SM-10888
Citrate salt (2 citrate 3SM-10888) || IC50 AChE 0.02884 microM
General
Type : Acridine,Derivative of Tacrine
Chemical_Nomenclature : 9-amino-8-fluoro-1,2,3,4-tetrahydro-2,4-methanoacridine
Canonical SMILES : C1C2CC1C3=NC4=C(C(=CC=C4)F)C(=C3C2)N.C1C2CC1C3=NC4=C(C(=CC=C4)F)C(=C3C2)N.C1C2CC1C3=NC4=C(C(=CC=C4)F)C(=C3C2)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI : InChI=1S\/3C14H13FN2.2C6H8O7\/c3*15-10-2-1-3-11-12(10)13(16)9-6-7-4-8(5-7)14(9)17-11\;2*7-3(8)1-6(13,5(11)12)2-4(9)10\/h3*1-3,7-8H,4-6H2,(H2,16,17)\;2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey : VHIZLRDZOSUTLU-UHFFFAOYSA-N
Other name(s) : 8-Fluoro-1,2,3,4-tetrahydro-2,4-methanoacridin-9-amine,CHEMBL1161714,SM 10888,SCHEMBL7654421
MW : 228.265 || 228.26
Formula : C14H13FN2
CAS_number : 129297-21-8 || 116208-23-2
UniChem : VHIZLRDZOSUTLU-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (6)
| Title : Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis - Martin-Santamaria_2004_J.Med.Chem_47_4471 |
| Author(s) : Martin-Santamaria S , Munoz-Muriedas J , Luque FJ , Gago F |
| Ref : Journal of Medicinal Chemistry , 47 :4471 , 2004 |
| Abstract : Martin-Santamaria_2004_J.Med.Chem_47_4471 |
| ESTHER : Martin-Santamaria_2004_J.Med.Chem_47_4471 |
| PubMedSearch : Martin-Santamaria_2004_J.Med.Chem_47_4471 |
| PubMedID: 15317459 |
| Title : Pharmacokinetics of SM-10888 and its metabolites depending on their physicochemical properties - Yabuki_1994_Drug.Metab.Dispos_22_294 |
| Author(s) : Yabuki M , Mine T , Iba K , Nakatsuka I , Yoshitake A |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 22 :294 , 1994 |
| Abstract : Yabuki_1994_Drug.Metab.Dispos_22_294 |
| ESTHER : Yabuki_1994_Drug.Metab.Dispos_22_294 |
| PubMedSearch : Yabuki_1994_Drug.Metab.Dispos_22_294 |
| PubMedID: 8013284 |
| Title : Metabolism of a tetrahydroaminoacridine derivative (SM-10888) in rat: structural analysis of an N-glucuronide of SM-10888 and an O-glucuronide of hydroxylated SM-10888 by FAB-MS\/MS - Yabuki_1993_Xenobiotica_23_1367 |
| Author(s) : Yabuki M , Mine T , Iba K , Nakatsuka I , Yoshitake A |
| Ref : Xenobiotica , 23 :1367 , 1993 |
| Abstract : Yabuki_1993_Xenobiotica_23_1367 |
| ESTHER : Yabuki_1993_Xenobiotica_23_1367 |
| PubMedSearch : Yabuki_1993_Xenobiotica_23_1367 |
| PubMedID: 8135040 |
| Title : Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease - Xu_1991_Neurosci.Lett_123_179 |
| Author(s) : Xu M , Nakamura Y , Yamamoto T , Natori K , Irie T , Utsumi H , Kato T |
| Ref : Neuroscience Letters , 123 :179 , 1991 |
| Abstract : Xu_1991_Neurosci.Lett_123_179 |
| ESTHER : Xu_1991_Neurosci.Lett_123_179 |
| PubMedSearch : Xu_1991_Neurosci.Lett_123_179 |
| PubMedID: 2027531 |
| Title : Pharmacological and biochemical assessment of SM-10888, a novel cholinesterase inhibitor - Natori_1990_Jpn.J.Pharmacol_53_145 |
| Author(s) : Natori K , Okazaki Y , Irie T , Katsube J |
| Ref : Japanese Journal of Pharmacology , 53 :145 , 1990 |
| Abstract : Natori_1990_Jpn.J.Pharmacol_53_145 |
| ESTHER : Natori_1990_Jpn.J.Pharmacol_53_145 |
| PubMedSearch : Natori_1990_Jpn.J.Pharmacol_53_145 |
| PubMedID: 2385001 |
| Title : Effect of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice - Okazaki_1990_Jpn.J.Pharmacol_53_211 |
| Author(s) : Okazaki Y , Natori K , Irie T , Katsube J |
| Ref : Japanese Journal of Pharmacology , 53 :211 , 1990 |
| Abstract : Okazaki_1990_Jpn.J.Pharmacol_53_211 |
| ESTHER : Okazaki_1990_Jpn.J.Pharmacol_53_211 |
| PubMedSearch : Okazaki_1990_Jpn.J.Pharmacol_53_211 |
| PubMedID: 2385006 |