ESTHER Database

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The server ESTHER (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases.

NEW The 15th International Meeting on Cholinesterases and 9th Conference of Paraoxonases will take place autumn 2024 in Slovenia.

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Jump to: Mutalign, human-ACHE, Esther overview, OverallTable, Meetings page, Table structures, Hall of Fame. Human a/b hydrolases
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  • March 29, 2023:
    Crystal structure of the Fusarium oxysporum tannase-like feruloyl esterase FaeC in complex with p-coumaric acid provides insight into ligand binding is published by Ferousi et al. and structure will be available soon (8BHH) Complete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases is published by Yang et al. and structures are available (7XTR, 7XTS, 7XTT, 7XTU, 7XTV, 7XTW) A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands is published by Mottillo et al. .Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation is published by Pidany et al. and structure will be available soon (8CGO)

  • March 22, 2023:
    Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity is published by Atkinson et al. and structures are available (8BT8, 8BTA, 8BT2, 8BTC, 8BSZ, 8BT0).

  • March 15, 2023:
    Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies is published by Jing et al. and structures of human BCHE in complex with alkyl linked bis-ligand derivatives of tacrine are available (7QHD, 7QHE). An analysis of connectivity between surface and interior in catalytic subunits of acetylcholinesterases inferred from their X-ray structures is published by Radic et al. A novel thermostable and salt-tolerant carboxylesterase involved in the initial aerobic degradation pathway for pyrethroids in Glycomyces salinus is described by Liu et al. Structural insights into catalytical capability for CPT11 hydrolysis and substrate specificity of a novel marine microbial carboxylesterase, E93 are published by Li et al. and structure (7X8L) is available. Improvement of thermostability and activity of PET-degrading enzyme Cut190 towards a detailed understanding and application of the enzymatic reaction mechanism, is published in a preprint by Numoto et al. and structures are available (8IBL, 8IBM). Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase is published by Chen et al. and structures are availble (8HGV, 8HGW) A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4 as published by Voss et al. and the first structure of an EDS1 entity beyond the model plant Arabidopsis thaliana will be available soon (8B28).

  • March 08, 2023:
    Structures of Arctic bacterium Paenibacillus sp. R4 PsEst3 psychrophilic esterase are available (7V8U; 7V8V; 7V8W; 7V8X) and are published by Son et al. Inhibition of diacylglycerol lipase beta modulates lipid and endocannabinoid levels in the ex vivo human placenta as published by Berger et al. Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism, as published by Gan et al. Crystal structure of cutinases from Pseudomonas bauzanensis (PbauzCut), Rhizobacter gummiphilus (RgCutII), Pseudomonas saudimassiliensis (PsCut) are available (8AIS; 8AIR; 8AIT) and are published by Avilan et al.

  • March 01, 2023:
    Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery is published by Dileep et al. and structure is available (7XN1) Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders are published by Zhang et al. and structure (8GS4) is available Molecular insights on PS-PLA1 lipase activity of human ABHD16B is published by Narayanasamy et al. Endocannabinoid 2-Arachidonoylglycerol synthesis and metabolism at neuronal nuclear matrix fractions derived from adult rat brain cortex is described by Aretxabala et al. and involve diacylglycerol lipase-alpha (DAGLA) and alpha/beta-hydrolase domain 12 protein (ABHD12)

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Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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