The IC50 for AChE and BuChE were 0.54 +/- 0.06 and 32.49 +/- 1.2 nM respectively. Selectivity ratio of 60.16 towards AChE
Type : Derivative of Tacrine
Chemical_Nomenclature : 5-amino-N1,N3-bis(2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl)isophthalamide
Canonical SMILES : C1=CC=C2C(=C1)C(=C3C(=N2)CCCC3)NCCNC(C4=CC(=CC(=C4)C(=O)NCCNC5=C7C(=NC6=CC=CC=C56)CCCC7)N)=O
InChI : InChI=1S\/C38H41N7O2\/c39-26-22-24(37(46)42-19-17-40-35-27-9-1-5-13-31(27)44-32-14-6-2-10-28(32)35)21-25(23-26)38(47)43-20-18-41-36-29-11-3-7-15-33(29)45-34-16-8-4-12-30(34)36\/h1,3,5,7,9,11,13,15,21-23H,2,4,6,8,10,12,14,16-20,39H2,(H,40,44)(H,41,45)(H,42,46)(H,43,47)
InChIKey : QBPQXDNQVSIESE-UHFFFAOYSA-N
Other name(s) :
MW : 627.78
Formula : C38H41N7O2
CAS_number :
PubChem :
UniChem : QBPQXDNQVSIESE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Title : Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics - Meena_2019_Mol.Pharm_16_2296 |
Author(s) : Meena VK , Chaturvedi S , Sharma RK , Mishra AK , Hazari PP |
Ref : Mol Pharm , 16 :2296 , 2019 |
Abstract : Meena_2019_Mol.Pharm_16_2296 |
ESTHER : Meena_2019_Mol.Pharm_16_2296 |
PubMedSearch : Meena_2019_Mol.Pharm_16_2296 |
PubMedID: 31059278 |