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Inhibitor Report for: Diphenyl-chlorophosphate

Acetylcholinesterase is readily inhibited by 10-5 M diphenylphosphorochloridate even though the inhibitor hydrolyzes in a few seconds. Diphenyl phosphoryl enzyme spontaneously recovers only about 50% of its activity with a half time of about 17 min at pH 7.0 and 6 min at pH 8.0. The fact that only 50% of the original activity returns is due to aging.


General
Type Organophosphate
Chemical_Nomenclature [chloro(phenoxy)phosphoryl]oxybenzene
Canonical SMILES C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl
InChI InChI=1S/C12H10ClO3P/c13-17(14,15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H
InChIKey BHIIGRBMZRSDRI-UHFFFAOYSA-N
Other name(s) Diphenyl chlorophosphate ; Diphenyl phosphorochloridate ; Diphenylchlorophosphate ; Chlorodiphenyl Phosphate ; Chlorodiphenoxyphosphine oxide
________________________________________________________________________________________________
MW|268.63
Formula|C12H10ClO3P
CAS_number|2524-64-3
PubChem|75654
UniChem|BHIIGRBMZRSDRI-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Diphenyl-chlorophosphate ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Diphenyl-chlorophosphate
    Title: Reactivation and aging of diphenyl phosphoryl acetylcholinesterase
    Maglothin JA, Wins P, Wilson IB
    Ref: Biochimica & Biophysica Acta, 403:370, 1975 : PubMed