Icopezil
Unii-RY1AR8DY6G CID 10318177 is a derivative of icopezil with a methyl group that could be labeled 11C to be used as a pet probe
General
Type : Piperidine,Derivative of Donepezil
Chemical_Nomenclature : 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one || 3-[2-(1-benzylpiperidin-4-yl)ethyl]-5,7-dihydropyrrolo[3,2-f][1,2]benzoxazol-6-one
Canonical SMILES : C1CN(CCC1CCC2=C3C=C4CC(=O)N=C4C=C3ON2)CC5=CC=CC=C5 || C1CN(CCC1CCC2=NOC3=C2C=C4CC(=O)NC4=C3)CC5=CC=CC=C5
InChI : InChI=1S\/C23H25N3O2\/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17\/h1-5,12,14,16,25H,6-11,13,15H2 || InChI=1S\/C23H25N3O2\/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17\/h1-5,12,14,16H,6-11,13,15H2,(H,24,27)
InChIKey : DNFGPFRQSJOKEZ-UHFFFAOYSA-N || MTCMTKNMZCPKLX-UHFFFAOYSA-N
Other name(s) : CP-118954,CP-118,954,CP 118,954,UNII-ERZ60E6B7C,CHEMBL359570,CP 118954
MW : 375.46
Formula : C23H25N3O2
CAS_number : 145508-78-7
UniChem : DNFGPFRQSJOKEZ-UHFFFAOYSA-N || MTCMTKNMZCPKLX-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (6)
| Title : Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE) - Araujo_2011_Eur.J.Med.Chem_46_39 |
| Author(s) : Araujo JQ , de Brito MA , Hoelz LV , de Alencastro RB , Castro HC , Rodrigues CR , Albuquerque MG |
| Ref : Eur Journal of Medicinal Chemistry , 46 :39 , 2011 |
| Abstract : Araujo_2011_Eur.J.Med.Chem_46_39 |
| ESTHER : Araujo_2011_Eur.J.Med.Chem_46_39 |
| PubMedSearch : Araujo_2011_Eur.J.Med.Chem_46_39 |
| PubMedID: 21074294 |
| Title : Synthesis and evaluation of 2-[18F]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase - Ryu_2005_Nucl.Med.Biol_32_185 |
| Author(s) : Ryu EK , Choe YS , Park EY , Paik JY , Kim YR , Lee KH , Choi Y , Kim SE , Kim BT |
| Ref : Nucl Med Biol , 32 :185 , 2005 |
| Abstract : Ryu_2005_Nucl.Med.Biol_32_185 |
| ESTHER : Ryu_2005_Nucl.Med.Biol_32_185 |
| PubMedSearch : Ryu_2005_Nucl.Med.Biol_32_185 |
| PubMedID: 15721764 |
| Title : Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease - Liston_2004_Eur.J.Pharmacol_486_9 |
| Author(s) : Liston DR , Nielsen JA , Villalobos A , Chapin D , Jones SB , Hubbard ST , Shalaby IA , Ramirez A , Nason D , White WF |
| Ref : European Journal of Pharmacology , 486 :9 , 2004 |
| Abstract : Liston_2004_Eur.J.Pharmacol_486_9 |
| ESTHER : Liston_2004_Eur.J.Pharmacol_486_9 |
| PubMedSearch : Liston_2004_Eur.J.Pharmacol_486_9 |
| PubMedID: 14751402 |
| Title : Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f] -1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase - Lee_2004_Nucl.Med.Commun_25_591 |
| Author(s) : Lee SY , Choe YS , Kim YR , Paik JY , Choi BW , Kim SE , Lee KH , Choi Y , Kim BT |
| Ref : Nucl Med Commun , 25 :591 , 2004 |
| Abstract : Lee_2004_Nucl.Med.Commun_25_591 |
| ESTHER : Lee_2004_Nucl.Med.Commun_25_591 |
| PubMedSearch : Lee_2004_Nucl.Med.Commun_25_591 |
| PubMedID: 15167519 |
| Title : Radiosynthesis and mouse brain distribution studies of [11C] CP-126,998: a PET ligand for in vivo study of acetylcholinesterase - Musachio_2002_Nucl.Med.Biol_29_547 |
| Author(s) : Musachio JL , Flesher JE , Scheffel UA , Rauseo P , Hilton J , Mathews WB , Ravert HT , Dannals RF , Frost JJ |
| Ref : Nucl Med Biol , 29 :547 , 2002 |
| Abstract : Musachio_2002_Nucl.Med.Biol_29_547 |
| ESTHER : Musachio_2002_Nucl.Med.Biol_29_547 |
| PubMedSearch : Musachio_2002_Nucl.Med.Biol_29_547 |
| PubMedID: 12088724 |
| Title : 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety - Villalobos_1995_J.Med.Chem_38_2802 |
| Author(s) : Villalobos A , Butler TW , Chapin DS , Chen YL , DeMattos SB , Ives JL , Jones SB , Liston DR , Nagel AA , Nason DM , et al. |
| Ref : Journal of Medicinal Chemistry , 38 :2802 , 1995 |
| Abstract : Villalobos_1995_J.Med.Chem_38_2802 |
| ESTHER : Villalobos_1995_J.Med.Chem_38_2802 |
| PubMedSearch : Villalobos_1995_J.Med.Chem_38_2802 |
| PubMedID: 7636841 |