Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....
9acto-d9ukw7   	------------------------------------------------------MPR------------------------RGGLR----------GP--H-----------------RERLPHEGPL-----LAPVRGRSGAHPPRAP-----PARPRRQGLAAPPGDPGRPAG------------RRLLRG--PAVRAAH----GPGLRSGTRDDPRHLPPRRNGARLMTSPRPLSPWD-------FPP--GHPGTAL-LTGAT----PQFALSTDPRFSFCLQVPR--RHTP--DG-PPRPLLVVVHGTGRRS-----QALRDAFADFAE-----------RYDCVVLAPLFPAGIDGP--------NDVDGYKLL--------------------------------SPAGYRADTLLLAMVEEAAARWH-IRTDRFHLHGFSGGGQFAHRFACLHPGR---------LASLSVGAPGRVTPFDPAT---------------------PWPRGTADAKRL------FGHEADPARLREVPVQFVIGADDTRTEEL-A-------------PGDEAPTVHRLARLRALRANWHDH--GI------ASR-LDTVPGTGHDHFAVLPAVRDFLAECVDGRGGRRQGR-CSTGA---------------------------------------------------------------------     =====>
9acto-d9wjn1   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIVTGTAPCRWRRIA-GGHVTPRIKTTKAFY-RTGAT----TFFASQHDQRFSYSLHVPS--VH-E--TTTTPLPLLVIQHGTGRTA-----AEYRNAMAEFSE-----------RHGVVILTPLFPAAIGDP--------DDLHNFKFI--------------------------------EYDGIRYDRELLAIVDEVGTRFT-VDTDRFMLQGFSGGGQFAHRFLYLHPER---------LCAVSIGAPGRVTLIDPDR---------------------EWWLGTAGFEER------FGAPVRLEEIRKVAVHMVVGAEDTETWEI-N-NPGDS----NWMDGADALGRTRVERITALRDNYVAL--GI------DVT-LDIVPGVGHSGTGVLDAVRDFAARVLTTR----------------------------------------------------------------------------------     =====>
9alte-a6ez29   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKMIAIFL---AALFSLLTG--CQTVTTEPVAYSE-DSESDIFDPETF--------------ERY--SSIVVE---------AGTP----------------EKPVDMRLWYTRPD--ELTA------DTPVVMVMHGGRRDA-----DVYRDFWGAYAN-----------EYDVLIVAPEISQEDFPT-------GWGYQTGNWVTPDSSSV------------------DETKGQRNPPEQSSFAALERAFDKLRDAFAL-EATEYDIWGHGSGAQFVTRMVMLYPQA--------RIGTAVAANSGTYTFPDWTL---------------------PLRYGLKNTGV---------EADDLRPSYAHHLVVMLGTADNDPSHR-LL---------SKLDIAIAQGAHRLEKGKNFYAANKAK--AEELGTEFNWE-LETVYGIGHSGQKMSVAG--ARYLLAGEKERALFPLDDESD----------RVENGESREKNELLQGSGA---EDDPFSDMD-----------------------------     =====>
9bace-b3c5f6   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKRLIL---FFAIVFL--GAGLR--------------------------------------AA--SVLPVG---------EGKF---------TYKDYPPFADRPVDVHYYIPAS-GDVR------RMPIVFVFEGADRGF-----TYLLKAWKQEAE-----------KHKFMVFIPHFDLERFPL-------PDYQEVGVMNDKD--------------------------HTIRPAEKQTPALVDKIFEYVRQSSGS-ERKGYMIYGHSAGGQFVQRFMLFYDSP--------YVEKAVIGSPGWYTFPDASQ---------------------DFPYGVRNIPYV--------TPETIRKYLAKPIILQLATGDTIRE--SYL---------RKTPEAEAQGRNRYERGNQFYRYLHRI--AAEHNWPCNWQ-KIEEQGIGHHSAGMGRRA--VPAMLGDSLRALFIGN---------------------------------------------------------------------------     =====>
9bact-a3i1k2   	------------------------------------------------------------------------------------------------------------------------------------------------------------MPL-V-KV------------SELE----------KLN--NLV-------------------------------------VNQ--IDIQEG---------SGAF---------LIEGGKGKESKSIKVFYHKPI--NFSE------DSKILLVIPGAGRNG-----DSYRDAWIPESE-----------KFNVLILSPMYAEDEYL--------FEDYHLGGIMTGLNLEEAAEAVPNT--NQVKLNEEIFNFTINPDRETWLFEDFDRIFELAKEATGS-AQSTYDIFGHSAGGQILHRYTILKPYS--------KADQIIAGNSGFFTMPDTTL---------------------NLPFGIKGLEV---------SKEDLKASFQQNLVLLLGENDNETETGGTM---------LKSPTADLQGNGRLAKGQYFYEKSKKL--AEQLGYEFNWK-LVTVPNVGHDQELMGDAA--AKILYE-------------------------------------------------------------------------------------     =====>
9bact-d1pue9   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKHIFYSLVL---ILLFFSM--SSCWKDDV---LLEDGKSGDDVST------------------SLS--LIQDNT---------PHTF---------NYGELPTLADKPIKVHYLLPSA-GDVS------RMPILFIFPGESRDA-----DIHLEYFSSWAK-----------KNRVMIFAFEFPVAYYPS-------TTEYILGGINKSQ---S---------------------NVGILAKASWNFNYVEAIFDAVKLLTKS-IQTSYDMWGHSAGGQFVHRFCTFMETT--------HVNRAVAANSGWYTLPDAKE---------------------SFPYGYKEITDVK-------WNKQLPRLLARNFYVQLGGNDTSTS--G-L---------NNKEGSVAQGSNRLERGKFYYTTSQSI--AKNNGVSFNWK-LSIVSGVGHEPEKMAKAA--MEIFTY-------------------------------------------------------------------------------------     =====>
9brad-d6v1p2   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSKTKKLVS---AACVAVLAS--CIGGMVQVRS-AA-AQTNDAFAQEN--------------------KTIPVG---------EGEF-------------RLVVKRGPVNVFTYRPK--SFTP------NSPIWVVIHGQKRDVAEHSAFDYYDTWAPLAE-----------KAGALLLVPEFVEQSWPT-------SWQFQFGNVMTKS--------------------------LKPVPWEDSGFAVVEMAFKRAVAMTGS-HRQRFSIFGHGGGAQWVQRYVLHSGGR--------YIARAVAANPGWYMLPDDEF---------------------KYPYGIQGTSI---------TPATLRGAFATDFVLLLGQADVQTGGI--I---------RNNRETSAQGTTRFARGHFYFNRAAAD--AKRIGAKFAWH-LREVPGAGHDDADMAPAA--AAAMMERR-----------------------------------------------------------------------------------     =====>
9caul-f4qiu2   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRHERDWP-----------VS-EALRP-E--------R-LFHHAATAASYFGFVPA--GAGP------ATPVVVSVHGISRNS-----AEHLFRLSALAR-----------SGRFALVVPVFDKA-------------TYGQYQQVV------------------------------DPRKAVRADESLLAMLKDFSGRTG-INTARVVLTGFSGGGQFAHRFAMMHADR---------VAACLPCSAGWYSFPDAGL---------------------AFPAGIGTLPL-------------HPQWDAVPIHVVVGGDDTRRDPS-LNTTPAI---------DAQQGRHRLTRARRWTRALQQY--RSDRAGAGGVH-LTVAADVGHDFADLA-ATEAFASAL-GDALTTLQG----------------------------------------------------------------------------     =====>
9clot-c0cw58   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNYNWK------------ATALMGIGTAKAP----ILKACRRDQRFSYFLYLPK--GFQE--ESASEYMITVVVHGTTRNA-----EKLKNVFAEYAD-----------EMKSLILAPLFPAGIIDE--------EDIHNYKFI--------------------------------KYCDIRFDHILLDMVAEVCETFG-VSGDQFYLHGFSGGGQFAHRMLYLHPER---------LRAVSIGAPGRSTYLDDTE---------------------DWYAGTRNFEEV------FGQPIDAAALRAVPVLLIIGAQDTERIDY-S---QDT----TFIPASRKNGSNRVERMRALYKNYQDY--GL------KVR-FLAVPGVAHEGMKIIPQVVEFFKEIAKEVNV--------------------------------------------------------------------------------     =====>
9flao-a3j5l9   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYITL---MFFFILIS---CSKDEV---SKNA-----DI-A------------------TPI--DNLSTG---------SGLF---------TFTYNVVSFNKTMNIYYYIPE--NKTA------STPILFVFHGTERNA-----SDYRNTLITKAQ-----------LLGFIVIAPEFSEQNFPG-------GDGYNLGNVFIDGDNPS---------------------ASSLNPESEWTFSIIEPLFDFVKTQINN-TNGTYYMFGHSAGGQFVHRFLMFNPIA--------RVEKAVVSASGWYTFPTNTI---------------------VFPYGTNQSPL---------ENMSSSLFFDKKVYVQVGENDDDPNAAGLR---------HNSFAD-AQGLNRKERAINYFQFCEQL--ATTNAMNFNWT-FRIVSNANHDYNEAAENA--VSSLFN-------------------------------------------------------------------------------------     =====>
9flao-a4bw79   	MITIREILKKSTVFAIVLCLPFLVGCSDADNDSIPLTILSIKANGAPLEMGSVKIPINSVIEIAFSSEIIPAKFEALFSVTK------------------ESEALDYTISYT--NVSSRV---------------TVTL----EQMATS-----TAYNL-K-I--LAGDLGVNGSFFNNEL---LVSFITKT---QSNSGG---------------G------------------LVI--N--ANT---------TGSF---------DFSPKAPLNLAPIKVFYHIPA--GDLK------KMPILMAFHGAGRNA-----SAQRNYWIQLAN-----------EKGFMVIAPEFSEINYPGL------GDDYLMANIFDDGDNPS---------------------TTSFNSSEEWTFSSLDPIFEAVKVAVSG-SQEKYSAWGHSAGAQFLHRFATYLPNS--------KLDVAVCSNSGWYTVPENTV---------------------SFPYGILNGQL---------PDENIKKVFSKKIIVHLGLNDTNPD-GGVR---------RNTVVDSQQGIHRLERGRYYFNTSKTQ--AQNRADSFNWE-LQEVSNIGHDEALMANDA--FQYLEASLRVH--------------------------------------------------------------------------------     =====>
9flao-a8umh7   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK---QRFLI---LLIALLGAQ--ILV-------------------------------------AQS--VTINKG---------AGSF---------KINGSSNHQADSITIFYHKPE--NFTR------SSEILLVVSGAGRNG-----DDYRDSWIETSE-----------KYGVLIISPSYPEKEYN--------YGDYHLGGIVKDLNLSKGVSFKKGT--NQVHINENMIEFNINKNKEDWIFNDFDRIFKLVKKATKS-KQRKYDMFGHSAGGQILHRFALFYPNS--------KANRILASNAGTYTFPDFNT---------------------NFPFGIMNVGI---------QKKQLKKSFKTKLVLFLGELDNDSETRGRM---------FRSETADKQGTNRFDRGNNFYKFSEEL--SKKHGMKFNWK-LELVTNVGHDQKKMAEAA--AEYLYRK------------------------------------------------------------------------------------     =====>
9flao-q1vqh8   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK-F---L---AFIFVVLI---STVQLV---------------G------------------QNL--S--QNS---------TGSF---------TFTPTGPLSNQPVEVYYHIPN--GDIS------TMPIVMSFHGSSRNG-----SDYRDYWITMAN-----------ANGFMVFAPEFSDSNYPGL------GDSYLMANIFDDGDNPS---------------------LSSYNNPDEWTFSVLDPIFEDIKSDISG-TQEVYNGWGHSGGAQFLHRFIMYMPSS--------KLDVAVCSNAGWYTVPENTV---------------------SFPYGILNGQL---------PSSTLITAFSKKLIVHLGQNDTDPNSPGLR---------RNNVVDNQQGIHRLERGQYFFSTSQSI--AQGLNTAFNWE-KHEVAGIGHDAQQMANAA--LPYILMRTLSPTEYESKTDVNLYPNPTSNHIFFDNSSVRLKKVKLYTSHGQFVKTFEFSTFEKSQKINLSDLNSGLYILKINENYIKLLKK     =====>
9prot-d5rji3   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP-------RPAGHGRRLSYY-DFGRT----TVRACQADQRFSYCAYVPE--SYEE--DGSQDYPLLVAMHGTGRMM-----ELYRDTFAPLAE-----------ARQVIVLAPLFPAGITGP--------EDLSSYKML--------------------------------RAGALHYDAVLLAMVEEMRARYR-IRGHRFSLFGFSGGGHFAHRFLYLHPGR---------LSAVSIGAPGLVTLLDDSY---------------------DFWPGVRDWESR------FGQRIDIGAMRDVAVQMVVGGDDTDTWEI-TIRPGDR----LWMPGADAAGANRQDRLRALRASLEAQ--RI------AVR-HDTVPGVAHWMPGVAPAVIDFFTEHHAA-----------------------------------------------------------------------------------     =====>
9psed-f2zpn2   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI--KPLLVLLLSTAFVSLGA--HAED---------------------QAVN----------SISP--DRLAIN-------------------------------GAEATLGLSQEWVHPKPK------IERVVIVLHGRLRNA-----QTYLRSIERAANQSRE-------RSKTLLIAPQFLDEKDIVAHHLPESILRWRQNSWMEGAT------------------------ASNPK--PVSSFLVLDHILKRLSDSKLFPNLKEIVIAGHSGGAQVVQRYAMIGGKEDALLHREGVKLRYVIANPSSYAYFDAERPE--------PVTAQSCPNFNDWKYGLNKMPFYSG---KETPADIEKNYVKRDITYLMGELDTDRNHP-AL---------DKTCAAEAQGPYRLIRGQNYFNYLQKR-----HPEGLNQR-LVIVPKVGHNGDGIFTSPEGQAVLFKPF-----------------------------------------------------------------------------------     =====>
9rhob-c9ctk5   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKHLSTTV-----------LK-DCTRI-SASID----RVVVPTPAGRLRAFVLHPT--HDA-------GRAPLVVLHGISRNA-----KELARLFAPEAA-----------RTGRRIVVPHFTPN-------------RWPHFQR---------------------------------PCRAARPDVALAGLMDFLATQDA-AFARPAQIFGHSGGAQLAHRFAMLYPNR---------VARLSLVAAGWYCLPDDRM---------------------AYPYGLNDKNDRQLALWVRRHRAGLARFLSIPTEILVGDSDTDRDES-LRQTSDL---------DVVQGTTRVARAATYAEALRTA--ASQAGVSADVT-LTALSGVQHDVAQAI-RVAGLARHVAGPDLFPFAQA-V-------------------------------------------------------------------------     =====>
9sphi-b6vqa9   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MITTKHLTTIA---AFCLIVMANSVCEAHKA---HKQP-----HR-Q------------------TIN--PKIDEG---------VGEF---------IYQDYKPLDNKPIKVRYYNPG--KND--------AQVLFIMHGNGRNA-----EGYFKAMLKHAQ-----------QHNVLLVVPEFDEQQFSS--------REYHQGGILD-----K---------------------QSKLRPREDWTFSIIEPLFDYVKKLTGN-TSAGYMLYGFSAGSQFVHRFLMFNPEN--------RVTRAIAGSAGTYTMPDYNI---------------------DYSYGLKNVNL---------PQKNLNKFFAKNLMVIVGDADTVLSRTDLV---------KTP-AANQQGRDRVERGQTFFNRSKAI--AEQLKTPFNWK-FQLIPHVGHSQGEMAGPV--AKLLFEDK-----------------------------------------------------------------------------------     =====>
acicj-a5g251   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------EERLGIA-------------------------------VKRA----------MLAP--ERFAPG-----------------------------ASGFSVPAVFR---GAEGAA------ARQALIVLHGARRDC-----IEYADIATDA---FGD------RLGTLALAVPQFPIAADLAGVEDAARLARWPDRIWIEGGA------------------------AVAPA--GLDAFSVLDALIGHFSDRTAYPLVSEIVIAGHSAGGQLAHRHAVLSPL--------GDAVRYVVANPASYVWFGPAA--------------------GPWKYGLAGRPAYGG---PLDDAAIEARYARRDVVYLLGRRDCDPEHR-ML---------DRTPPALAQGPHRLARGRNYIAHLAAR-----QGAALRHR-LIEIEGVGHDPGALFAAAAARDAVLGAARNNQEEETR--------------------------------------------------------------------------     =====>
acima-f0j5m5   	------------------------------------------------------------------------------------------------------------------------------------------------------------MRY-H-EG---------M--------EERLGIA-------------------------------VKRA----------MLAP--ERFAPG-----------------------------ASGFSVPAVFR---GAEGAA------ARQALIVLHGARRDC-----IEYADIATDA---FGD------RLGTLALAVPQFPIAADLAGVEGAARLARWPDRIWIEGGA------------------------AVAPA--GLDAFSVLDALIGHFSDRTAYPLVSEIVIAGHSAGGQLAHRHAVLSPL--------GDAVRYVVANPASYVWFGPAA--------------------GPWKYGLAGRPAYGG---ALDDAAIEARYARRDVVYLLGRRDCDPEHR-ML---------DRTPPALAQGPHRLARGRNYIAHLAAR-----QGAALRHR-LIEIEGVGHDPGALFAAAAARDAVLGAARNNQEEETR--------------------------------------------------------------------------     =====>
agrsh-f0lfg1   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVTQKAVPLNFY-RRGRT----PIFASRMDQRFSWCCYIPE--GYDP--AGEIVHPLAVLVHGSLRDA-----DILRDEFIDFAE-----------QHQCVLLAPLFPAGIDDP--------DDLHNYKHM--------------------------------IYHGIRYDLVLLDMIDELATRYR-VEKDKVLMHGFSGGAQFAHRFLYLHPHR---------LRAVSVGAPGTVTLPDDRA---------------------KWWVGLNGMEEI------FGQPIGIDAMRRVAVQLVIGDADIETWDV-TVGPKSP----FWMEGINDSGETRVERLRTLEKGLKAI--GV------EPR-FDTVAGISHDGTGIQPPVKAFFSAVLKD-----------------------------------------------------------------------------------     =====>
amymu-d8i4g6   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIR---------------VEDLPVAHPGRRL-LTKRT----PFFAAPDEPRCSYCAYIPT--SWTP--DA--ELPVLVAVHGTGRSV-----GELREGLIPFAE-----------QHEVIVVTPLFPVGIDDR--------DDVHDYKLL--------------------------------DAHGIRFDRVLLGILEQVRFRWN-ARVDTVLLCGHSGGGQFAHRFLYLHPDR---------VAAVAVGAPGGVTLLDDSL---------------------AWPEGTGDTRQR------FGITVDPAAVARVPVLLVIGGDDDGRADL-AV--------------MGDHGRNRPEQLDRLARSLTRH--GT------AVR-QVVVPGVGHSAAGTRPPVVEFFTGLLPG-----------------------------------------------------------------------------------     =====>
bacov-d4wwr0   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMRVANLLI---LLIAVLM--TSCFKDDE---SESLGETSKFL-----------------------------PG---------DGIV---------TYSGYAPLADRPVRIHFHIPAN-GDMK------KMPVLFVFPGLERNA-----ADYLNAWRTEAS-----------NRNVMVFVFEFPTETYST--------AQYIEGGMFQG---------------------------NTLLDRSEWTFSLIESVFDTVRKDTGA-SRTKYDMWGHSAGAQFVHRYVTFMPDT--------RVDRAVSANAGWYTLPDVDV---------------------AYPYGLKNT-DVA-------TSSQVASLLARKLIVHLGTADTDRN--G-L---------NTSTGAEAQGANRYQRGKYYFSEAKRI--SVKGGYSLNWD-KYEVTGVAHEYAKMAAAG--AKILY--------------------------------------------------------------------------------------     =====>
borpa-Q7W3B7   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKPADL--------------TNA--DRIALE---------LGHA----GRNAIPYLDDDRNADRPFTLNTYRPY--GYTP------DRPVVVVQHGVLRNG-----ADYRDFWIPAAD-----------RHKLLIVAPTFSDEIWPG-------VESYNNGRAFTAA--------------------------GNPRHVDGWTYALVARVLANIRAAEIA-DCEQVYLFGHSAGGQFVHRLMSSQPHA--------PFHAVTAANPGWYTLPTFEH---------------------RFPEGLDGVGL---------TEDHLARLLAYPMTILAGDQDIATDDP-NL---------PSEPAALRQGPHRYARARHYYEAGQRA--AAQRGLPFGWQ-LQVVPGIGHDGQAMSQVC--ASLWFDGRMPDAAELARLAGSQ--------SA-----------------------------------------------------------     =====>
braja-q89y23   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFV-MRALACLAALVLVLICG--HAF-------------AADEDAPNRKPVK----------AIGD--ARLS------------------------------VGGRGTLRLYLSRDWSMPQPA------ISRAVIVLHGRLRNA-----DEYYISANNAQAAAGD------DGKAALMIVPQFLAEIDIEAHKLTEDTLRWSLEGWEGGDA------------------------ALAPN--PVSSFEALDAILARLADRRVFPNLKQVVVAGHSGGGQVVQRYAIAGKGE-TALSRQHIDVRYVVANPSSYAYFSADRPV--------PAIAASCPGYNNWKYGMGDRPPYLA---DATPAALEQRYVEREVIYLLGTLDTNPKHS-AL---------DKSCMAEAQGPYRYARGHAYVDAMAKR-----DHGTPNHR-VWDVPGVGHDGDKMLTSKCGLAALFDIPGCGAER-----------------------------------------------------------------------------     =====>
burgb-c5ail4   	------------------------------------------------------------------------------------------------------------------------------------------------------------MPF-D-TS-------LPRR-LRGVGPACALGLALAGG--PAAAAQAAGP----ASAPHAYQPHLRPVA----------RIAA--TRMRID---------T------------------PAGSAQFPLYLSRDWSQPLPG------VTRAVIVIHGKLRNA-----DRYFRLAEAARAAAREQGAAAADQAGTLLVAPQFLATLDLAGRDAPAALLRWDANGWMAGDD------------------------AVSPV--PLSSYAVLDAIVARLADRRRFPNLKTVVLAGHSGGGQVVQRYAVAARET-GALSREGIALRYVVSSPSSYAYFDAERPGAHG--KPAAFDAAACPGFDDWKYGMAKRPPYLA---DRSAAQLEAAYAARRVTYLVGGNDDDPRQR-AL---------DRSCPAEAQGPQRLARAEAYFGYLRAR-----HPEGLNQR-LQVVPGVGHDGAKMLGSACALAAIYDTAACGS-------------------------------------------------------------------------------     =====>
cupnh-q0k4q3   	-------------------------------------------------------------------------------------------------------------------------------------------------------------ML-Q-AL----ALVVPSK-PCRALAGAAIAMAVLAG--CASAPDTPSA----ATAVE----AAATPA----------QAKPHWQRVHLG---------T-------------------GAGYDFPVYTNHPLDQDLSR------IREVVFVQHGLQRNG-----DDYYAAGAALLKASGR------NPDEVLLVAPNFPGTPDHGK--GFDGMPQWSVQGWMSGEN------------------------AVNAPFT-VSSLQVLDDMMAFVTDKARLPRVARVTVAGHSGGAQIVHRYAVLNNVD-ERIRARGIDLRYVVANPSSYLYFTAVRPAGADGRSFAPYDKAVCPDYDKYRYGMQDIVPYAK---GANGQSLYQRYAGRQVTYLAGTEDNDPNHR-VL---------DKACGAEAEGPTRLQRARGYLRYE---RYLASPGLVIRHQ-AYEVVGVGHDQARMFGSQCGARAVFDMAETANPDGAACRAPQL--------------------------------------------------------------------     =====>
cuptr-b2ai31   	------------------------------------------------------------------------------------------------------------------------------------------------------------MSR-Q-TA----RLPQPAR-SRLAMTLAAAAIAALAG--CAGTHPMPPA----A---D----KAADAA----------PASPHWQRLHLG---------A-------------------GPGYDFPVYANHRLDGDLSR------IREVVFVQHGLQRNG-----DDYYAAGAELLKASGR------KPDEVLLLAPNFPGTPDQKK--GFTGMPHWSVQGWLSGED------------------------AVDGPAR-VSSLQVLDDLLAFVTNKARLPQVRKVTIAGHSGGAQIVHRYAALNHAD-ERIRAGGIDLRYVVANPSSYLYFTPVRPAGAEGKSFAPYDIARCPDYDKYRYGMQDMVPYAK---GADGMALYRRYAGRQVTYLAGTEDNDPNHR-VL---------DKSCGAEAEGPTRLQRARGYLRYE---RYLAGPGLVTRHQ-AYEVVGVGHDQARMFGSQCGAQAVFGMPEAANAGGAACRAPQL--------------------------------------------------------------------     =====>
gemat-c1abv8   	----------------------------------------------------------------------------------------------------------MST---RREFMRHG-ITLAGASVTGDAVWSRGLNHGATYACAPCG---CAMDG-K-VFDAPGKCP---------A---CGMVLIERQTAPLP-------------------------------------FEP--KTLAQG---------RGAF---------LTAGGAGHESHRITVAYYVPS--RFTP------QSPVLLILPGSARDA-----ADYREPWIARAE-----------SANVLVAALGYPEASYD--------FSAYQMGGVIGNLIMRNMPPSVNGESPTVINLRDEDISFTVNPHRESWLFPDFDRIFGLLVKVTGS-AATQYDMFGHSAGAQILHRLALFHATS--------KARRLLAANAGLYTLPSLDE---------------------PQLSGLAGTGI---------TSRELTTALSAQLHVLLGELDNDGERGGIH---------LHTPKLDQHGISRLERGRHFFAAGQQQ--ARRLNVPLHWH-LHEIPGVGHDHERMGAAA--AQILYGMP-----------------------------------------------------------------------------------     =====>
gluox-q5fn27   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPELKT------------AACLVGAILAVMAG--A-------------------------AET--QALPEG---------RSL-------------ETATLAGERFEVSVFRPAA---CQ------IRAILFVLAGKNRNS-----ATYRDDTIPLAR-----------HECSLVFAPDFPVARFSV--------QQYQRGGFPALQRTPPA--------------------ATYMKLLEQ-----------WARAVSGE-PRVPIILMGHSAGAQYLERVEAYAPGE--------EVMT-VIMNPATYVEPETET---------------------AVPYGFRNWPESG-------SRPDLKRYLSRNIAVILGAEDTETSSA--T---------EHIPAATEQGRNRLERGQWAYAQGREQ--AEKLNVPFGWT-ITLVPATGHVASKMLASA--ELQ-------DAVETAI----------------RSASSR----------------------------------------------------     =====>
marah-e4plh6   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVLSG--CASVQPGGAAYSE-ESESDLFQPETF--------------ESY--GSFVVS---------AGTD----------------AKPVDMRLWYSRPD--QITA------DTRVIMVMHGGRRDA-----DKYRDYWGAYAK-----------QYGVLIVAPEISEKDFPT-------GWGYQTGNWVTPDSDST------------------DETKGERVPVEQTSFAAFERAFDELKKHFNL-NAETYDIWGHGSGAQFVTRMIMLYPQA--------RIGTGIAANSGTYTFPDWTL---------------------PLRYGLKNTGI---------EPEDLKESYKHHLVIMLGTDDDDTSHR-LL---------SQLEIAKAQGAHRLEKGKNFYRVNKEQ--AEQLNTEYNWE-LQTVYGIGHSGRKMSEAG--AEYLLEGKTEEPLFTDDLQVNE--------SYRSDNDSREENELLKGSDDG--EESPF---------------------------------     =====>
marsh-a4av43   	-----------------------------------------------KGLGNISMREAGI--------DDKTKFENFFLVYHGGWITAMVLDVDIRTKTDNEKSLDDLMKWLYANFLRTENLYDTNDIINGI-IITTGL--DYTEFFNTYIYNSEAIPV-S-NYLDPGKAIWDYKWNEEGK---PNHKYFYKT--LGI-------------------------------------DRD--INIQTG---------SGSF---------FIEGGIDSEEKTVKVYYHRPE--NFTI------DSEILLVIPGAGRNG-----DSYRNAWIEESE-----------KYGLLILSPMYPENEYG--------FDDYHLGGLIKDSNLQECIERVENS--NKIKLDEDKLTFKMNLITDEWIFNDFDRIFDLAVEALKS-NQKSYDLFGHSAGGHILHRFALFQENS--------KAGKILASNASFYTLPKFND---------------------SYPFGLKDTPV---------DEVLLKNAFRKNLIVLLGELDNENETGGSF---------LSSPTANLQGLHRLERGKYFYEMAKAK--ALEMKTEFNWE-IKIIPNVGHNHRLMGAAA--GDYLYK-------------------------------------------------------------------------------------     =====>
penmq-b6qm40   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDPIQSLDNIDPRVASEL--L-YTGSS----PAWTCVSDPRFCYFLYIPR--NYYTLPATPQSLNLIVLIHGSGRNP-----YTLRREFSTFAE-----------THSCALLAPLFPVGLIDP--------QDTANYKYI--------------------------------TYKDVRYDQVLLSMIDEAAARFRRIDTSAFCLYGYSGGGQFVHRFAYLHPRR---------VRALACGAPGTQTFLNFSQ---------------------RFPDGVQDWEEV------FGAPLDIKAVMGIPSMFVAGDQDTDIFYA-IARGRIREDQKDDEVAMAKFKDGRYGATNRLCENWVQV--GV------RSCVMVSVEGVKHEERPMLESVKGFFEKFVST-----------------------------------------------------------------------------------     =====>
psepf-q3k6f3   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MH--KWL------LALLFIGG--TAQA---------------------AGVD----------AISP--GRLQLQ-------------------------------AGEMAVGIGP----APAK------IERVLIVIHGRLRNA-----ETYRKSGEVAAELAGQ-------TANTLVIAPQFLNESDVSLYSLPASVLRWQGNDWMGGGL------------------------STGPN--PLSSYAALDEIVGRLSDRKQFPDVKQIVIFGHSGGAQVVQRYALLAQEQ-PALKTEGIRLRYVVANPSSYAYFNEQRPV--------AFDHAKCPGFNRWKYGLMDPPIYSG---GQTPAQLEGRYVKREVIYLLGQQDTDPQHP-AL---------DKSCAAKAQGAYRLERGKLFFGYLLRR-----HPEGINQR-LIEVPGVGHNGDGMLTSPEGQKALFEQ------------------------------------------------------------------------------------     =====>
ralso-b5slf2   	------------------------------------------------------------------------------------------------------------------------------------------------------------MER-D-VL-------RGLR-RLALLAGCATAALVLGA--CAGPEPASPP----AAA-P----VQVPAA----------ASGPAWQRIHLG---------S-----------------S-GAGYDFPVYANHPLDGDLRG------IREVVFVQHGLQRNG-----NDYFAAGIALLQASGR------HPDEILLVAPNFPGEPDVGK--GFDRMPMWSVNGWLGGFS------------------------AVNARYTGLSSLQVLDDLIAFVTDPARLPNVRRVTVAGHSGGAQIVHRYAVLNNVD-ERIRARGVELRYVVANPSSYLYFTPERPR---GRGFAPYDASACPDYDHYKYGMVDMVPYAA---GMDGMMLFKRYAQRQVTYLVGGNDNDPNHR-VL---------DKACGAEAEGPTRLDRARNYLRYERYERYLAGARKPSRHQ-AYEVIGVGHDQARMFGSRCGAQAVFGMPAAANATGAACRPPQR--------------------------------------------------------------------     =====>
ralso-d8njk6   	------------------------------------------------------------------------------------------------------------------------------------------------------------MER-D-VL-------TGLR-RLA-LAGCAMAALGLGA--CAGPEPASPP----AAA-P----VQVPAA----------ASGPAWQRIHLG---------S-----------------SSSAGYDFPVYANHPLDGDLRG------IREVVFVQHGLQRNG-----NDYFTAGAALLQASGR------HPDEILLVAPNFPGEPDVGK--GFDRMPMWSVEGWLGGFN------------------------AVNVPYTGLSSLQVLDDLIAFVTDPARLPNVRRVTVAGHSGGAQIVHRYAVLNNVD-ERIRARGVELRYVVANPSSYLYFTPERPR---GRGFAPYDASACPDYDHYKYGMVDMVPYAA---GMDGMTLFKRYAQRQVTYLVGGNDNDPNHR-VL---------DKACGAEAEGPTRLDRARNYLRY---ERYLAGARKPSRHQ-AYEVIGVGHDQARMFGSRCGAQAVFGVPAAANATGAACRPPQF--------------------------------------------------------------------     =====>
robbh-a4ck49   	----------------------------------------------------------------------------------------------------------MSFSWL-----RTL------GLLFGILVIPHGI--NAQYICKPCN---AACDT-L-AFARPGSCH---------G---CGMQLIPGT--QEV-------------------------------------ADP--ITLEIG---------HGNF---------LVRDSRD-PSKRIRVFYYRPE--SYSV------DSDILIVIPGTGRNA-----DEYREAWVQMSE-----------AYQILVVSPSFNEMYYD--------FEDYHLGALVHSSNLTEAIRRIEGT--NRVELDESRYAYKVQPEEDQWIFSQFDQIFDKVKEATGS-VRETYDLFGHSAGGHILHRMALFYTGS--------KANRILASNASFYTLPTEEY---------------------NYPFGIGNIPF---------GEAGLAGSFENHLVVFLGGEDNADETGGTF---------MVSESANRQGKHRLERGRYFYKMARQV--AGENGMHFNWK-LVTIPGVGHNHSEMSAAA--GEYLYGVRD----------------------------------------------------------------------------------     =====>
shewm-b1klb6   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKFFI---SIIIVLFSS--CTF-------------------------------------AAN--ENINLG---------SGKF---------TIEGGKGHTEKKIDIYYHLPN--SYDE------NTKVLIVIPGAGRNG-----WSYRDSWVEASE-----------KHNVLILSPSYSEKLYPR-------FWNYNIARMLSDVKINKAKSA--------------IESYTVVSDSNEWIFSDFDRVFDYSVSKLSL-TAKKYDMFGHSAGGQILHRLALFDFKN--------KANRILASNSGWYTVPTFKE---------------------NFPYGLNKGVS---------TREKISSAFKSKLTLFLGELDNEHETRGHL---------VRNPQLDIQGTYRLSRGKHFFKKSKEL--ASNLNVKFNWN-IHVVQGVGHDYKNMGKAA--AIYLYSE------------------------------------------------------------------------------------     =====>
strbb-d7cds1   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTPRVKTTKAFY-RTGST----TVFASQYDQRFSYCLHIPS--VH-E--TTSTPLPLMVIQHGTGRTA-----AQYRDAMAEFSE-----------AHGCAVLAPLFPAGIGDP--------DDLHNFKFI--------------------------------KYRGIRYDEVLLAIVAEAGERFT-IDAERFLLQGFSGGGQFAHRFLYLHPDR---------LCGVSIGAPGRVTLIDPDR---------------------EWWLGTAGFEER------FGTPVRLEEIRKVPVHMVVGAEDTETWEI-N-NPGDS----NWMDGADAVGRTRVERITALRDNYTEL--GI------DVT-LDIVPGVAHQGMGVLDAVRQFATRVLPRVS---------------------------------------------------------------------------------     =====>
yere8-a1jj49   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKNILM---LLSTLLF---NCPAT-------------------------------------DA--AVLPTD---------SGSF---------NFT--VPQSTKKIEVFSYQPP--EANA------RTPIVFVLTGLNCDA-----DKYRDDWVESAP-----------I----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AV-------SQQQLAHYFALPVLIAVGGKDNNPHPP-LL---------RRSSQALAQGNSRLQRARAYFMAAEQQ--ARHNKRPFDWQ-FTILSDVGHSGSKMSAYA--AQQFGWFEQQGKFKVQ-DD------------------------------------------------------------------------     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....