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Inhibitor Report for: Coumarin-Pyridine-3f

AChE inhibitor (IC50 = 2 nM) BuChE inhibitor activity (IC50 = 24 nM)


General
Type Coumarin, Pyridine
Chemical_Nomenclature 1-(3-(4-(6-Nitro-2-oxo-2H-chromen-3-yl)phenoxy) propyl)pyridinium Bromide
Canonical SMILES C1(=CC=C2C(=C1)C=C(C(O2)=O)C3=CC=C(C=C3)OCCC[N+]4=CC=CC=C4)[N+](=O)[O-].[Br-]
InChI InChI=1S/C23H19N2O5.BrH/c26-23-21(16-18-15-19(25(27)28)7-10-22(18)30-23)17-5-8-20(9-6-17)29-14-4-13-24-11-2-1-3-12-24;/h1-3,5-12,15-16H,4,13-14H2;1H/q+1;/p-1
InChIKey FGLFWZQQABVJGL-UHFFFAOYSA-M
Other name(s)
________________________________________________________________________________________________
MW|483.31
Formula|C23H19BrN2O5
CAS_number|
PubChem|
UniChem|FGLFWZQQABVJGL-UHFFFAOYSA-M
IUPHAR|
Wikipedia|

Target
Families | Coumarin-Pyridine-3f ligand of proteins in family: ACHE, BCHE
Protein | human-ACHE, human-BCHE

References:
Search PubMed for references concerning: Coumarin-Pyridine-3f
    Title: Novel Coumarin-Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer's Disease
    Babaei E, Kucukkilinc TT, Jalili-Baleh L, Nadri H, Oz E, Forootanfar H, Hosseinzadeh E, Akbari T, Ardestani MS and Khoobi M <4 more author(s)>
    Ref: Front Chem, 10:895483, 2022 : PubMed