Dichlorvos
Anthelmintic, insecticide, acaricide, metabolite of metrifonate ( Trichlorfon~Metrifonate is slowly converted in the body by a nonenzymatic process to the long-acting cholinesterase inhibitor Dichlorvos). Trade names used outside of the U.S. include Doom, Nogos and Nuvan
General
Type : Insecticide, Organophosphate
Chemical_Nomenclature : 2,2-dichloroethenyl dimethyl phosphate
Canonical SMILES : COP(=O)(OC)OC=C(Cl)Cl
InChI : InChI=1S\/C4H7Cl2O4P\/c1-8-11(7,9-2)10-3-4(5)6\/h3H,1-2H3
InChIKey : OEBRKCOSUFCWJD-UHFFFAOYSA-N
Other name(s) : Phosphoric acid 2,2-dichloroethenyl dimethyl ester || O,O-dimethyl-O-(2,2 dichlorovinyl phosphate || 2,2-dichlorovinyl dimethyl phosphate || dimethyl-dichloro-vinyl phosphate || DDVP || Apavap || Benfos || Cekusan || Cypona || Derriban || Derribante || Devikol || Didivane || Duo-Kill || Duravos || Elastrel || Fly-Die || Fly-Fighter || Herkol || Marvex || No-Pest || Prentox || Vapona || Vaponite || Verdican || Verdipor || Verdisol
MW : 220.98
Formula : C4H7Cl2O4P
CAS_number : 62-73-7
PubChem : 3039
UniChem : OEBRKCOSUFCWJD-UHFFFAOYSA-N
Wikipedia : Dichlorvos
Target
Families : Dichlorvos ligand of proteins in family
ACHE
ACPH_Peptidase_S9
Structure :
9GOU
Protein :
human-APEH
pig-acph
References (34)
| Title : A Rare Presentation of Severe Organophosphate Poisoning: A Case Report and Review of Literature - Ibrahim_2022_Cureus_14_e31497 |
| Author(s) : Ibrahim AE , Ghantarchyan H , Le T , Bhagat A , Maknouni B , Arabian S |
| Ref : Cureus , 14 :e31497 , 2022 |
| Abstract : |
| PubMedSearch : Ibrahim_2022_Cureus_14_e31497 |
| PubMedID: 36532913 |
| Title : Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants - Quistad_2005_Toxicol.Sci_86_291 |
| Author(s) : Quistad GB , Klintenberg R , Casida JE |
| Ref : Toxicol Sci , 86 :291 , 2005 |
| Abstract : |
| PubMedSearch : Quistad_2005_Toxicol.Sci_86_291 |
| PubMedID: 15888665 |
| Gene_locus related to this paper: human-APEH |
| Title : The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases - Radic_1999_Chem.Biol.Interact_119-120_111 |
| Author(s) : Radic Z , Taylor P |
| Ref : Chemico-Biological Interactions , 119-120 :111 , 1999 |
| Abstract : |
| PubMedSearch : Radic_1999_Chem.Biol.Interact_119-120_111 |
| PubMedID: 10421444 |
| Title : Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters - Ehrich_1998_J.Toxicol.Environ.Health_53_385 |
| Author(s) : Ehrich M , Correll L |
| Ref : J Toxicol Environ Health , 53 :385 , 1998 |
| Abstract : |
| PubMedSearch : Ehrich_1998_J.Toxicol.Environ.Health_53_385 |
| PubMedID: 9515941 |
| Title : Preclinical pharmacology of metrifonate - Jann_1998_Pharmacotherapy_18_55 |
| Author(s) : Jann MW |
| Ref : Pharmacotherapy , 18 :55 , 1998 |
| Abstract : |
| PubMedSearch : Jann_1998_Pharmacotherapy_18_55 |
| PubMedID: 9543466 |
| Title : Pharmacokinetics, pharmacodynamics, and safety of metrifonate in patients with Alzheimer's disease - Pettigrew_1998_J.Clin.Pharmacol_38_236 |
| Author(s) : Pettigrew LC , Bieber F , Lettieri J , Wermeling DP , Schmitt FA , Tikhtman AJ , Ashford JW , Smith CD , Wekstein DR , Markesbery WR , Orazem J , Ruzicka BB , Mas J , Gulanski B |
| Ref : Journal of Clinical Pharmacology , 38 :236 , 1998 |
| Abstract : |
| PubMedSearch : Pettigrew_1998_J.Clin.Pharmacol_38_236 |
| PubMedID: 98210831 |
| Title : Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure - Sarin_1998_Pharmacol.Biochem.Behav_59_1081 |
| Author(s) : Sarin S , Gill KD |
| Ref : Pharmacol Biochem Behav , 59 :1081 , 1998 |
| Abstract : |
| PubMedSearch : Sarin_1998_Pharmacol.Biochem.Behav_59_1081 |
| PubMedID: 9586870 |
| Title : Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds - Cavaliere_1998_J.Toxicol.Clin.Toxicol_36_295 |
| Author(s) : Cavaliere MJ , Puga FR , Calore EE , Calore NM , Pelegrino JR , da Rosa AR , Weg R |
| Ref : Journal of Toxicology Clinical Toxicology , 36 :295 , 1998 |
| Abstract : |
| PubMedSearch : Cavaliere_1998_J.Toxicol.Clin.Toxicol_36_295 |
| PubMedID: 9711194 |
| Title : Human mortality in organophosphate poisonings - Yamashita_1997_Vet.Hum.Toxicol_39_84 |
| Author(s) : Yamashita M , Tanaka J , Ando Y |
| Ref : Vet Hum Toxicol , 39 :84 , 1997 |
| Abstract : |
| PubMedSearch : Yamashita_1997_Vet.Hum.Toxicol_39_84 |
| PubMedID: 9080632 |
| Title : Tissue distribution of DDVP after fatal ingestion - Shimizu_1996_Forensic.Sci.Int_83_61 |
| Author(s) : Shimizu K , Shiono H , Fukushima T , Sasaki M , Akutsu H , Sakata M |
| Ref : Forensic Science International , 83 :61 , 1996 |
| Abstract : |
| PubMedSearch : Shimizu_1996_Forensic.Sci.Int_83_61 |
| PubMedID: 8939014 |
| Title : Dissociation of DDVP-induced DNA strand breaks from oxidative damage in isolated rat hepatocytes - Yamano_1996_Toxicology_108_49 |
| Author(s) : Yamano T |
| Ref : Toxicology , 108 :49 , 1996 |
| Abstract : |
| PubMedSearch : Yamano_1996_Toxicology_108_49 |
| PubMedID: 8644117 |
| Title : Organophosphate resistance in Culex pipiens from Cyprus - Wirth_1996_J.Am.Mosq.Control.Assoc_12_112 |
| Author(s) : Wirth MC , Georghiou GP |
| Ref : J Am Mosq Control Assoc , 12 :112 , 1996 |
| Abstract : |
| PubMedSearch : Wirth_1996_J.Am.Mosq.Control.Assoc_12_112 |
| PubMedID: 8723267 |
| Title : Life-time exposure to dichlorvos affects behaviour of mature rats - Schulz_1995_Human.Exp.Toxicol_14_721 |
| Author(s) : Schulz H , Nagymajtenyi L , Desi I |
| Ref : Hum Exp Toxicol , 14 :721 , 1995 |
| Abstract : |
| PubMedSearch : Schulz_1995_Human.Exp.Toxicol_14_721 |
| PubMedID: 8579882 |
| Title : [Experimental research on treatment of acute organophosphorus insecticides poisoning with high-dose atropine: upregulation of muscarinic receptor]. [Chinese] - Si_1994_Zhonghua.Nei.Ke.Za.Zhi_33_583 |
| Author(s) : Si FZ , Wang DX , Yang GQ |
| Ref : Chinese Journal of Internal Medicine , 33 :583 , 1994 |
| Abstract : |
| PubMedSearch : Si_1994_Zhonghua.Nei.Ke.Za.Zhi_33_583 |
| PubMedID: 7712923 |
| Title : Pharmacokinetics and pharmacodynamics of metrifonate in humans - Unni_1994_Meth.Find.Exp.Clin.Pharmacol_16_285 |
| Author(s) : Unni LK , Womack C , Hannant ME , Becker RE |
| Ref : Methods Find Exp Clin Pharmacol , 16 :285 , 1994 |
| Abstract : |
| PubMedSearch : Unni_1994_Meth.Find.Exp.Clin.Pharmacol_16_285 |
| PubMedID: 8051989 |
| Title : Retina, brain and blood cholinesterase levels in cats treated with oral dichlorvos - Harlin_1993_Vet.Hum.Toxicol_35_201 |
| Author(s) : Harlin KS , Dellinger JA |
| Ref : Vet Hum Toxicol , 35 :201 , 1993 |
| Abstract : |
| PubMedSearch : Harlin_1993_Vet.Hum.Toxicol_35_201 |
| PubMedID: 8351788 |
| Title : Transdermal patch delivery of acetylcholinesterase inhibitors - Moriearty_1993_Meth.Find.Exp.Clin.Pharmacol_15_407 |
| Author(s) : Moriearty PL , Thornton SL , Becker RE |
| Ref : Methods Find Exp Clin Pharmacol , 15 :407 , 1993 |
| Abstract : |
| PubMedSearch : Moriearty_1993_Meth.Find.Exp.Clin.Pharmacol_15_407 |
| PubMedID: 8231460 |
| Title : Susceptibility of the bedbug, Cimex lectularius, to selected insecticides and various treated surfaces - Fletcher_1993_Med.Vet.Entomol_7_69 |
| Author(s) : Fletcher MG , Axtell RC |
| Ref : Med Vet Entomol , 7 :69 , 1993 |
| Abstract : |
| PubMedSearch : Fletcher_1993_Med.Vet.Entomol_7_69 |
| PubMedID: 8435492 |
| Title : Determination of organophosphorous and carbamate insecticides by flow injection analysis - Kumaran_1992_Anal.Biochem_200_187 |
| Author(s) : Kumaran S , Tran-Minh C |
| Ref : Analytical Biochemistry , 200 :187 , 1992 |
| Abstract : |
| PubMedSearch : Kumaran_1992_Anal.Biochem_200_187 |
| PubMedID: 1595894 |
| Title : The therapeutic effects of 2,3-butanedione monoxime and atropine in severe dichlorvos intoxication in buffalo calves - Raina_1991_Vet.Res.Commun_15_319 |
| Author(s) : Raina R , Malik JK |
| Ref : Vet Res Com , 15 :319 , 1991 |
| Abstract : |
| PubMedSearch : Raina_1991_Vet.Res.Commun_15_319 |
| PubMedID: 1949606 |
| Title : Zinc chloride-diphenylamine reagent for thin layer chromatographic detection of some organophosphorus and carbamate insecticides - Sevalkar_1991_J.Assoc.Off.Anal.Chem_74_545 |
| Author(s) : Sevalkar MT , Patil VB , Katkar HN |
| Ref : J Assoc Off Analytical Chemistry , 74 :545 , 1991 |
| Abstract : |
| PubMedSearch : Sevalkar_1991_J.Assoc.Off.Anal.Chem_74_545 |
| PubMedID: 1874701 |
| Title : [Catalytic properties of cholinesterases immobilized in a gelatin membrane] - Kuznetsova_1990_Ukr.Biokhim.Zh_62_42 |
| Author(s) : Kuznetsova LP , Kugusheva LI , Nikol'skaia EB |
| Ref : Ukr Biokhim Zh , 62 :42 , 1990 |
| Abstract : |
| PubMedSearch : Kuznetsova_1990_Ukr.Biokhim.Zh_62_42 |
| PubMedID: 2087792 |
| Title : Cytotoxicity of certain organic solvents and organophosphorus insecticides to the ciliated protozoan Paramecium caudatum - Rajini_1989_Microbios_59_157 |
| Author(s) : Rajini PS , Krishnakumari MK , Majumder SK |
| Ref : Microbios , 59 :157 , 1989 |
| Abstract : |
| PubMedSearch : Rajini_1989_Microbios_59_157 |
| PubMedID: 2593868 |
| Title : Insecticide-insensitive acetylcholinesterase from a laboratory selected and a field strain of housefly (Musca domestica) (L.) - Price_1988_Comp.Biochem.Physiol.C_90_221 |
| Author(s) : Price NR |
| Ref : Comparative Biochemistry & Physiology C , 90 :221 , 1988 |
| Abstract : |
| PubMedSearch : Price_1988_Comp.Biochem.Physiol.C_90_221 |
| PubMedID: 2904862 |
| Title : Effect of the cold environment on organophosphate toxicity and inhibition of cholinesterase activity - Ryhanen_1988_Gen.Pharmacol_19_741 |
| Author(s) : Ryhanen R , Honkakoski P , Harri M , Ylitalo P , Hanninen O |
| Ref : General Pharmacology , 19 :741 , 1988 |
| Abstract : |
| PubMedSearch : Ryhanen_1988_Gen.Pharmacol_19_741 |
| PubMedID: 3215484 |
| Title : Insecticidal organophosphates: Nature made them first - Neumann_1987_Experientia_43_1235 |
| Author(s) : Neumann R , Peter HH |
| Ref : Experientia , 43 :1235-1237 , 1987 |
| Abstract : |
| PubMedSearch : Neumann_1987_Experientia_43_1235 |
| PubMedID: |
| Title : Cholinergic system of brain tissue in rats poisoned with the organophosphate, 0,0-dimethyl 0-(2,2-dichlorovinyl) phosphate - Kobayashi_1986_Toxicol.Appl.Pharmacol_82_32 |
| Author(s) : Kobayashi H , Yuyama A , Chiba K |
| Ref : Toxicol Appl Pharmacol , 82 :32 , 1986 |
| Abstract : |
| PubMedSearch : Kobayashi_1986_Toxicol.Appl.Pharmacol_82_32 |
| PubMedID: 3945941 |
| Title : Observations on the accidental poisoning of birds by organophosphate insecticides and other toxic substances - Reece_1982_Vet.Rec_111_453 |
| Author(s) : Reece RL , Handson P |
| Ref : Vet Rec , 111 :453 , 1982 |
| Abstract : |
| PubMedSearch : Reece_1982_Vet.Rec_111_453 |
| PubMedID: 7179689 |
| Title : Effects of acute and chronic administration of DDVP (dichlorvos) on distribution of brain acetylcholine in rats - Kobayashi_1980_J.Toxicol.Sci_5_311 |
| Author(s) : Kobayashi H , Yuyama A , Imajo S , Matsusaka N |
| Ref : Journal of Toxicological Sciences , 5 :311 , 1980 |
| Abstract : |
| PubMedSearch : Kobayashi_1980_J.Toxicol.Sci_5_311 |
| PubMedID: 7218377 |
| Title : A detection tube for cholinesterase inhibiting compounds - Barendsz_1979_Int.J.Environ.Anal.Chem_6_89 |
| Author(s) : Barendsz AW |
| Ref : Int J Environ Analytical Chemistry , 6 :89 , 1979 |
| Abstract : |
| PubMedSearch : Barendsz_1979_Int.J.Environ.Anal.Chem_6_89 |
| PubMedID: 573244 |
| Title : Mutagenicity of dichlorvos and other structurally related pesticides in Salmonella and Streptomyces - Carere_1978_Chem.Biol.Interact_22_297 |
| Author(s) : Carere A , Ortali VA , Cardamone G , Morpurgo G |
| Ref : Chemico-Biological Interactions , 22 :297 , 1978 |
| Abstract : |
| PubMedSearch : Carere_1978_Chem.Biol.Interact_22_297 |
| PubMedID: 699179 |
| Title : The activities of some esterases of the rat brain after intoxication by organophosphate insecticides, dichlorvos and trichlorphon - |
| Author(s) : Pachecka J , Sulinski A , Ziolkowska G |
| Ref : Neuropatol Pol , 13 :455 , 1975 |
| PubMedID: 1207914 |