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Inhibitor Report for: N-10-Phenothiazine-1-Naphtyl-carbamate

(Compound 28 Darvesh et al. 2008) Ki BCHE 0.036 micro M (for comparison Donepezil 2.21 for BCHE and 0.024 for ACHE), Ka ACHE 1650 M-1min-1 (for comparison rivastigmine 1130 M-1min-1)


General
Type Phenothiazine, Carbamate, Sulfur Compound
Chemical_Nomenclature naphthalen-1-yl phenothiazine-10-carboxylate
Canonical SMILES C1=CC=C2C(=C1)C=CC=C2OC(=O)N3C4=CC=CC=C4SC5=CC=CC=C53
InChI InChI=1S/C23H15NO2S/c25-23(26-20-13-7-9-16-8-1-2-10-17(16)20)24-18-11-3-5-14-21(18)27-22-15-6-4-12-19(22)24/h1-15H
InChIKey BJICBLMMTYZFKB-UHFFFAOYSA-N
Other name(s) CHEMBL451838 ; naphthalen-1-yl 10H-phenothiazine-10-carboxylate ; BDBM50292622 ; ZINC27529770 ; AKOS002279100
________________________________________________________________________________________________
MW|369.4
Formula|C23H15NO2S
CAS_number|
PubChem|16645664
UniChem|BJICBLMMTYZFKB-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | N-10-Phenothiazine-1-Naphtyl-carbamate ligand of proteins in family: BCHE
Protein | human-BCHE

References:
Search PubMed for references concerning: N-10-Phenothiazine-1-Naphtyl-carbamate
    Title: Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems
    Darvesh S, Macdonald IR, Martin E
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:3822, 2013 : PubMed

            

    Title: Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase
    Darvesh S, Darvesh KV, McDonald RS, Mataija D, Walsh R, Mothana S, Lockridge O, Martin E
    Ref: Journal of Medicinal Chemistry, 51:4200, 2008 : PubMed