 2 types of exposure: dermal contact with liquid nerve agent or inhalation of nerve agent vapor.Sarin is an acronym for the names of the members of the development team: Schrader. Ambrose. Rudriger. and van der Linde. The Germans deignated it T-I44 or Trilon-46. The United Slates eventually designated it GB

General

Type : Chemical Warfare Agent,Organophosphate,Nerve Agent G-series,Derivative of Sarin

Chemical_Nomenclature : 2-[fluoro(methyl)phosphoryl]oxypropane

Canonical SMILES : CC(C)OP(=O)(C)F

InChI : InChI=1S\/C4H10FO2P\/c1-4(2)7-8(3,5)6\/h4H,1-3H3

InChIKey : DYAHQFWOVKZOOW-UHFFFAOYSA-N

Other name(s) : Zarin,Sarin II,Trilone 46,IMPF,Methylphosphonofluoridic acid 1-methyl-ethyl esther,Isopropylmethylphosphonofluoridate,Isopropoxymethylphosphorylfluoride,GB,T144,T-144,Trilon-46


MW : 140.09

Formula : C4H10FO2P

CAS_number : 107-44-8

PubChem : 7871

UniChem : DYAHQFWOVKZOOW-UHFFFAOYSA-N

IUPHAR :

Wikipedia : Sarin

Target

Families : Sarin ligand of proteins in family: ACHE || BCHE || PAF-Acetylhydrolase || Carboxypeptidase_S10

Stucture :

Protein : human-ACHE || human-BCHE || human-CTSA

References (48)

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Author(s) : Jacquet P , Remy B , Bross RPT , van Grol M , Gaucher F , Chabriere E , De Koning MC , Daude D
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Abstract : Jacquet_2021_Int.J.Mol.Sci_22_
ESTHER : Jacquet_2021_Int.J.Mol.Sci_22_
PubMedSearch : Jacquet_2021_Int.J.Mol.Sci_22_
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Title : Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6 - McGuire_2021_Chem.Res.Toxicol_34_804
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ESTHER : McGuire_2021_Chem.Res.Toxicol_34_804
PubMedSearch : McGuire_2021_Chem.Res.Toxicol_34_804
PubMedID: 33538594
Gene_locus related to this paper: human-ACHE

Title : Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects - Blumenthal_2021_J.Biol.Chem__
Author(s) : Blumenthal DK , Cheng X , Fajer M , Ho KY , Rohrer J , Gerlits O , Taylor P , Juneja P , Kovalevsky A , Radic Z
Ref : Journal of Biological Chemistry , :101007 , 2021
Abstract : Blumenthal_2021_J.Biol.Chem__
ESTHER : Blumenthal_2021_J.Biol.Chem__
PubMedSearch : Blumenthal_2021_J.Biol.Chem__
PubMedID: 34324828
Gene_locus related to this paper: human-ACHE

Title : A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study - Bzdrenga_2021_Molecules_26_657
Author(s) : Bzdrenga J , Trenet E , Chantegreil F , Bernal K , Nachon F , Brazzolotto X
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Abstract : Bzdrenga_2021_Molecules_26_657
ESTHER : Bzdrenga_2021_Molecules_26_657
PubMedSearch : Bzdrenga_2021_Molecules_26_657
PubMedID: 33513869
Gene_locus related to this paper: 9bact-TtEst2

Title : Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A - Bouknight_2020_Biochem.Pharmacol__113980
Author(s) : Bouknight KD , Jurkouich KM , Compton JR , Khavrutskii IV , Guelta MA , Harvey SP , Legler PM
Ref : Biochemical Pharmacology , :113980 , 2020
Abstract : Bouknight_2020_Biochem.Pharmacol__113980
ESTHER : Bouknight_2020_Biochem.Pharmacol__113980
PubMedSearch : Bouknight_2020_Biochem.Pharmacol__113980
PubMedID: 32305437
Gene_locus related to this paper: human-CTSA

Title : Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network - John_2018_Forensic.Toxicol_36_61
Author(s) : John H , van der Schans MJ , Koller M , Spruit HET , Worek F , Thiermann H , Noort D
Ref : Forensic Toxicol , 36 :61 , 2018
Abstract : John_2018_Forensic.Toxicol_36_61
ESTHER : John_2018_Forensic.Toxicol_36_61
PubMedSearch : John_2018_Forensic.Toxicol_36_61
PubMedID: 29367863

Title : Sarin Exposures in A Cohort of British Military Participants in Human Experimental Research at Porton Down 1945-1987 - Keegan_2017_Ann.Work.Expo.Health_62_17
Author(s) : Keegan TJ , Carpenter LM , Brooks C , Langdon T , Venables KM
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Abstract : Keegan_2017_Ann.Work.Expo.Health_62_17
ESTHER : Keegan_2017_Ann.Work.Expo.Health_62_17
PubMedSearch : Keegan_2017_Ann.Work.Expo.Health_62_17
PubMedID: 29136135

Title : Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6 - Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
Author(s) : Allgardsson A , Berg L , Akfur C , Hornberg A , Worek F , Linusson A , Ekstrom F
Ref : Proc Natl Acad Sci U S A , 113 :5514 , 2016
Abstract : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
ESTHER : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
PubMedSearch : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
PubMedID: 27140636
Gene_locus related to this paper: human-ACHE

Title : Syrian gas attack reinforces need for better anti-sarin drugs -
Author(s) : Dolgin E
Ref : Nat Med , 19 :1194 , 2013
PubMedID: 24100968

Title : Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes - Samanta_2009_Biochem.Pharmacol_78_420
Author(s) : Samanta U , Kirby SD , Srinivasan P , Cerasoli DM , Bahnson BJ
Ref : Biochemical Pharmacology , 78 :420 , 2009
Abstract : Samanta_2009_Biochem.Pharmacol_78_420
ESTHER : Samanta_2009_Biochem.Pharmacol_78_420
PubMedSearch : Samanta_2009_Biochem.Pharmacol_78_420
PubMedID: 19394314
Gene_locus related to this paper: human-PLA2G7

Title : Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design - Ekstrom_2009_PLoS.One_4_e5957
Author(s) : Ekstrom F , Hornberg A , Artursson E , Hammarstrom LG , Schneider G , Pang YP
Ref : PLoS ONE , 4 :e5957 , 2009
Abstract : Ekstrom_2009_PLoS.One_4_e5957
ESTHER : Ekstrom_2009_PLoS.One_4_e5957
PubMedSearch : Ekstrom_2009_PLoS.One_4_e5957
PubMedID: 19536291
Gene_locus related to this paper: mouse-ACHE

Title : Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase - Bartling_2007_Toxicology_233_166
Author(s) : Bartling A , Worek F , Szinicz L , Thiermann H
Ref : Toxicology , 233 :166 , 2007
Abstract : Bartling_2007_Toxicology_233_166
ESTHER : Bartling_2007_Toxicology_233_166
PubMedSearch : Bartling_2007_Toxicology_233_166
PubMedID: 16904809

Title : Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes - Worek_2004_Biochem.Pharmacol_68_2237
Author(s) : Worek F , Thiermann H , Szinicz L , Eyer P
Ref : Biochemical Pharmacology , 68 :2237 , 2004
Abstract : Worek_2004_Biochem.Pharmacol_68_2237
ESTHER : Worek_2004_Biochem.Pharmacol_68_2237
PubMedSearch : Worek_2004_Biochem.Pharmacol_68_2237
PubMedID: 15498514

Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032
Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : Biochemistry , 38 :7032 , 1999
Abstract : Millard_1999_Biochemistry_38_7032
ESTHER : Millard_1999_Biochemistry_38_7032
PubMedSearch : Millard_1999_Biochemistry_38_7032
PubMedID: 10353814
Gene_locus related to this paper: torca-ACHE

Title : Effects of various drugs including organophosphorus compounds (OPC) and therapeutic compounds against OPC on DRL responding - Bizot_1998_Pharmacol.Biochem.Behav_59_1069
Author(s) : Bizot JC
Ref : Pharmacol Biochem Behav , 59 :1069 , 1998
Abstract : Bizot_1998_Pharmacol.Biochem.Behav_59_1069
ESTHER : Bizot_1998_Pharmacol.Biochem.Behav_59_1069
PubMedSearch : Bizot_1998_Pharmacol.Biochem.Behav_59_1069
PubMedID: 9586869

Title : Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase - Millard_1998_Biochemistry_37_237
Author(s) : Millard CB , Lockridge O , Broomfield CA
Ref : Biochemistry , 37 :237 , 1998
Abstract : Millard_1998_Biochemistry_37_237
ESTHER : Millard_1998_Biochemistry_37_237
PubMedSearch : Millard_1998_Biochemistry_37_237
PubMedID: 9425044
Gene_locus related to this paper: human-BCHE

Title : Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase -
Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998
PubMedID:
Gene_locus related to this paper: torca-ACHE

Title : A preliminary study on delayed vestibulo-cerebellar effects of Tokyo Subway Sarin Poisoning in relation to gender difference: frequency analysis of postural sway - Yokoyama_1998_J.Occup.Environ.Med_40_17
Author(s) : Yokoyama K , Araki S , Murata K , Nishikitani M , Okumura T , Ishimatsu S , Takasu N
Ref : J Occup Environ Med , 40 :17 , 1998
Abstract : Yokoyama_1998_J.Occup.Environ.Med_40_17
ESTHER : Yokoyama_1998_J.Occup.Environ.Med_40_17
PubMedSearch : Yokoyama_1998_J.Occup.Environ.Med_40_17
PubMedID: 9467116

Title : [Legionella pneumonia caused by aspiration of hot spring water after sarin exposure] - Kamimura_1998_Nihon.Kokyuki.Gakkai.Zasshi_36_278
Author(s) : Kamimura M , Katoh O , Kawata H , Kudo K , Yagishita Y , Niino H , Saitoh K , Saitoh A
Ref : Nihon Kokyuki Gakkai Zasshi , 36 :278 , 1998
Abstract : Kamimura_1998_Nihon.Kokyuki.Gakkai.Zasshi_36_278
ESTHER : Kamimura_1998_Nihon.Kokyuki.Gakkai.Zasshi_36_278
PubMedSearch : Kamimura_1998_Nihon.Kokyuki.Gakkai.Zasshi_36_278
PubMedID: 9656677

Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237
Author(s) : Worek F , Widmann R , Knopff O , Szinicz L
Ref : Archives of Toxicology , 72 :237 , 1998
Abstract : Worek_1998_Arch.Toxicol_72_237
ESTHER : Worek_1998_Arch.Toxicol_72_237
PubMedSearch : Worek_1998_Arch.Toxicol_72_237
PubMedID: 9587020

Title : Detection of the sarin hydrolysis product in formalin-fixed brain tissues of victims of the Tokyo subway terrorist attack - Matsuda_1998_Toxicol.Appl.Pharmacol_150_310
Author(s) : Matsuda Y , Nagao M , Takatori T , Niijima H , Nakajima M , Iwase H , Kobayashi M , Iwadate K
Ref : Toxicol Appl Pharmacol , 150 :310 , 1998
Abstract : Matsuda_1998_Toxicol.Appl.Pharmacol_150_310
ESTHER : Matsuda_1998_Toxicol.Appl.Pharmacol_150_310
PubMedSearch : Matsuda_1998_Toxicol.Appl.Pharmacol_150_310
PubMedID: 9653062

Title : Chronic neurobehavioral effects of Tokyo subway sarin poisoning in relation to posttraumatic stress disorder - Yokoyama_1998_Arch.Environ.Health_53_249
Author(s) : Yokoyama K , Araki S , Murata K , Nishikitani M , Okumura T , Ishimatsu S , Takasu N , White RF
Ref : Archives of Environmental Health , 53 :249 , 1998
Abstract : Yokoyama_1998_Arch.Environ.Health_53_249
ESTHER : Yokoyama_1998_Arch.Environ.Health_53_249
PubMedSearch : Yokoyama_1998_Arch.Environ.Health_53_249
PubMedID: 9709988

Title : Definitive evidence for the acute sarin poisoning diagnosis in the Tokyo subway - Nagao_1997_Toxicol.Appl.Pharmacol_144_198
Author(s) : Nagao M , Takatori T , Matsuda Y , Nakajima M , Iwase H , Iwadate K
Ref : Toxicol Appl Pharmacol , 144 :198 , 1997
Abstract : Nagao_1997_Toxicol.Appl.Pharmacol_144_198
ESTHER : Nagao_1997_Toxicol.Appl.Pharmacol_144_198
PubMedSearch : Nagao_1997_Toxicol.Appl.Pharmacol_144_198
PubMedID: 9169085

Title : Eighteen cases exposed to sarin in Matsumoto, Japan - Suzuki_1997_Intern.Med_36_466
Author(s) : Suzuki J , Kohno T , Tsukagosi M , Furuhata T , Yamazaki K
Ref : Intern Med , 36 :466 , 1997
Abstract : Suzuki_1997_Intern.Med_36_466
ESTHER : Suzuki_1997_Intern.Med_36_466
PubMedSearch : Suzuki_1997_Intern.Med_36_466
PubMedID: 9240494

Title : Sarin poisoning on Tokyo subway - Ohbu_1997_South.Med.J_90_587
Author(s) : Ohbu S , Yamashina A , Takasu N , Yamaguchi T , Murai T , Nakano K , Matsui Y , Mikami R , Sakurai K , Hinohara S
Ref : South Med J , 90 :587 , 1997
Abstract : Ohbu_1997_South.Med.J_90_587
ESTHER : Ohbu_1997_South.Med.J_90_587
PubMedSearch : Ohbu_1997_South.Med.J_90_587
PubMedID: 9191733

Title : [Acute poisoning by neuroparalytic agents and its long-term effects] - Ianno_1997_Med.Tr.Prom.Ekol_6_5
Author(s) : Ianno LV , Musiichuk Iu I
Ref : Med Tr Prom Ekol , 6 :5 , 1997
Abstract : Ianno_1997_Med.Tr.Prom.Ekol_6_5
ESTHER : Ianno_1997_Med.Tr.Prom.Ekol_6_5
PubMedSearch : Ianno_1997_Med.Tr.Prom.Ekol_6_5
PubMedID: 9273141

Title : Differential inhibition of the brain acetylcholinesterase molecular forms following sarin, soman and VX intoxication in laboratory rats - Bajgar_1997_Acta.Medica_40_89
Author(s) : Bajgar J
Ref : Acta Medica , 40 :89 , 1997
Abstract : Bajgar_1997_Acta.Medica_40_89
ESTHER : Bajgar_1997_Acta.Medica_40_89
PubMedSearch : Bajgar_1997_Acta.Medica_40_89
PubMedID: 9481881

Title : Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin - Worek_1995_Toxicology_95_123
Author(s) : Worek F , Kirchner T , Szinicz L
Ref : Toxicology , 95 :123 , 1995
Abstract : Worek_1995_Toxicology_95_123
ESTHER : Worek_1995_Toxicology_95_123
PubMedSearch : Worek_1995_Toxicology_95_123
PubMedID: 7825179

Title : Phosphotriesterase--a promising candidate for use in detoxification of organophosphates - Tuovinen_1994_Fundam.Appl.Toxicol_23_578
Author(s) : Tuovinen K , Kaliste-Korhonen E , Raushel FM , Hanninen O
Ref : Fundamental & Applied Toxicology , 23 :578 , 1994
Abstract : Tuovinen_1994_Fundam.Appl.Toxicol_23_578
ESTHER : Tuovinen_1994_Fundam.Appl.Toxicol_23_578
PubMedSearch : Tuovinen_1994_Fundam.Appl.Toxicol_23_578
PubMedID: 7867909

Title : Use of hemoperfusion in experimental intoxication with nerve agents - Monhart_1994_Artif.Organs_18_770
Author(s) : Monhart V , Fusek J , Brndiar M , Tlustakova M
Ref : Artif Organs , 18 :770 , 1994
Abstract : Monhart_1994_Artif.Organs_18_770
ESTHER : Monhart_1994_Artif.Organs_18_770
PubMedSearch : Monhart_1994_Artif.Organs_18_770
PubMedID: 7832660

Title : Erythrocyte and plasma cholinesterase activity in male and female rhesus monkeys before and after exposure to sarin - Woodard_1994_Fundam.Appl.Toxicol_23_342
Author(s) : Woodard CL , Calamaio CA , Kaminskis A , Anderson DR , Harris LW , Martin DG
Ref : Fundamental & Applied Toxicology , 23 :342 , 1994
Abstract : Woodard_1994_Fundam.Appl.Toxicol_23_342
ESTHER : Woodard_1994_Fundam.Appl.Toxicol_23_342
PubMedSearch : Woodard_1994_Fundam.Appl.Toxicol_23_342
PubMedID: 7835534

Title : Action of nerve agents to cholinesterases - Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_63
Author(s) : Bajgar J
Ref : Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity , 36 :63 , 1993
Abstract : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_63
ESTHER : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_63
PubMedSearch : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_63
PubMedID: 8165432

Title : Long-term effects of the anticholinesterases sarin and soman on latencies of muscle action potentials in mouse diaphragm muscle - Smith_1993_J.Pharm.Pharmacol_45_176
Author(s) : Smith AP
Ref : J Pharm Pharmacol , 45 :176 , 1993
Abstract : Smith_1993_J.Pharm.Pharmacol_45_176
ESTHER : Smith_1993_J.Pharm.Pharmacol_45_176
PubMedSearch : Smith_1993_J.Pharm.Pharmacol_45_176
PubMedID: 8097774

Title : Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX - Gupta_1992_Neurotoxicol_13_649
Author(s) : Gupta RC , Dettbarn WD
Ref : Neurotoxicology , 13 :649 , 1992
Abstract : Gupta_1992_Neurotoxicol_13_649
ESTHER : Gupta_1992_Neurotoxicol_13_649
PubMedSearch : Gupta_1992_Neurotoxicol_13_649
PubMedID: 1475066

Title : Successful pretreatment\/therapy of soman, sarin and VX intoxication - Lennox_1992_Drug.Chem.Toxicol_15_271
Author(s) : Lennox WJ , Harris LW , Anderson DR , Solana RP , Murrow ML , Wade JV
Ref : Drug & Chemical Toxicology , 15 :271 , 1992
Abstract : Lennox_1992_Drug.Chem.Toxicol_15_271
ESTHER : Lennox_1992_Drug.Chem.Toxicol_15_271
PubMedSearch : Lennox_1992_Drug.Chem.Toxicol_15_271
PubMedID: 1459040

Title : The influence of inhibitors and other factors on cholinesterases - Bajgar_1991_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_34_5
Author(s) : Bajgar J
Ref : Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove , 34 :5 , 1991
Abstract : Bajgar_1991_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_34_5
ESTHER : Bajgar_1991_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_34_5
PubMedSearch : Bajgar_1991_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_34_5
PubMedID: 1759111

Title : Comparison of cholinergic and neuromuscular toxicity following acute exposure to sarin and VX in rat - Gupta_1991_Fundam.Appl.Toxicol_16_449
Author(s) : Gupta RC , Patterson GT , Dettbarn WD
Ref : Fundamental & Applied Toxicology , 16 :449 , 1991
Abstract : Gupta_1991_Fundam.Appl.Toxicol_16_449
ESTHER : Gupta_1991_Fundam.Appl.Toxicol_16_449
PubMedSearch : Gupta_1991_Fundam.Appl.Toxicol_16_449
PubMedID: 1855618

Title : The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog - Heppner_1991_Neuropharmacol_30_843
Author(s) : Heppner TJ , Fiekers JF
Ref : Neuropharmacology , 30 :843 , 1991
Abstract : Heppner_1991_Neuropharmacol_30_843
ESTHER : Heppner_1991_Neuropharmacol_30_843
PubMedSearch : Heppner_1991_Neuropharmacol_30_843
PubMedID: 1664071

Title : Anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by highly toxic organophosphorus compounds - Bokonjic_1991_Arh.Hig.Rada.Toksikol_42_359
Author(s) : Bokonjic D , Rosic N
Ref : Arh Hig Rada Toksikol , 42 :359 , 1991
Abstract : Bokonjic_1991_Arh.Hig.Rada.Toksikol_42_359
ESTHER : Bokonjic_1991_Arh.Hig.Rada.Toksikol_42_359
PubMedSearch : Bokonjic_1991_Arh.Hig.Rada.Toksikol_42_359
PubMedID: 1815490

Title : Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication - Harris_1991_Drug.Chem.Toxicol_14_265
Author(s) : Harris LW , Talbot BG , Lennox WJ , Anderson DR , Solana RP
Ref : Drug & Chemical Toxicology , 14 :265 , 1991
Abstract : Harris_1991_Drug.Chem.Toxicol_14_265
ESTHER : Harris_1991_Drug.Chem.Toxicol_14_265
PubMedSearch : Harris_1991_Drug.Chem.Toxicol_14_265
PubMedID: 1935706

Title : A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro - Alberts_1990_Eur.J.Pharmacol_184_191
Author(s) : Alberts P
Ref : European Journal of Pharmacology , 184 :191 , 1990
Abstract : Alberts_1990_Eur.J.Pharmacol_184_191
ESTHER : Alberts_1990_Eur.J.Pharmacol_184_191
PubMedSearch : Alberts_1990_Eur.J.Pharmacol_184_191
PubMedID: 2209712

Title : [The effect of the oxime HI-6 on miosis induced by topical administration of sarin and VX in the rabbit eye] - Macic_1990_Vojnosanit.Pregl_47_399
Author(s) : Macic I , Vojvodic V , Knezevic D , Maksimovic M
Ref : Vojnosanit Pregl , 47 :399 , 1990
Abstract : Macic_1990_Vojnosanit.Pregl_47_399
ESTHER : Macic_1990_Vojnosanit.Pregl_47_399
PubMedSearch : Macic_1990_Vojnosanit.Pregl_47_399
PubMedID: 2075700

Title : Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases - Silveira_1990_Toxicol.Appl.Pharmacol_103_474
Author(s) : Silveira CL , Eldefrawi AT , Eldefrawi ME
Ref : Toxicol Appl Pharmacol , 103 :474 , 1990
Abstract : Silveira_1990_Toxicol.Appl.Pharmacol_103_474
ESTHER : Silveira_1990_Toxicol.Appl.Pharmacol_103_474
PubMedSearch : Silveira_1990_Toxicol.Appl.Pharmacol_103_474
PubMedID: 2339420

Title : Histochemical demonstration of calcium accumulation in muscle fibres after experimental organophosphate poisoning - Inns_1990_Hum.Exp.Toxicol_9_245
Author(s) : Inns RH , Tuckwell NJ , Bright JE , Marrs TC
Ref : Hum Exp Toxicol , 9 :245 , 1990
Abstract : Inns_1990_Hum.Exp.Toxicol_9_245
ESTHER : Inns_1990_Hum.Exp.Toxicol_9_245
PubMedSearch : Inns_1990_Hum.Exp.Toxicol_9_245
PubMedID: 2390321

Title : Comparison of the effects of diisopropylfluorophosphate, sarin, soman, and tabun on toxicity and brain acetylcholinesterase activity in mice - Tripathi_1989_J.Toxicol.Environ.Health_26_437
Author(s) : Tripathi HL , Dewey WL
Ref : J Toxicol Environ Health , 26 :437 , 1989
Abstract : Tripathi_1989_J.Toxicol.Environ.Health_26_437
ESTHER : Tripathi_1989_J.Toxicol.Environ.Health_26_437
PubMedSearch : Tripathi_1989_J.Toxicol.Environ.Health_26_437
PubMedID: 2709438

Title : Reactivation of Sarin- or Soman-phosphonylated human acetylcholinesterase by bis-pyridinium mono-oximes -
Author(s) : Sun MC , Li FZ , Chou TC
Ref : Biochemical Pharmacology , 35 :347 , 1986
PubMedID: 3942603

Title : Studies on low dose sub-acute administration of soman, sarin and tabun in the rat - Dulaney_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_234
Author(s) : Dulaney MD, Jr. , Hoskins B , Ho IK
Ref : Acta Pharmacologica et Toxicologica (Copenh) , 57 :234 , 1985
Abstract : Dulaney_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_234
ESTHER : Dulaney_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_234
PubMedSearch : Dulaney_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_234
PubMedID: 4083033

Title : Formation of nonreactivatible isopropylmethylphosphonofluoridate-inhibited acetylcholinesterase -
Author(s) : Smith TE , Usdin E
Ref : Biochemistry , 5 :2914 , 1966
PubMedID: 5961880