torca-ACHE ------------------------------------------------------------ 0 9neop-ACHE1 ----------------------------------------------MRVVLAALTALAAR 14 cydpo-ACHE1 ----------------------------------------------MRVVLAALAALAAR 14 pluxy-ACHE1 ----------------------------------------------MRALLAVLCAAAAA 14 bemta-ACHE1 ----------------------------------------------MDFDHLPLRASPET 14 aphgo-ACHE1 ----------------------------------------------MDQWLLWFGYLVAS 14 rhopd-ACHE1 ----------------------------------------------MDQWLLWFGYLVVS 14 myzpe-ACHEM ----------------------------------------------MDQWLLWFSYLVAS 14 sitav-ACHE1 ----------------------------------------------MDQWLLWFGYLVAS 14 culpi-ACHE1 -----------------------------MEIRGLITR--LLGPCHLRHLILCSLGLYSI 29 cultr-ACHE1 -----------------------MRPLQAMEIRGLITR--LLGPCHLRHLILCSLGLYSI 35 anoga-ACHE1 -----------------------------MEIRGLLMGRLRLGRRMVPLGLLGVTALLLI 31 tetka-ACHE ------------------------------------------MVPMFNHNINHFNNVIVT 18 tetur-ACHE ------------------------------------------MVPMFNHNINHFNNVIVT 18 bacdo-ACHE --------------------------------------------------MAHTTSLLSG 10 bacol-ACHE --------------------------------------------------MAHPTSLLAG 10 cerca-ACHE --------------------------------------------------MARTLALQAP 10 haeir-ACHE --------------------MARSTTTISSSSSSSSSSPPSLSSSSSSISLTSSPSSYSL 40 musdo-ACHE ------------------------------------------------------------ 0 luccu-ACHE MEFEIFFLFVYLKQQISSGASTIMARFITTSSSPTLTTSTAATAPSSSWSSNATSTATSI 60 drome-ACHE ------------------------------------------------------------ 0 aedae-ACHE ------------------------------------------------------------ 0 aphgo-ACHE2 --------------------------------------------------MSVDCVYTSA 10 rhopd-ACHE2 --------------------------------------------------MSVDCVYTSA 10 sitav-ACHE2 --------------------------------------------------MSVDCVYTSA 10 lepde-ACHE --------------------------------------------------MGQLSILCLF 10 boomi-este13 ------------------------------------------------------------ 0 boomi-acche3 ---------------------------------------------MYSRIVVLLLYGYAL 15 luccu-E3aest7 ------------------------------------------------------------ 0 musdo-EST23aes07 ------------------------------------------------------------ 0 colho-E3aest7 ------------------------------------------------------------ 0 drome-EST23aes07 ------------------------------------------------------------ 0 anica-cxest ------------------------------------------------------------ 0 aphgo-cxest ------------------------------------------------------------ 0 Consensus torca-ACHE ------------------------------------------------------------ 0 9neop-ACHE1 ALAGP--HEHRARHH----------APDHPLHFPAPANPAQPYRG--------------- 47 cydpo-ACHE1 ALGSP--HEHRARHH----------APDHPLHFPAPA-PPQPYRG--------------- 46 pluxy-ACHE1 AGASAGAHEHRARHH----------APEH-------AYPPPPYRG--------------- 42 bemta-ACHE1 DQLRNPRHGFGFRDG----------ISDE------------------------------- 33 aphgo-ACHE1 TYGLSLRHARHQSVG----------TPTA-----EEILEPQILIE--------------- 44 rhopd-ACHE1 TYGLSLRHARHQSVG----------TPTA-----EEILEPQILIE--------------- 44 myzpe-ACHEM TYGLSLRHARHQSVG----------TPTA-----EEILEPQILIE--------------- 44 sitav-ACHE1 TYGLSLRHARHQSVG----------TPTV-----EEILEPQILIE--------------- 44 culpi-ACHE1 LVQS--VHCRHHDIG-----------SSVAHQLGSKYSQSSSLSS-----------SSQS 65 cultr-ACHE1 LVQS--VHCRHHDIG-----------SSAAHQLGSKYSQSSSLSS-----------SSQS 71 anoga-ACHE1 LPPSALVQGRHHELNNGAAIGSHQLSAAAGVGLSSQSAQSGSLASGVMSSVPAAGASSSS 91 tetka-ACHE TLTHHQYTNSRCNSN-----------NNVIKRITNSILKSVTVFT--------------- 52 tetur-ACHE TLTHHQYTNSRCNSN-----------NNVIKRITNSILKSVTVFT--------------- 52 bacdo-ACHE ASSAAASPLSSRQYS--------------------------------------------- 25 bacol-ACHE ASLAAASSLSSRQYS--------------------------------------------- 25 cerca-ACHE SSLSASSRQHSFASS--------------------------------------------- 25 haeir-ACHE KSSSTSSRQSRPSSS--------------------------------------------- 55 musdo-ACHE ------------------------------------------------------------ 0 luccu-ACHE SSHSRTSRKSRYTSSN-------------------------------------------- 76 drome-ACHE --MAISCRQSR------------------------------------------------- 9 aedae-ACHE ------------------------------------------------------------ 0 aphgo-ACHE2 VTLLLCCSAVLGRPS--------------------------------------------- 25 rhopd-ACHE2 VTLLLCCSAVLGRPS--------------------------------------------- 25 sitav-ACHE2 VTLLLCCSAVLGRPS--------------------------------------------- 25 lepde-ACHE VT---VCASVCGYSW--------------------------------------------- 22 boomi-este13 ------------------------------------------------------------ 0 boomi-acche3 RSAHARCYIFQPGDP--------------------------------------------- 30 luccu-E3aest7 ------------------------------------------------------------ 0 musdo-EST23aes07 ------------------------------------------------------------ 0 colho-E3aest7 ------------------------------------------------------------ 0 drome-EST23aes07 ------------------------------------------------------------ 0 anica-cxest ------------------------------------------------------------ 0 aphgo-cxest ------------------------------------------------------------ 0 Consensus torca-ACHE ------------------------------------------------------------ 0 9neop-ACHE1 -----------HGEAARYNPELDTILPRVEDHETSSKRAKLDDAETSSKRDDDRFYSNHE 96 cydpo-ACHE1 -----------HGEAVRYNPELDTILPRIDEHETSSKRAKLEDAEILSKREE-KYFSNHE 94 pluxy-ACHE1 -----------HGEAVRYNPELDTILPRLD-HETSSRRAKYAD-----KHDD---YRARE 82 bemta-ACHE1 ------------GLNFRHS-------------EHEGERSKYKG----------------- 51 aphgo-ACHE1 -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82 rhopd-ACHE1 -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82 myzpe-ACHEM -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82 sitav-ACHE1 -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82 culpi-ACHE1 SSSLA--------EEATLNKDSDAFFTPYIGHGDSVRIVDAELG------TLEREHIHST 111 cultr-ACHE1 SSSLA--------EEATLNKDS--------GHGDSVRIVDAELG------TLEREHIHST 109 anoga-ACHE1 SSSLLSSSAEDDVARITLSKDADAFFTPYIGHGESVRIIDAELG------TLEHVHSG-A 144 tetka-ACHE ------------VKTLWNHLLVPIVVILLFQSSANVFSSALPHS------EINSFYADGP 94 tetur-ACHE ------------VKTLWNHLLVPIVVILLFQSSANVFSSALPHS------EINSFHADGP 94 bacdo-ACHE ------------------------------VASSPRLSGDIGRG---------------- 39 bacol-ACHE ------------------------------VASSSRLSGDIGRG---------------- 39 cerca-ACHE ------------------------------TSTLRLSSGDIGRG---------------- 39 haeir-ACHE -------------------------FSSVAYLLATSRSNDICRG---------------- 74 musdo-ACHE ------------------------------------------------------------ 0 luccu-ACHE -----------------LLNAFASLTSRSSLSLSSTSSNDLYRG---------------- 103 drome-ACHE -------------------------------VLPMSLPLPLTIP---------------- 22 aedae-ACHE --------------------------------MKMSAVVRLCCN---------------- 12 aphgo-ACHE2 --------------------------------SNGGADAGGGGGG--------GGGAGGA 45 rhopd-ACHE2 --------------------------------SNGGADGGGGGG---------------S 38 sitav-ACHE2 --------------------------------SNGGADGGGGGGG--------GGGAGAG 45 lepde-ACHE --------------------------------PSDETTTK-------------------- 30 boomi-este13 ----------------------------------MAVKAAVLIG---------------- 10 boomi-acche3 --------IQDTDEKIYLAQPFNVTIPLEAGIPTTAQPASTGKDQ----------LSLVV 72 luccu-E3aest7 ---------------------------------MNFNVSLMEKLK--------------- 12 musdo-EST23aes07 ---------------------------------MNFKVSQMERLS--------------- 12 colho-E3aest7 ---------------------------------MNFKVSQVEKLK--------------- 12 drome-EST23aes07 ------------------------------------------------------------ 0 anica-cxest ------------------------------------------------------------ 0 aphgo-cxest ------------------------------------------------------------ 0 Consensus ! ! ! ! ? !??! ! !! ? torca-ACHE ----------------DDHSELLVNTKSGKVMGT-RVPVLSS-HISAFLGIPFAEPPVGN 42 9neop-ACHE1 RIDDEGFLADEPQPGPEDDDPLIVRTRKGRVRGI-TLTAATGKKVDAWFGIPYAQKPIGD 155 cydpo-ACHE1 RGE-EVFMADEPQMGPDDDDPLVVRTRKGRVRGI-TLTAATGKKVDAWFGIPYAQKPLGD 152 pluxy-ACHE1 RLD--APQADQPALGPDDDDPLVVRTRKGRVRGI-TLTAATGKKVDAWFGIPYAQKPIGD 139 bemta-ACHE1 -----AEAEEEMMADEGDNDPLVVQTTKGKVRGT-TLTAATGKQVDAWLGIPYAQKPIGA 105 aphgo-ACHE1 DTN--FESSGATYSAYTSDDPLIIHTNKGKIRGI-TQEATTGKLVDAWLGIPYAKKPIGD 139 rhopd-ACHE1 DTD--FASSGETYSAYTSDDPLIIHTNKGKIRGI-TQTATTGKLVDAWLGIPYAKKPIGD 139 myzpe-ACHEM DND--FESSGETYSAYKSDDPLVIHTNKGKIRGI-TQAASTGKLVDAWLGIPYAKKPIGD 139 sitav-ACHE1 DND--FESSGETYSAYKSDDPLVIHTNKGKIRGI-TQAASSGKLVDAWLGIPYAKKPIGD 139 culpi-ACHE1 TTRRRGLTRRESSSDATDSDPLVITTDKGKIRGT-TLEAPSGKKVDAWMGIPYAQPPLGP 170 cultr-ACHE1 TTRRRGLTRRESNSDSTDSDPLVITTDKGKIRGT-TLEAPSGKKVDAWMGIPYAQPPLGP 168 anoga-ACHE1 TPRRRGLTRRESNSDANDNDPLVVNTDKGRIRGI-TVDAPSGKKVDVWLGIPYAQPPVGP 203 tetka-ACHE SSS--SSFNSEHHHHHHHNDPLVVLTKKGYVRGR-SVVSPTGKPVDAFLGIRYAKPPTGK 151 tetur-ACHE SSS--SSFNSEHHHHHHHNDPLVVLTKKGYVRGR-SVVSPTGKPVDAFLGIRYAKPPTGK 151 bacdo-ACHE LFAIVVLLLRMSSVYG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPLDD 96 bacol-ACHE LFAIVVLLLRMSSVYG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPLDD 96 cerca-ACHE LFAIVILLLRMSSVYG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPLDD 96 haeir-ACHE LLATFVILLRMSALASAMTDRLIVQTTSGPVRG--RAVTVQGREVHVFTGIPYAKPPVDD 132 musdo-ACHE -----------------MTDHLTVQTTSGPVRG--RSVTVQGRDVHVFTGIPYAKPPVDD 41 luccu-ACHE FLTTLVILLRMSSVAYGITDRLIVQTTSGPVRG--RAVTVQGREVHVFTGIPYAKPPVDD 161 drome-ACHE LPLVLVLSLHLSGVCG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPVED 79 aedae-ACHE MISLLLCITVISPVYG-IFDRLVVQTSSGPIRG--RSTMVLGREVHVFNGVPFAKPPVDG 69 aphgo-ACHE2 GGGGAGGGGGGGSAVDDTDEIPVVVTSTGLVQG--YTKIIANREVRVYTGIPFAKPPVGQ 103 rhopd-ACHE2 AGGGAGGGGGGGSAVDDTDESPVVVTSTGLVQG--YTKIIANREVRVYTGIPFAKPPVGH 96 sitav-ACHE2 GGGGGGGGGGGGSAVDDTDESPVVVTSSGMVQG--YTKIIANRGVRVYTGIPFAKPPVGP 103 lepde-ACHE ----------PSQFKDFHTDPLVVETTSGLVRG--YSKTVLGREVHVFTGIPFAKPPIEQ 78 boomi-este13 ------VILAFNLTATAEDMHVERETTEGRVRGK-VVHVLDNEPVEEYVGIPYAEPPLDK 63 boomi-acche3 PPDDIQSLSTTTSRPISTEESPIVETNSGPVQG--RRVYAANRTLYQFVGIPFAEPPVGP 130 luccu-E3aest7 -WKIKCIENKFLNYRLTTNETVVAETEYGKVKGVKRLTVYDDS-YYSFEGIPYAQPPVGE 70 musdo-EST23aes07 -WKLKCMVNKYTNYRLSTNETQIIDTEYGQIKGVKRMTVYDDS-YYSFESIPYAKPPVGE 70 colho-E3aest7 -WKIKCFENKFLNYRLSTNETAVAETEYGKVKGIKRLTVYDDS-YYSFEGIPYAQPPLGE 70 drome-EST23aes07 -----TIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDVP-YFSFEGIPYAQPPVGE 54 anica-cxest ------------------MERPEVKTLSGQVRGLKQISVEGIG-FYAFKGIPYAKPPVGE 41 aphgo-cxest ---------------------MEVVIEQGALKGLKKKTLLSNKPYVSFLGIPYAQPPVND 39 Consensus * : * : .: :*: * ! ! !? ??? ?!!!?!! !??!! ? !! ! torca-ACHE MRFRRPEPKKPWS-----GVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYL 97 9neop-ACHE1 LRFRHPRPAESWG----EEILNTTTLPHPCVQIIDTVFGDFPGAMMWNPNTDMQEDCLYI 211 cydpo-ACHE1 LRFRHPRPVESWG----EEILNATTLPHSCVQIVDTVFGDFPGAMMWNPNTDMQEDCLYI 208 pluxy-ACHE1 LRFRHPRPVENWG----DEILNATTLPHSCVQIIDTVFGDFPGAMMWNPNTDMQEDCLYI 195 bemta-ACHE1 LRFRHPRPIDKW-----EGILNATKMPNSCTQIVDTVFGDFAGSAMWNPNTPMSEDCLYI 160 aphgo-ACHE1 LRFRHPRPIDRWDTTSPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199 rhopd-ACHE1 LRFRHPRPIDRWDTTSPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199 myzpe-ACHEM LRFRHPRPIDRWDNTNPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199 sitav-ACHE1 LRFRHPRPIDRWDKTSPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199 culpi-ACHE1 LRFRHPRPAERWT-----GVLNATKPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYI 225 cultr-ACHE1 LRFRHPRPAERWS-----GVLNATKPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYI 223 anoga-ACHE1 LRFRHPRPAEKWT-----GVLNTTTPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYI 258 tetka-ACHE FRFRHPKPIDSWQ-----GIFNATSFSGACYQVNDTFFGNFMGATEWNPNVPLDEDCLSV 206 tetur-ACHE FRFRHPKPIDSWQ-----GIFNATSFSGACYQVNDTFFGNFMGATEWNPNVPLDEDCLSV 206 bacdo-ACHE LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 151 bacol-ACHE LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 151 cerca-ACHE LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 151 haeir-ACHE LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEMWNPNTNVSEDCLFM 187 musdo-ACHE LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLFM 96 luccu-ACHE LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYM 216 drome-ACHE LRFRKPVPAEPWH-----GVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 134 aedae-ACHE LRFRKPVPAEPWH-----GVLDATRLPPSCIQERYEYFPGFAGEEMWNPNTNVSEDCLYL 124 aphgo-ACHE2 LRFRRPVPVDPWT-----GVLNATRLPNTCYQERYEYFPGFVGEEMWSPNTKLSEDCLYL 158 rhopd-ACHE2 LRFRRPVPVDPWP-----GVLNATRLPNTCYQERYEYFPGFVGEDMWNPNTKLSEDCLYL 151 sitav-ACHE2 LRFRRPVPVDPWT-----GVLNATRLPNTCYQERYEYFPGFVGEEMWNPNTKLSEDCLYL 158 lepde-ACHE LRFKKPVPIDPWH-----GILDATKQPNSCFQERYEYFPGFEGEEMWNPNTNISEDCLYL 133 boomi-este13 LRFRPPQPKKRWQ-----DTLDATSTRTACPQIEMQLVIMN--------NVTYTEDCLHL 110 boomi-acche3 LRFRNPVPVKPWS-----SVYQATKKPFPCLQT-----DFYINSNVTIPTANSSEDCLYL 180 luccu-E3aest7 LRFKAPQRPTPWD-----GVRDCCNHKDKSVQVDFIT-----------GKVCGSEDCLYL 114 musdo-EST23aes07 LRFKAPQRPVPWE-----GVRDCCGPANRSVQTDFIS-----------GKPTGSEDCLYL 114 colho-E3aest7 LRFKAPQRPTPWD-----GVRDCCNNKDKSVQVDFIT-----------GKTCGSEDCLYL 114 drome-EST23aes07 LRFKAPQRPIPWE-----GVRDCSQPKDKAVQVQFVF-----------DKVEGSEDCLYL 98 anica-cxest LRFKDPVPIEPWQ-----EVREATEFGPMAAQFDVIS-----------KFSGGSDDCLYI 85 aphgo-cxest LRFKAPVKHPGWS-----GVLNAVSERDKCTQYVFMT-----------NHIVGSEDCLYL 83 Consensus :**: * * : . * :*** : ! !! ? ! !!? ?!! torca-ACHE NIWVP-SPRPKS--------------------------------TTVMVWIYGGGFYSGS 124 9neop-ACHE1 NIVSP-RPRPKN--------------------------------AAVMLWVFGGGFYSGT 238 cydpo-ACHE1 NIVTP-RPRPKN--------------------------------AAVMLWVFGGGFYSGT 235 pluxy-ACHE1 NIVTP-RPRPKN--------------------------------AAVMLWVFGGGFYSGT 222 bemta-ACHE1 NVITP-KPRPRN--------------------------------AAVMVWIFGGGFYTGT 187 aphgo-ACHE1 NVVVP-RPRPQN--------------------------------AAVMVWIFGGGFYSGS 226 rhopd-ACHE1 NVVVP-KPRPQN--------------------------------AAVMVWIFGEGFYSGS 226 myzpe-ACHEM NVVVP-KPRPQN--------------------------------AAVMVWIFGGGFYSGS 226 sitav-ACHE1 NVVVP-KLRPQN--------------------------------AAVVVWIFGGGFYSGS 226 culpi-ACHE1 NVVVP-RPRPKN--------------------------------AAVMLWIFGGGFYSGT 252 cultr-ACHE1 NVVAP-RPRPKN--------------------------------AAVMLWIFGGGFYSGT 250 anoga-ACHE1 NVVAP-RPRPKN--------------------------------AAVMLWIFGGGFYSGT 285 tetka-ACHE NIWVP-RPRPKS--------------------------------AAVLLWIYGGGFWSGS 233 tetur-ACHE NIWVP-RPRPKS--------------------------------AAVLLWIYGGGFWSGS 233 bacdo-ACHE NVWAPAKARLRHGRGANGGEHSN--KADTDHLIHNGNPQNTTNGLPVLIWIYGGGFMTGT 209 bacol-ACHE NVWAPAKARLRHGRGANGGEHSN--KADTDHLIHNGNPQNITNGLPVLIWIYGGGFMTGT 209 cerca-ACHE NVWAPAKARLRHGRGANGGEHSN--KADTDHLIHNGNPQNTTNGLPVLIWIYGGGFMTGT 209 haeir-ACHE NIWAPAKARLRHGRGTNGGEHSS--KTDQDHLIHSATPQNTTNGLPILIWIYGGGFMTGS 245 musdo-ACHE NIWAPAKARLRHGRGTNGGEHSS--KTDQDHLIHSATPQNTTNGLPILIWIYGGGFMTGS 154 luccu-ACHE NIWAPAKARLRHGRGANGGEHSS--KTDPDHLIHSATPQNTTNGLPILIWIYGGGFMTGS 274 drome-ACHE NVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGS 194 aedae-ACHE NIWVPTKTRLRHGRGLNFGNNDY--FQDDDDFQR---QHQSKGGLAMLVWIYGGGFMSGT 179 aphgo-ACHE2 NIWIPKKQRTRHHSNN--AHHAK---------------------IPVLVWIYGGGYMSGT 195 rhopd-ACHE2 NIWIPRKQRTRHHSNN--AHHAK---------------------IPVLVWIYGGGYMSGT 188 sitav-ACHE2 NIWIPKKQRTRHHSNN--AHHAK---------------------IPVLVWIYGGGYMSGT 195 lepde-ACHE NIWVPQRLRIRHHADKPTIDRPK---------------------VPVLIWIYGGGYMSGT 172 boomi-este13 NIWVPEKAMNPG------------------------------AKQPVLVWIHGGGFTFGS 140 boomi-acche3 NVWTPSRECVLG--------------------------KFSCVPKTVIVYIYGGTFSFGS 214 luccu-E3aest7 SVYTNNLN-PETKR-------------------------------PVLVYIHGGGFIIGE 142 musdo-EST23aes07 NVYTNDLN-PDKKR-------------------------------PVMVFIHGGGFIFGE 142 colho-E3aest7 SVYTNNLA-PETKR-------------------------------PVLVYIHGGGFVIGE 142 drome-EST23aes07 NVYTNNVK-PDKAR-------------------------------PVMVWIHGGGFIIGE 126 anica-cxest NVYTKKIN-SNVKQ-------------------------------PVMFYIHGGGFIFGS 113 aphgo-cxest NISVPQQNELNGKL-------------------------------AVMIFIHGGAFNYGS 112 Consensus .: .::.::.* : * !!???! ? ! ! ! !? ! ? ! torca-ACHE STLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALH-------GSQEAPGNVGLLDQRMAL 177 9neop-ACHE1 ATLDVYDPKIMVSEEKIVYVSMQYRVASLGFLFFD--------TPDVPGNAGMFDQLMAL 290 cydpo-ACHE1 ATLDVYDPKILVSEEKVVYVSMQYRVASLGFLFFD--------TPDVPGNSGLFDQLMAL 287 pluxy-ACHE1 ATLDVYDPKILVSEEKIVYVSMQYRVASLGFLFFD--------TPDVPGNAGLFDQLMAL 274 bemta-ACHE1 ATLDIYDYKILASEENVILVSMQYRITCLGFLYFD--------TQDVPGNAGLFDQLMAL 239 aphgo-ACHE1 ATLDIYDPKILVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278 rhopd-ACHE1 ATLDIYDPKILVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278 myzpe-ACHEM ATLDIYDPKVLVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278 sitav-ACHE1 ATLDIYDPKVLVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278 culpi-ACHE1 ATLDVYDHRTLASEENVIVVSLQYRVASLGFLFLG--------TPEAPGNAGLFDQNLAL 304 cultr-ACHE1 ATLDVYDHRTLASEENVIVVSLQYRVASLGFLFLG--------TPEAPGNAGLFDQNLAL 302 anoga-ACHE1 ATLDVYDHRALASEENVIVVSLQYRVASLGFLFLG--------TPEAPGNAGLFDQNLAL 337 tetka-ACHE SSLDFYDGSVLAGEESIIFVSINYRVASLGFIFFD--------TSDAPGNAGLFDQLMAM 285 tetur-ACHE SSLDFYDGSVLAGEESIIFVSINYRVASLGFIFFD--------TSDAPGNAGLFDQLMAM 285 bacdo-ACHE ATLDIYNADIMSAVGNVIVASFQYRVGAFGFLHLSPAMP-GY-EEEAPGNVGLWDQALAI 267 bacol-ACHE ATLDIYNADIMSAVGNVIVASFQYRVGAFGFLHLSPAMP-GY-EEEAPGNVGLWDQALAI 267 cerca-ACHE ATLDIYNADIMSAVGNVIVASFQYRVGAFGFLHLSPAMP-GY-EEEAPGNVGLWDQALAI 267 haeir-ACHE ATLDIYNAEIMSAVGNVIVASFQYRVGAFGFLHLSPVMP-GF-EEEAPGNVGLWDQALAL 303 musdo-ACHE ATLDIYNAEIMSAVGNVIVASFQYRVGAFGFLHLSPVMP-GF-EEEAPGNVGLWDQALAL 212 luccu-ACHE ATLDIYNADIYS-VGNVSVASFQYRVGAFGFLHLSPVMP-GF-EEEAPGNVGLWDQALAL 331 drome-ACHE ATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEF-AEEAPGNVGLWDQALAI 253 aedae-ACHE STLDVYNAEMLAAVGNVIVASMQYRVGSFGFFYLAPYLN----DDDAPGNVGLWDQALAI 235 aphgo-ACHE2 STLDIYDGDLLAATFDVMIASMQYRLGAFGSLYLTPELP-ED-SDDAPGNMGLWDQALAI 253 rhopd-ACHE2 STLDIYDGDLLAATFDVMIASMQYRLGAFGSLYITPELP-ED-SDDAPGNMGLWDQALAI 246 sitav-ACHE2 STLDIYDGDLLAVTFDVMIASMQYRLGAFGSLYLTPELP-ED-SDDAPGNMGLWDQALAI 253 lepde-ACHE ATLDVYDADIIAATSDVIVASMQYRLGSFGFLYLNRYFP-RG-SDETPGNMGLWDQILAI 230 boomi-este13 ANQWEYNGAVLAATTDVVVVAMNYRLSILGFMSAN--------SPEAPGNVGMLDQVMVL 192 boomi-acche3 SGWDWYDGKEFVARGDVVMVSMNYRVGPMGFFHSG--------TTHSSGNAGLHDQLLAM 266 luccu-E3aest7 NHRDMYG-PDYFIKKDVVLINIQYRLGALGFLSLNS------EDLNVPGNAGLKDQVMAL 195 musdo-EST23aes07 ANRNWFG-PDYFMKKPVVLVTVQYRLGVLGFLSLKS------ENLNVPGNAGLKDQVMAL 195 colho-E3aest7 NHREYYG-PDYFIKKDVVLITIQYRLGVLGFLSLNS------EELNVPGNAGLKDQVMAL 195 drome-EST23aes07 ANREWYG-PDYFMKEDVVLVTIQYRLGALGFMSLKS------PELNVPGNAGLKDQVLAL 179 anica-cxest GNDFFYG-PDFLMRKDIVLVTFNYRLGVFGFLNLEH------EVA--PGNQGLKDQVMAL 164 aphgo-cxest GSMNEYS-PDYFIDENVIVVTINYRLNALGFLNLDI------DEC--PGNVGLKDQLFAI 163 Consensus :. : ..**: :* : .** *: ** :.: ! ? !?!? ! !! !??! !?? torca-ACHE QWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVS 237 9neop-ACHE1 QWVKDNIAYFGGNPHNVTLFGESAGAVSVSLHLLSPLSRNLFSQAIMQSGAATAPWAIIS 350 cydpo-ACHE1 QWVKDNIAYFGGNPHNVTLFGESAGAVSVSLHLLSPLSRNLFSQAIMQSGAATAPWAIIS 347 pluxy-ACHE1 QWVKDNIQYFGGNPHNVTLFGESSGAVSVSLHLLSPLSRNMFSQAIMQSAAASAPWAIIS 334 bemta-ACHE1 QWIRNNIHAFGGNPHNITLFGESAGAVSVSMHLLSPLSRNLFSQAIMESGSATAPWAIIS 299 aphgo-ACHE1 QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTVPWAILS 338 rhopd-ACHE1 QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTAPWAILS 338 myzpe-ACHEM QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTAPWAILS 338 sitav-ACHE1 QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTAPWAILS 338 culpi-ACHE1 RWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVS 364 cultr-ACHE1 RWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVS 362 anoga-ACHE1 RWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVS 397 tetka-ACHE EWIRENIAAFGGNPANITIFGESAGAVSAALHLLSPLSRNVFSQAILQSGSATCPWAISD 345 tetur-ACHE EWIRENIAAFGGNPANITIFGESAGAVSAALHLLSPLSRNVFSQAILQSGSATCPWAISD 345 bacdo-ACHE RWLKTNAHAFGGNPEWMTLFGESAGSSSVNAQLVSPVTAGLVKRGMMQSGTMNAPWSHMT 327 bacol-ACHE RWLKTNAHAFGGNPEWMTLFGESAGSSSVNAQLVSPVTAGLVKRGMMQSGTMNAPWSHMT 327 cerca-ACHE RWLKTNAHAFGGNPEWMTLFGESAGSSSVNAQLVSPVTAGLVKRGMMQSGTMNAPWSHMT 327 haeir-ACHE RWLKENARAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMT 363 musdo-ACHE RWLKENARAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMT 272 luccu-ACHE RWLKENARAFGGNPEWMTLFGESAGSSSVNAQLASPVTRGLVKRGMMQSGTMNAPWSHMT 391 drome-ACHE RWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMT 313 aedae-ACHE RWLKENAKAFGGDPDLITLFGESAGGSSVSLHLLSPVTRGLSRRGILQSGTLNAPWSHMS 295 aphgo-ACHE2 KWIKENAAAFGADPETITLFGESAGGGSVSVHLISPETGGMVKRGIIQSGTVNAPWSYMT 313 rhopd-ACHE2 KWIKENAAAFGADPETITLFGESAGGGSVSVHLISPETRGMVKRGIIQSGTVNAPWSYMT 306 sitav-ACHE2 KWIKENATVFGADPETITLFGESAGGGSVSVHLISPETRGMVRRGIIQSGTVNAPWSYMT 313 lepde-ACHE RWIKDNAAAFGGDPDLITLFGESAGGGSISIHLISPVTKGLVRRGIMQSGTMNAPWSYMS 290 boomi-este13 KWIQRNIEHFGGDPDRVTLFGESAGAMSAHAHVLSPMSEGLFKRAVLMSGTMYNIDLWDM 252 boomi-acche3 KWVKQNIRNFGGDPDDVTLVGQSAGAISIGLHLVSPLSKGLFKRIIMESGSPYFRIADNT 326 luccu-E3aest7 RWIKNNCANFGGNPDNITVFGESAGAASTHYMMLTEQTRGLFHRGILMSGNAICPWANT- 254 musdo-EST23aes07 RWVKSNIANFGGDVDNITVFGESAGGASTHYMMITEQTRGLFHRGIMMSGNSMCSWAST- 254 colho-E3aest7 RWIKNNCANFGGNPDNITVFGESAGGASAHYMMLTEQTRGLFHRGILMSGNAVCPWAIS- 254 drome-EST23aes07 KWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNG 239 anica-cxest KWVRDNIANFGGDSENVTIFGESAGGASVHYLTVSPLAKGLFHKAISQSGVFMNPWASVS 224 aphgo-cxest KWVKANIAAFGGDVNNITIFGESAGSASVHYHTISPQSRGLFQKAIMQSGSAFNPWAFT- 222 Consensus .*:: * **.: :*:.*:*:*. * : : .: : : *. ? ! ! ? ?! !! ? ! ! ?!!?? !!?! !?!? torca-ACHE VAEGRRRAVELGRNLNCN---LNSD----EELIHCLREKKPQELIDVEWNVLPFDSIFRF 290 9neop-ACHE1 REESILRGTRLAEAVHCP---HSLK--DMGPMIECLRKKSADELVNNEWGTL---GICEF 402 cydpo-ACHE1 REESILRGIRLAEAVHCP---HSRI--DMGPMIECLRKKSADELVNNEWGTL---GICEF 399 pluxy-ACHE1 REESVIRGIRLAEAVHCP---HSKT--DMGPMIECLRKKSADELVNNEWGTL---GICEF 386 bemta-ACHE1 RQESIIRGLRLAEAVGCP---HTRA--QIPEAIECLRKVNASVLVENESGTL---GICDF 351 aphgo-ACHE1 REESFSRGLKLAKAMGCP---DDRN--EIHKTVECLRKVNSSAMVEKEWDHV---AMCFF 390 rhopd-ACHE1 REESFSRGLKLAKAMGCP---DDRN--AIHKTVECLRKANSSMMVEKEWDHV---AICFF 390 myzpe-ACHEM REESYSRGLRLARAMGCP---DDRN--EIHKTVECLRKANSSTMVEKEWDHV---AICFF 390 sitav-ACHE1 REESYNRGLKLAKAMGCP---DDRN--AIHKTVECLRKVNSSAMVEKEWDHV---AICFF 390 culpi-ACHE1 REEATLRALRLAEAVNCP---HDAT--KLSDAVECLRTKDPNELVDNEWGTL---GICEF 416 cultr-ACHE1 REEATLRALRLAEAVNCP---HDAT--KLSEAVECLRTKDPNELVDNEWGTL---GICEF 414 anoga-ACHE1 REEATLRALRLAEAVGCP---HEPS--KLSDAVECLRGKDPHVLVNNEWGTL---GICEF 449 tetka-ACHE RKKAYQRSLALAQAVGCG---STSTR-SVHAIIECMQSIPASELVAQEEATT---GVVEF 398 tetur-ACHE RKKAYQRSLALAQAVGCG---STSTR-SVHAIIECMQSIPASELVAQEETTT---GVVEF 398 bacdo-ACHE SEKAVEIGKALINDCNCN---ASLLSENPQAVMACMRAVDAKTISVQQWNS--YSGILSF 382 bacol-ACHE SEKAVEIGKALINDCNCN---ASLLSENPQAVMACMRAVDAKTISVQQWNS--YSGILSF 382 cerca-ACHE SEKAVEIGKALINDCNCN---ASLLAENPQAVMACMRAVDAKTISVQQWNS--YSGILSF 382 haeir-ACHE SEKAVEIGKALINDCNCN---ASLLPENPQAVMACMRSVDAKTISVQQWNS--YSGILSF 418 musdo-ACHE SEKAVEIGKALVNDCNCN---ASLLPENPQAVMACMRQVDAKTISVQQWNS--YSGILSF 327 luccu-ACHE SEKAVEIGKALINDCNCN---ASLLPANPQSVMACMRAVDAKTISVQQWNS--YSGILSF 446 drome-ACHE SEKAVEIGKALINDCNCN---ASMLKTNPAHVMSCMRSVDAKTISVQQWNS--YSGILSF 368 aedae-ACHE AEKALSVAEALIDDCNCN---VTLLKDNPNYVMNCMRNVDAKTISVQQWNS--YSGILGF 350 aphgo-ACHE2 GERAVEIAKKLLDDCNCN---STSLDSNPIGTMSCMRPVDASTISKKQWNS--YSGILGF 368 rhopd-ACHE2 GERAVDIAKKLLDDCNCN---STSLDSNPIGTMSCMRSVDASTISKKQWNS--YSGILGF 361 sitav-ACHE2 GERAVDIAKKLLDDCNCN---STSLDSNPIGTMSCLRSVDASTISKKQWNS--YSGILGF 368 lepde-ACHE SERAEQIGKILIQDCGCN---VSLLENSPRKVMDCMRAVDAKTISLQQWNS--YSGILGF 345 boomi-este13 VHESMVKGNKVANIVGCSKGGSIDLSSNAEEIVDCFRKKSADELVKAAAESVAP---KKI 309 boomi-acche3 RE-GPHKVEKLARALQCARN-DMTIESHMAEMVECLRKIDGKELLIMSNTIFG---VHAL 381 luccu-E3aest7 -QCQHR-AFTLAKLAGYK---GEDNDKDVLEFLMKAKPQDLIKLEEKVLTLEERTNKVMF 309 musdo-EST23aes07 -ECQSR-ALTMAKRVGYK---GEDNEKDILEFLMKANPYDLIKEEPQVLTPEEMQNKVMF 309 colho-E3aest7 -QNQHR-AYAIAKLNGYK---GENNDKDVLEFLMKAKAHDLIKLEDKVLTPEEHVNKVMF 309 drome-EST23aes07 -DITHN-PYRIAKLVGYK---GEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMF 294 anica-cxest GEPRKK-AYELCELLGKK---TTDP-VEIVKFLRTVDTMKLIEHQG-ELQIQELQKKCLS 278 aphgo-cxest ENHKAS-AYKLAKNLGCL---SNDP-KEILKYLKNVSAIDLVKETE----FKDETDFMDY 273 Consensus : : ! ! ! ! ! ! ! !!? ??! ???? !!! torca-ACHE SFVPVIDG-----EFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPG-FSKDSE 344 9neop-ACHE1 PFVPIIDG-----SFLDEMPIRSLAHQNFKKTNILMGSNTEEGYYFILYYLTELFPKEEN 457 cydpo-ACHE1 PFVPIIDG-----SFLDEMPIRSLAHQNFKKTNLLLGSNTEEGYYFILYYLTELFPKEEN 454 pluxy-ACHE1 PFVPIIDG-----SFLDEMPIRSLAHQNFKKTNILMGSNTEEGYYFILYYLTELFPKEEN 441 bemta-ACHE1 PFVPVVDG-----SFLDEMPSKSLATKNFKKTNILMGSNTEEGNYFIMYYLTDLFRKEEN 406 aphgo-ACHE1 PFVPVVDG-----AFLDDHPQKSLSTNNFKKTNILMGSNSEEGYYFIFYYLTELFKKEEN 445 rhopd-ACHE1 PFVPVVDG-----AFLDDHPQKSLSTNNFKKTNILMGSNSEEGYYSIFYYLTELFKKEEN 445 myzpe-ACHEM PFVPVVDG-----AFLDDYPQKSLSTNNFKKTNILMGSNSEEGYYSIFYYLTELFKKEEN 445 sitav-ACHE1 PFVPVVDG-----AFLDDYPQKSLSTNNFKKTNILMGSNSEEGYYSIFYYLTELFKKEEN 445 culpi-ACHE1 PFVPVVDG-----AFLDETPQRSLASGRFKKTDILTGSNTEEGYYFIIYYLTELLRKEEG 471 cultr-ACHE1 PFVPVVDG-----AFLDETPQRSLASGRFKKTEILTGSNTEEGYYFIIYYLTELLRKEEG 469 anoga-ACHE1 PFVPVVDG-----AFLDETPQRSLASGRFKKTEILTGSNTEEGYYFIIYYLTELLRKEEG 504 tetka-ACHE AFIPIVDG-----SFLDEDPEVSLRTKNFKHTPILTGSNRDEGTYFLVYHSPHIFNLSEG 453 tetur-ACHE AFIPIVDG-----SFLDEDPEVSLRTKNFKHTPILTGSNRDEGTYFLVYHSPHIFNLSEG 453 bacdo-ACHE PSAPTIDG-----AFLPDHPMKMMETADLRGYDILMGNVRDEGTYFLLYDFIDYFDKDEA 437 bacol-ACHE PSAPTIDG-----AFLPDHPMKMMETADLRGYDILMGNVRDEGTYFLLYDFIDYFDKDEA 437 cerca-ACHE PSAPTIDG-----AFLPDDPMKMMETADMRGYDILMGNVRDEGTYFLLYDFIDYFDKDEA 437 haeir-ACHE PSAPTIDG-----AFLPADPMTLLKTADLTGYDILMGNVKDEGTYFLLYDFIDYFDKDDA 473 musdo-ACHE PSAPTIDG-----AFLPADPMTLLKTADLSGYDILIGNVKDEGTYFLLYDFIDYFDKDDA 382 luccu-ACHE PSAPTIDG-----AFLPADPMTLMKTADMSGYDIMIGNVKDEGTYFLLYDFIDYFDKDEA 501 drome-ACHE PSAPTIDG-----AFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDA 423 aedae-ACHE PSAPTIDG-----VFMTADPMTMLREANLEGVEILVGSNRDEGTYFLLYDFIDYFEKDAA 405 aphgo-ACHE2 PSAPTVDG-----ILLPEHPLDMLAKANFSDIDILIGSNLNEGTYFLLYDFVDFFDRTSA 423 rhopd-ACHE2 PSAPTVDG-----IFLPEHPLDMLAKANFSDIDILIGSNLNEGTYFLLYDFVDFFDRTSA 416 sitav-ACHE2 PSAPTVDG-----VLLPEHPLDMLAKANFSDIDILIGSNLNEGTYFLLYDFVDFFDRTSA 423 lepde-ACHE PSTPTIEG-----VLLPKHPMDMLAEGDYEDMEILLGSNHDEGTYFLLYDFIDFFEKDGP 400 boomi-este13 PFAPIYHD-----AFLPKMPLVAMNRGFFASVDIVAGVTSDEGALALVFPPKLELLPDDL 364 boomi-acche3 TFFPVFGD-----DIIPDDPYLMMEQKKFHKADLLIGNNLDEGSYFVFYLFGRALDLEQA 436 luccu-E3aest7 PFGPTVEPYQTADCVLPKHPREMVKTAWGNSIPTMMGNTSYEGLFFTSILKQMPMLVKEL 369 musdo-EST23aes07 PFGPTVEPYQTADCVVPKPIREMVKSAWGNSIPTLIGNTSYEGLLFKSIAKQYPEVVKEL 369 colho-E3aest7 AFGPTVEPYQTADCVLPKHPREMVKTAWGNSIPTMMGNTSYEGLLFTPIVKQMPALLKEL 369 drome-EST23aes07 RFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQL 354 anica-cxest AFVPGVDDKSPNPFMP---FSREVAVEQAAHVPYLIGYNDREGTLLYKIFENDDFESKNL 335 aphgo-cxest KFVPSIESDVISNPFLPAHPKTLATSTFP--VPVIIGVNNMEGIVALTEDRIS--LFSDD 329 Consensus * . . * ** ? ! ? ! ! ! !! ! ! ?! !! ! torca-ACHE SKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMD--DNNGIKNRDGLDDIVGDHNVIC 402 9neop-ACHE1 VGITREQYLQAVRELNPYVSDVGRQAIVFEYTDWLN--PEDPVRNRNALDKMVGDYHFTC 515 cydpo-ACHE1 VGITREQYLQAVRELNPYVTDVARQAIVFEYTDWLN--PDDPIKNRNALDKMVGDYHFTC 512 pluxy-ACHE1 VGISREQYLQAVRELNPYVNDVARQAIVFEYTDWLN--PDDPIRNRNALDKMVGDYHFTC 499 bemta-ACHE1 IHVSRDQFIQAVSELNPYN-FIVRRAIIFEYTDWLN--PDDPVKNRDALDKIVGDFHFTC 463 aphgo-ACHE1 VVVSRENFIKAIGQLNPNADAAVKSAIEFEYTDWFN--PNDPEKNRNALDKMVGDYQFTC 503 rhopd-ACHE1 VMVSRENFVKAIGQLNPNADAAVKSAIEFEYTDWFS--PNDPEKNRNALDKMVGDYQFTC 503 myzpe-ACHEM VVVSRENFVKAIGQLNPNADAAVKSAIEFEYTDWFS--PNDPEKNRNALDKMVGDYQFTC 503 sitav-ACHE1 VVVSRENFVKAIGQLNPNADAAVKSAIEFEYTDWFS--PNDPEKNRNALDKMVGDYQFTC 503 culpi-ACHE1 VTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWIE--PDNPNSNRDALDKMVGDYHFTC 529 cultr-ACHE1 VTVSREEFLQAVRELNPYVNGAARQAIVFEYTDWIE--PDNPNSNRDALDKMVGDYHFTC 527 anoga-ACHE1 VTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE--PDNPNSNRDALDKMVGDYHFTC 562 tetka-ACHE IYISRSEFQSLIRIIYPHLSPLAQEAVIQEYTHWIN--PDDQIENREATDKFVGDYHFTC 511 tetur-ACHE IYISRSEFQSLIRIIYPHLSPLAQEAVIQEYTHWIN--PDDQIENREATDKFVGDYHFTC 511 bacdo-ACHE TSLPRDKYLEIMNNIFGKVTQAEREAIIFRHTSWV---GNPGLENQQQIGRAVGDHFFTC 494 bacol-ACHE TSLPRDKYLEIMNNIFGKVKPAERDAIIFRHTSWV---GNPGLENQQQIGRAVGDHFFTC 494 cerca-ACHE TSLPRDKYLEIMNNIFGKVTQAEREAIIFRHTSWV---GNPGLENQQQIGRAVGDHFFTC 494 haeir-ACHE TSLPRDKYLEIMNNIFNKATQAEREAIIFQYTSWE---GNPGYQNQQQIGRAVGDHFFTC 530 musdo-ACHE TSLPRDKYLEIMNNIFQKASQAEREAIIFQYTSWE---GNPGYQNQQQIGRAVGDHFFTC 439 luccu-ACHE TSLPRDKYLEIMNNIFNKATQAEREAIIFQYTSWE---GNPGYQNQQQNGRAVGDHFFTC 558 drome-ACHE TALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE---GNPGYQNQQQIGRAVGDHFFTC 480 aedae-ACHE TSLPRDKFLEIMNTIFSKASEPEREAIIFQYTGWES--GNDGYQNQQQVGRSVGDHFFIC 463 aphgo-ACHE2 TALPREKFVQIVNVIFKDRTQLERDAIIYQYSGWEKKEVDDIYSNQKQLSDVVADYFFVC 483 rhopd-ACHE2 TALPREKFVQIVNVIFKDRTQLERDAIIYQYSGWEKKEVDDIYSNQKQLSDVVADYFFVC 476 sitav-ACHE2 TALPKEKFVQIVNVIFKDRTQLERDAIIYQYSGWEKKEVDDKYSNQKQLSDVVADYFFVC 483 lepde-ACHE SFLQREKYHDIIDTIFKNMSRLERDAIVFQYTNWEH--VHDGYLNQKMIGDVVGDYFFVC 458 boomi-este13 DGSNPEKLKDSLRTALSSWVKEDIPDIEDKYADDAP--QGDGNALRRQYLDYLSDRLFNC 422 boomi-acche3 HKITKYEVDLYVSYCLQMLLRKNVSPIRHYYLSHIG--ERENIKALQKAAEAVGDFAIIC 494 luccu-E3aest7 ETCVNFVPSELADAERTAPETLEMGAKIKKAHVTGE------TPTADNFMDLCSHIYFWF 423 musdo-EST23aes07 ESCVNYVPWELADSERSAPETLERAAIVKKAHVDGE------TPTLDNFMELCSYFYFLF 423 colho-E3aest7 ETCANFVPTELADSERSSAETLELGAKIKKAHVTGE------TPTNDNFLDLCSHFYFWF 423 drome-EST23aes07 DAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGS------ESTPDNYMDLCSIYYFVF 408 anica-cxest R-FEEFIHPNFAETLKRKKISLEDLKRMYFKNKKIS------KETTGKFIDLFSDMYFIQ 388 aphgo-cxest HHITDEISKLFRNRYSTETISKIKNFYFNKSNISSE------TMKLENICNLHSDVFFFN 383 Consensus . . ! !!! ! ! !? !!?!!! ! torca-ACHE PLMHFVNKYTKFGNGTYLYFFNHRASNLV--------------WPEWMGVIHGYEIEFVF 448 9neop-ACHE1 GVNEFAHRYAETGNNVYTYYYKHRSKNNP--------------WPSWTGVMHADEINYVF 561 cydpo-ACHE1 GVNELAHRYAETGNNVYTYYYKHRSKNNP--------------WPSWTGVMHADEINYVF 558 pluxy-ACHE1 GVNEFAHRYAETGNNVYTYYYKHRSKNNP--------------WPSWTGVMHGDEINYVF 545 bemta-ACHE1 NVNEFAYRYAETGNTVYMYYFKHRSTSSP--------------WPTWSGALHGDEINYIF 509 aphgo-ACHE1 NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549 rhopd-ACHE1 NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549 myzpe-ACHEM NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549 sitav-ACHE1 NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549 culpi-ACHE1 NVNEFAQRYAEEGNNVFMYLYTHRSKGNP--------------WPRWTGVMHGDEINYVF 575 cultr-ACHE1 NVNEFAQRYAEEGNNVFMYLYTHRSKGNP--------------WPRWTGVMHGDEINYVF 573 anoga-ACHE1 NVNEFAQRYAEEGNNVYMYLYTHRSKGNP--------------WPRWTGVMHGDEINYVF 608 tetka-ACHE PVNEMSYRYALYGNDVWTYHFTHRSSKSF--------------WPSWMGVIHGEEIKFVL 557 tetur-ACHE PVNEMSYRYALYGNDVWTYHFTHRSSKSF--------------WPSWMGVIHGEEIKFVL 557 bacdo-ACHE PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 540 bacol-ACHE PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 540 cerca-ACHE PTNEYAQVLAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 540 haeir-ACHE PTNEYAQALAERGAGVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 576 musdo-ACHE PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 485 luccu-ACHE PTNEYAQALAERGAQVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 604 drome-ACHE PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 526 aedae-ACHE PTNEFALGLAERGASVYYYYFTHRTSTSL--------------WGEWMGVLHGDEVEYIF 509 aphgo-ACHE2 PTNLFANIVSSRGARVYYYFFTHRTDSHL--------------WGDWMGVLHGDEMQYVF 529 rhopd-ACHE2 PTNLFANIVSSRGARVYYYFFTHRTDSHL--------------WGDWMGVLHGDEMQYVF 522 sitav-ACHE2 PTNLFANIVSSRGARVYYYFFTHRTDSHL--------------WGDWMGVLHGDEMQYVF 529 lepde-ACHE PTNNFAEVAADRGMKVFYYYFTHRTSTSL--------------WGEWMGVIHGDEVEYVF 504 boomi-este13 PLQFFAEKHSERGNKVFAYVFGHKYDAFN--------------LPAWMGVPHATDLQFAF 468 boomi-acche3 PTKYFAESFASMNNKVHYYYFTHRPSFST--------------WPGWVGPTHGDEVFFVM 540 luccu-E3aest7 PMHRLLQLRFNHTSGTPVYLYRFDFDSEDLINPYRIMRS----GRGVKGVSHADELTYFF 479 musdo-EST23aes07 PMHRFLQLRFNHTAGTPIYLYRFDFDSEEIINPYRIMRF----GRGVKGVSHADELTYLF 479 colho-E3aest7 PMHRLLQIRFKHTSGTPVYLYRFDFDSEEIINPYRIMRH----GRGVKGVSHADELTYLF 479 drome-EST23aes07 PALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRM----GRGVKGVSHADDLSYQF 464 anica-cxest GIHQVARVQAERNS-APTYMYQFTYDQG---PNFSKGMF----SIDEPGSTHMDELIYLF 440 aphgo-cxest GVYETFDCFLKQNG-SPVYEYEFKFDGELNGAKNMIFATRPILRHAIKGACHADDVNYFF 442 Consensus * : . * * :: : : ? !! ! ! !! !! ! ! torca-ACHE GLPLVKELNYTAEEE-------ALSRRIMHYWATFAKTGNPNE-----PHSQESKWPLFT 496 9neop-ACHE1 GEPLNPGKNYSPEEV-------EFSKRIMRYWANFARSGNPSL--NPNGDMTKVHWPVHT 612 cydpo-ACHE1 GEPLNPGKNYSPEEV-------EFSKRMMRYWANFAKTGNPSL--SPNGEMTKVHWPVHT 609 pluxy-ACHE1 GEPSNPGKNYSPEEV-------EFSKTIMRYWANFARTGNPSQ--SPNGELTKVHWPVHT 596 bemta-ACHE1 GEPLNPTKKYQPAEV-------ELAKRMMRYWANFAKTGNPSL--SSDGSWASVYWPQHT 560 aphgo-ACHE1 GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TLEGSWVTPKWPVRT 600 rhopd-ACHE1 GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TLEGSWVTPKWPVHT 600 myzpe-ACHEM GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TFEGSWVTPKWPVHT 600 sitav-ACHE1 GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TFEGSWVTPKWPVHT 600 culpi-ACHE1 GEPLNSALGYQDDEK-------DFSRKIMRYWSNFAKTGNPNP--STP-SVDLPEWPKHT 625 cultr-ACHE1 GEPLNAALGYQEDEK-------DFSRKIMRYWSNFAKTGNPNP--SPP-NADLPEWPKHT 623 anoga-ACHE1 GEPLNPTLGYTEDEK-------DFSRKIMRYWSNFAKTGNPNP--NTA-SSEFPEWPKHT 658 tetka-ACHE GEPLDPVHGYTPAEV-------QLSKRIMRYWANFARTGNPNKQFPDGDDTESIVWPEYT 610 tetur-ACHE GEPLDPVHGYTPAEV-------QLSKRIMRYWANFARTGNPNKQFPDGDDTESIVWPEYT 610 bacdo-ACHE GQPLNTSLQYRQVER-------ELGKRMLNAVIEFAKTGNPAT--------DGEEWPNFT 585 bacol-ACHE GQPSNTSLQYRQVER-------ELGKRMLNAVIEFAKTGNPAT--------DGEEWPYFS 585 cerca-ACHE GQPLNTSLQYRQVER-------ELGKRMLNAVIEFAKTGNPAT--------DGEEWPNFT 585 haeir-ACHE GQPLNTSLQYRPVER-------ELGKRMLNAVIEFAKTGNPAV--------DGEEWPNFS 621 musdo-ACHE GQPLNNSLQYRPVER-------ELGKRMLNSVIEFAKSGNPAV--------DGEEWPNFS 530 luccu-ACHE GQPLNTSLQYRAVER-------ELGKRMLNSVIEFAKTGNPAV--------DGEEWPNFS 649 drome-ACHE GQPLNNSLQYRPVER-------ELGKRMLSAVIEFAKTGNPAQ--------DGEEWPNFS 571 aedae-ACHE GQPMNVSMQYRQRER-------DLSRRMVLSVSEFARSGNPAL--------EGEHWPVYT 554 aphgo-ACHE2 GHLLNMSMPYNARER-------DLSIRIMEAFTRFSLTGTPVS--------DDIDWPLYN 574 rhopd-ACHE2 GHPLNMSMPYNARER-------DLSIRIMEAFTRFSLTGTPVS--------DDIDWPLYN 567 sitav-ACHE2 GHPLNMSMPYNARER-------DLSIRIMEAFTRFSLTGTPVS--------DDIDWPLYN 574 lepde-ACHE GHPLNMSLQFNSRER-------ELSLKIMQAFARFATTGKPVT--------DDVNWPLYT 549 boomi-este13 GIPYAAER--DSLNG-------RMSEAYMRMLGSFSENGRPELP-------SKQKWPRYT 512 boomi-acche3 GLPFSSPTIATDQER-------ELSKLMIETWTTFAKTGKVPD-------VASKPWPEFT 586 luccu-E3aest7 WNQLAKR--MPKE-----SREYKTIERMTGIWIQFATTGNPYS--NEIEGMENVSWDPIK 530 musdo-EST23aes07 WNILSKR--LPKE-----SREYKTIERMVGIWTEFATTGKPYS--NDIAGMENLTWDPIK 530 colho-E3aest7 WNALAKR--LPKE-----SREYKTIERMVGIWTQFATTGNPYS--NEIDGLENIIWDPIK 530 drome-EST23aes07 SSLLARR--LPKE-----SREYRNIERTVGIWTQFAATGNPYS--EKINGMDTLTIDPVR 515 anica-cxest SMKFQET--LNMEPIDKKSPHFRVMEQMVELWTNFAKYGRPIP--APTELLP-VHWLPMN 495 aphgo-cxest RDLSGVDPKPN-------SPELEMCKMMCKMWTNFAKTSNPNS--PDLS----FKWINAT 489 Consensus *: . ! ! ! ! ! !!!!!!!! ! ?!! ! ! torca-ACHE TKEQKFIDLNTEPM------KVHQRLRVQMCVFWNQFLPKLLNATETIDEAERQWKTEFH 550 9neop-ACHE1 AFGGEYLSLAVNSS------AVGHGLKVKQCAFWQKYLPQLMAATTKPEPIQ--NCTSNS 664 cydpo-ACHE1 AFGREYLSLAVNSS------AVGHGLRVKQCAFWQKYLPQLISATKKTEPPR--NCTGSS 661 pluxy-ACHE1 AFGREHLSLSANSSG-----TVDHGLRVKQCAFWQKYLPQLIAATSKPEPPK--NCTSSA 649 bemta-ACHE1 TYGREFLTLDINST------AIGQGPRLRQCAFWKKYLPQLISTTSYLVPANSSNCTSAA 614 aphgo-ACHE1 AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLTVISKSMKSDK--NCTTIS 652 rhopd-ACHE1 AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLTAISKSMKSDK--NCTTIS 652 myzpe-ACHEM AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLMAISKSMKSDK--NCTTIS 652 sitav-ACHE1 AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLTAISKSMKSDK--NCTTIS 652 culpi-ACHE1 AHGRHYLELGLNTT------FVGRGPRLRQCAFWKKYLPQLVAATSNLQVTP----APSV 675 cultr-ACHE1 AHGRHYLELGLNTS------FVGRGPRLRQCAFWKKYLPQLVAATSNLQVTP----APSV 673 anoga-ACHE1 AHGRHYLELGLNTS------FVGRGPRLRQCAFWKKYLPQLVAATSNLPGPA----PPSE 708 tetka-ACHE AHEKEYLVISTNDS------SIGRGLRAKQCAFWKNFLPKLINALENRHNST---CTSHS 661 tetur-ACHE AHEKEYLVISTNDS------SIGRGLRAKQCAFWKNFLPKLINALENRHNST---CTSHS 661 bacdo-ACHE KKDPVYYVFSTDDKE----EKLQRGPLEGRCAFWNEYLREVRKWGSQCELKPSSASSLQQ 641 bacol-ACHE KKDPVYYVFSTDDKE----EKLQRGPLEGRCAFWNEYLREVRKWGSQCEVKPSSASSLQQ 641 cerca-ACHE KKDPVYYVFSTDDKD----EKLQRGPLEGRCAFWNEYLREVRKWGSQCDVKQSSASTIQQ 641 haeir-ACHE KEDPVYYVFSTDEKI----EKLQRGPLAKRCSFWNDYLPKVRSWAGSECEDGSSQSASGA 677 musdo-ACHE KEDPVYYVFSTDEKI----EKLQRGPLAKRCSFWNDYLPKVRSWIGSECENKSSTSASAA 586 luccu-ACHE KEDPVYYVFSTDEKT----EKLQRGPLAKRCSFWNDYLPKVRSWVGSECENNSAESAAVS 705 drome-ACHE KEDPVYYIFSTDDKI----EKLARGPLAARCSFWNDYLPKVRSWAG-TCD---GDSGSAS 623 aedae-ACHE KENPIYFIFNAEGEDDLRGEKYGRGPMATACAFWNDFLPRLRAWSVPPKS---SCNILEQ 611 aphgo-ACHE2 ESKPIYHVWNAAEMH------VGYGPRAAECQFWNGFFPKIAQALKETSKTTCEDYPDSM 628 rhopd-ACHE2 ESKPIYHVWNAAEMH------VGYGPRAAECQFWNGFFPKIAQALKETSKTTCEDYPDSM 621 sitav-ACHE2 ESNPIYHVWNAAELH------VGYGPRAAECQFWNGFFPKIAQALRETTKITCEDYPDSM 628 lepde-ACHE KDQPQYFIFNADKNG------IGKGPRATACAFWNDFLPKLRDNSGSEEAPCVNTYLSKI 603 boomi-este13 KRSPTVIHMNSDHFN------ETKGFRAEQCERWKSLF---------------------- 544 boomi-acche3 AKNQVYMELNPKRYT------YGRGPNEKNCNFWKSYLKPRGPNEKNCNFWKSYLKP--- 637 luccu-E3aest7 KSDEVYKCLNISDEL-----KMIDVPEMDKIKQWESMFEKHRDLF--------------- 570 musdo-EST23aes07 KSDDVYKCLNIGDEL-----KVMDLPEMDKIKQWASIFDKKKELF--------------- 570 colho-E3aest7 KSDEVYKCLNISDEL-----KIIDVPEMEKIKQWESLYEKRKDLF--------------- 570 drome-EST23aes07 KSDEVIKCLNISDDL-----KFIDLPEWPKLKVWESLYDDNKDLLF-------------- 556 anica-cxest DG-TVLRYLNIGEEL-----RMEKVLNIEERYDYKLICHREKV----------------- 532 aphgo-cxest ACDLKYLSIDGDRTC-----MIQGMMNNKRFRFWKELSESIV------------------ 526 Consensus : ?! ?? ! ! ! ! torca-ACHE R------WSSYMMHWKNQFDHYSR------HESCAEL--- 575 9neop-ACHE1 ------GTRHYYGVTSLSLVTVFG---FLQPTILKYIII- 694 cydpo-ACHE1 S--LLRPSLHTLGLGVAAAAAPFTHHLLLTHLVSMFINID 699 pluxy-ACHE1 E--APRASYHVLGLAVVAAVSFSQ------KTIVKLII-- 679 bemta-ACHE1 PSSLLQHGFNKLSSHSSPFILLLAVFQFLLLLLSNSAIL- 653 aphgo-ACHE1 G----GTKTNMIKLSVWTIVMTTA------VLML------ 676 rhopd-ACHE1 G----GTKTNVIELSVWTIVMTTA------VLML------ 676 myzpe-ACHEM G----GTKTYMIELSLWTIVMTTA------VLML------ 676 sitav-ACHE1 G----GTKTNMIKLSLWTIVMTTA------VLVL------ 676 culpi-ACHE1 P-----CESSSTSYR-STLLLIVT------LLLVTRFKI- 702 cultr-ACHE1 P-----CESSSTSYRSSTLLLIVT------LLLVIRFKI- 701 anoga-ACHE1 P-----CESSAFFYRPDLIVLLVS------LLTATVRFIQ 737 tetka-ACHE N----QIGSSNWSLAISLISLIMC------FLPSLR---- 687 tetur-ACHE N----QIGSSNWSLAISLISLIMC------FLPSLR---- 687 bacdo-ACHE K-------QQHLLLQQRSIVTFMLTLSLVLGIPSVNAFF- 673 bacol-ACHE Q-------QQHLLLQQRSIVAFMLALSLVLKIPSVNAFF- 673 cerca-ACHE N-----------MLQQKIIMALLLALSIVLGIPSINAFF- 669 haeir-ACHE IY-------KTQQQQHTTLLTVALILVMVISIFQ------ 704 musdo-ACHE IY-------EMKMQQLT-LLAVAIILTMVNSIFQ------ 612 luccu-ACHE II-------YEK--QQNLLKWVIMLTIMVTCIFQ------ 730 drome-ACHE IS-------PRLQLLGIAALIYICAALRTKRVF------- 649 aedae-ACHE TS-------AATILYVDIKIVTVLMVFILVRLY------- 637 aphgo-ACHE2 PTINENCTFTSSFATVNPQISFTIIFIFVLPAYGLF---- 664 rhopd-ACHE2 PTTNENCTFTSSFATINPQISFTIIFILVLPAHGLF---- 657 sitav-ACHE2 PTTNENCTFTSSFATINPRISFTIIFIFVLPAHGLF---- 664 lepde-ACHE R--------SSSNELLPPSTSLVLIWIMTLLNAL------ 629 boomi-este13 ---------------------------------------- 544 boomi-acche3 ---------------------------------------- 637 luccu-E3aest7 ---------------------------------------- 570 musdo-EST23aes07 ---------------------------------------- 570 colho-E3aest7 ---------------------------------------- 570 drome-EST23aes07 ---------------------------------------- 556 anica-cxest ---------------------------------------- 532 aphgo-cxest ---------------------------------------- 526 Consensus