Human RBC AChE, IC50 [microM] 0.224+/-0.017; Equine Serum BChE, IC50 [microM] 0.0104+/-0.0013; Porcine Liver CES, [%inhibition at 20microM] 29.5+/-2.5
Type : Multitarget,Derivative of Tacrine,Alkyl linked bis-ligand,Antioxidant,Salicylic
Chemical_Nomenclature : N-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl)salicylamide
Canonical SMILES : C1=CC=C2C(=C1)C=C3C(=N2)CCCC3NCCCCCCCCNC(=O)C4=C(C=CC=C4)O
InChI : InChI=1S\/C28H35N3O2\/c32-27-17-8-6-13-22(27)28(33)30-19-10-4-2-1-3-9-18-29-25-15-11-16-26-23(25)20-21-12-5-7-14-24(21)31-26\/h5-8,12-14,17,20,25,29,32H,1-4,9-11,15-16,18-19H2,(H,30,33)
InChIKey : LZLGDQZILKXGLJ-UHFFFAOYSA-N
Other name(s) : 6d
MW : 445.60
Formula : C28H35N3O2
CAS_number :
PubChem :
UniChem : LZLGDQZILKXGLJ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : Salicylamide-8-Tacrine ligand of proteins in family: ACHE || BCHE
Stucture :
Protein : human-ACHE || human-BCHE
Title : Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease - Grishchenko_2022_ChemMedChem__e202200080 |
Author(s) : Grishchenko MV , Makhaeva GF , Burgart YV , Rudakova EV , Boltneva NP , Kovaleva NV , Serebryakova OG , Lushchekina SV , Astakhova TY , Zhilina EF , Shchegolkov EV , Richardson RJ , Saloutin VI |
Ref : ChemMedChem , :e202200080 , 2022 |
Abstract : Grishchenko_2022_ChemMedChem__e202200080 |
ESTHER : Grishchenko_2022_ChemMedChem__e202200080 |
PubMedSearch : Grishchenko_2022_ChemMedChem__e202200080 |
PubMedID: 35322571 |