Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....
9uroc-q676a9   	-------------MIFLSITVILFAAIGVEFERIISTLTYFVNAKEVFTDKEQFCYDDLGCFNNSFPWTT--FPTKLSSIPISPEKIAVEMLFYKNKSLSVFNEE-----------VFDPNLPTIIGIHGWSPLLKRTSRKYVPKHIIFIADIFNAIQEKMDGNFIIVNWKKGSST-LNYPQSCSNIRVIGRQIAISLDKIE---NLDIENVHIIGHSLGAHMAGYIGKELH--LGRITGLDPAGPAFTFPSMWYDEFPNELEKTHLWYSDAEFVDVIHSDAGTFG-GGHYG-LSKPIGHIDFYPSMGRDQPFCNIYRYHNRLIEII----QFNRLAFCDHRLSKVYFIDSIKRPNLYQ----------------FCN-ETICNTLGFSATKQ------SSRQTFYIPEN-NLPKFNKRN-------------------------------------------------------------------------------------------------------------------------------     =====>
angja-1plip    	-------------MMSVVWILGLF--------------------LLGTASGAEVCYENLGCFTDDVPWAG-TTERPIAKLPWSPEKIGTRFMLFTRQNPNNHQEI-TTKEDILLASNYNGTRKTRFITHGYVDKG----------DENWLIDMCKLMLQVEDINCICVDWKKGGR--TLYTQSASNIRVIGAQMAYMIQLFQKVYQQRPESVHIIGHSLGAHCAGEAGRRTPN-LGRITGLDPAEPYFQG----------CPSLVRLDPSDAKFVDVIHTDAKPMIPYLGMG-MAQAVGHLDFYPNGGEHMPGCDKNIISQT-VDIDGIWEGTRDFVACNHLRSYKYYSDSILNPEGFTGYPCSDGGVFESGRCFPCG-DGACPFMGHHADKFRRPNG-AEKMKFYLNTA-DAKPFGRYRYKVTVTIRADRALLLTGTMSVAIYGTQGNTRQYQIRKGLLKPGNTYEAYIDTETDAGEVTKMKFIW--DN-SVINPMFPKLGAEKIVLQRGKDRRIFSFCSSETVREE-----MLQTVPPC------     =====>
bovin-lipr2    	--------------MLPSWTIGLL--------------------LLATVRGKEICYEPFGCFSDEKPWTG-ILQRPLKLFPWSPEDIDAHFLLYTNENPNNYQRINITDLATVRASNFQLDRKTRFVIHGFIDDG----------DSGWPTDLCKKMFKVEKVNCICVDWEHGAW--TKYTQAVHNTRVVGAEIAFFIQGLSTELGYGPENVHLIGHSLGAQLAAEAGRRLGGQVGRITGLDPAQPCFEG----------TPEEVRLDPSDAMFVDVIHTDSASIIPFLSLG-IRQKVGHLDFYPNGGKEMPGCQKNILSTI-IDINGIWQGIQDFVACSHLRSYKYYSSSILNPDGFLGYPCASYEEFQEGGCFPCP-AGGCPKMGHYADQFQGKTS-AVGQTFFLNTG-SSGNFTSWRYRVSVTLAGTK--KVRGSIRIALYGSNGNSKQYQIFKGSLQPNASHTHDIDVDLNVGKVQKVKFLW--NN-NVINLFWPKLGASRVTVQGGEDRTEYNFCSNDTMREN-----ALQTLYPC------     =====>
camdr-Q9TS81   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEVCFER----------LGCFRDDAPWAGIFVDVIHTDAAPMIPNLGFG-MSQTRGS---------------------------------------------------------------------TANKCFPCP-SEGCPQ------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
canfa-1plip    	--------------MVSIWTIALF--------------------LLGAAKAKEVCYEQIGCFSDAEPWAG-TAIRPLKVLPWSPERIGTRFLLYTNKNPNNFQTLLPSDPSTIEASNFQTDKKTRFIIHGFIDKG----------EENWLLDMCKNMFKVEEVNCICVDWKKGSQ--TSYTQAANNVRVVGAQVAQMLSMLSANYSYSPSQVQLIGHSLGAHVAGEAGSRTPG-LGRITGLDPVEASFQG----------TPEEVRLDPTDADFVDVIHTDAAPLIPFLGFG-TSQQMGHLDFFPNGGEEMPGCKKNALSQI-VDLDGIWEGTRDFVACNHLRSYKYYSESILNPDGFASYPCASYRAFESNKCFPCP-DQGCPQMGHYADKFAVKTS-DETQKYFLNTG-DSSNFARWRYGVSITLS-GK--RATGQAKVALFGSKGNTHQFNIFKGILKPGSTHSNEFDAKLDVGTIEKVKFLW--NN-NVVNPTFPKVGAAKITVQKGEEKTVHSFCSESTVRED-----VLLTLTPC------     =====>
cavpo-1plip    	--------------MLLLWILSL---------------------FLETVAGGEVCFDRLGCFSDNKPWAG-TSERPRKGLPWDPSAINVRFLLYTNENPNNYQRI-TADSSVIRSSDFKTDRKTRFIIHGFIDKG----------EENWLADLCKALFQVESVNCICVDWRGGSR--TLYSQASQNIQVVGAEVAYLINFLQSQLDYPPSSVHIIGHSLGSHAAGEAGRRTNGAIGRITGLDPAEPYFQY----------TPEIVRLDPSDAQFVDVIHTDGNPIIPNLGFG-MSQTVGHLDFFPNGGLQMPGCQKNILSQI-VDIDGIWEGTRDFAACNHLRSYKYYIDSITNPKGFAGFSCDSYSSFSSNKCFPCA-TGECPQMGHYADKFPGKTK-ENFQNFYLNTG-DKSNFSRWRYRIAVTLS-GQ--KVTGHVLVSLFGDAGNTKQYEIYRGSLKPGNNHSNEIDSDVDVGDLQKVKFIW--YN-NVINITLPKVGASRITVTRSDG-RVFDFCSQDTVREE-----VLLTLQPC------     =====>
cavpo-2plrp    	---------------------------------------------------AEVCYSHLGCFSDEKPWAG-TSQRPIKSLPD-PKKINTRFLLYTNENQNSYQLITATDIATIKASNFNLNRKTRFIIHGFTDSG----------ENSWLSDMCKNMFQVEKVNCICVDWKGGSK--AQYSQASQNIRVVGAEVAYLVQVLSTSLNYAPENVHIIGHSLGAHTAGEAGKRLNGLVGRITGLDPAEPYFQD----------TPEEVRLDPSDAKFVDVIHTDISPILPSLGFG-MSQKVGHMDFFPNGGKDMPGCKTGI-------------------SCNHHRSIEYYHSSILNPEGFLGYPCASYDEFQESGCFPCP-AKGCPKMGHFADQYPGKTN-AVEQTFFLNTG-ASDNFTRWRYKVTVTLSGEK--DPSGNINVALLGKNGNSAQYQVFKGTLKPDASYTNSIDVELNVGTIQKVTFLW--KR-SGISVSKPKMGASRITVQSGKDGTKYNFCSSDIVQEN-----VEQTLSPC------     =====>
horse-1plip    	------------------WTLSL---------------------LLGAVVGNEVCYERLGCFSDDSPWAG-IVERPLKILPWSPEKVNTRFLLYTNENPDNFQEI-VADPSTIQSSNFNTGRKTRFIIHGFIDKG----------EESWLSTMCQNMFKVESVNCICVDWKSGSR--TAYSQASQNVRIVGAEVAYLVGVLQSSFDYSPSNVHIIGHSLGSHAAGEAGRRTNGAVGRITGLDPAEPCFQG----------TPELVRLDPSDAQFVDVIHTDIAPFIPNLGFG-MSQTAGHLDFFPNGGKEMPGCQKNVLSQI-VDIDGIWQGTRDFAACNHLRSYKYYTDSILNPDGFAGFSCASYSDFTANKCFPCS-SEGCPQMGHYADRFPGRTK-GVGQLFYLNTG-DASNFARWRYRVDVTLS-GK--KVTGHVLVSLFGNKGNSRQYEIFQGTLKPDNTYSNEFDSDVEVGDLEKVKFIW--YN-NVINLTLPKVGASKITVERNDG-SVFNFCSEETVRED-----VLLTLTAC------     =====>
horse-2plrp    	---------------------------------------------------KEVCYTPLGCFSDDKPWAG-TLQRPLKSLPWSPEEVNTRFLLYTNKNPDSYQLITARDVATIKSSNFQSSRKTHFVIHGFRDRG----------EDSWPSDMCKKILQVETTNCISVDWSSGAK--AEYTQAVQNIRIVGAETAYLIQQLLTELSYNPENVHIIGHSLGAHTAGEAGRRLEGRVGRVTGLDPAEPCFQD----------ASEEVRLDPSDAQFVDVIHTDASPMLPSLGFG-MSQKVGHMDFFPNGGKQMPGCKRSSFSTF-IDINGIWQGAQDYLACNHLKSFEYYSSSILNPDGFLAYPCDSYDKFQENGCFPCP-AGGCPKMGHYADQYKEKTS-AVEQTFFLNTG-ESGDYTSWRYRVSITLAGSG--KANGYLKVTLRGSNGNSKQYEIFKGSLQPDSSYTLDVDVNFIIGKIQEVKFVW--NK-TVLNLSKPQLGASRITVQSGADGTEYKFCGSGTVQDN-----VEQSLYPC------     =====>
human-1plip    	--------------MLPLWTLSL---------------------LLGAVAGKEVCYERLGCFSDDSPWSG-ITERPLHILPWSPKDVNTRFLLYTNENPNNFQEV-AADSSSISGSNFKTNRKTRFIIHGFIDKG----------EENWLANVCKNLFKVESVNCICVDWKGGSR--TGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQG----------TPELVRLDPSDAKFVDVIHTDGAPIVPNLGFG-MSQVVGHLDFFPNGGVEMPGCKKNILSQI-VDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCP-SGGCPQMGHYADRYPGKTN-DVGQKFYLDTG-DASNFARWRYKVSVTLS-GK--KVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIW--YN-NVINPTLPRVGASKIIVETNVG-KQFNFCSPETVREE-----VLLTLTPC------     =====>
human-1plrp    	--------------MLIFWTITLF--------------------LLGAAKGKEVCYEDLGCFSDTEPWGG-TAIRPLKILPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKG----------DESWVTDMCKKLFEVEEVNCICVDWKKGSQ--ATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPG-LSRITGLDPVEASFES----------TPEEVRLDPSDADFVDVIHTDAAPLIPFLGFG-TNQQMGHLDFFPNGGESMPGCKKNALSQI-VDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCP-DQGCPQMGHYADKFAGRTS-EEQQKFFLNTG-EASNFARWRYGVSITLS-GR--TATGQIKVALFGNKGNTHQYSIFRGILKPGSTHSYEFDAKLDVGTIEKVKFLW--NN-NVINPTLPKVGATKITVQKGEEKTVYNFCSEDTVRED-----TLLTLTPC------     =====>
human-2plrp    	--------------MLPPWTLGLL--------------------LLATVRGKEVCYGQLGCFSDEKPWAG-TLQRPVKLLPWSPEDIDTRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKA----------EDSWPSDMCKKMFEVEKVNCICVDWRHGSR--AMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQD----------EPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFG-MSQKVGHLDFFPNGGKEMPGCKKNVLSTI-TDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCP-AEGCPKMGHYADQFKGKTS-AVEQTFFLNTG-ESGNFTSWRYKVSVTLSGKE--KVNGYIRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKFLW--NK-RGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEEN-----VLQSLYPC------     =====>
human-lipr3    	--------------MLGIWIVAFL--------------------FFGTSRGKEVCYERLGCFKDGLPWTR-TFSTELVGLPWSPEKINTRFLLYTIHNPNAYQEISAVNSSTIQASYFGTDKITRINIAGWKTDG------------KWQRDMCNVLLQLEDINCINLDWINGSR--E-YIHAVNNLRVVGAEVAYFIDVLMKKFEYSPSKVHLIGHSLGAHLAGEAGSRIPG-LGRITGLDPAGPFFHN----------TPKEVRLDPSDANFVDVIHTNAARILFELGVG-TIDACGHLDFYPNGGKHMPGCEDLITPLLKFNFNAYKKEMASFFDCNHARSYQFYAESILNPDAFIAYPCRSYTSFKAGNCFFCS-KEGCPTMGHFADRFHFKNMKTNGSHYFLNTG-SLSPFARWRHKLSVKLSGSE--VTQGTVFLRVGGAVRKTGEFAIVSGKLEPGMTYTKLIDADVNVGNITSVQFIW--KK-HLFEDSQNKLGAEMVINTSGKYGYKSTFCSQDIMGPN-----ILQNLKPC------     =====>
human-q5jyh9   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAASST-----LMASWAIPVPPTMSFGSCFPCP-AEGCPKMGHYADQFKGKTS-AVEQIFFLNTG-ESGNFTSWRYKVSVTLSGKK--KVSGYIRIALYGSNGNSKQYEIFKGSLKPDASHMHDIDVDLNVGKIQKVKFLW--NN-HVINLFWPKLGASQITVQSGEDGTE-------------------------------     =====>
mouse-1plip    	--------------MLMLWTFAV---------------------LLGAVAGREVCFDKLGCFSDDAPWSG-TLDRPLKALPWSPAQINTRFLLYTNENPDNYQLI-TSDASNIRNSNFRTNRKTRIIIHGFIDKG----------EENWLSDMCKNMFRVESVNCICVDWKGGSR--TTYTQATQNVRVVGAEVALLVNVLQSDLGYSLNNVHLIGHSLGSHIAGEAGKRTFGAIGRITGLDPAEPYFQG----------TPEEVRLDPTDAQFVDAIHTDAGPIIPNLGFG-MSQTVGHLDFFPNGGIEMPGCQKNILSQI-VDIDGIWEGTRNFAACNHLRSYKFYTDSIVNPTGFAGFSCSSYSLFTANKCFPCG-SGGCPQMGHYADRYPGKTS-RLYQTFYLNTG-DKSNFARWRYQVTVTLS-GQ--KVTGHILVSLFGNGGNSKQYEVFKGSLQPGTSHVNEFDSDVDVGDLQKVKFIW--YN-NVINPTLPKVGASRITVERNDG-RVFNFCSQETVRED-----VLLTLSPC------     =====>
mouse-1plrp    	--------------MLILWTIPLF--------------------LLGAAQGKEVCYDNLGCFSDAEPWAG-TAIRPLKLLPWSPEKINTRFLLYTNENPTAFQTLQLSDPSTIEASNFQVARKTRFIIHGFIDKG----------EENWVVDMCKNMFQVEEVNCICVDWKRGSQ--TTYTQAANNVRVVGAQVAQMIDILVRNFNYSASKVHLIGHSLGAHVAGEAGSRTPG-LGRITGLDPVEANFEG----------TPEEVRLDPSDADFVDVIHTDAAPLIPFLGFG-TNQMVGHFDFFPNGGQYMPGCKKNALSQI-VDIDGIWSGTRDFVACNHLRSYKYYLESILNPDGFAAYPCASYRDFESNKCFPCP-DQGCPQMGHYADKFANNTS-VEPQKFFLNTG-EAKNFARWRYRVSLTFS-GR--TVTGQVKVSLFGSNGNTRQCDIFRGIIKPGATHSNEFDAKLDVGTIEKVKFLW--NN-HVVNPSFPKVGAAKITVQKGEERTEHNFCSEETVRED-----ILLTLLPCKTSDTM     =====>
mouse-cttli    	--------------MLLCWLVS-L--------------------LLATVGGKEVCYGHLGCFSNDKPWAG-MIQRPSKIFPWSPEDIDTRFLLYTNENPNNYQIISATDPATINASNFQLDRKTRFIIHGFIDKG----------EEGWLLDMCKKMFQVEKVNCICVDWKRGSR--TEYTQASYNTRVLGAEIAFLVQVLSTEMGYSPENVHLIPHSLGSHVAGEAGRRLEGHVGRITGLDPAEPCFQG----------LPEEVRLDPSDAMFVDVIHTDSAPIIPYLGFG-MSQKVGHLDFFPNGGKEIPGCQKNILSTI-VDINGIWEGTRNFAACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQHNDCFPSP-EQGCPKMGHYADQFEGKTA-TVEQTFFLNTA-DTGNFTRWRYKVSVTLSGPK--KLSGYILVALYGCNANSKQYEVFKGSLQPEARYIRDIDVDVNVGEIQKVKFLW--NN-KVINLFRPTMGASQITLQRAKDGKEFNFCTSNTVHED-----VLQSLYPC------     =====>
myoco-1plip    	----------------------L---------------------LLGAVAGSEVCYDRLGCFSDDSPWAG-IVERPLKVLPWSPSTINTRFLLYTNESPNNYQIV-TADSSTIRSSNFRTDRKTRFIIHGYIDKG----------EENWLANMCEALLQVESVNCICVDWKGGSR--ALYTQATQNIRVVGAEVAYFVDALQSQLGYSPSNVHIIGHSLGSHVAGEAGRRTNGNIGRITGLDPAEPCFQG----------TPELVRLDPSDAQFVDVIHTDGAPIIPNLGFG-MSQTVGHLDFFPNGGVEMPGCQKNIISQI-VDINGIWEGTRDFAACNHLRSYKYYIDSILNPTGFAGFSCSSYNTFSSNNCFPCA-SGGCPQMGHYADRFSGKTN-ELFQQFYLNTG-DASNFSRWRYQIAVTLS-GR--KVTGHVLVSLYGSGGTSKQYEIYKGSLQPGTSYVNQIDSDVDVGDIEKVKFIW--YN-NIINPTLPKVGASSIQVTRNDG-RVFNFCSQDTVRED-----ILLTLTPC------     =====>
myoco-2plrp    	-------------MMLFVWTTGLL--------------------LLATARGNEVCYSHLGCFSDEKPWAG-TLQRPVKSLPASPESINTRFLLYTNENPNNYQLITATDPATIKASNFNLHRKTRFVIHGFIDNG----------EKDWLTDICKRMFQVEKVNCICVDWQGGSL--AIYSQAVQNIRVVGAEVAYLVQVLSDQLGYKPGNVHMIGHSLGAHTAAEAGRRLKGLVGRITGLDPAEPCFQD----------TPEEVRLDPSDAMFVDVIHTDIAPIIPSFGFG-MSQKVGHMDFFPNGGKEMPGCEKNIISTI-VDVNGFLEGITSLAACNHMRSYQYYSSSILNPDGFLGYPCASYEEFQKDGCFPCP-AEGCPKMGHYADQFQGKAN-GVEKTYFLNTG-DSDNFPRWRYKVSVTLSGEK--ELSGDIKIALFGRNGNSKQYEIFKGSLKPDARYTHDIDVDLNVGEIQKVKFLW--HN-NGINLLQPKLGASQITVQSGEYGTKYNFCSSNTVQED-----VLQSLSPC------     =====>
myted-q3s2w4   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCVECMACGSDTPCPIMGINADKYENTNR-KPRGKFYLATG-KSDPYCGYMYGIAVHVSSDM-QPTEGILDLTFTGDGGQIANHTVYRAEYRAGHMYSELLVSPNHLSTLSTLTIEFLEKSEVWSWLWTGKIKIDKIEVTDGLTDEITNFCGNDVIISSGGRVVLTGSSSPC------     =====>
rabit-1plip    	--------------MLLLWALPL---------------------LLGAVAGLEVCYERLGCFGNRIPWSGGTLERPFSTLPSTPKIVNTRFLLYTNENPNNFQEI-SADASTIRGSNFRTDRKTRFIIHGFTDKG----------EENWLSNLCENLFQVETVNCICVDWKGGSR--TTYPQATQNIRIVGAEVAYLVGTLQSSLGYSPSNIHVIGHSLGAHAAGEVGRRTNGTIGRITGLDPAEPYFQG----------TPEIVRLDPSDAQFVDVIHTDAAPMVPNLGFG-MSQTVGHLDFFPNGGKEMPGCQKNVLSQI-VDINGVWEGTRDFVACNHLRSYKYYADSIVNPNGFAGFSCASYTAFSANKCFPCS--NGCPQMGHYADRFSRKTD-GVGQTFYLNTG-DSSNFARWRYQVAVTLS-GR--RVTGHVLVSLYGSKGNSKQYEIFTGLLKPGDTHLNEFDSDVDVGDVQKVKFVW--YN-NVINPTLPKVGASQITVEQNDG-RVFKFCSTDTVRED-----ILLTLTPC------     =====>
ratno-1plip    	--------------MLMLWTFAV---------------------LLGAVAGKEVCFDKLGCFSDDAPWSG-TIDRPLKALPWSPAQINTRFLLYTNENQDNYQKI-TSDASSIRNSNFKTNRKTRIIIHGFIDKG----------EENWLSDMCKNMFKVESVNCICVDWKGGSR--ATYTQATQNVRVVGAEVALLVNVLKSDLGHPPDNVHLIGHSLGSHVAGEAGKRTFGAIGRITGLDAAEPYFQG----------TPEEVRLDPTDAQFVDAIHTDAAPIIPNLGFG-MSQTVGHLDFFPNGGMEMPGCQKNILSQI-VDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPTGFSGFSCSSYNVFSANKCFPCG-SEGCPQMGHYADKYPGKTK-ELYQKFYLNTG-DKSNFARWRYQVTVTLS-GQ--KVTGHILVSLFGNGGNSKQYEVFKGSLHPGDTHVKEFDSDMDVGDLQKVKFIW--YN-NVINPTLPKVGASRISVERNDG-RVFNFCSQDTVRED-----VLLTLSAC------     =====>
ratno-3plip    	--------------MLTLWTVSLF--------------------LLGAAQGKEVCYDNLGCFSDAEPWAG-TAIRPLKLLPWSPEKINTRFLLYTNENPTAFQTLQLSDPLTIGASNFQVARKTRFIIHGFIDKG----------EENWVVDMCKNMFQVEEVNCICVDWKKGSQ--TTYTQAANNVRVVGAQVAQMIDILVKNYSYSPSKVHLIGHSLGAHVAGEAGSRTPG-LGRITGLDPVEANFEG----------TPEEVRLDPSDADFVDVIHTDAAPLIPFLGFG-TNQMSGHLDFFPNGGQSMPGCKKNALSQI-VDIDGIWSGTRDFVACNHLRSYKYYLESILNPDGFAAYPCASYKDFESNKCFPCP-DQGCPQMGHYADKFAGKSG-DEPQKFFLNTG-EAKNFARWRYRVSLILS-GR--MVTGQVKVALFGSKGNTRQYDIFRGIIKPGATHSSEFDAKLDVGTIEKVKFLW--NN-QVINPSFPKVGAAKITVQKGEERTEYNFCSEETVRED-----TLLTLLPCETSDTV     =====>
ratno-4plip    	MPRGVSGNLFPSVQMLLCWIVS-L--------------------LLATVGGKEVCYGHLGCFSNDKPWAG-MLQRPLKIFPWSPEDIDTRFLLYTNENPNNYQKISATEPDTIKFSNFQLDRKTRFIVHGFIDKG----------EDGWLLDMCKKMFQVEKVNCICVDWRRGSR--TEYTQASYNTRVVGAEIAFLVQVLSTEMGYSPENVHLIGHSLGAHVVGEAGRRLEGHVGRITGLDPAEPCFQG----------LPEEVRLDPSDAMFVDVIHTDSAPIIPYLGFG-MSQKVGHLDFFPNGGKEMPGCQKNILSTI-VDINGIWEGTQNFVACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQQNDCFPCP-EEGCPKMGHYADQFEGKTA-TVEQTVYLNTG-DSGNFTRWRYKVSVTLSGAK--KLSGYILVALYGNNGNSKQYEIFKGSLKPEARHVRDIDVDINVGEIQKVKFLW--NN-KVINLFRPTLGASQITVQSGVDGKEYNFCSSDTVRED-----VLQSLYPC------     =====>
sheep-1plip    	---------------------------------------------------TEVCYDRLGCFSDDSPWAG-TIERPLXVLPWSPDKEVTRFWLYTN--------------------------------------------------------------------------------------------------------------------------------------------QITGLDPAEPYFQG----------TPELVRLDPSDAQFVDVIHTDAAPMIPNLGFGTMSQVVGHLDFFPNGGKEMPGCQKNALSQI-VDIDGIWEGTRGYA-----------------------------------------------------DNFPGKTK-S------------------------------------------------------------------------------------------ENVINPTLPKVGASKITVE-----------------EE-----VLLTLNPC------     =====>
spetr-1plip    	--------------MLLVWSLAL---------------------LLGAVAGKEVCYDRLGCFSDDSPWSG-IVERPLKVLPWSPADVNTRFFLYTNENQDNYQQI-TADSSRIQSSNFKTNRKTRFIIHGFIDKG----------EESWLANMCKKMFQVESVNCICVDWKGGSR--TGYTQASQNIRIVGAEVAYFVDFLRTQLGYSPSNVHVIGHSLGSHAAGEAGRRTNGAIGRITGLDPAEPCFEG----------TPELVRLDPSDAQFVDAIHTDGAPIVPNLGFG-MSQTVGHLDFFPNGGIEMPGCQKNILSQI-VDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPTGFAAFSCASYSVFSANKCFPCP-SGGCPQMGHYADRYSGKTN-GVGQKFYLNTG-DKNNFSRLRYKVSVTLS-GQ--KVTGHILVSLFGNAGNSQQYEIYKGSLHPGYTHSNEFDSDVDVGDLQRVKFIW--YN-NVINPSLPRMGASSISVERNDG-RVFKFCSAETVRED-----VLLTLNAC------     =====>
sussc-1plip    	---------------------------------------------------SEVCFPRLGCFSDDAPWAG-IVQRPLKILPP-DKDVDTRFLLYTNQNQNNYQEL-VADPSTITNSNFRMDRKTRFIIHGFIDKG----------EEDWLSNICKNLFKVESVNCICVDWKGGSR--TGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQG----------TPELVRLDPSDAKFVDVIHTDAAPIIPNLGFG-MSQTVGHLDFFPNGGKQMPGCQKNILSQI-VDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCP-SEGCPQMGHYADRFPGKTN-GVSQVFYLNTG-DASNFARWRYKVSVTLS-GK--KVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIW--YNNNVINPTLPRVGASKITVERNDG-KVYDFCSQETVREE-----VLLTLNPC------     =====>
xenla-Q7ZYK0   	--------------MLEILGLIML--------------------ISKCVQGGNVCYDRLGCFSDEAPWGG-TLQRPIARLPDSPEHINTRFLLFTRDNPDTFQEIKALNPSAISTSNFKASRKTRFIIHGFIERG----------TDKWLTHMCANLLQVEDVNCLCVDWAGGSY--ALFSQAANNVRVVGAEVAHFIQLLSNKYGCSPSDVHVIGHSLGSHAAGAVGKRIHG-IARITGLDPAGPFFHN----------TPPEVRLDKSDAELVDVIHTDVSQIFPITGFG-IGQSIGHLDFYPNGGKDMPGCERGSVFTL-MDVDRTFKAIFGAMNY--IR--KVF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
xenla-q4klb6   	-------------MISGLWLVAL---------------------LLGAAKGGEVCYSRIGCFPDSVPWSG-TVERPINHLPQSPEKINTRFLLFTQQNSNSFQEISAINPSTISSSNFRTNRKTRFIIHGFIDKG----------EESWLTDMCKTMLQVEDVNCFCVDWMGGSR--TLYTQASNNIRVVGAEVAYFIDILSSTYGYSPANVHVIGHSLGAQAAGEAGKRRKG-IGRITGLDPAEPYFQG----------TPTEVRLDPSDANFVDVIHTDAAPMIPNLGLG-MSQLAGHLDFFPNGGEEMPGCKKNALSQI-VDIDGIWQGTRDFVACNHLRSYKYYSNSILKRDGFVGYPSSTYNTFKTGSVFPCP-SGGCPLMGHYADTYKGPIT--GGQKFFLNTG-DEKDFARWRYRVTVQITSSS--DVQGYFHVSLYGVNGNTRQYEIYKGTLKSGSSYTGFIDVESDVGILDKVKFVW--NN-NVINILLPTVGAQSISVQYGKDGRTYRFCGSGSVREE-----VLQTLNAC------     =====>
xenla-q642r3   	--------------MSGCWGLIFF--------------------LLGYVQAGKVCYDKIGCFTDDKPWSG-TLERLIGRLPESPEHINTHLLMFTRENPDMFQELHSLNPSALPLTNFKTNRKSRFIIHGFLEQG----------EENWLVNMCKTMLKVEDVNCFCVDWSGGSR--TLYSQAANNIRVVGAELAYFISFLSNNMNYSLSKVHVIGHSLGSHTAGEVGKRVPG-IGRITGLDPAGPFFQD----------TPPEVRLDPTDALFVDVIHTDTSPLIPKMGYG-MRQSVGHMDFFPNGGESMRGCNKPIVAKL-LDIDGLWEGSRDIFACNHLRSYKYYTESITSPNGFIGYPSTSYGEFTKGNGFPCP-SSGCPLMGHYADLFSGHGI--NEHSYFLNTG-SEKPYSRWRYRVTVKTTGRL--NFFGSIQVSLHGVKGSTTGQEIARRLIKPGQTYTAFIDVEADVGPLTTVSFSW--NK-SLIDIIPSKVGAEMISVQYGKDGQTYKFCGKDTVRAK-----SLQSLTSCSSATK-     =====>
xenla-q66kx1   	--------------MSLLWAVALC--------------------FLTVAQGAQVCYDRIGCFADTSPYSG-TVQRPITKLPWTPEKINTRFLLYTRSNQNSFQTISAITPSTISSSNFRTSRKTRFVIHGFTDSG----------TSSWLTDICKKLFVIEDVNCIAVDWSGGSR--TLYSQASNNVRVVGAEVAYFVKILQSNFAYSPANVHLIGHSLGAHAAGEAGKRQRG-IARISGLDPAEPYFQN----------TPAEVRLDTSDAALVDVIHTDAGPLVPSLGFG-MSQVIGHLDFFPNGGVHMPGCPKNIEIPN-VNVEDIWNGVVNFVTCNHMRAIKYYTDSIGNSGTFVSYPCANWDTYQAARCKTCP-SAGCPKMGHYADTYRGVTS--SSQVFYLTTP-----------------------------------------------------------------------------------------------------------------------------------------     =====>
xenla-q6pad5   	----MLSADIPLCQ-LLILIILHG--------------------IFGTVKGKEICYEPFGCFSDKQPWSR-TKERPFAALPWTPESINTRFFLNTRRNPNQHQIISAQNITSIEASAFQTNQTTCFIVHGMGERA----------ENNWVSQMCKAILQVEDVNCIGVDWRNGSGNIQMYVQAANNIRVVGAEIALLLQVLQKELGYPASKVHVIGHSLGAHAAGEAGRRHEG-IWRITGLDPARQFFED----------TPPEVRLDPSDATFVDVIHTDISS---PLGAG-IAKPIGHLDFYPNGGKQMTGCPAK------LSFLGNFNALFDTMTCSHFRAFQYYTESLRSPGGFLGYPCESYDSFLSGSCFPCP-EGRCSLMGHFSRLPSALTA--TPQTFYLNTGGNISHFSNWRYKVSVTLGGTK--TFKGKFYVILSATGGDPQQYEVVSKSLIPGNNFSGFIDVGFELGPLDDVTCKW--EP-AFLNIFHDQFGAQRLEIQSGKDGKVSTFCGKGTVSEN-----VLQKLIPC------     =====>
xenla-q7sz70   	--------------MGLIWTLILC--------------------FLATVQGAQVCYDRLGCFSDTYPYAG-TLQRPIAKLPWSPETINVQFMLYTRTNQNSYQIISATNPSSISSSNFSTSRKTRFIIHGFITSG----------TNSWITNMCKTLFLVEDVNCIAVDWSGGSH--TLYSQASNNVRVVGAEVAYFVKTLQNDFAYSPANVHLIGHSLGAHAAGEAGKRQRG-IARISGLDPAEPCFQN----------TPPEVRLDTSDAALVDVIHTDAGPFIPDLGFG-MSQVIGHLDFFPNGGVHMPGCPQNMEVPD-ATVEDVWSGVINFLTCNHESAVKYYTDSITSCNAFVSYPCANWETYETARCISCP-SAGCPRMGHYADTYDGVTS--SSQVFYLSTA-----------------------------------------------------------------------------------------------------------------------------------------     =====>
xentr-q5eb42   	--------------MLEILGLILL--------------------TSGFVQGGQVCYERIGCFPDEAPWGG-TVQRPIARLPDSPEHINTRFLLFTKENPDTFQEIRALTPGAISTSNFKASRKTRFIIHGFIEHG----------YDRWLTHMCATLLKVEDVNCFCVDWTGGAY--ALYSQAANNVRVVGAEVAHFIQFLSNQYGYSAANVHVIGHSLGSHAAGETGKRTPG-IARITGLDPAGPFFQN----------TPPEVRLDQSDAQLVDVIHTDASAIFPLTGFG-IGQSVGHLDFYPNGGKNMPGCKKSPTLKY-LDNYRIFKGSKEIIFCSHIRSYKFYTESILTPDAFVAFPSSDYKTFKKGTGFPCP-SGGCPLMGHYAEEFLGPTS--GNLSFFLNTG-NSEPFARWRYRVTVRTTGT---GFLGSIQVSLHGIRGNSKQQEIASGFIKPGGTYSAFIDTESDVGPLTTASFTW--KK-SLIDLIPGTVGADTVTVQYGKDGQTYHFCSTETVKPK-----TIQNLTPCYIPDE-     =====>
xentr-q6p2z1   	--------------MLGLWGLFFF--------------------LLGCVQGEPVCYDKIGCFSDEKPWSG-TLERPIARLPSSPEHINTRLLLFTRENAENFQELRPLNPSAVSLTNFKTSRKSRFIIHGFIDEG----------EENWLVNMCKAMLKVEDVNCFCTDWSGGSR--TIYTQAANNIRVVGAELAYFIGYLSSKMKYPLSNVHIIGHSLGSHTAGEVGKRMPG-IGRITGLDPAGPYFQN----------TPIEVRLDPTDAVFVDAIHTDTDPLIPKMGYG-MSQSVAHMDFFPNGGENMPGCSKPILAKL-LDIDGLWEGSKDIFACNHLRSYKYYTESISSPDGFVGYPSTSYEAFTKGTGFPCP-TTGCPLMGHYADAFSSHGT--SDYSYFLNTG-SEKPYSRWRYRVTVKTTGSV--NFLGSVQVLLNGIKGSTKGEEIASGFIKPGSTYSAFIDVEADVGPLITVSFTW--KK-SLINLIPFTVGAEMITVQYGKDGQTYEFCGKDAVRPN-----NLQSLTSCYSATK-     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....