Chlorpyrifos-methyl-oxon
Chlorpyrifos-methyl-oxon is the oxon form of Methylchlorpyrifos. Chlorpyrifosmethyl oxon, Dichlorvos, and Diisopropylfluorophosphate (20-min IC50 values of 18.3 +/- 2.0, 118.7 +/- 9.7, and 22.5 +/- 1.2 nM, respectively (Richards et al.) || . Fospirate: L. cuprina AChE, IC50 [nM] 0.5 +/- 0.06 ; Human AChE, IC50 [nM] 1521 +/- 229
General
Type : Trichloro, Insecticide, Organophosphate, Organochlorine
Chemical_Nomenclature : dimethyl (3,5,6-trichloropyridin-2-yl) phosphate
Canonical SMILES : COP(=O)(OC)OC1=NC(=C(C=C1Cl)Cl)Cl
InChI : InChI=1S\/C7H7Cl3NO4P\/c1-13-16(12,14-2)15-7-5(9)3-4(8)6(10)11-7\/h3H,1-2H3
InChIKey : XCBOKUAJQWDYNI-UHFFFAOYSA-N
Other name(s) : 3,5,6-trichloro-2-pyridyl dimethyl phosphate || 2,3,5-trichloro-6-dimethoxyphosphoryloxy-pyridine || Fospirate || Torelle || Fospirate methyl || Caswell No. 465CC || Chlorpyrifos methyl oxon || Chlorpyrifos-methyl oxon
MW : 322.533
Formula : C7H7Cl3NO4P
CAS_number :
PubChem : 21805
UniChem : XCBOKUAJQWDYNI-UHFFFAOYSA-N
Target
Families : Chlorpyrifos-methyl-oxon ligand of proteins in family
ACHE
ACPH_Peptidase_S9
Structure :
7P29
Protein :
pig-acph
References (5)
| Title : Inhibition properties of three acetylcholinesterases of the pinewood nematode Bursaphelenchus xylophilus by organophosphates and carbamates - Kang_2012_Pestic.Biochem.Physiol_104_157 |
| Author(s) : Kang JS , Moon YS , Lee SH |
| Ref : Pesticide Biochemistry and Physiology , 104 :157 , 2012 |
| Abstract : |
| PubMedSearch : Kang_2012_Pestic.Biochem.Physiol_104_157 |
| PubMedID: |
| Gene_locus related to this paper: burxy-ACHE1 , burxy-ACHE2 , burxy-ACHE3 |
| Title : The characterization of Lucilia cuprina acetylcholinesterase as a drug target, and the identification of novel inhibitors by high throughput screening - Ilg_2011_Insect.Biochem.Mol.Biol_41_470 |
| Author(s) : Ilg T , Cramer J , Lutz J , Noack S , Schmitt H , Williams H , Newton T |
| Ref : Insect Biochemistry & Molecular Biology , 41 :470 , 2011 |
| Abstract : |
| PubMedSearch : Ilg_2011_Insect.Biochem.Mol.Biol_41_470 |
| PubMedID: 21530657 |
| Title : Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs - Richards_2000_Mol.Pharmacol_58_577 |
| Author(s) : Richards PG , Johnson MK , Ray DE |
| Ref : Molecular Pharmacology , 58 :577 , 2000 |
| Abstract : |
| PubMedSearch : Richards_2000_Mol.Pharmacol_58_577 |
| PubMedID: 10953051 |
| Gene_locus related to this paper: human-APEH , pig-acph |
| Title : Evaluation of the Role of Boll Weevil Aliesterases in Noncatalytic Detoxication of Four Organophosphorus Insecticides - Yuan_1998_Pestic.Biochem.Physiol_61_135 |
| Author(s) : Yuan J , Chambers HW |
| Ref : Pesticide Biochemistry and Physiology , 61 :135 , 1998 |
| Abstract : |
| PubMedSearch : Yuan_1998_Pestic.Biochem.Physiol_61_135 |
| PubMedID: |
| Title : Automated sample clean-up and fractionation of chlorpyrifos, chlorpyrifos-methyl and metabolites in mussels using normal-phase liquid chromatography - Serrano_1997_J.Chromatogr.A_778_151 |
| Author(s) : Serrano R , Lopez FJ , Roig-Navarro A , Hernandez F |
| Ref : Journal of Chromatography A , 778 :151 , 1997 |
| Abstract : |
| PubMedSearch : Serrano_1997_J.Chromatogr.A_778_151 |
| PubMedID: 9299732 |