Benzil
prototype of carboxylesterase inhibitors not inhibitor of Cholinesterases
General
Type : Aromatic dione
Chemical_Nomenclature : 1,2-diphenylethane-1,2-dione
Canonical SMILES : C1=CC=C(C=C1)C(=O)C(=O)C2=CC=CC=C2
InChI : InChI=1S\/C14H10O2\/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12\/h1-10H
InChIKey : WURBFLDFSFBTLW-UHFFFAOYSA-N
Other name(s) : Diphenylethanedione,Dibenzoyl,Diphenylglyoxal,Bibenzoyl,diphenylethane-1,2-dione,diphenyl-Ethanedione,1,2-Diphenylethanedione
MW : 210.23
Formula : C14H10O2
CAS_number : 134-81-6
PubChem : 8651
UniChem : WURBFLDFSFBTLW-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Benzil
Target
Families : Benzil ligand of proteins in family: Carboxylesterase || Carb_B_Chordata
Stucture : 1YAJ Crystal Structure of Human Liver Carboxylesterase in complex with benzil
Protein : human-CES1
References (7)
| Title : Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors - Tsurkan_2013_Chem.Biol.Interact_203_226 |
| Author(s) : Tsurkan LG , Hatfield MJ , Edwards CC , Hyatt JL , Potter PM |
| Ref : Chemico-Biological Interactions , 203 :226 , 2013 |
| Abstract : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| ESTHER : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedSearch : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedID: 23123248 |
| Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876 |
| Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007 |
| Abstract : Hyatt_2007_J.Med.Chem_50_1876 |
| ESTHER : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedID: 17378546 |
| Title : Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity - Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| Author(s) : Hyatt JL , Tsurkan L , Wierdl M , Edwards CC , Danks MK , Potter PM |
| Ref : Mol Cancer Ther , 5 :2281 , 2006 |
| Abstract : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| ESTHER : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| PubMedSearch : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| PubMedID: 16985062 |
| Title : Mammalian carboxylesterases: from drug targets to protein therapeutics - Redinbo_2005_Drug.Discov.Today_10_313 |
| Author(s) : Redinbo MR , Potter PM |
| Ref : Drug Discov Today , 10 :313 , 2005 |
| Abstract : Redinbo_2005_Drug.Discov.Today_10_313 |
| ESTHER : Redinbo_2005_Drug.Discov.Today_10_313 |
| PubMedSearch : Redinbo_2005_Drug.Discov.Today_10_313 |
| PubMedID: 15749280 |
| Title : Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety - Hyatt_2005_J.Med.Chem_48_5543 |
| Author(s) : Hyatt JL , Stacy V , Wadkins RM , Yoon KJ , Wierdl M , Edwards CC , Zeller M , Hunter AD , Danks MK , Crundwell G , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :5543 , 2005 |
| Abstract : Hyatt_2005_J.Med.Chem_48_5543 |
| ESTHER : Hyatt_2005_J.Med.Chem_48_5543 |
| PubMedSearch : Hyatt_2005_J.Med.Chem_48_5543 |
| PubMedID: 16107154 |
| Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165 |
| Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR |
| Ref : Journal of Molecular Biology , 352 :165 , 2005 |
| Abstract : Fleming_2005_J.Mol.Biol_352_165 |
| ESTHER : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedSearch : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedID: 16081098 |
| Gene_locus related to this paper: human-CES1 |
| Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906 |
| Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005 |
| Abstract : Wadkins_2005_J.Med.Chem_48_2906 |
| ESTHER : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedSearch : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedID: 15828829 |