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DEP-2PAM

Reactivators of organophosphate-inhibited ChEs give rise to instable phosphorylated oximes that reinhibit the enzyme

General

Type : Organophosphate,Phosphonylated oxime

Chemical_Nomenclature : diethyl[(1-methylpyridin-1-ium-2-yl)methylideneamino] phosphate

Canonical SMILES : CCOP(=O)(OCC)ON=CC1=CC=CC=[N+]1C

InChI : InChI=1S\/C11H18N2O4P\/c1-4-15-18(14,16-5-2)17-12-10-11-8-6-7-9-13(11)3\/h6-10H,4-5H2,1-3H3\/q+1

InChIKey : DIMPVBIGENLFEF-UHFFFAOYSA-N

Other name(s) : 1-methyl-2-pyridinium carboxaldehyde oxime,diethylphosphoryl-2PAM

MW : 273.25

Formula : C11H18N2O4P+

CAS_number :

PubChem : 85140815

UniChem : DIMPVBIGENLFEF-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : DEP-2PAM ligand of proteins in family: ACHE

Stucture :

Protein :

References (1)

Title : Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases - Leader_1999_Biochem.Pharmacol_58_503
Author(s) : Leader H , Vincze A , Manisterski B , Rothschild N , Dosoretz C , Ashani Y
Ref : Biochemical Pharmacology , 58 :503 , 1999
Abstract : Leader_1999_Biochem.Pharmacol_58_503
ESTHER : Leader_1999_Biochem.Pharmacol_58_503
PubMedSearch : Leader_1999_Biochem.Pharmacol_58_503
PubMedID: 10424771