CHEMBL4293015
indolylpiperidine IC50 nM ACHE 3550+/-32 BCHE 0.87 +/- 0.15
General
Type : Indole,Piperidine,Derivative of Donepezil,Alkyl linked bis-ligand
Chemical_Nomenclature : N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(1-methylindol-3-yl)acetamide\
Canonical SMILES : CN1C=C(C2=CC=CC=C21)CC(=O)NCCC3CCN(CC3)CC4=CC=CC=C4
InChI : InChI=1S\/C25H31N3O\/c1-27-19-22(23-9-5-6-10-24(23)27)17-25(29)26-14-11-20-12-15-28(16-13-20)18-21-7-3-2-4-8-21\/h2-10,19-20H,11-18H2,1H3,(H,26,29)
InChIKey : YMWXRPAGHCBLJY-UHFFFAOYSA-N
Other name(s) : Compond 2,N-[2-(l-Benzyl-piperidin-4-yl)-ethyl]-2-(l-methyI-1H-indol-3-yI)-acetamide,SCHEMBL3155847,BDBM50464942
MW : 389.5
Formula : C25H31N3O
CAS_number :
PubChem : 11603489
UniChem : YMWXRPAGHCBLJY-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors - Chierrito_2018_Eur.J.Med.Chem_145_431 |
| Author(s) : Chierrito TPC , Pedersoli-Mantoani S , Roca C , Sebastian-Perez V , Martinez-Gonzalez L , Perez DI , Perez C , Canales A , Canada FJ , Campillo NE , Carvalho I , Martinez A |
| Ref : Eur Journal of Medicinal Chemistry , 145 :431 , 2018 |
| Abstract : Chierrito_2018_Eur.J.Med.Chem_145_431 |
| ESTHER : Chierrito_2018_Eur.J.Med.Chem_145_431 |
| PubMedSearch : Chierrito_2018_Eur.J.Med.Chem_145_431 |
| PubMedID: 29335209 |