LIPG-inhib-Compound32
mPlasma IC50 120 nM, human-LIPG (endothelial) EL IC50 4.6 (nM), human-LIPC (hepatic) HL IC50 230 (nM)
General
Type : Pyridine,Benzothiazol,Sulfur Compound,Sulfonyl,Cyclopropyl
Chemical_Nomenclature : N-[(cyclopropylcarbamoyl)methyl]-2-[6-(6-fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-2-(2-methoxyethanesulfonyl)acetamide
Canonical SMILES : C1=C(N=CC(=C1)C2=CC3=C(C=C2)N=C(S3)C(C(=O)CNC(NC4CC4)=O)[S](CCOC)(=O)=O)F
InChI : InChI=1S\/C22H23FN4O5S2\/c1-32-8-9-34(30,31)20(17(28)12-25-22(29)26-15-4-5-15)21-27-16-6-2-13(10-18(16)33-21)14-3-7-19(23)24-11-14\/h2-3,6-7,10-11,15,20H,4-5,8-9,12H2,1H3,(H2,25,26,29)
InChIKey : GKMCWXRBVOBYGF-UHFFFAOYSA-N
Other name(s) :
MW : 506.56
Formula : C22H23FN4O5S2
CAS_number :
PubChem :
UniChem : GKMCWXRBVOBYGF-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : LIPG-inhib-Compound32 ligand of proteins in family: Lipoprotein_Lipase
Stucture :
Protein : human-LIPG
References (2)
| Title : Benzothiazole-based compounds as potent endothelial lipase inhibitors - Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| Author(s) : Meng W , Adam LP , Behnia K , Zhao L , Yang R , Kopcho LM , Locke GA , Taylor DS , Yin X , Wexler RR , Finlay H |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126673 , 2019 |
| Abstract : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| ESTHER : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| PubMedSearch : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| PubMedID: 31519373 |
| Gene_locus related to this paper: human-LIPG |
| Title : Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase - Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| Author(s) : Kim SH , Johnson JA , Jiang J , Parkhurst B , Phillips M , Pi Z , Qiao JX , Tora G , Ye Chen A , Liu E , Yin X , Yang R , Zhao L , Taylor DS , Basso M , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Adam LP , Gordon D , Wexler RR , Finlay HJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 29 :1918 , 2019 |
| Abstract : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| ESTHER : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| PubMedSearch : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| PubMedID: 31176700 |
| Gene_locus related to this paper: human-LIPG |