Mivacurium
Neuromuscular Nondepolarizing Agents,short-acting nondepolarising muscle relaxant of the benzylisoquinoline type, Mivacurium is hydrolysed by BChE like succinylcholine but unlike other neuromuscular blocking agent.
General
Type : Neuromuscular Nondepolarizing Agents,Isoquinoline,Bisquaternary,Drug,Not A\/B H target
Chemical_Nomenclature : bis[3-[(1S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] oct-4-enedioate dichloride
Canonical SMILES : C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CCC=CCCC(=O)OCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)C
InChI : InChI=1S\/C58H80N2O14\/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10\/h13-14,31-38,45-46H,15-30H2,1-12H3\/q+2\/b14-13+\/t45-,46-,59?,60?\/m1\/s1
InChIKey : ILVYCEVXHALBSC-OTBYEXOQSA-N
Other name(s) : Mivacron,BW B1090U
MW : 1029.26
Formula : C58H80N2O14
CAS_number : 106791-40-6
PubChem : 5281042
UniChem : ILVYCEVXHALBSC-OTBYEXOQSA-N
IUPHAR : 7243
Wikipedia : Mivacurium_chloride
Target
References (23)
| Title : Reversal of mivacurium-induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review - Brinch_2019_Acta.Anaesthesiologica.Scandinavica_63_564 |
| Author(s) : Brinch JHW , Soderstrom CM , Gatke MR , Madsen MV |
| Ref : Acta Anaesthesiol Scand , 63 :564 , 2019 |
| Abstract : Brinch_2019_Acta.Anaesthesiologica.Scandinavica_63_564 |
| ESTHER : Brinch_2019_Acta.Anaesthesiologica.Scandinavica_63_564 |
| PubMedSearch : Brinch_2019_Acta.Anaesthesiologica.Scandinavica_63_564 |
| PubMedID: 30548256 |
| Title : The pharmacokinetics and steady state pharmacodynamics of mivacurium in children - Markakis_1998_Anesthesiology_88_978 |
| Author(s) : Markakis DA , Lau M , Brown R , Luks AM , Sharma ML , Fisher DM |
| Ref : Anesthesiology , 88 :978 , 1998 |
| Abstract : Markakis_1998_Anesthesiology_88_978 |
| ESTHER : Markakis_1998_Anesthesiology_88_978 |
| PubMedSearch : Markakis_1998_Anesthesiology_88_978 |
| PubMedID: 9579507 |
| Title : [Muscle relaxants. New substances and neuromuscular monitoring] - Diefenbach_1997_Anaesthesist_46_3 |
| Author(s) : Diefenbach C , Nigrovic V , Mellinghoff H , Buzello W |
| Ref : Anaesthesist , 46 :3 , 1997 |
| Abstract : Diefenbach_1997_Anaesthesist_46_3 |
| ESTHER : Diefenbach_1997_Anaesthesist_46_3 |
| PubMedSearch : Diefenbach_1997_Anaesthesist_46_3 |
| PubMedID: 9082865 |
| Title : [New muscle relaxants] - Diefenbach_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_2 |
| Author(s) : Diefenbach C , Buzello W |
| Ref : Anasthesiol Intensivmed Notfallmed Schmerzther , 31 :2 , 1996 |
| Abstract : Diefenbach_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_2 |
| ESTHER : Diefenbach_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_2 |
| PubMedSearch : Diefenbach_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_2 |
| PubMedID: 8868525 |
| Title : Recovery from mivacurium block with or without anticholinesterase following continuous infusion in obstetric patients - Jan_1996_Anaesth.Intensive.Care_24_585 |
| Author(s) : Jan GS , Tong WN , Chan AM , Hui TW , Lo JW |
| Ref : Anaesthesia & Intensive Care , 24 :585 , 1996 |
| Abstract : Jan_1996_Anaesth.Intensive.Care_24_585 |
| ESTHER : Jan_1996_Anaesth.Intensive.Care_24_585 |
| PubMedSearch : Jan_1996_Anaesth.Intensive.Care_24_585 |
| PubMedID: 8909671 |
| Title : Neostigmine but not edrophonium prolongs the action of mivacurium - Symington_1996_Can.J.Anaesth_43_1220 |
| Author(s) : Symington MJ , Mirakhur RK , Kumar N |
| Ref : Canadian Journal of Anaesthesia , 43 :1220 , 1996 |
| Abstract : Symington_1996_Can.J.Anaesth_43_1220 |
| ESTHER : Symington_1996_Can.J.Anaesth_43_1220 |
| PubMedSearch : Symington_1996_Can.J.Anaesth_43_1220 |
| PubMedID: 8955970 |
| Title : Dose responses for neostigmine and edrophonium as antagonists of mivacurium in adults and children - Bevan_1996_Anesthesiology_84_354 |
| Author(s) : Bevan JC , Tousignant C , Stephenson C , Blackman L , Reimer E , Smith MF , Bevan DR |
| Ref : Anesthesiology , 84 :354 , 1996 |
| Abstract : Bevan_1996_Anesthesiology_84_354 |
| ESTHER : Bevan_1996_Anesthesiology_84_354 |
| PubMedSearch : Bevan_1996_Anesthesiology_84_354 |
| PubMedID: 8602666 |
| Title : Mivacurium chloride--a comparative profile - Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
| Author(s) : Diffenbach C , Buzello W , Mellinghoff H |
| Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :23 , 1995 |
| Abstract : Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
| ESTHER : Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
| PubMedSearch : Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
| PubMedID: 8533540 |
| Title : Interaction between mivacurium and succinylcholine - Erkola_1995_Anesth.Analg_80_534 |
| Author(s) : Erkola O , Rautoma P , Meretoja OA |
| Ref : Anesthesia & Analgesia , 80 :534 , 1995 |
| Abstract : Erkola_1995_Anesth.Analg_80_534 |
| ESTHER : Erkola_1995_Anesth.Analg_80_534 |
| PubMedSearch : Erkola_1995_Anesth.Analg_80_534 |
| PubMedID: 7864420 |
| Title : The effect of plasma cholinesterase activity on mivacurium infusion rates - Hart_1995_Anesth.Analg_80_760 |
| Author(s) : Hart PS , McCarthy GJ , Brown R , Lau M , Fisher DM |
| Ref : Anesthesia & Analgesia , 80 :760 , 1995 |
| Abstract : Hart_1995_Anesth.Analg_80_760 |
| ESTHER : Hart_1995_Anesth.Analg_80_760 |
| PubMedSearch : Hart_1995_Anesth.Analg_80_760 |
| PubMedID: 7893031 |
| Title : Mivacurium-induced prolonged neuromuscular block [see comments] - Sockalingam_1995_Br.J.Anaesth_74_234 |
| Author(s) : Sockalingam I , Green DW |
| Ref : British Journal of Anaesthesia , 74 :234 , 1995 |
| Abstract : Sockalingam_1995_Br.J.Anaesth_74_234 |
| ESTHER : Sockalingam_1995_Br.J.Anaesth_74_234 |
| PubMedSearch : Sockalingam_1995_Br.J.Anaesth_74_234 |
| PubMedID: 7696076 |
| Title : Prolonged neuromuscular block associated with mivacurium [see comments] - Fox_1995_Br.J.Anaesth_74_237 |
| Author(s) : Fox MH , Hunt PC |
| Ref : British Journal of Anaesthesia , 74 :237 , 1995 |
| Abstract : Fox_1995_Br.J.Anaesth_74_237 |
| ESTHER : Fox_1995_Br.J.Anaesth_74_237 |
| PubMedSearch : Fox_1995_Br.J.Anaesth_74_237 |
| PubMedID: 7696077 |
| Title : Comparison of the neuromuscular effects of mivacurium and suxamethonium in infants and children - Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
| Author(s) : Cook DR , Gronert BJ , Woelfel SK |
| Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :35 , 1995 |
| Abstract : Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
| ESTHER : Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
| PubMedSearch : Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
| PubMedID: 8533543 |
| Title : Mivacurium in special patient groups. - Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
| Author(s) : Jones RM |
| Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :47 , 1995 |
| Abstract : Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
| ESTHER : Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
| PubMedSearch : Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
| PubMedID: 8533546 |
| Title : Effect of neostigmine at different levels of mivacurium-induced neuromuscular blockade - Trevien_1995_Acta.Anaesth.Scand.Supplementum_106_66 |
| Author(s) : Trevien V , Lienhart A , Just B , Chandon M , Baras E , Camatte S |
| Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :66 , 1995 |
| Abstract : Trevien_1995_Acta.Anaesth.Scand.Supplementum_106_66 |
| ESTHER : Trevien_1995_Acta.Anaesth.Scand.Supplementum_106_66 |
| PubMedSearch : Trevien_1995_Acta.Anaesth.Scand.Supplementum_106_66 |
| PubMedID: 8533550 |
| Title : Spontaneous recovery or evoked reversal of neuromuscular block - Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
| Author(s) : Mirakhur RK |
| Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :62 , 1995 |
| Abstract : Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
| ESTHER : Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
| PubMedSearch : Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
| PubMedID: 8533549 |
| Title : Pharmacokinetics of the three isomers of mivacurium and pharmacodynamics of the chiral mixture in hepatic cirrhosis - Head-Rapson_1994_Br.J.Anaesth_73_613 |
| Author(s) : Head-Rapson AG , Devlin JC , Parker CJ , Hunter JM |
| Ref : British Journal of Anaesthesia , 73 :613 , 1994 |
| Abstract : Head-Rapson_1994_Br.J.Anaesth_73_613 |
| ESTHER : Head-Rapson_1994_Br.J.Anaesth_73_613 |
| PubMedSearch : Head-Rapson_1994_Br.J.Anaesth_73_613 |
| PubMedID: 7826789 |
| Title : Mivacurium apnoea [letter\; comment] - |
| Author(s) : Lightman DJ |
| Ref : Anaesthesia , 49 :835 , 1994 |
| PubMedID: 7978163 |
| Title : Mivacurium. A review of its pharmacology and therapeutic potential in general anaesthesia - Frampton_1993_Drugs_45_1066 |
| Author(s) : Frampton JE , McTavish D |
| Ref : Drugs , 45 :1066 , 1993 |
| Abstract : Frampton_1993_Drugs_45_1066 |
| ESTHER : Frampton_1993_Drugs_45_1066 |
| PubMedSearch : Frampton_1993_Drugs_45_1066 |
| PubMedID: 7691494 |
| Title : Pharmacodynamics of mivacurium chloride in patients with hepatic cirrhosis - Devlin_1993_Br.J.Anaesth_71_227 |
| Author(s) : Devlin JC , Head-Rapson AG , Parker CJ , Hunter JM |
| Ref : British Journal of Anaesthesia , 71 :227 , 1993 |
| Abstract : Devlin_1993_Br.J.Anaesth_71_227 |
| ESTHER : Devlin_1993_Br.J.Anaesth_71_227 |
| PubMedSearch : Devlin_1993_Br.J.Anaesth_71_227 |
| PubMedID: 8123397 |
| Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35 |
| Author(s) : Lockridge O |
| Ref : Pharmacol Ther , 47 :35 , 1990 |
| Abstract : Lockridge_1990_Pharmacol.Ther_47_35 |
| ESTHER : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedID: 2195556 |
| Gene_locus related to this paper: human-BCHE |
| Title : The clinical neuromuscular pharmacology of mivacurium chloride (BW B1090U). A short-acting nondepolarizing ester neuromuscular blocking drug - Savarese_1988_Anesthesiology_68_723 |
| Author(s) : Savarese JJ , Ali HH , Basta SJ , Embree PB , Scott RP , Sunder N , Weakly JN , Wastila WB , el-Sayad HA |
| Ref : Anesthesiology , 68 :723 , 1988 |
| Abstract : Savarese_1988_Anesthesiology_68_723 |
| ESTHER : Savarese_1988_Anesthesiology_68_723 |
| PubMedSearch : Savarese_1988_Anesthesiology_68_723 |
| PubMedID: 2967039 |
| Title : Clinical pharmacology of mivacurium chloride (BW B1090U) infusion: comparison with vecuronium and atracurium - Ali_1988_Br.J.Anaesth_61_541 |
| Author(s) : Ali HH , Savarese JJ , Embree PB , Basta SJ , Stout RG , Bottros LH , Weakly JN |
| Ref : British Journal of Anaesthesia , 61 :541 , 1988 |
| Abstract : Ali_1988_Br.J.Anaesth_61_541 |
| ESTHER : Ali_1988_Br.J.Anaesth_61_541 |
| PubMedSearch : Ali_1988_Br.J.Anaesth_61_541 |
| PubMedID: 2905143 |