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Inhibitor Report for: Compound-9368

IC50 around 90 nM. human-LIPE. hDAGL-alpha LEI103: IC50=3.8+/-0.4 microM


General
Type Oxadiazol
Chemical_Nomenclature N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3-yl)-2-methylphenyl]-2-phenylacetamide
Canonical SMILES CC1=C(C=CC(=C1)N2C(=O)OC(=N2)OC)NC(=O)CC3=CC=CC=C3
InChI InChI=1S/C18H17N3O4/c1-12-10-14(21-18(23)25-17(20-21)24-2)8-9-15(12)19-16(22)11-13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,19,22)
InChIKey TYRSXXKVBQHZIC-UHFFFAOYSA-N
Other name(s) Compound 9368 ; LEI103
________________________________________________________________________________________________
MW|339.3
Formula|C18H17N3O4
CAS_number|
PubChem|57325525
UniChem|TYRSXXKVBQHZIC-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Compound-9368 ligand of proteins in family: Hormone-sensitive_lipase_like, Lipase_3
Protein | human-LIPE, human-DAGLA

References:
Search PubMed for references concerning: Compound-9368
    Title: Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification
    van Rooden EJ, Florea BI, Deng H, Baggelaar MP, van Esbroeck ACM, Zhou J, Overkleeft HS, van der Stelt M
    Ref: Nat Protoc, 13:752, 2018 : PubMed

            

    Title: The molecular mechanism of human hormone-sensitive lipase inhibition by substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones
    Ben Ali Y, Verger R, Carriere F, Petry S, Muller G, Abousalham A
    Ref: Biochimie, 94:137, 2012 : PubMed

            

    Title: Use of an inhibitor to identify members of the hormone-sensitive lipase family
    Ben Ali Y, Chahinian H, Petry S, Muller G, Lebrun R, Verger R, Carriere F, Mandrich L, Rossi M and Abousalham A <2 more author(s)>
    Ref: Biochemistry, 45:14183, 2006 : PubMed