ESTHER Database

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Alignment and mutations related to insecticide resistance

Mutalign

  • help on mutalign and consensus marks
  • Question marks (?) indicate positions were insecticide resistance related mutations were described in the aligned sequences.(!) indicate positions mutated in other cholinesterases not related to insecticide resistance
                                                                                 
    torca-ACHE       ------------------------------------------------------------ 0
    9neop-ACHE1      ----------------------------------------------MRVVLAALTALAAR 14
    cydpo-ACHE1      ----------------------------------------------MRVVLAALAALAAR 14
    pluxy-ACHE1      ----------------------------------------------MRALLAVLCAAAAA 14
    bemta-ACHE1      ----------------------------------------------MDFDHLPLRASPET 14
    aphgo-ACHE1      ----------------------------------------------MDQWLLWFGYLVAS 14
    rhopd-ACHE1      ----------------------------------------------MDQWLLWFGYLVVS 14
    myzpe-ACHEM      ----------------------------------------------MDQWLLWFSYLVAS 14
    sitav-ACHE1      ----------------------------------------------MDQWLLWFGYLVAS 14
    culpi-ACHE1      -----------------------------MEIRGLITR--LLGPCHLRHLILCSLGLYSI 29
    cultr-ACHE1      -----------------------MRPLQAMEIRGLITR--LLGPCHLRHLILCSLGLYSI 35
    anoga-ACHE1      -----------------------------MEIRGLLMGRLRLGRRMVPLGLLGVTALLLI 31
    tetka-ACHE       ------------------------------------------MVPMFNHNINHFNNVIVT 18
    tetur-ACHE       ------------------------------------------MVPMFNHNINHFNNVIVT 18
    bacdo-ACHE       --------------------------------------------------MAHTTSLLSG 10
    bacol-ACHE       --------------------------------------------------MAHPTSLLAG 10
    cerca-ACHE       --------------------------------------------------MARTLALQAP 10
    haeir-ACHE       --------------------MARSTTTISSSSSSSSSSPPSLSSSSSSISLTSSPSSYSL 40
    musdo-ACHE       ------------------------------------------------------------ 0
    luccu-ACHE       MEFEIFFLFVYLKQQISSGASTIMARFITTSSSPTLTTSTAATAPSSSWSSNATSTATSI 60
    drome-ACHE       ------------------------------------------------------------ 0
    aedae-ACHE       ------------------------------------------------------------ 0
    aphgo-ACHE2      --------------------------------------------------MSVDCVYTSA 10
    rhopd-ACHE2      --------------------------------------------------MSVDCVYTSA 10
    sitav-ACHE2      --------------------------------------------------MSVDCVYTSA 10
    lepde-ACHE       --------------------------------------------------MGQLSILCLF 10
    boomi-este13     ------------------------------------------------------------ 0
    boomi-acche3     ---------------------------------------------MYSRIVVLLLYGYAL 15
    luccu-E3aest7    ------------------------------------------------------------ 0
    musdo-EST23aes07 ------------------------------------------------------------ 0
    colho-E3aest7    ------------------------------------------------------------ 0
    drome-EST23aes07 ------------------------------------------------------------ 0
    anica-cxest      ------------------------------------------------------------ 0
    aphgo-cxest      ------------------------------------------------------------ 0
    Consensus                                                                    
    
                                                                                 
    torca-ACHE       ------------------------------------------------------------ 0
    9neop-ACHE1      ALAGP--HEHRARHH----------APDHPLHFPAPANPAQPYRG--------------- 47
    cydpo-ACHE1      ALGSP--HEHRARHH----------APDHPLHFPAPA-PPQPYRG--------------- 46
    pluxy-ACHE1      AGASAGAHEHRARHH----------APEH-------AYPPPPYRG--------------- 42
    bemta-ACHE1      DQLRNPRHGFGFRDG----------ISDE------------------------------- 33
    aphgo-ACHE1      TYGLSLRHARHQSVG----------TPTA-----EEILEPQILIE--------------- 44
    rhopd-ACHE1      TYGLSLRHARHQSVG----------TPTA-----EEILEPQILIE--------------- 44
    myzpe-ACHEM      TYGLSLRHARHQSVG----------TPTA-----EEILEPQILIE--------------- 44
    sitav-ACHE1      TYGLSLRHARHQSVG----------TPTV-----EEILEPQILIE--------------- 44
    culpi-ACHE1      LVQS--VHCRHHDIG-----------SSVAHQLGSKYSQSSSLSS-----------SSQS 65
    cultr-ACHE1      LVQS--VHCRHHDIG-----------SSAAHQLGSKYSQSSSLSS-----------SSQS 71
    anoga-ACHE1      LPPSALVQGRHHELNNGAAIGSHQLSAAAGVGLSSQSAQSGSLASGVMSSVPAAGASSSS 91
    tetka-ACHE       TLTHHQYTNSRCNSN-----------NNVIKRITNSILKSVTVFT--------------- 52
    tetur-ACHE       TLTHHQYTNSRCNSN-----------NNVIKRITNSILKSVTVFT--------------- 52
    bacdo-ACHE       ASSAAASPLSSRQYS--------------------------------------------- 25
    bacol-ACHE       ASLAAASSLSSRQYS--------------------------------------------- 25
    cerca-ACHE       SSLSASSRQHSFASS--------------------------------------------- 25
    haeir-ACHE       KSSSTSSRQSRPSSS--------------------------------------------- 55
    musdo-ACHE       ------------------------------------------------------------ 0
    luccu-ACHE       SSHSRTSRKSRYTSSN-------------------------------------------- 76
    drome-ACHE       --MAISCRQSR------------------------------------------------- 9
    aedae-ACHE       ------------------------------------------------------------ 0
    aphgo-ACHE2      VTLLLCCSAVLGRPS--------------------------------------------- 25
    rhopd-ACHE2      VTLLLCCSAVLGRPS--------------------------------------------- 25
    sitav-ACHE2      VTLLLCCSAVLGRPS--------------------------------------------- 25
    lepde-ACHE       VT---VCASVCGYSW--------------------------------------------- 22
    boomi-este13     ------------------------------------------------------------ 0
    boomi-acche3     RSAHARCYIFQPGDP--------------------------------------------- 30
    luccu-E3aest7    ------------------------------------------------------------ 0
    musdo-EST23aes07 ------------------------------------------------------------ 0
    colho-E3aest7    ------------------------------------------------------------ 0
    drome-EST23aes07 ------------------------------------------------------------ 0
    anica-cxest      ------------------------------------------------------------ 0
    aphgo-cxest      ------------------------------------------------------------ 0
    Consensus                                                                    
    
                                                                                 
    torca-ACHE       ------------------------------------------------------------ 0
    9neop-ACHE1      -----------HGEAARYNPELDTILPRVEDHETSSKRAKLDDAETSSKRDDDRFYSNHE 96
    cydpo-ACHE1      -----------HGEAVRYNPELDTILPRIDEHETSSKRAKLEDAEILSKREE-KYFSNHE 94
    pluxy-ACHE1      -----------HGEAVRYNPELDTILPRLD-HETSSRRAKYAD-----KHDD---YRARE 82
    bemta-ACHE1      ------------GLNFRHS-------------EHEGERSKYKG----------------- 51
    aphgo-ACHE1      -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82
    rhopd-ACHE1      -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82
    myzpe-ACHEM      -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82
    sitav-ACHE1      -----------DTDHVFRQRASDMFAQEPEYTEKRNLNHRRRSE-----------FSGNQ 82
    culpi-ACHE1      SSSLA--------EEATLNKDSDAFFTPYIGHGDSVRIVDAELG------TLEREHIHST 111
    cultr-ACHE1      SSSLA--------EEATLNKDS--------GHGDSVRIVDAELG------TLEREHIHST 109
    anoga-ACHE1      SSSLLSSSAEDDVARITLSKDADAFFTPYIGHGESVRIIDAELG------TLEHVHSG-A 144
    tetka-ACHE       ------------VKTLWNHLLVPIVVILLFQSSANVFSSALPHS------EINSFYADGP 94
    tetur-ACHE       ------------VKTLWNHLLVPIVVILLFQSSANVFSSALPHS------EINSFHADGP 94
    bacdo-ACHE       ------------------------------VASSPRLSGDIGRG---------------- 39
    bacol-ACHE       ------------------------------VASSSRLSGDIGRG---------------- 39
    cerca-ACHE       ------------------------------TSTLRLSSGDIGRG---------------- 39
    haeir-ACHE       -------------------------FSSVAYLLATSRSNDICRG---------------- 74
    musdo-ACHE       ------------------------------------------------------------ 0
    luccu-ACHE       -----------------LLNAFASLTSRSSLSLSSTSSNDLYRG---------------- 103
    drome-ACHE       -------------------------------VLPMSLPLPLTIP---------------- 22
    aedae-ACHE       --------------------------------MKMSAVVRLCCN---------------- 12
    aphgo-ACHE2      --------------------------------SNGGADAGGGGGG--------GGGAGGA 45
    rhopd-ACHE2      --------------------------------SNGGADGGGGGG---------------S 38
    sitav-ACHE2      --------------------------------SNGGADGGGGGGG--------GGGAGAG 45
    lepde-ACHE       --------------------------------PSDETTTK-------------------- 30
    boomi-este13     ----------------------------------MAVKAAVLIG---------------- 10
    boomi-acche3     --------IQDTDEKIYLAQPFNVTIPLEAGIPTTAQPASTGKDQ----------LSLVV 72
    luccu-E3aest7    ---------------------------------MNFNVSLMEKLK--------------- 12
    musdo-EST23aes07 ---------------------------------MNFKVSQMERLS--------------- 12
    colho-E3aest7    ---------------------------------MNFKVSQVEKLK--------------- 12
    drome-EST23aes07 ------------------------------------------------------------ 0
    anica-cxest      ------------------------------------------------------------ 0
    aphgo-cxest      ------------------------------------------------------------ 0
    Consensus                                                                    
    
                                     !   ! !      !     ?    !??!   !    !!  ?   
    torca-ACHE       ----------------DDHSELLVNTKSGKVMGT-RVPVLSS-HISAFLGIPFAEPPVGN 42
    9neop-ACHE1      RIDDEGFLADEPQPGPEDDDPLIVRTRKGRVRGI-TLTAATGKKVDAWFGIPYAQKPIGD 155
    cydpo-ACHE1      RGE-EVFMADEPQMGPDDDDPLVVRTRKGRVRGI-TLTAATGKKVDAWFGIPYAQKPLGD 152
    pluxy-ACHE1      RLD--APQADQPALGPDDDDPLVVRTRKGRVRGI-TLTAATGKKVDAWFGIPYAQKPIGD 139
    bemta-ACHE1      -----AEAEEEMMADEGDNDPLVVQTTKGKVRGT-TLTAATGKQVDAWLGIPYAQKPIGA 105
    aphgo-ACHE1      DTN--FESSGATYSAYTSDDPLIIHTNKGKIRGI-TQEATTGKLVDAWLGIPYAKKPIGD 139
    rhopd-ACHE1      DTD--FASSGETYSAYTSDDPLIIHTNKGKIRGI-TQTATTGKLVDAWLGIPYAKKPIGD 139
    myzpe-ACHEM      DND--FESSGETYSAYKSDDPLVIHTNKGKIRGI-TQAASTGKLVDAWLGIPYAKKPIGD 139
    sitav-ACHE1      DND--FESSGETYSAYKSDDPLVIHTNKGKIRGI-TQAASSGKLVDAWLGIPYAKKPIGD 139
    culpi-ACHE1      TTRRRGLTRRESSSDATDSDPLVITTDKGKIRGT-TLEAPSGKKVDAWMGIPYAQPPLGP 170
    cultr-ACHE1      TTRRRGLTRRESNSDSTDSDPLVITTDKGKIRGT-TLEAPSGKKVDAWMGIPYAQPPLGP 168
    anoga-ACHE1      TPRRRGLTRRESNSDANDNDPLVVNTDKGRIRGI-TVDAPSGKKVDVWLGIPYAQPPVGP 203
    tetka-ACHE       SSS--SSFNSEHHHHHHHNDPLVVLTKKGYVRGR-SVVSPTGKPVDAFLGIRYAKPPTGK 151
    tetur-ACHE       SSS--SSFNSEHHHHHHHNDPLVVLTKKGYVRGR-SVVSPTGKPVDAFLGIRYAKPPTGK 151
    bacdo-ACHE       LFAIVVLLLRMSSVYG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPLDD 96
    bacol-ACHE       LFAIVVLLLRMSSVYG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPLDD 96
    cerca-ACHE       LFAIVILLLRMSSVYG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPLDD 96
    haeir-ACHE       LLATFVILLRMSALASAMTDRLIVQTTSGPVRG--RAVTVQGREVHVFTGIPYAKPPVDD 132
    musdo-ACHE       -----------------MTDHLTVQTTSGPVRG--RSVTVQGRDVHVFTGIPYAKPPVDD 41
    luccu-ACHE       FLTTLVILLRMSSVAYGITDRLIVQTTSGPVRG--RAVTVQGREVHVFTGIPYAKPPVDD 161
    drome-ACHE       LPLVLVLSLHLSGVCG-VIDRLVVQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPVED 79
    aedae-ACHE       MISLLLCITVISPVYG-IFDRLVVQTSSGPIRG--RSTMVLGREVHVFNGVPFAKPPVDG 69
    aphgo-ACHE2      GGGGAGGGGGGGSAVDDTDEIPVVVTSTGLVQG--YTKIIANREVRVYTGIPFAKPPVGQ 103
    rhopd-ACHE2      AGGGAGGGGGGGSAVDDTDESPVVVTSTGLVQG--YTKIIANREVRVYTGIPFAKPPVGH 96
    sitav-ACHE2      GGGGGGGGGGGGSAVDDTDESPVVVTSSGMVQG--YTKIIANRGVRVYTGIPFAKPPVGP 103
    lepde-ACHE       ----------PSQFKDFHTDPLVVETTSGLVRG--YSKTVLGREVHVFTGIPFAKPPIEQ 78
    boomi-este13     ------VILAFNLTATAEDMHVERETTEGRVRGK-VVHVLDNEPVEEYVGIPYAEPPLDK 63
    boomi-acche3     PPDDIQSLSTTTSRPISTEESPIVETNSGPVQG--RRVYAANRTLYQFVGIPFAEPPVGP 130
    luccu-E3aest7    -WKIKCIENKFLNYRLTTNETVVAETEYGKVKGVKRLTVYDDS-YYSFEGIPYAQPPVGE 70
    musdo-EST23aes07 -WKLKCMVNKYTNYRLSTNETQIIDTEYGQIKGVKRMTVYDDS-YYSFESIPYAKPPVGE 70
    colho-E3aest7    -WKIKCFENKFLNYRLSTNETAVAETEYGKVKGIKRLTVYDDS-YYSFEGIPYAQPPLGE 70
    drome-EST23aes07 -----TIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDVP-YFSFEGIPYAQPPVGE 54
    anica-cxest      ------------------MERPEVKTLSGQVRGLKQISVEGIG-FYAFKGIPYAKPPVGE 41
    aphgo-cxest      ---------------------MEVVIEQGALKGLKKKTLLSNKPYVSFLGIPYAQPPVND 39
    Consensus                                    * : *              : .: :*: *   
    
                      !    !           !?            ??? ?!!!?!! !??!!  ?  !!   !
    torca-ACHE       MRFRRPEPKKPWS-----GVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYL 97
    9neop-ACHE1      LRFRHPRPAESWG----EEILNTTTLPHPCVQIIDTVFGDFPGAMMWNPNTDMQEDCLYI 211
    cydpo-ACHE1      LRFRHPRPVESWG----EEILNATTLPHSCVQIVDTVFGDFPGAMMWNPNTDMQEDCLYI 208
    pluxy-ACHE1      LRFRHPRPVENWG----DEILNATTLPHSCVQIIDTVFGDFPGAMMWNPNTDMQEDCLYI 195
    bemta-ACHE1      LRFRHPRPIDKW-----EGILNATKMPNSCTQIVDTVFGDFAGSAMWNPNTPMSEDCLYI 160
    aphgo-ACHE1      LRFRHPRPIDRWDTTSPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199
    rhopd-ACHE1      LRFRHPRPIDRWDTTSPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199
    myzpe-ACHEM      LRFRHPRPIDRWDNTNPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199
    sitav-ACHE1      LRFRHPRPIDRWDKTSPETILNCTTPPNTCVQIFDTLFGDFPGATMWNPNSPVSEDCLYI 199
    culpi-ACHE1      LRFRHPRPAERWT-----GVLNATKPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYI 225
    cultr-ACHE1      LRFRHPRPAERWS-----GVLNATKPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYI 223
    anoga-ACHE1      LRFRHPRPAEKWT-----GVLNTTTPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYI 258
    tetka-ACHE       FRFRHPKPIDSWQ-----GIFNATSFSGACYQVNDTFFGNFMGATEWNPNVPLDEDCLSV 206
    tetur-ACHE       FRFRHPKPIDSWQ-----GIFNATSFSGACYQVNDTFFGNFMGATEWNPNVPLDEDCLSV 206
    bacdo-ACHE       LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 151
    bacol-ACHE       LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 151
    cerca-ACHE       LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 151
    haeir-ACHE       LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEMWNPNTNVSEDCLFM 187
    musdo-ACHE       LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLFM 96
    luccu-ACHE       LRFRKPVPAEPWH-----GVLDATRLPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYM 216
    drome-ACHE       LRFRKPVPAEPWH-----GVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYI 134
    aedae-ACHE       LRFRKPVPAEPWH-----GVLDATRLPPSCIQERYEYFPGFAGEEMWNPNTNVSEDCLYL 124
    aphgo-ACHE2      LRFRRPVPVDPWT-----GVLNATRLPNTCYQERYEYFPGFVGEEMWSPNTKLSEDCLYL 158
    rhopd-ACHE2      LRFRRPVPVDPWP-----GVLNATRLPNTCYQERYEYFPGFVGEDMWNPNTKLSEDCLYL 151
    sitav-ACHE2      LRFRRPVPVDPWT-----GVLNATRLPNTCYQERYEYFPGFVGEEMWNPNTKLSEDCLYL 158
    lepde-ACHE       LRFKKPVPIDPWH-----GILDATKQPNSCFQERYEYFPGFEGEEMWNPNTNISEDCLYL 133
    boomi-este13     LRFRPPQPKKRWQ-----DTLDATSTRTACPQIEMQLVIMN--------NVTYTEDCLHL 110
    boomi-acche3     LRFRNPVPVKPWS-----SVYQATKKPFPCLQT-----DFYINSNVTIPTANSSEDCLYL 180
    luccu-E3aest7    LRFKAPQRPTPWD-----GVRDCCNHKDKSVQVDFIT-----------GKVCGSEDCLYL 114
    musdo-EST23aes07 LRFKAPQRPVPWE-----GVRDCCGPANRSVQTDFIS-----------GKPTGSEDCLYL 114
    colho-E3aest7    LRFKAPQRPTPWD-----GVRDCCNNKDKSVQVDFIT-----------GKTCGSEDCLYL 114
    drome-EST23aes07 LRFKAPQRPIPWE-----GVRDCSQPKDKAVQVQFVF-----------DKVEGSEDCLYL 98
    anica-cxest      LRFKDPVPIEPWQ-----EVREATEFGPMAAQFDVIS-----------KFSGGSDDCLYI 85
    aphgo-cxest      LRFKAPVKHPGWS-----GVLNAVSERDKCTQYVFMT-----------NHIVGSEDCLYL 83
    Consensus        :**: *     *         :       . *                      :*** :
    
                     !  !!    ? !                                        !!? ?!! 
    torca-ACHE       NIWVP-SPRPKS--------------------------------TTVMVWIYGGGFYSGS 124
    9neop-ACHE1      NIVSP-RPRPKN--------------------------------AAVMLWVFGGGFYSGT 238
    cydpo-ACHE1      NIVTP-RPRPKN--------------------------------AAVMLWVFGGGFYSGT 235
    pluxy-ACHE1      NIVTP-RPRPKN--------------------------------AAVMLWVFGGGFYSGT 222
    bemta-ACHE1      NVITP-KPRPRN--------------------------------AAVMVWIFGGGFYTGT 187
    aphgo-ACHE1      NVVVP-RPRPQN--------------------------------AAVMVWIFGGGFYSGS 226
    rhopd-ACHE1      NVVVP-KPRPQN--------------------------------AAVMVWIFGEGFYSGS 226
    myzpe-ACHEM      NVVVP-KPRPQN--------------------------------AAVMVWIFGGGFYSGS 226
    sitav-ACHE1      NVVVP-KLRPQN--------------------------------AAVVVWIFGGGFYSGS 226
    culpi-ACHE1      NVVVP-RPRPKN--------------------------------AAVMLWIFGGGFYSGT 252
    cultr-ACHE1      NVVAP-RPRPKN--------------------------------AAVMLWIFGGGFYSGT 250
    anoga-ACHE1      NVVAP-RPRPKN--------------------------------AAVMLWIFGGGFYSGT 285
    tetka-ACHE       NIWVP-RPRPKS--------------------------------AAVLLWIYGGGFWSGS 233
    tetur-ACHE       NIWVP-RPRPKS--------------------------------AAVLLWIYGGGFWSGS 233
    bacdo-ACHE       NVWAPAKARLRHGRGANGGEHSN--KADTDHLIHNGNPQNTTNGLPVLIWIYGGGFMTGT 209
    bacol-ACHE       NVWAPAKARLRHGRGANGGEHSN--KADTDHLIHNGNPQNITNGLPVLIWIYGGGFMTGT 209
    cerca-ACHE       NVWAPAKARLRHGRGANGGEHSN--KADTDHLIHNGNPQNTTNGLPVLIWIYGGGFMTGT 209
    haeir-ACHE       NIWAPAKARLRHGRGTNGGEHSS--KTDQDHLIHSATPQNTTNGLPILIWIYGGGFMTGS 245
    musdo-ACHE       NIWAPAKARLRHGRGTNGGEHSS--KTDQDHLIHSATPQNTTNGLPILIWIYGGGFMTGS 154
    luccu-ACHE       NIWAPAKARLRHGRGANGGEHSS--KTDPDHLIHSATPQNTTNGLPILIWIYGGGFMTGS 274
    drome-ACHE       NVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGS 194
    aedae-ACHE       NIWVPTKTRLRHGRGLNFGNNDY--FQDDDDFQR---QHQSKGGLAMLVWIYGGGFMSGT 179
    aphgo-ACHE2      NIWIPKKQRTRHHSNN--AHHAK---------------------IPVLVWIYGGGYMSGT 195
    rhopd-ACHE2      NIWIPRKQRTRHHSNN--AHHAK---------------------IPVLVWIYGGGYMSGT 188
    sitav-ACHE2      NIWIPKKQRTRHHSNN--AHHAK---------------------IPVLVWIYGGGYMSGT 195
    lepde-ACHE       NIWVPQRLRIRHHADKPTIDRPK---------------------VPVLIWIYGGGYMSGT 172
    boomi-este13     NIWVPEKAMNPG------------------------------AKQPVLVWIHGGGFTFGS 140
    boomi-acche3     NVWTPSRECVLG--------------------------KFSCVPKTVIVYIYGGTFSFGS 214
    luccu-E3aest7    SVYTNNLN-PETKR-------------------------------PVLVYIHGGGFIIGE 142
    musdo-EST23aes07 NVYTNDLN-PDKKR-------------------------------PVMVFIHGGGFIFGE 142
    colho-E3aest7    SVYTNNLA-PETKR-------------------------------PVLVYIHGGGFVIGE 142
    drome-EST23aes07 NVYTNNVK-PDKAR-------------------------------PVMVWIHGGGFIIGE 126
    anica-cxest      NVYTKKIN-SNVKQ-------------------------------PVMFYIHGGGFIFGS 113
    aphgo-cxest      NISVPQQNELNGKL-------------------------------AVMIFIHGGAFNYGS 112
    Consensus        .:                                           .::.::.*  :  * 
    
                       !!???!   ?  !    !  ! !?                         !  ? !   
    torca-ACHE       STLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALH-------GSQEAPGNVGLLDQRMAL 177
    9neop-ACHE1      ATLDVYDPKIMVSEEKIVYVSMQYRVASLGFLFFD--------TPDVPGNAGMFDQLMAL 290
    cydpo-ACHE1      ATLDVYDPKILVSEEKVVYVSMQYRVASLGFLFFD--------TPDVPGNSGLFDQLMAL 287
    pluxy-ACHE1      ATLDVYDPKILVSEEKIVYVSMQYRVASLGFLFFD--------TPDVPGNAGLFDQLMAL 274
    bemta-ACHE1      ATLDIYDYKILASEENVILVSMQYRITCLGFLYFD--------TQDVPGNAGLFDQLMAL 239
    aphgo-ACHE1      ATLDIYDPKILVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278
    rhopd-ACHE1      ATLDIYDPKILVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278
    myzpe-ACHEM      ATLDIYDPKVLVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278
    sitav-ACHE1      ATLDIYDPKVLVSEENVILVSMQYRVASLGFLYFD--------TEDVPGNAGLFDQLMAL 278
    culpi-ACHE1      ATLDVYDHRTLASEENVIVVSLQYRVASLGFLFLG--------TPEAPGNAGLFDQNLAL 304
    cultr-ACHE1      ATLDVYDHRTLASEENVIVVSLQYRVASLGFLFLG--------TPEAPGNAGLFDQNLAL 302
    anoga-ACHE1      ATLDVYDHRALASEENVIVVSLQYRVASLGFLFLG--------TPEAPGNAGLFDQNLAL 337
    tetka-ACHE       SSLDFYDGSVLAGEESIIFVSINYRVASLGFIFFD--------TSDAPGNAGLFDQLMAM 285
    tetur-ACHE       SSLDFYDGSVLAGEESIIFVSINYRVASLGFIFFD--------TSDAPGNAGLFDQLMAM 285
    bacdo-ACHE       ATLDIYNADIMSAVGNVIVASFQYRVGAFGFLHLSPAMP-GY-EEEAPGNVGLWDQALAI 267
    bacol-ACHE       ATLDIYNADIMSAVGNVIVASFQYRVGAFGFLHLSPAMP-GY-EEEAPGNVGLWDQALAI 267
    cerca-ACHE       ATLDIYNADIMSAVGNVIVASFQYRVGAFGFLHLSPAMP-GY-EEEAPGNVGLWDQALAI 267
    haeir-ACHE       ATLDIYNAEIMSAVGNVIVASFQYRVGAFGFLHLSPVMP-GF-EEEAPGNVGLWDQALAL 303
    musdo-ACHE       ATLDIYNAEIMSAVGNVIVASFQYRVGAFGFLHLSPVMP-GF-EEEAPGNVGLWDQALAL 212
    luccu-ACHE       ATLDIYNADIYS-VGNVSVASFQYRVGAFGFLHLSPVMP-GF-EEEAPGNVGLWDQALAL 331
    drome-ACHE       ATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEF-AEEAPGNVGLWDQALAI 253
    aedae-ACHE       STLDVYNAEMLAAVGNVIVASMQYRVGSFGFFYLAPYLN----DDDAPGNVGLWDQALAI 235
    aphgo-ACHE2      STLDIYDGDLLAATFDVMIASMQYRLGAFGSLYLTPELP-ED-SDDAPGNMGLWDQALAI 253
    rhopd-ACHE2      STLDIYDGDLLAATFDVMIASMQYRLGAFGSLYITPELP-ED-SDDAPGNMGLWDQALAI 246
    sitav-ACHE2      STLDIYDGDLLAVTFDVMIASMQYRLGAFGSLYLTPELP-ED-SDDAPGNMGLWDQALAI 253
    lepde-ACHE       ATLDVYDADIIAATSDVIVASMQYRLGSFGFLYLNRYFP-RG-SDETPGNMGLWDQILAI 230
    boomi-este13     ANQWEYNGAVLAATTDVVVVAMNYRLSILGFMSAN--------SPEAPGNVGMLDQVMVL 192
    boomi-acche3     SGWDWYDGKEFVARGDVVMVSMNYRVGPMGFFHSG--------TTHSSGNAGLHDQLLAM 266
    luccu-E3aest7    NHRDMYG-PDYFIKKDVVLINIQYRLGALGFLSLNS------EDLNVPGNAGLKDQVMAL 195
    musdo-EST23aes07 ANRNWFG-PDYFMKKPVVLVTVQYRLGVLGFLSLKS------ENLNVPGNAGLKDQVMAL 195
    colho-E3aest7    NHREYYG-PDYFIKKDVVLITIQYRLGVLGFLSLNS------EELNVPGNAGLKDQVMAL 195
    drome-EST23aes07 ANREWYG-PDYFMKEDVVLVTIQYRLGALGFMSLKS------PELNVPGNAGLKDQVLAL 179
    anica-cxest      GNDFFYG-PDFLMRKDIVLVTFNYRLGVFGFLNLEH------EVA--PGNQGLKDQVMAL 164
    aphgo-cxest      GSMNEYS-PDYFIDENVIVVTINYRLNALGFLNLDI------DEC--PGNVGLKDQLFAI 163
    Consensus             :.         :    ..**:  :* :               .** *: ** :.:
    
                             !        ?  !?!? ! !!                   !??! !??    
    torca-ACHE       QWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVS 237
    9neop-ACHE1      QWVKDNIAYFGGNPHNVTLFGESAGAVSVSLHLLSPLSRNLFSQAIMQSGAATAPWAIIS 350
    cydpo-ACHE1      QWVKDNIAYFGGNPHNVTLFGESAGAVSVSLHLLSPLSRNLFSQAIMQSGAATAPWAIIS 347
    pluxy-ACHE1      QWVKDNIQYFGGNPHNVTLFGESSGAVSVSLHLLSPLSRNMFSQAIMQSAAASAPWAIIS 334
    bemta-ACHE1      QWIRNNIHAFGGNPHNITLFGESAGAVSVSMHLLSPLSRNLFSQAIMESGSATAPWAIIS 299
    aphgo-ACHE1      QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTVPWAILS 338
    rhopd-ACHE1      QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTAPWAILS 338
    myzpe-ACHEM      QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTAPWAILS 338
    sitav-ACHE1      QWVHENIKLFGGNPNNVTLFGESAGAVSVSLHLLSPLSRNLFNQAIMESGSSTAPWAILS 338
    culpi-ACHE1      RWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVS 364
    cultr-ACHE1      RWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVS 362
    anoga-ACHE1      RWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVS 397
    tetka-ACHE       EWIRENIAAFGGNPANITIFGESAGAVSAALHLLSPLSRNVFSQAILQSGSATCPWAISD 345
    tetur-ACHE       EWIRENIAAFGGNPANITIFGESAGAVSAALHLLSPLSRNVFSQAILQSGSATCPWAISD 345
    bacdo-ACHE       RWLKTNAHAFGGNPEWMTLFGESAGSSSVNAQLVSPVTAGLVKRGMMQSGTMNAPWSHMT 327
    bacol-ACHE       RWLKTNAHAFGGNPEWMTLFGESAGSSSVNAQLVSPVTAGLVKRGMMQSGTMNAPWSHMT 327
    cerca-ACHE       RWLKTNAHAFGGNPEWMTLFGESAGSSSVNAQLVSPVTAGLVKRGMMQSGTMNAPWSHMT 327
    haeir-ACHE       RWLKENARAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMT 363
    musdo-ACHE       RWLKENARAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMT 272
    luccu-ACHE       RWLKENARAFGGNPEWMTLFGESAGSSSVNAQLASPVTRGLVKRGMMQSGTMNAPWSHMT 391
    drome-ACHE       RWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMT 313
    aedae-ACHE       RWLKENAKAFGGDPDLITLFGESAGGSSVSLHLLSPVTRGLSRRGILQSGTLNAPWSHMS 295
    aphgo-ACHE2      KWIKENAAAFGADPETITLFGESAGGGSVSVHLISPETGGMVKRGIIQSGTVNAPWSYMT 313
    rhopd-ACHE2      KWIKENAAAFGADPETITLFGESAGGGSVSVHLISPETRGMVKRGIIQSGTVNAPWSYMT 306
    sitav-ACHE2      KWIKENATVFGADPETITLFGESAGGGSVSVHLISPETRGMVRRGIIQSGTVNAPWSYMT 313
    lepde-ACHE       RWIKDNAAAFGGDPDLITLFGESAGGGSISIHLISPVTKGLVRRGIMQSGTMNAPWSYMS 290
    boomi-este13     KWIQRNIEHFGGDPDRVTLFGESAGAMSAHAHVLSPMSEGLFKRAVLMSGTMYNIDLWDM 252
    boomi-acche3     KWVKQNIRNFGGDPDDVTLVGQSAGAISIGLHLVSPLSKGLFKRIIMESGSPYFRIADNT 326
    luccu-E3aest7    RWIKNNCANFGGNPDNITVFGESAGAASTHYMMLTEQTRGLFHRGILMSGNAICPWANT- 254
    musdo-EST23aes07 RWVKSNIANFGGDVDNITVFGESAGGASTHYMMITEQTRGLFHRGIMMSGNSMCSWAST- 254
    colho-E3aest7    RWIKNNCANFGGNPDNITVFGESAGGASAHYMMLTEQTRGLFHRGILMSGNAVCPWAIS- 254
    drome-EST23aes07 KWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNG 239
    anica-cxest      KWVRDNIANFGGDSENVTIFGESAGGASVHYLTVSPLAKGLFHKAISQSGVFMNPWASVS 224
    aphgo-cxest      KWVKANIAAFGGDVNNITIFGESAGSASVHYHTISPQSRGLFQKAIMQSGSAFNPWAFT- 222
    Consensus        .*:: *   **.:   :*:.*:*:*. *      :  : .:  : :  *.          
    
                     ?  !   !      ?  ?!   !!       ?      !   !  ?!!?? !!?! !?!?
    torca-ACHE       VAEGRRRAVELGRNLNCN---LNSD----EELIHCLREKKPQELIDVEWNVLPFDSIFRF 290
    9neop-ACHE1      REESILRGTRLAEAVHCP---HSLK--DMGPMIECLRKKSADELVNNEWGTL---GICEF 402
    cydpo-ACHE1      REESILRGIRLAEAVHCP---HSRI--DMGPMIECLRKKSADELVNNEWGTL---GICEF 399
    pluxy-ACHE1      REESVIRGIRLAEAVHCP---HSKT--DMGPMIECLRKKSADELVNNEWGTL---GICEF 386
    bemta-ACHE1      RQESIIRGLRLAEAVGCP---HTRA--QIPEAIECLRKVNASVLVENESGTL---GICDF 351
    aphgo-ACHE1      REESFSRGLKLAKAMGCP---DDRN--EIHKTVECLRKVNSSAMVEKEWDHV---AMCFF 390
    rhopd-ACHE1      REESFSRGLKLAKAMGCP---DDRN--AIHKTVECLRKANSSMMVEKEWDHV---AICFF 390
    myzpe-ACHEM      REESYSRGLRLARAMGCP---DDRN--EIHKTVECLRKANSSTMVEKEWDHV---AICFF 390
    sitav-ACHE1      REESYNRGLKLAKAMGCP---DDRN--AIHKTVECLRKVNSSAMVEKEWDHV---AICFF 390
    culpi-ACHE1      REEATLRALRLAEAVNCP---HDAT--KLSDAVECLRTKDPNELVDNEWGTL---GICEF 416
    cultr-ACHE1      REEATLRALRLAEAVNCP---HDAT--KLSEAVECLRTKDPNELVDNEWGTL---GICEF 414
    anoga-ACHE1      REEATLRALRLAEAVGCP---HEPS--KLSDAVECLRGKDPHVLVNNEWGTL---GICEF 449
    tetka-ACHE       RKKAYQRSLALAQAVGCG---STSTR-SVHAIIECMQSIPASELVAQEEATT---GVVEF 398
    tetur-ACHE       RKKAYQRSLALAQAVGCG---STSTR-SVHAIIECMQSIPASELVAQEETTT---GVVEF 398
    bacdo-ACHE       SEKAVEIGKALINDCNCN---ASLLSENPQAVMACMRAVDAKTISVQQWNS--YSGILSF 382
    bacol-ACHE       SEKAVEIGKALINDCNCN---ASLLSENPQAVMACMRAVDAKTISVQQWNS--YSGILSF 382
    cerca-ACHE       SEKAVEIGKALINDCNCN---ASLLAENPQAVMACMRAVDAKTISVQQWNS--YSGILSF 382
    haeir-ACHE       SEKAVEIGKALINDCNCN---ASLLPENPQAVMACMRSVDAKTISVQQWNS--YSGILSF 418
    musdo-ACHE       SEKAVEIGKALVNDCNCN---ASLLPENPQAVMACMRQVDAKTISVQQWNS--YSGILSF 327
    luccu-ACHE       SEKAVEIGKALINDCNCN---ASLLPANPQSVMACMRAVDAKTISVQQWNS--YSGILSF 446
    drome-ACHE       SEKAVEIGKALINDCNCN---ASMLKTNPAHVMSCMRSVDAKTISVQQWNS--YSGILSF 368
    aedae-ACHE       AEKALSVAEALIDDCNCN---VTLLKDNPNYVMNCMRNVDAKTISVQQWNS--YSGILGF 350
    aphgo-ACHE2      GERAVEIAKKLLDDCNCN---STSLDSNPIGTMSCMRPVDASTISKKQWNS--YSGILGF 368
    rhopd-ACHE2      GERAVDIAKKLLDDCNCN---STSLDSNPIGTMSCMRSVDASTISKKQWNS--YSGILGF 361
    sitav-ACHE2      GERAVDIAKKLLDDCNCN---STSLDSNPIGTMSCLRSVDASTISKKQWNS--YSGILGF 368
    lepde-ACHE       SERAEQIGKILIQDCGCN---VSLLENSPRKVMDCMRAVDAKTISLQQWNS--YSGILGF 345
    boomi-este13     VHESMVKGNKVANIVGCSKGGSIDLSSNAEEIVDCFRKKSADELVKAAAESVAP---KKI 309
    boomi-acche3     RE-GPHKVEKLARALQCARN-DMTIESHMAEMVECLRKIDGKELLIMSNTIFG---VHAL 381
    luccu-E3aest7    -QCQHR-AFTLAKLAGYK---GEDNDKDVLEFLMKAKPQDLIKLEEKVLTLEERTNKVMF 309
    musdo-EST23aes07 -ECQSR-ALTMAKRVGYK---GEDNEKDILEFLMKANPYDLIKEEPQVLTPEEMQNKVMF 309
    colho-E3aest7    -QNQHR-AYAIAKLNGYK---GENNDKDVLEFLMKAKAHDLIKLEDKVLTPEEHVNKVMF 309
    drome-EST23aes07 -DITHN-PYRIAKLVGYK---GEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMF 294
    anica-cxest      GEPRKK-AYELCELLGKK---TTDP-VEIVKFLRTVDTMKLIEHQG-ELQIQELQKKCLS 278
    aphgo-cxest      ENHKAS-AYKLAKNLGCL---SNDP-KEILKYLKNVSAIDLVKETE----FKDETDFMDY 273
    Consensus                  :                     :                           
    
                     ! !  !              !  !     ! !        !!? ??! ????    !!! 
    torca-ACHE       SFVPVIDG-----EFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPG-FSKDSE 344
    9neop-ACHE1      PFVPIIDG-----SFLDEMPIRSLAHQNFKKTNILMGSNTEEGYYFILYYLTELFPKEEN 457
    cydpo-ACHE1      PFVPIIDG-----SFLDEMPIRSLAHQNFKKTNLLLGSNTEEGYYFILYYLTELFPKEEN 454
    pluxy-ACHE1      PFVPIIDG-----SFLDEMPIRSLAHQNFKKTNILMGSNTEEGYYFILYYLTELFPKEEN 441
    bemta-ACHE1      PFVPVVDG-----SFLDEMPSKSLATKNFKKTNILMGSNTEEGNYFIMYYLTDLFRKEEN 406
    aphgo-ACHE1      PFVPVVDG-----AFLDDHPQKSLSTNNFKKTNILMGSNSEEGYYFIFYYLTELFKKEEN 445
    rhopd-ACHE1      PFVPVVDG-----AFLDDHPQKSLSTNNFKKTNILMGSNSEEGYYSIFYYLTELFKKEEN 445
    myzpe-ACHEM      PFVPVVDG-----AFLDDYPQKSLSTNNFKKTNILMGSNSEEGYYSIFYYLTELFKKEEN 445
    sitav-ACHE1      PFVPVVDG-----AFLDDYPQKSLSTNNFKKTNILMGSNSEEGYYSIFYYLTELFKKEEN 445
    culpi-ACHE1      PFVPVVDG-----AFLDETPQRSLASGRFKKTDILTGSNTEEGYYFIIYYLTELLRKEEG 471
    cultr-ACHE1      PFVPVVDG-----AFLDETPQRSLASGRFKKTEILTGSNTEEGYYFIIYYLTELLRKEEG 469
    anoga-ACHE1      PFVPVVDG-----AFLDETPQRSLASGRFKKTEILTGSNTEEGYYFIIYYLTELLRKEEG 504
    tetka-ACHE       AFIPIVDG-----SFLDEDPEVSLRTKNFKHTPILTGSNRDEGTYFLVYHSPHIFNLSEG 453
    tetur-ACHE       AFIPIVDG-----SFLDEDPEVSLRTKNFKHTPILTGSNRDEGTYFLVYHSPHIFNLSEG 453
    bacdo-ACHE       PSAPTIDG-----AFLPDHPMKMMETADLRGYDILMGNVRDEGTYFLLYDFIDYFDKDEA 437
    bacol-ACHE       PSAPTIDG-----AFLPDHPMKMMETADLRGYDILMGNVRDEGTYFLLYDFIDYFDKDEA 437
    cerca-ACHE       PSAPTIDG-----AFLPDDPMKMMETADMRGYDILMGNVRDEGTYFLLYDFIDYFDKDEA 437
    haeir-ACHE       PSAPTIDG-----AFLPADPMTLLKTADLTGYDILMGNVKDEGTYFLLYDFIDYFDKDDA 473
    musdo-ACHE       PSAPTIDG-----AFLPADPMTLLKTADLSGYDILIGNVKDEGTYFLLYDFIDYFDKDDA 382
    luccu-ACHE       PSAPTIDG-----AFLPADPMTLMKTADMSGYDIMIGNVKDEGTYFLLYDFIDYFDKDEA 501
    drome-ACHE       PSAPTIDG-----AFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDA 423
    aedae-ACHE       PSAPTIDG-----VFMTADPMTMLREANLEGVEILVGSNRDEGTYFLLYDFIDYFEKDAA 405
    aphgo-ACHE2      PSAPTVDG-----ILLPEHPLDMLAKANFSDIDILIGSNLNEGTYFLLYDFVDFFDRTSA 423
    rhopd-ACHE2      PSAPTVDG-----IFLPEHPLDMLAKANFSDIDILIGSNLNEGTYFLLYDFVDFFDRTSA 416
    sitav-ACHE2      PSAPTVDG-----VLLPEHPLDMLAKANFSDIDILIGSNLNEGTYFLLYDFVDFFDRTSA 423
    lepde-ACHE       PSTPTIEG-----VLLPKHPMDMLAEGDYEDMEILLGSNHDEGTYFLLYDFIDFFEKDGP 400
    boomi-este13     PFAPIYHD-----AFLPKMPLVAMNRGFFASVDIVAGVTSDEGALALVFPPKLELLPDDL 364
    boomi-acche3     TFFPVFGD-----DIIPDDPYLMMEQKKFHKADLLIGNNLDEGSYFVFYLFGRALDLEQA 436
    luccu-E3aest7    PFGPTVEPYQTADCVLPKHPREMVKTAWGNSIPTMMGNTSYEGLFFTSILKQMPMLVKEL 369
    musdo-EST23aes07 PFGPTVEPYQTADCVVPKPIREMVKSAWGNSIPTLIGNTSYEGLLFKSIAKQYPEVVKEL 369
    colho-E3aest7    AFGPTVEPYQTADCVLPKHPREMVKTAWGNSIPTMMGNTSYEGLLFTPIVKQMPALLKEL 369
    drome-EST23aes07 RFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQL 354
    anica-cxest      AFVPGVDDKSPNPFMP---FSREVAVEQAAHVPYLIGYNDREGTLLYKIFENDDFESKNL 335
    aphgo-cxest      KFVPSIESDVISNPFLPAHPKTLATSTFP--VPVIIGVNNMEGIVALTEDRIS--LFSDD 329
    Consensus           *          .                   . *    **                 
    
                      ?    !    ?   !    ! !                !!    !   !   ?! !! !
    torca-ACHE       SKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMD--DNNGIKNRDGLDDIVGDHNVIC 402
    9neop-ACHE1      VGITREQYLQAVRELNPYVSDVGRQAIVFEYTDWLN--PEDPVRNRNALDKMVGDYHFTC 515
    cydpo-ACHE1      VGITREQYLQAVRELNPYVTDVARQAIVFEYTDWLN--PDDPIKNRNALDKMVGDYHFTC 512
    pluxy-ACHE1      VGISREQYLQAVRELNPYVNDVARQAIVFEYTDWLN--PDDPIRNRNALDKMVGDYHFTC 499
    bemta-ACHE1      IHVSRDQFIQAVSELNPYN-FIVRRAIIFEYTDWLN--PDDPVKNRDALDKIVGDFHFTC 463
    aphgo-ACHE1      VVVSRENFIKAIGQLNPNADAAVKSAIEFEYTDWFN--PNDPEKNRNALDKMVGDYQFTC 503
    rhopd-ACHE1      VMVSRENFVKAIGQLNPNADAAVKSAIEFEYTDWFS--PNDPEKNRNALDKMVGDYQFTC 503
    myzpe-ACHEM      VVVSRENFVKAIGQLNPNADAAVKSAIEFEYTDWFS--PNDPEKNRNALDKMVGDYQFTC 503
    sitav-ACHE1      VVVSRENFVKAIGQLNPNADAAVKSAIEFEYTDWFS--PNDPEKNRNALDKMVGDYQFTC 503
    culpi-ACHE1      VTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWIE--PDNPNSNRDALDKMVGDYHFTC 529
    cultr-ACHE1      VTVSREEFLQAVRELNPYVNGAARQAIVFEYTDWIE--PDNPNSNRDALDKMVGDYHFTC 527
    anoga-ACHE1      VTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE--PDNPNSNRDALDKMVGDYHFTC 562
    tetka-ACHE       IYISRSEFQSLIRIIYPHLSPLAQEAVIQEYTHWIN--PDDQIENREATDKFVGDYHFTC 511
    tetur-ACHE       IYISRSEFQSLIRIIYPHLSPLAQEAVIQEYTHWIN--PDDQIENREATDKFVGDYHFTC 511
    bacdo-ACHE       TSLPRDKYLEIMNNIFGKVTQAEREAIIFRHTSWV---GNPGLENQQQIGRAVGDHFFTC 494
    bacol-ACHE       TSLPRDKYLEIMNNIFGKVKPAERDAIIFRHTSWV---GNPGLENQQQIGRAVGDHFFTC 494
    cerca-ACHE       TSLPRDKYLEIMNNIFGKVTQAEREAIIFRHTSWV---GNPGLENQQQIGRAVGDHFFTC 494
    haeir-ACHE       TSLPRDKYLEIMNNIFNKATQAEREAIIFQYTSWE---GNPGYQNQQQIGRAVGDHFFTC 530
    musdo-ACHE       TSLPRDKYLEIMNNIFQKASQAEREAIIFQYTSWE---GNPGYQNQQQIGRAVGDHFFTC 439
    luccu-ACHE       TSLPRDKYLEIMNNIFNKATQAEREAIIFQYTSWE---GNPGYQNQQQNGRAVGDHFFTC 558
    drome-ACHE       TALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE---GNPGYQNQQQIGRAVGDHFFTC 480
    aedae-ACHE       TSLPRDKFLEIMNTIFSKASEPEREAIIFQYTGWES--GNDGYQNQQQVGRSVGDHFFIC 463
    aphgo-ACHE2      TALPREKFVQIVNVIFKDRTQLERDAIIYQYSGWEKKEVDDIYSNQKQLSDVVADYFFVC 483
    rhopd-ACHE2      TALPREKFVQIVNVIFKDRTQLERDAIIYQYSGWEKKEVDDIYSNQKQLSDVVADYFFVC 476
    sitav-ACHE2      TALPKEKFVQIVNVIFKDRTQLERDAIIYQYSGWEKKEVDDKYSNQKQLSDVVADYFFVC 483
    lepde-ACHE       SFLQREKYHDIIDTIFKNMSRLERDAIVFQYTNWEH--VHDGYLNQKMIGDVVGDYFFVC 458
    boomi-este13     DGSNPEKLKDSLRTALSSWVKEDIPDIEDKYADDAP--QGDGNALRRQYLDYLSDRLFNC 422
    boomi-acche3     HKITKYEVDLYVSYCLQMLLRKNVSPIRHYYLSHIG--ERENIKALQKAAEAVGDFAIIC 494
    luccu-E3aest7    ETCVNFVPSELADAERTAPETLEMGAKIKKAHVTGE------TPTADNFMDLCSHIYFWF 423
    musdo-EST23aes07 ESCVNYVPWELADSERSAPETLERAAIVKKAHVDGE------TPTLDNFMELCSYFYFLF 423
    colho-E3aest7    ETCANFVPTELADSERSSAETLELGAKIKKAHVTGE------TPTNDNFLDLCSHFYFWF 423
    drome-EST23aes07 DAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGS------ESTPDNYMDLCSIYYFVF 408
    anica-cxest      R-FEEFIHPNFAETLKRKKISLEDLKRMYFKNKKIS------KETTGKFIDLFSDMYFIQ 388
    aphgo-cxest      HHITDEISKLFRNRYSTETISKIKNFYFNKSNISSE------TMKLENICNLHSDVFFFN 383
    Consensus                                                             .   .  
    
                                      !    !!!   !              ! !?   !!?!!!   !
    torca-ACHE       PLMHFVNKYTKFGNGTYLYFFNHRASNLV--------------WPEWMGVIHGYEIEFVF 448
    9neop-ACHE1      GVNEFAHRYAETGNNVYTYYYKHRSKNNP--------------WPSWTGVMHADEINYVF 561
    cydpo-ACHE1      GVNELAHRYAETGNNVYTYYYKHRSKNNP--------------WPSWTGVMHADEINYVF 558
    pluxy-ACHE1      GVNEFAHRYAETGNNVYTYYYKHRSKNNP--------------WPSWTGVMHGDEINYVF 545
    bemta-ACHE1      NVNEFAYRYAETGNTVYMYYFKHRSTSSP--------------WPTWSGALHGDEINYIF 509
    aphgo-ACHE1      NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549
    rhopd-ACHE1      NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549
    myzpe-ACHEM      NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549
    sitav-ACHE1      NVNEFAHKYALTGNNVYMYYFKHRSLNNP--------------WPKWTGVMHGDEISYVF 549
    culpi-ACHE1      NVNEFAQRYAEEGNNVFMYLYTHRSKGNP--------------WPRWTGVMHGDEINYVF 575
    cultr-ACHE1      NVNEFAQRYAEEGNNVFMYLYTHRSKGNP--------------WPRWTGVMHGDEINYVF 573
    anoga-ACHE1      NVNEFAQRYAEEGNNVYMYLYTHRSKGNP--------------WPRWTGVMHGDEINYVF 608
    tetka-ACHE       PVNEMSYRYALYGNDVWTYHFTHRSSKSF--------------WPSWMGVIHGEEIKFVL 557
    tetur-ACHE       PVNEMSYRYALYGNDVWTYHFTHRSSKSF--------------WPSWMGVIHGEEIKFVL 557
    bacdo-ACHE       PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 540
    bacol-ACHE       PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 540
    cerca-ACHE       PTNEYAQVLAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 540
    haeir-ACHE       PTNEYAQALAERGAGVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 576
    musdo-ACHE       PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 485
    luccu-ACHE       PTNEYAQALAERGAQVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 604
    drome-ACHE       PTNEYAQALAERGASVHYYYFTHRTSTSL--------------WGEWMGVLHGDEIEYFF 526
    aedae-ACHE       PTNEFALGLAERGASVYYYYFTHRTSTSL--------------WGEWMGVLHGDEVEYIF 509
    aphgo-ACHE2      PTNLFANIVSSRGARVYYYFFTHRTDSHL--------------WGDWMGVLHGDEMQYVF 529
    rhopd-ACHE2      PTNLFANIVSSRGARVYYYFFTHRTDSHL--------------WGDWMGVLHGDEMQYVF 522
    sitav-ACHE2      PTNLFANIVSSRGARVYYYFFTHRTDSHL--------------WGDWMGVLHGDEMQYVF 529
    lepde-ACHE       PTNNFAEVAADRGMKVFYYYFTHRTSTSL--------------WGEWMGVIHGDEVEYVF 504
    boomi-este13     PLQFFAEKHSERGNKVFAYVFGHKYDAFN--------------LPAWMGVPHATDLQFAF 468
    boomi-acche3     PTKYFAESFASMNNKVHYYYFTHRPSFST--------------WPGWVGPTHGDEVFFVM 540
    luccu-E3aest7    PMHRLLQLRFNHTSGTPVYLYRFDFDSEDLINPYRIMRS----GRGVKGVSHADELTYFF 479
    musdo-EST23aes07 PMHRFLQLRFNHTAGTPIYLYRFDFDSEEIINPYRIMRF----GRGVKGVSHADELTYLF 479
    colho-E3aest7    PMHRLLQIRFKHTSGTPVYLYRFDFDSEEIINPYRIMRH----GRGVKGVSHADELTYLF 479
    drome-EST23aes07 PALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRM----GRGVKGVSHADDLSYQF 464
    anica-cxest      GIHQVARVQAERNS-APTYMYQFTYDQG---PNFSKGMF----SIDEPGSTHMDELIYLF 440
    aphgo-cxest      GVYETFDCFLKQNG-SPVYEYEFKFDGELNGAKNMIFATRPILRHAIKGACHADDVNYFF 442
    Consensus                          * : .                         *  *  :: : :
    
                         ?  !!  !  !         !!    !!  !    !                    
    torca-ACHE       GLPLVKELNYTAEEE-------ALSRRIMHYWATFAKTGNPNE-----PHSQESKWPLFT 496
    9neop-ACHE1      GEPLNPGKNYSPEEV-------EFSKRIMRYWANFARSGNPSL--NPNGDMTKVHWPVHT 612
    cydpo-ACHE1      GEPLNPGKNYSPEEV-------EFSKRMMRYWANFAKTGNPSL--SPNGEMTKVHWPVHT 609
    pluxy-ACHE1      GEPSNPGKNYSPEEV-------EFSKTIMRYWANFARTGNPSQ--SPNGELTKVHWPVHT 596
    bemta-ACHE1      GEPLNPTKKYQPAEV-------ELAKRMMRYWANFAKTGNPSL--SSDGSWASVYWPQHT 560
    aphgo-ACHE1      GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TLEGSWVTPKWPVRT 600
    rhopd-ACHE1      GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TLEGSWVTPKWPVHT 600
    myzpe-ACHEM      GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TFEGSWVTPKWPVHT 600
    sitav-ACHE1      GDPLNPNKRYEIEEI-------ELSKKMMRYWTNFAKTGNPSK--TFEGSWVTPKWPVHT 600
    culpi-ACHE1      GEPLNSALGYQDDEK-------DFSRKIMRYWSNFAKTGNPNP--STP-SVDLPEWPKHT 625
    cultr-ACHE1      GEPLNAALGYQEDEK-------DFSRKIMRYWSNFAKTGNPNP--SPP-NADLPEWPKHT 623
    anoga-ACHE1      GEPLNPTLGYTEDEK-------DFSRKIMRYWSNFAKTGNPNP--NTA-SSEFPEWPKHT 658
    tetka-ACHE       GEPLDPVHGYTPAEV-------QLSKRIMRYWANFARTGNPNKQFPDGDDTESIVWPEYT 610
    tetur-ACHE       GEPLDPVHGYTPAEV-------QLSKRIMRYWANFARTGNPNKQFPDGDDTESIVWPEYT 610
    bacdo-ACHE       GQPLNTSLQYRQVER-------ELGKRMLNAVIEFAKTGNPAT--------DGEEWPNFT 585
    bacol-ACHE       GQPSNTSLQYRQVER-------ELGKRMLNAVIEFAKTGNPAT--------DGEEWPYFS 585
    cerca-ACHE       GQPLNTSLQYRQVER-------ELGKRMLNAVIEFAKTGNPAT--------DGEEWPNFT 585
    haeir-ACHE       GQPLNTSLQYRPVER-------ELGKRMLNAVIEFAKTGNPAV--------DGEEWPNFS 621
    musdo-ACHE       GQPLNNSLQYRPVER-------ELGKRMLNSVIEFAKSGNPAV--------DGEEWPNFS 530
    luccu-ACHE       GQPLNTSLQYRAVER-------ELGKRMLNSVIEFAKTGNPAV--------DGEEWPNFS 649
    drome-ACHE       GQPLNNSLQYRPVER-------ELGKRMLSAVIEFAKTGNPAQ--------DGEEWPNFS 571
    aedae-ACHE       GQPMNVSMQYRQRER-------DLSRRMVLSVSEFARSGNPAL--------EGEHWPVYT 554
    aphgo-ACHE2      GHLLNMSMPYNARER-------DLSIRIMEAFTRFSLTGTPVS--------DDIDWPLYN 574
    rhopd-ACHE2      GHPLNMSMPYNARER-------DLSIRIMEAFTRFSLTGTPVS--------DDIDWPLYN 567
    sitav-ACHE2      GHPLNMSMPYNARER-------DLSIRIMEAFTRFSLTGTPVS--------DDIDWPLYN 574
    lepde-ACHE       GHPLNMSLQFNSRER-------ELSLKIMQAFARFATTGKPVT--------DDVNWPLYT 549
    boomi-este13     GIPYAAER--DSLNG-------RMSEAYMRMLGSFSENGRPELP-------SKQKWPRYT 512
    boomi-acche3     GLPFSSPTIATDQER-------ELSKLMIETWTTFAKTGKVPD-------VASKPWPEFT 586
    luccu-E3aest7    WNQLAKR--MPKE-----SREYKTIERMTGIWIQFATTGNPYS--NEIEGMENVSWDPIK 530
    musdo-EST23aes07 WNILSKR--LPKE-----SREYKTIERMVGIWTEFATTGKPYS--NDIAGMENLTWDPIK 530
    colho-E3aest7    WNALAKR--LPKE-----SREYKTIERMVGIWTQFATTGNPYS--NEIDGLENIIWDPIK 530
    drome-EST23aes07 SSLLARR--LPKE-----SREYRNIERTVGIWTQFAATGNPYS--EKINGMDTLTIDPVR 515
    anica-cxest      SMKFQET--LNMEPIDKKSPHFRVMEQMVELWTNFAKYGRPIP--APTELLP-VHWLPMN 495
    aphgo-cxest      RDLSGVDPKPN-------SPELEMCKMMCKMWTNFAKTSNPNS--PDLS----FKWINAT 489
    Consensus                                          *:  .                     
    
                       !  !       !            !  !  !!!!!!!! !   ?!!  !   !     
    torca-ACHE       TKEQKFIDLNTEPM------KVHQRLRVQMCVFWNQFLPKLLNATETIDEAERQWKTEFH 550
    9neop-ACHE1      AFGGEYLSLAVNSS------AVGHGLKVKQCAFWQKYLPQLMAATTKPEPIQ--NCTSNS 664
    cydpo-ACHE1      AFGREYLSLAVNSS------AVGHGLRVKQCAFWQKYLPQLISATKKTEPPR--NCTGSS 661
    pluxy-ACHE1      AFGREHLSLSANSSG-----TVDHGLRVKQCAFWQKYLPQLIAATSKPEPPK--NCTSSA 649
    bemta-ACHE1      TYGREFLTLDINST------AIGQGPRLRQCAFWKKYLPQLISTTSYLVPANSSNCTSAA 614
    aphgo-ACHE1      AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLTVISKSMKSDK--NCTTIS 652
    rhopd-ACHE1      AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLTAISKSMKSDK--NCTTIS 652
    myzpe-ACHEM      AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLMAISKSMKSDK--NCTTIS 652
    sitav-ACHE1      AYGKEFLTLDTNNT------SIGVGPRLEQCAFWKNYVPDLTAISKSMKSDK--NCTTIS 652
    culpi-ACHE1      AHGRHYLELGLNTT------FVGRGPRLRQCAFWKKYLPQLVAATSNLQVTP----APSV 675
    cultr-ACHE1      AHGRHYLELGLNTS------FVGRGPRLRQCAFWKKYLPQLVAATSNLQVTP----APSV 673
    anoga-ACHE1      AHGRHYLELGLNTS------FVGRGPRLRQCAFWKKYLPQLVAATSNLPGPA----PPSE 708
    tetka-ACHE       AHEKEYLVISTNDS------SIGRGLRAKQCAFWKNFLPKLINALENRHNST---CTSHS 661
    tetur-ACHE       AHEKEYLVISTNDS------SIGRGLRAKQCAFWKNFLPKLINALENRHNST---CTSHS 661
    bacdo-ACHE       KKDPVYYVFSTDDKE----EKLQRGPLEGRCAFWNEYLREVRKWGSQCELKPSSASSLQQ 641
    bacol-ACHE       KKDPVYYVFSTDDKE----EKLQRGPLEGRCAFWNEYLREVRKWGSQCEVKPSSASSLQQ 641
    cerca-ACHE       KKDPVYYVFSTDDKD----EKLQRGPLEGRCAFWNEYLREVRKWGSQCDVKQSSASTIQQ 641
    haeir-ACHE       KEDPVYYVFSTDEKI----EKLQRGPLAKRCSFWNDYLPKVRSWAGSECEDGSSQSASGA 677
    musdo-ACHE       KEDPVYYVFSTDEKI----EKLQRGPLAKRCSFWNDYLPKVRSWIGSECENKSSTSASAA 586
    luccu-ACHE       KEDPVYYVFSTDEKT----EKLQRGPLAKRCSFWNDYLPKVRSWVGSECENNSAESAAVS 705
    drome-ACHE       KEDPVYYIFSTDDKI----EKLARGPLAARCSFWNDYLPKVRSWAG-TCD---GDSGSAS 623
    aedae-ACHE       KENPIYFIFNAEGEDDLRGEKYGRGPMATACAFWNDFLPRLRAWSVPPKS---SCNILEQ 611
    aphgo-ACHE2      ESKPIYHVWNAAEMH------VGYGPRAAECQFWNGFFPKIAQALKETSKTTCEDYPDSM 628
    rhopd-ACHE2      ESKPIYHVWNAAEMH------VGYGPRAAECQFWNGFFPKIAQALKETSKTTCEDYPDSM 621
    sitav-ACHE2      ESNPIYHVWNAAELH------VGYGPRAAECQFWNGFFPKIAQALRETTKITCEDYPDSM 628
    lepde-ACHE       KDQPQYFIFNADKNG------IGKGPRATACAFWNDFLPKLRDNSGSEEAPCVNTYLSKI 603
    boomi-este13     KRSPTVIHMNSDHFN------ETKGFRAEQCERWKSLF---------------------- 544
    boomi-acche3     AKNQVYMELNPKRYT------YGRGPNEKNCNFWKSYLKPRGPNEKNCNFWKSYLKP--- 637
    luccu-E3aest7    KSDEVYKCLNISDEL-----KMIDVPEMDKIKQWESMFEKHRDLF--------------- 570
    musdo-EST23aes07 KSDDVYKCLNIGDEL-----KVMDLPEMDKIKQWASIFDKKKELF--------------- 570
    colho-E3aest7    KSDEVYKCLNISDEL-----KIIDVPEMEKIKQWESLYEKRKDLF--------------- 570
    drome-EST23aes07 KSDEVIKCLNISDDL-----KFIDLPEWPKLKVWESLYDDNKDLLF-------------- 556
    anica-cxest      DG-TVLRYLNIGEEL-----RMEKVLNIEERYDYKLICHREKV----------------- 532
    aphgo-cxest      ACDLKYLSIDGDRTC-----MIQGMMNNKRFRFWKELSESIV------------------ 526
    Consensus                                         :                          
    
                     ?!      ??     !  !              !  !   
    torca-ACHE       R------WSSYMMHWKNQFDHYSR------HESCAEL--- 575
    9neop-ACHE1      ------GTRHYYGVTSLSLVTVFG---FLQPTILKYIII- 694
    cydpo-ACHE1      S--LLRPSLHTLGLGVAAAAAPFTHHLLLTHLVSMFINID 699
    pluxy-ACHE1      E--APRASYHVLGLAVVAAVSFSQ------KTIVKLII-- 679
    bemta-ACHE1      PSSLLQHGFNKLSSHSSPFILLLAVFQFLLLLLSNSAIL- 653
    aphgo-ACHE1      G----GTKTNMIKLSVWTIVMTTA------VLML------ 676
    rhopd-ACHE1      G----GTKTNVIELSVWTIVMTTA------VLML------ 676
    myzpe-ACHEM      G----GTKTYMIELSLWTIVMTTA------VLML------ 676
    sitav-ACHE1      G----GTKTNMIKLSLWTIVMTTA------VLVL------ 676
    culpi-ACHE1      P-----CESSSTSYR-STLLLIVT------LLLVTRFKI- 702
    cultr-ACHE1      P-----CESSSTSYRSSTLLLIVT------LLLVIRFKI- 701
    anoga-ACHE1      P-----CESSAFFYRPDLIVLLVS------LLTATVRFIQ 737
    tetka-ACHE       N----QIGSSNWSLAISLISLIMC------FLPSLR---- 687
    tetur-ACHE       N----QIGSSNWSLAISLISLIMC------FLPSLR---- 687
    bacdo-ACHE       K-------QQHLLLQQRSIVTFMLTLSLVLGIPSVNAFF- 673
    bacol-ACHE       Q-------QQHLLLQQRSIVAFMLALSLVLKIPSVNAFF- 673
    cerca-ACHE       N-----------MLQQKIIMALLLALSIVLGIPSINAFF- 669
    haeir-ACHE       IY-------KTQQQQHTTLLTVALILVMVISIFQ------ 704
    musdo-ACHE       IY-------EMKMQQLT-LLAVAIILTMVNSIFQ------ 612
    luccu-ACHE       II-------YEK--QQNLLKWVIMLTIMVTCIFQ------ 730
    drome-ACHE       IS-------PRLQLLGIAALIYICAALRTKRVF------- 649
    aedae-ACHE       TS-------AATILYVDIKIVTVLMVFILVRLY------- 637
    aphgo-ACHE2      PTINENCTFTSSFATVNPQISFTIIFIFVLPAYGLF---- 664
    rhopd-ACHE2      PTTNENCTFTSSFATINPQISFTIIFILVLPAHGLF---- 657
    sitav-ACHE2      PTTNENCTFTSSFATINPRISFTIIFIFVLPAHGLF---- 664
    lepde-ACHE       R--------SSSNELLPPSTSLVLIWIMTLLNAL------ 629
    boomi-este13     ---------------------------------------- 544
    boomi-acche3     ---------------------------------------- 637
    luccu-E3aest7    ---------------------------------------- 570
    musdo-EST23aes07 ---------------------------------------- 570
    colho-E3aest7    ---------------------------------------- 570
    drome-EST23aes07 ---------------------------------------- 556
    anica-cxest      ---------------------------------------- 532
    aphgo-cxest      ---------------------------------------- 526
    Consensus                                                
    
    

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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