Aricept~Donepezil~E2020
Treatment of Alzheimer Disease, trademark is Aricept || Reversible inhibitor of AChE but not of BChE
General
Type : Derivative of Donepezil,Piperidine,Drug,Inden
Chemical_Nomenclature : 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one\;hydrochloride
Canonical SMILES : COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChI : InChI=1S\/C24H29NO3.ClH\/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18\;\/h3-7,14-15,17,20H,8-13,16H2,1-2H3\;1H
InChIKey : XWAIAVWHZJNZQQ-UHFFFAOYSA-N
Other name(s) : Donepezil hydrochloride,DPZ,Donepezilo,Donepezilum,1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine,(+\/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one,Donepezil,E2020,Aricept
MW : 415.953
Formula : C24H30ClNO3
CAS_number : 120011-70-3 || 120014-06-4
UniChem : XWAIAVWHZJNZQQ-UHFFFAOYSA-N
IUPHAR : 6599
Wikipedia : Donepezil
Target
Families : Aricept~Donepezil~E2020 ligand of proteins in family: ACHE
Stucture :
Protein : torca-ACHE || human-ACHE
References (56)
| Title : Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle - Redman_2022_Br.J.Pharmacol__ |
| Author(s) : Redman RR , Mackenzie H , Dissanayake KN , Eddleston M , Ribchester RR |
| Ref : British Journal of Pharmacology , : , 2022 |
| Abstract : Redman_2022_Br.J.Pharmacol__ |
| ESTHER : Redman_2022_Br.J.Pharmacol__ |
| PubMedSearch : Redman_2022_Br.J.Pharmacol__ |
| PubMedID: 36028305 |
| Title : Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients - Zhang_2018_Clin.Interv.Aging_13_1963 |
| Author(s) : Zhang N , Gordon ML |
| Ref : Clin Interv Aging , 13 :1963 , 2018 |
| Abstract : Zhang_2018_Clin.Interv.Aging_13_1963 |
| ESTHER : Zhang_2018_Clin.Interv.Aging_13_1963 |
| PubMedSearch : Zhang_2018_Clin.Interv.Aging_13_1963 |
| PubMedID: 30349215 |
| Title : Efficacy and Safety of Sustained Release Donepezil High Dose versus Immediate Release Donepezil Standard Dose in Japanese Patients with Severe Alzheimer's Disease: A Randomized, Double-Blind Trial - Homma_2016_J.Alzheimers.Dis_52_345 |
| Author(s) : Homma A , Atarashi H , Kubota N , Nakai K , Takase T |
| Ref : J Alzheimers Dis , 52 :345 , 2016 |
| Abstract : Homma_2016_J.Alzheimers.Dis_52_345 |
| ESTHER : Homma_2016_J.Alzheimers.Dis_52_345 |
| PubMedSearch : Homma_2016_J.Alzheimers.Dis_52_345 |
| PubMedID: 26967222 |
| Title : Structures of human acetylcholinesterase in complex with pharmacologically important ligands - Cheung_2012_J.Med.Chem_55_10282 |
| Author(s) : Cheung J , Rudolph MJ , Burshteyn F , Cassidy MS , Gary EN , Love J , Franklin MC , Height JJ |
| Ref : Journal of Medicinal Chemistry , 55 :10282 , 2012 |
| Abstract : Cheung_2012_J.Med.Chem_55_10282 |
| ESTHER : Cheung_2012_J.Med.Chem_55_10282 |
| PubMedSearch : Cheung_2012_J.Med.Chem_55_10282 |
| PubMedID: 23035744 |
| Gene_locus related to this paper: human-ACHE |
| Title : beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies - Bartolini_2003_Biochem.Pharmacol_65_407 |
| Author(s) : Bartolini M , Bertucci C , Cavrini V , Andrisano V |
| Ref : Biochemical Pharmacology , 65 :407 , 2003 |
| Abstract : Bartolini_2003_Biochem.Pharmacol_65_407 |
| ESTHER : Bartolini_2003_Biochem.Pharmacol_65_407 |
| PubMedSearch : Bartolini_2003_Biochem.Pharmacol_65_407 |
| PubMedID: 12527333 |
| Title : Use of donepezil in elderly patients with Alzheimer's disease--a Hawaii based study - Alagiakrishnan_2000_Hawaii.Med.J_59_57 |
| Author(s) : Alagiakrishnan K , Wong W , Blanchette PL |
| Ref : Hawaii Med J , 59 :57 , 2000 |
| Abstract : Alagiakrishnan_2000_Hawaii.Med.J_59_57 |
| ESTHER : Alagiakrishnan_2000_Hawaii.Med.J_59_57 |
| PubMedSearch : Alagiakrishnan_2000_Hawaii.Med.J_59_57 |
| PubMedID: 10800254 |
| Title : Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease - Camps_2000_Mol.Pharmacol_57_409 |
| Author(s) : Camps P , Cusack B , Mallender WD , Achab RE , Morral J , Munoz-Torrero D , Rosenberry TL |
| Ref : Molecular Pharmacology , 57 :409 , 2000 |
| Abstract : Camps_2000_Mol.Pharmacol_57_409 |
| ESTHER : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedSearch : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedID: 10648652 |
| Title : [Pharmacological properties of donepezil hydrochloride (Aricept), a drug for Alzheimer's disease] - Ogura_2000_Nihon.Yakurigaku.Zasshi_115_45 |
| Author(s) : Ogura H , Kosasa T , Araki S , Yamanishi Y |
| Ref : Nihon Yakurigaku Zasshi , 115 :45 , 2000 |
| Abstract : Ogura_2000_Nihon.Yakurigaku.Zasshi_115_45 |
| ESTHER : Ogura_2000_Nihon.Yakurigaku.Zasshi_115_45 |
| PubMedSearch : Ogura_2000_Nihon.Yakurigaku.Zasshi_115_45 |
| PubMedID: 10876815 |
| Title : Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats - Kosasa_2000_Eur.J.Pharmacol_389_173 |
| Author(s) : Kosasa T , Kuriya Y , Matsui K , Yamanishi Y |
| Ref : European Journal of Pharmacology , 389 :173 , 2000 |
| Abstract : Kosasa_2000_Eur.J.Pharmacol_389_173 |
| ESTHER : Kosasa_2000_Eur.J.Pharmacol_389_173 |
| PubMedSearch : Kosasa_2000_Eur.J.Pharmacol_389_173 |
| PubMedID: 10688981 |
| Title : Effects of donepezil on emotional\/behavioral symptoms in Alzheimer's disease patients - Weiner_2000_J.Clin.Psychiatry_61_487 |
| Author(s) : Weiner MF , Martin-Cook K , Foster BM , Saine K , Fontaine CS , Svetlik DA |
| Ref : J Clin Psychiatry , 61 :487 , 2000 |
| Abstract : Weiner_2000_J.Clin.Psychiatry_61_487 |
| ESTHER : Weiner_2000_J.Clin.Psychiatry_61_487 |
| PubMedSearch : Weiner_2000_J.Clin.Psychiatry_61_487 |
| PubMedID: 10937606 |
| Title : Donepezil Hydrochloride (E2020) and Other Acetylcholinesterase Inhibitors - Sugimoto_2000_Curr.Med.Chem_7_303 |
| Author(s) : Sugimoto H , Iimura Y , Kawakami Y , Yamanishi Y |
| Ref : Curr Med Chem , 7 :303 , 2000 |
| Abstract : Sugimoto_2000_Curr.Med.Chem_7_303 |
| ESTHER : Sugimoto_2000_Curr.Med.Chem_7_303 |
| PubMedSearch : Sugimoto_2000_Curr.Med.Chem_7_303 |
| PubMedID: 10637367 |
| Title : Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats - Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_89 |
| Author(s) : Ogura H , Kosasa T , Kuriya Y , Yamanishi Y |
| Ref : Methods Find Exp Clin Pharmacol , 22 :89 , 2000 |
| Abstract : Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_89 |
| ESTHER : Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_89 |
| PubMedSearch : Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_89 |
| PubMedID: 10849891 |
| Title : Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro - Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_609 |
| Author(s) : Ogura H , Kosasa T , Kuriya Y , Yamanishi Y |
| Ref : Methods Find Exp Clin Pharmacol , 22 :609 , 2000 |
| Abstract : Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_609 |
| ESTHER : Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_609 |
| PubMedSearch : Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_609 |
| PubMedID: 11256231 |
| Title : The relationship between donepezil and behavioral disturbances in patients with Alzheimer's disease - Cummings_2000_Am.J.Geriatr.Psychiatry_8_134 |
| Author(s) : Cummings JL , Donohue JA , Brooks RL |
| Ref : American Journal of Geriatry & Psychiatry , 8 :134 , 2000 |
| Abstract : Cummings_2000_Am.J.Geriatr.Psychiatry_8_134 |
| ESTHER : Cummings_2000_Am.J.Geriatr.Psychiatry_8_134 |
| PubMedSearch : Cummings_2000_Am.J.Geriatr.Psychiatry_8_134 |
| PubMedID: 10804074 |
| Title : Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease - Jann_2000_Pharmacotherapy_20_1 |
| Author(s) : Jann MW |
| Ref : Pharmacotherapy , 20 :1 , 2000 |
| Abstract : Jann_2000_Pharmacotherapy_20_1 |
| ESTHER : Jann_2000_Pharmacotherapy_20_1 |
| PubMedSearch : Jann_2000_Pharmacotherapy_20_1 |
| PubMedID: 10641971 |
| Title : Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors - Kaur_2000_Curr.Med.Chem_7_273 |
| Author(s) : Kaur J , Zhang MQ |
| Ref : Curr Med Chem , 7 :273 , 2000 |
| Abstract : Kaur_2000_Curr.Med.Chem_7_273 |
| ESTHER : Kaur_2000_Curr.Med.Chem_7_273 |
| PubMedSearch : Kaur_2000_Curr.Med.Chem_7_273 |
| PubMedID: 10637365 |
| Title : Clinical profile of donepezil in the treatment of Alzheimer's disease - Doody_1999_Gerontology_45_23 |
| Author(s) : Doody RS |
| Ref : Gerontology , 45 :23 , 1999 |
| Abstract : Doody_1999_Gerontology_45_23 |
| ESTHER : Doody_1999_Gerontology_45_23 |
| PubMedSearch : Doody_1999_Gerontology_45_23 |
| PubMedID: 9876215 |
| Title : Huperzine-A in capsules and tablets for treating patients with Alzheimer disease - Xu_1999_Zhongguo.Yao.Li.Xue.Bao_20_486 |
| Author(s) : Xu SS , Cai ZY , Qu ZW , Yang RM , Cai YL , Wang GQ , Su XQ , Zhong XS , Cheng RY , Xu WA , Li JX , Feng B |
| Ref : Zhongguo Yao Li Xue Bao , 20 :486 , 1999 |
| Abstract : Xu_1999_Zhongguo.Yao.Li.Xue.Bao_20_486 |
| ESTHER : Xu_1999_Zhongguo.Yao.Li.Xue.Bao_20_486 |
| PubMedSearch : Xu_1999_Zhongguo.Yao.Li.Xue.Bao_20_486 |
| PubMedID: 10678137 |
| Title : Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs - Kryger_1999_Structure_7_297 |
| Author(s) : Kryger G , Silman I , Sussman JL |
| Ref : Structure , 7 :297 , 1999 |
| Abstract : Kryger_1999_Structure_7_297 |
| ESTHER : Kryger_1999_Structure_7_297 |
| PubMedSearch : Kryger_1999_Structure_7_297 |
| PubMedID: 10368299 |
| Gene_locus related to this paper: torca-ACHE |
| Title : [Treatment of Alzheimer's disease: acetylcholinesterase inhibitors]. - Lopez-Pousa_1999_Neurologia_14_180 |
| Author(s) : Lopez-Pousa S , Lombardia Fernandez C |
| Ref : Neurologia , 14 :180 , 1999 |
| Abstract : Lopez-Pousa_1999_Neurologia_14_180 |
| ESTHER : Lopez-Pousa_1999_Neurologia_14_180 |
| PubMedSearch : Lopez-Pousa_1999_Neurologia_14_180 |
| PubMedID: 10363493 |
| Title : Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: an interim analysis of the results of a US multicentre open label extension study - Rogers_1998_Eur.Neuropsychopharmacol_8_67 |
| Author(s) : Rogers SL , Friedhoff LT |
| Ref : European Neuropsychopharmacology , 8 :67 , 1998 |
| Abstract : Rogers_1998_Eur.Neuropsychopharmacol_8_67 |
| ESTHER : Rogers_1998_Eur.Neuropsychopharmacol_8_67 |
| PubMedSearch : Rogers_1998_Eur.Neuropsychopharmacol_8_67 |
| PubMedID: 9452942 |
| Title : Donepezil use in Alzheimer disease - Barner_1998_Ann.Pharmacother_32_70 |
| Author(s) : Barner EL , Gray SL |
| Ref : Annals of Pharmacotherapy , 32 :70 , 1998 |
| Abstract : Barner_1998_Ann.Pharmacother_32_70 |
| ESTHER : Barner_1998_Ann.Pharmacother_32_70 |
| PubMedSearch : Barner_1998_Ann.Pharmacother_32_70 |
| PubMedID: 9475825 |
| Title : Donepezil medicated memory improvement in traumatic brain injury during post acute rehabilitation - Taverni_1998_Brain.Inj_12_77 |
| Author(s) : Taverni JP , Seliger G , Lichtman SW |
| Ref : Brain Injury , 12 :77 , 1998 |
| Abstract : Taverni_1998_Brain.Inj_12_77 |
| ESTHER : Taverni_1998_Brain.Inj_12_77 |
| PubMedSearch : Taverni_1998_Brain.Inj_12_77 |
| PubMedID: 9483340 |
| Title : How to cope with Alzheimer's disease? - Hasegawa_1998_Neurobiol.Aging_19_S107 |
| Author(s) : Hasegawa K |
| Ref : Neurobiology of Aging , 19 :S107 , 1998 |
| Abstract : Hasegawa_1998_Neurobiol.Aging_19_S107 |
| ESTHER : Hasegawa_1998_Neurobiol.Aging_19_S107 |
| PubMedSearch : Hasegawa_1998_Neurobiol.Aging_19_S107 |
| PubMedID: 9562478 |
| Title : Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities - Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| Author(s) : Cheng DH , Tang XC |
| Ref : Pharmacol Biochem Behav , 60 :377 , 1998 |
| Abstract : Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| ESTHER : Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| PubMedSearch : Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| PubMedID: 9632220 |
| Title : Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells - Svensson_1998_Neuroreport_9_1519 |
| Author(s) : Svensson AL , Nordberg A |
| Ref : Neuroreport , 9 :1519 , 1998 |
| Abstract : Svensson_1998_Neuroreport_9_1519 |
| ESTHER : Svensson_1998_Neuroreport_9_1519 |
| PubMedSearch : Svensson_1998_Neuroreport_9_1519 |
| PubMedID: 9631459 |
| Title : Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease - Costagli_1998_Biochem.Pharmacol_55_1733 |
| Author(s) : Costagli C , Galli A |
| Ref : Biochemical Pharmacology , 55 :1733 , 1998 |
| Abstract : Costagli_1998_Biochem.Pharmacol_55_1733 |
| ESTHER : Costagli_1998_Biochem.Pharmacol_55_1733 |
| PubMedSearch : Costagli_1998_Biochem.Pharmacol_55_1733 |
| PubMedID: 9634011 |
| Title : Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine - Wang_1998_Eur.J.Pharmacol_349_137 |
| Author(s) : Wang T , Tang XC |
| Ref : European Journal of Pharmacology , 349 :137 , 1998 |
| Abstract : Wang_1998_Eur.J.Pharmacol_349_137 |
| ESTHER : Wang_1998_Eur.J.Pharmacol_349_137 |
| PubMedSearch : Wang_1998_Eur.J.Pharmacol_349_137 |
| PubMedID: 9671090 |
| Title : Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica - Kryger_1998_J.Physiol.Paris_92_191 |
| Author(s) : Kryger G , Silman I , Sussman JL |
| Ref : Journal de Physiologie Paris , 92 :191 , 1998 |
| Abstract : Kryger_1998_J.Physiol.Paris_92_191 |
| ESTHER : Kryger_1998_J.Physiol.Paris_92_191 |
| PubMedSearch : Kryger_1998_J.Physiol.Paris_92_191 |
| PubMedID: 9789806 |
| Title : Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group - Rogers_1998_Arch.Intern.Med_158_1021 |
| Author(s) : Rogers SL , Doody RS , Mohs RC , Friedhoff LT |
| Ref : Archives of Internal Medicine , 158 :1021 , 1998 |
| Abstract : Rogers_1998_Arch.Intern.Med_158_1021 |
| ESTHER : Rogers_1998_Arch.Intern.Med_158_1021 |
| PubMedSearch : Rogers_1998_Arch.Intern.Med_158_1021 |
| PubMedID: 9588436 |
| Title : Aricept-induced nightmares in Alzheimer's disease: 2 case reports [letter] - |
| Author(s) : Ross JS , Shua-Haim JR |
| Ref : J Am Geriatr Soc , 46 :119 , 1998 |
| PubMedID: 9434681 |
| Title : A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group - Rogers_1998_Neurology_50_136 |
| Author(s) : Rogers SL , Farlow MR , Doody RS , Mohs R , Friedhoff LT |
| Ref : Neurology , 50 :136 , 1998 |
| Abstract : Rogers_1998_Neurology_50_136 |
| ESTHER : Rogers_1998_Neurology_50_136 |
| PubMedSearch : Rogers_1998_Neurology_50_136 |
| PubMedID: 9443470 |
| Title : Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications - Giacobini_1998_Neurochem.Int_32_413 |
| Author(s) : Giacobini E |
| Ref : Neurochem Int , 32 :413 , 1998 |
| Abstract : Giacobini_1998_Neurochem.Int_32_413 |
| ESTHER : Giacobini_1998_Neurochem.Int_32_413 |
| PubMedSearch : Giacobini_1998_Neurochem.Int_32_413 |
| PubMedID: 9676739 |
| Title : Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys - Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| Author(s) : Tsukada H , Kakiuchi T , Ando I , Ouchi Y |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :1408 , 1997 |
| Abstract : Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| ESTHER : Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| PubMedSearch : Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| PubMedID: 9190877 |
| Title : Advertisements for donepezil. Prices charged for private prescriptions for donepezil show huge variation - |
| Author(s) : Jones RW , Mann JB , Saunders SA |
| Ref : BMJ , 315 :1624 , 1997 |
| PubMedID: 9437306 |
| Title : Advertisements for donepezil. Review of drug in Drug and Therapeutics Bulletin is uninformed - |
| Author(s) : Wilkinson D |
| Ref : BMJ , 315 :1625 , 1997 |
| PubMedID: 9437307 |
| Title : Donepezil (Aricept) therapy for Alzheimer's disease - |
| Author(s) : Geldmacher DS |
| Ref : Compr Ther , 23 :492 , 1997 |
| PubMedID: 9262925 |
| Title : Enhancing cognition in the intellectually intact - Whitehouse_1997_Hastings.Cent.Rep_27_14 |
| Author(s) : Whitehouse PJ , Juengst E , Mehlman M , Murray TH |
| Ref : Hastings Center Report , 27 :14 , 1997 |
| Abstract : Whitehouse_1997_Hastings.Cent.Rep_27_14 |
| ESTHER : Whitehouse_1997_Hastings.Cent.Rep_27_14 |
| PubMedSearch : Whitehouse_1997_Hastings.Cent.Rep_27_14 |
| PubMedID: 9219019 |
| Title : Alzheimer's disease: an overview for the pharmacist - McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| Author(s) : McGuffey EC |
| Ref : J Am Pharm Assoc , 3 :347 , 1997 |
| Abstract : McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| ESTHER : McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| PubMedSearch : McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| PubMedID: 9170813 |
| Title : Donepezil - Bryson_1997_Drugs.Aging_10_234 |
| Author(s) : Bryson HM , Benfield P |
| Ref : Drugs & Aging , 10 :234 , 1997 |
| Abstract : Bryson_1997_Drugs.Aging_10_234 |
| ESTHER : Bryson_1997_Drugs.Aging_10_234 |
| PubMedSearch : Bryson_1997_Drugs.Aging_10_234 |
| PubMedID: 9108896 |
| Title : Absence of central cholinergic deficits in ApoE knockout mice - Anderson_1997_Psychopharmacology.(Berl)_132_135 |
| Author(s) : Anderson R , Higgins GA |
| Ref : Psychopharmacology (Berl) , 132 :135 , 1997 |
| Abstract : Anderson_1997_Psychopharmacology.(Berl)_132_135 |
| ESTHER : Anderson_1997_Psychopharmacology.(Berl)_132_135 |
| PubMedSearch : Anderson_1997_Psychopharmacology.(Berl)_132_135 |
| PubMedID: 9266610 |
| Title : Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys - Rupniak_1997_Psychopharmacology_131_406 |
| Author(s) : Rupniak NM , Tye SJ , Field MJ |
| Ref : Psychopharmacology , 131 :406 , 1997 |
| Abstract : Rupniak_1997_Psychopharmacology_131_406 |
| ESTHER : Rupniak_1997_Psychopharmacology_131_406 |
| PubMedSearch : Rupniak_1997_Psychopharmacology_131_406 |
| PubMedID: 9226744 |
| Title : Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia [published erratum appears in Methods Find Exp Clin Pharmacol 1997 Jun\;19(5):364] - Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| Author(s) : Kojima J , Nakajima K , Ochiai M , Nakayama K |
| Ref : Methods Find Exp Clin Pharmacol , 19 :245 , 1997 |
| Abstract : Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| ESTHER : Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| PubMedSearch : Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| PubMedID: 9228650 |
| Title : The simulated binding of (+\/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]m eth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses - Inoue_1996_J.Med.Chem_39_4460 |
| Author(s) : Inoue A , Kawai T , Wakita M , Iimura Y , Sugimoto H , Kawakami Y |
| Ref : Journal of Medicinal Chemistry , 39 :4460 , 1996 |
| Abstract : Inoue_1996_J.Med.Chem_39_4460 |
| ESTHER : Inoue_1996_J.Med.Chem_39_4460 |
| PubMedSearch : Inoue_1996_J.Med.Chem_39_4460 |
| PubMedID: 8893840 |
| Title : The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US Multicentre, Randomized, Double-Blind, Placebo- Controlled Trial. The Donepezil Study Group - Rogers_1996_Dementia_7_293 |
| Author(s) : Rogers SL , Friedhoff LT |
| Ref : Dementia , 7 :293 , 1996 |
| Abstract : Rogers_1996_Dementia_7_293 |
| ESTHER : Rogers_1996_Dementia_7_293 |
| PubMedSearch : Rogers_1996_Dementia_7_293 |
| PubMedID: 8915035 |
| Title : Huperzine A, a novel promising acetylcholinesterase inhibitor - Cheng_1996_Neuroreport_8_97 |
| Author(s) : Cheng DH , Ren H , Tang XC |
| Ref : Neuroreport , 8 :97 , 1996 |
| Abstract : Cheng_1996_Neuroreport_8_97 |
| ESTHER : Cheng_1996_Neuroreport_8_97 |
| PubMedSearch : Cheng_1996_Neuroreport_8_97 |
| PubMedID: 9051760 |
| Title : Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020) - Nochi_1995_Biol.Pharm.Bull_18_1145 |
| Author(s) : Nochi S , Asakawa N , Sato T |
| Ref : Biol Pharm Bull , 18 :1145 , 1995 |
| Abstract : Nochi_1995_Biol.Pharm.Bull_18_1145 |
| ESTHER : Nochi_1995_Biol.Pharm.Bull_18_1145 |
| PubMedSearch : Nochi_1995_Biol.Pharm.Bull_18_1145 |
| PubMedID: 8535413 |
| Title : Direct determination of E2020 enantiomers in plasma by liquid chromatography-mass spectrometry and column-switching techniques - Matsui_1995_J.Chromatogr.A_694_209 |
| Author(s) : Matsui K , Oda Y , Ohe H , Tanaka S , Asakawa N |
| Ref : Journal of Chromatography A , 694 :209 , 1995 |
| Abstract : Matsui_1995_J.Chromatogr.A_694_209 |
| ESTHER : Matsui_1995_J.Chromatogr.A_694_209 |
| PubMedSearch : Matsui_1995_J.Chromatogr.A_694_209 |
| PubMedID: 7719466 |
| Title : Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2- yl)methyl]piperidine hydrochloride and related compounds - Sugimoto_1995_J.Med.Chem_38_4821 |
| Author(s) : Sugimoto H , Iimura Y , Yamanishi Y , Yamatsu K |
| Ref : Journal of Medicinal Chemistry , 38 :4821 , 1995 |
| Abstract : Sugimoto_1995_J.Med.Chem_38_4821 |
| ESTHER : Sugimoto_1995_J.Med.Chem_38_4821 |
| PubMedSearch : Sugimoto_1995_J.Med.Chem_38_4821 |
| PubMedID: 7490731 |
| Title : Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program - Pang_1994_J.Comput.Aided.Mol.Des_8_683 |
| Author(s) : Pang YP , Kozikowski AP |
| Ref : J Comput Aided Mol Des , 8 :683 , 1994 |
| Abstract : Pang_1994_J.Comput.Aided.Mol.Des_8_683 |
| ESTHER : Pang_1994_J.Comput.Aided.Mol.Des_8_683 |
| PubMedSearch : Pang_1994_J.Comput.Aided.Mol.Des_8_683 |
| PubMedID: 7738604 |
| Title : Acetylcholinesterase protection and the anti-diisopropylfluorophosphate efficacy of E2020 - Galli_1994_Eur.J.Pharmacol_270_189 |
| Author(s) : Galli A , Mori F , Benini L , Cacciarelli N |
| Ref : European Journal of Pharmacology , 270 :189 , 1994 |
| Abstract : Galli_1994_Eur.J.Pharmacol_270_189 |
| ESTHER : Galli_1994_Eur.J.Pharmacol_270_189 |
| PubMedSearch : Galli_1994_Eur.J.Pharmacol_270_189 |
| PubMedID: 8039548 |
| Title : The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory - Dawson_1993_Behav.Brain.Res_57_143 |
| Author(s) : Dawson GR , Iversen SD |
| Ref : Behavioural Brain Research , 57 :143 , 1993 |
| Abstract : Dawson_1993_Behav.Brain.Res_57_143 |
| ESTHER : Dawson_1993_Behav.Brain.Res_57_143 |
| PubMedSearch : Dawson_1993_Behav.Brain.Res_57_143 |
| PubMedID: 8117420 |