Coralox
Oxon form of Coumaphos. Ophthalmic anticholinesterase || . Coumaphos-oxon: L. cuprina AChE, IC50 [nM] 6 +/- 0.4 ; Human AChE, IC50 [nM] 1430 +/- 31
General
Type : Coumarin, Anthelmintic, Insecticide, Organophosphate, Chromen, Organochlorine
Chemical_Nomenclature : (3-chloro-4-methyl-2-oxochromen-7-yl) diethyl phosphate
Canonical SMILES : CCOP(=O)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C
InChI : InChI=1S\/C14H16ClO6P\/c1-4-18-22(17,19-5-2)21-10-6-7-11-9(3)13(15)14(16)20-12(11)8-10\/h6-8H,4-5H2,1-3H3
InChIKey : FDYMERLIFOUIRZ-UHFFFAOYSA-N
Other name(s) : Phosphoric acid 3-chloro-4-methyl-2-oxo2H-1benzopyran-7-yl diethyl ester || diethyl(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) phosphate || Coroxon || coumaphosoxon || Coumaphos-oxon || Co-Ral oxygen analog
MW : 346.70
Formula : C14H16ClO6P
CAS_number : 321-54-0
PubChem : 9453
UniChem : FDYMERLIFOUIRZ-UHFFFAOYSA-N
Target
Families : Coralox ligand of proteins in family
ACHE
References (6)
| Title : The characterization of Lucilia cuprina acetylcholinesterase as a drug target, and the identification of novel inhibitors by high throughput screening - Ilg_2011_Insect.Biochem.Mol.Biol_41_470 |
| Author(s) : Ilg T , Cramer J , Lutz J , Noack S , Schmitt H , Williams H , Newton T |
| Ref : Insect Biochemistry & Molecular Biology , 41 :470 , 2011 |
| Abstract : |
| PubMedSearch : Ilg_2011_Insect.Biochem.Mol.Biol_41_470 |
| PubMedID: 21530657 |
| Title : Toxicological and biochemical characterization of coumaphos resistance in the San Roman strain of Boophilus microplus (Acari: Ixodidae) - Li_2005_Pestic.Biochem.Physiol_81_145 |
| Author(s) : Li AY , Pruett JH , Davey RB , George JE |
| Ref : Pesticide Biochemistry and Physiology , 81 :145 , 2005 |
| Abstract : |
| PubMedSearch : Li_2005_Pestic.Biochem.Physiol_81_145 |
| PubMedID: |
| Title : Isolation of a Pseudomonas monteilli strain with a novel phosphotriesterase - Horne_2002_FEMS.Microbiol.Lett_206_51 |
| Author(s) : Horne I , Harcourt RL , Sutherland TD , Russell RJ , Oakeshott JG |
| Ref : FEMS Microbiology Letters , 206 :51 , 2002 |
| Abstract : |
| PubMedSearch : Horne_2002_FEMS.Microbiol.Lett_206_51 |
| PubMedID: 11786256 |
| Title : Crystal and molecular structure of organophosphorus insecticides. II. Coroxon - |
| Author(s) : Gifkins MR , Jacobson RA |
| Ref : Journal of Agricultural and Food Chemistry , 24 :232 , 1976 |
| PubMedID: 1254802 |
| Title : Biochemical genetics of resistance to organophosphorus acaricides in three strains of the cattle tick, Boophilus microplus - Stone_1976_Aust.J.Biol.Sci_29_265 |
| Author(s) : Stone BF , Nolan J , Schuntner CA |
| Ref : Australian Journal of Biological Science , 29 :265 , 1976 |
| Abstract : |
| PubMedSearch : Stone_1976_Aust.J.Biol.Sci_29_265 |
| PubMedID: 985226 |
| Title : Determination of coumaphos and its oxygen analog in eggs by in situ fluorometry - Zakrevsky_1975_J.Assoc.Off.Anal.Chem_58_554 |
| Author(s) : Zakrevsky JG , Mallet VN |
| Ref : J Assoc Off Analytical Chemistry , 58 :554 , 1975 |
| Abstract : |
| PubMedSearch : Zakrevsky_1975_J.Assoc.Off.Anal.Chem_58_554 |
| PubMedID: 1141186 |