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Inhibitor Report for: Imipramine

Imipramine is the prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.


General
Type Adrenergic Uptake Inhibitors, Not A/B H target, Drug
Chemical_Nomenclature 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5propanamine
Canonical SMILES CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
InChIKey BCGWQEUPMDMJNV-UHFFFAOYSA-N
Other name(s) Imidobenzyle ; Antideprin ; Dimipressin ; Melipramin ; Melipramine ; Nelipramin ; Berkomine ; Impramine ; Intalpram ; imizin
________________________________________________________________________________________________
MW|280.407
Formula|C19H24N2
CAS_number|50-49-7
PubChem|3696
UniChem|BCGWQEUPMDMJNV-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Imipramine

Target
Families | Imipramine ligand of proteins in family: BCHE

References:
Search PubMed for references concerning: Imipramine

1 more
    Title: Parasympatholytic activity of psychoactive drugs in rat brain mitochondria
    Nag M, Basu PS, Nandi N
    Ref: Indian Journal of Experimental Biology, 33:462, 1995 : PubMed

            

    Title: Neurochemical and histopathologic alterations characteristic of Pick's disease in a non-demented individual
    Sparks DL, Danner FW, Davis DG, Hackney C, Landers T, Coyne CM
    Ref: Journal of Neuropathology & Experimental Neurology, 53:37, 1994 : PubMed

            

    Title: Chemical modification of the bifunctional human serum pseudocholinesterase. Effect on the pseudocholinesterase and aryl acylamidase activities
    Boopathy R, Balasubramanian AS
    Ref: European Journal of Biochemistry, 151:351, 1985 : PubMed