Citric-acid
Citric acid is a tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms. It has a role as a food acidity regulator, a chelator, an antimicrobial agent and a fundamental metabolite. It is a conjugate acid of a citrate(1-) and a citrate anion. Anhydrous Citric Acid is found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in blood.
General
Type :
Chemical_Nomenclature : 2-hydroxypropane-1,2,3-tricarboxylic acid
Canonical SMILES : C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI : InChI=1S\/C6H8O7\/c7-3(8)1-6(13,5(11)12)2-4(9)10\/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey : KRKNYBCHXYNGOX-UHFFFAOYSA-N
Other name(s) : DB04272,SCHEMBL7206089,CH2COOH-C(OH)COOH-CH2COOH,citric acid,Citric acid, anhydrous,Anhydrous citric acid,CHEBI:30769,CHEMBL1261
MW : 192.12
Formula : C6H8O7
CAS_number : 77-92-9
UniChem : KRKNYBCHXYNGOX-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Citric-acid ligand of proteins in family: Polyesterase-lipase-cutinase
Stucture : 7E30 Crystal structure of a novel alpha\/beta hydrolase in apo form PHL7 PES-H1 in complex with citrate
Protein : 9firm-PHL7
References (1)
| Title : Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase - Pfaff_2022_ACS.Catalysis_12_9790 |
| Author(s) : Pfaff L , Gao J , Li Z , Jackering A , Weber G , Mican J , Chen Y , Dong W , Han X , Feiler CG , Ao YF , Badenhorst CPS , Bednar D , Palm GJ , Lammers M , Damborsky J , Strodel B , Liu W , Bornscheuer UT , Wei R |
| Ref : ACS Catal , 12 :9790 , 2022 |
| Abstract : Pfaff_2022_ACS.Catalysis_12_9790 |
| ESTHER : Pfaff_2022_ACS.Catalysis_12_9790 |
| PubMedSearch : Pfaff_2022_ACS.Catalysis_12_9790 |
| PubMedID: 35966606 |
| Gene_locus related to this paper: 9firm-PHL7 |