HuprineW
Carbobicyclic substructure of huperzine A with the 4-aminoquinoline substructure of tacrine
General
Type : Derivative of Huperzine,Derivative of Tacrine,Quinoline,Natural_modified
Chemical_Nomenclature : 2-[(7S,11S)-12-amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl]ethanol
Canonical SMILES : C1C2CC3=NC4=C(C=CC(=C4)Cl)C(=C3C1CC(=C2)CCO)N
InChI : InChI=1S\/C18H19ClN2O\/c19-13-1-2-14-15(9-13)21-16-8-11-5-10(3-4-22)6-12(7-11)17(16)18(14)20\/h1-2,5,9,11-12,22H,3-4,6-8H2,(H2,20,21)\/t11-,12+\/m0\/s1
InChIKey : GAOPELPOAHCRBF-NWDGAFQWSA-N
Other name(s) :
MW : 314.81
Formula : C18H19ClN2O
CAS_number :
PubChem : 71463576
UniChem : GAOPELPOAHCRBF-NWDGAFQWSA-N
IUPHAR :
Wikipedia :
Target
Families : HuprineW ligand of proteins in family: ACHE
Stucture : 4BDT Human acetylcholinesterase in complex with huprine W and fasciculin 2
Protein : human-ACHE
References (1)
| Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393 |
| Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY |
| Ref : Biochemical Journal , 453 :393 , 2013 |
| Abstract : Nachon_2013_Biochem.J_453_393 |
| ESTHER : Nachon_2013_Biochem.J_453_393 |
| PubMedSearch : Nachon_2013_Biochem.J_453_393 |
| PubMedID: 23679855 |
| Gene_locus related to this paper: human-ACHE , human-BCHE |