JS0-7ZPB

General

Type : Quinoline,Piperazine,Multitarget,Monoamine-oxidase-inhibitor

Chemical_Nomenclature : 8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinoline-2-carbaldehyde

Canonical SMILES : C#CCN1CCN(CC1)CCCOc2cccc3c2nc(cc3)CO

InChI : InChI=1S\/C20H25N3O2\/c1-2-9-22-11-13-23(14-12-22)10-4-15-25-19-6-3-5-17-7-8-18(16-24)21-20(17)19\/h1,3,5-8,24H,4,9-16H2

InChIKey : CFRADSLCUQTFCF-UHFFFAOYSA-N

Other name(s) :

MW : 339.43

Formula : C20 H25 N3 O2

CAS_number :

PubChem :

UniChem : CFRADSLCUQTFCF-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : JS0-7ZPB ligand of proteins in family: BCHE

Stucture : 7ZPB Structure of hemiacetylated human butyrylcholinesterase upon reaction with 8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinoline-2-carbaldehyde

Protein :

References (1)

Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152

Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelle J

Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023

Abstract : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152

ESTHER : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152

PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152

PubMedID: 37250172

Gene_locus related to this paper: human-BCHE

JS0-7ZPB

General

Target

References (1)

1. 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases