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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....790..5....800..5....810..5....820..5....830..5....840..5....850..5....860..5....870..5....880..5....890..5....
anoga-q7q837   	SDIRAADWHLGEVKGRKESARKNTLQDKMPQSDGGYVSLGG--GGPNSIYNSTTEPQSGSKSVMETVKRVIGTAIGAQDK--HALLERDG--TGAQPYIVSARDRDKTGKSANARMPSAPAHTAEEARLLG--------------------AMPVDPMDDIE----LRSVQLQYPNQRGSIVGACDLRRVPTD-KGDILVA--VQGDTT----KPAIVTYHDLGLNY------------------------------------------ASSFAGFFNFPTMR-SLLDNFCVYHVNAPGQEDG-------------------APTFPE---------------------------------------------DYVYPTFDELASQMLFVMTHFNLKSIIGFGVGAGANILARFAL--------------------------ANPDKVGALCLINCSSTAAGWIEWGYQLLNTRNLRTKG------------------------------------------------------------------------------------------MTQGVLDYLMWHHFGRNPEERNL----DLVQLYKSNFERSINPVNLAMLIDAYIKRTDLNIARTPSGSPQ----T--SAPSLKMP-VLNITGALSPHIDDT---------------VTFNGRL---------IPEKTNWMK------------------------ISD-CGLVLEEQPGKLAEAFRLFLQGEGY---------------VSKKLPSPTKA-----QAPAGV-------------------------------------------------------------------------------     =====>
anoga-q7qbc4   	----------------------------------------------------------------------------------------------------------------------------------M--------------------SPP------TG----QPRR--------TSESKDAQRYAVNTEKSGEIIVT--VQGDLSQQEKRAVFLTVHDLGTNH-------------------------------------------SSFEEFVNSACMI-EIKERSCFIHIDVPGHADN-------------------APNLAD---------------------------------------------SFQFPSLQLLGEELVTVLDFLHVKYVIGVGEGAGANVLARFGL--------------------------AHPSRCLGLILINVTGSAASVLDVFKTKFISWKGDEVGQSAEDFLLYHKFGYFPSLQLLGEELVTVLDFLHVKYVIGVGEGAGANVLARFGLAHPSRCLGLILINVTGSAASVLDVFKTKFISWKGDEVGQSAEDFLLYHKFGYQLVGDNP-DKEKIVSEFQSRLHSSLNSKNLKQYVKAFMSRKDLPL------------------KNCKVD-CLLITGIMSPYASVV---------------EKLYKDL---------NKEKVTLLK------------------------VER-AGDVLADAPAKVAQSILLFCKGQGL---------------LTSVAMPGVDRNR-------AFSTSSSGSTEGSTGARRLSRGMSMEDYD--KPNIRRLSVTINEQL-----------------------PPIKK-------     =====>
arath-AT2G19620	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MVGLNNAVSLDIEEICNGGKEHHVKTC-HGSVSVV--VYGDQE----KPALITYPDVALNY------------------------------------------MSCFQGLFLCPEAVSLLLHNFCIYHISPPGHEFG-------------------AAPVCS---------------------------------------------NDPSPSVEDLADQILEVLNFFSLEAVMCMGITAGAYILSLFAI--------------------------KHKERVLGLILISPLCKAPSWSEWFYYKVVSNLLYYYG------------------------------------------------------------------------------------------MSGLLKDIFLQRYFSKEARGSSEVPERDVVHECRRLLG-ERHGSSLMRFLEAVNRRHDLTDGL----------------KSLKCR-TLIFVGDQSPFHSET---------------LHMVTAL---------DRKYSALVE------------------------VQACGSMVTEEQPHAMLIPMEFFFMGFGL---------------YRPGRVSDSPRSP---LSPSC-------------ISPELLSPESLGLKL--KPIKTRVPTKC---------------------------------------     =====>
arath-T22P22.18	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MADSSDSVSIDMEALSLGGQEHLVETT-YGPVCVA--VCGDPD----KPALITYPDIALNY------------------------------------------MFCFQGLLFCPEASSLLLHNFCIYHISPLGHEVGNWTLIVYKLLYVSESLQLGAPMISV---------------------------------------------DAPLLSADDLADQIVEVLNYFGLGAVMCMGVTAGAYILTLFAM--------------------------KYRQRVLGLILVSPLCQAPSWSEWLCNKVMSNLLYYYG------------------------------------------------------------------------------------------TCGVVKEMLLKRYFSKEVRGNGHVPESDIVQECRRLLS-ERQSTNVWRFLEAINGRVDLSEGL----------------RKLQCR-TLIFIGENSAYHSEA---------------VHMTTKL---------DRRYGALVE--------------------------GSGSLVSEEQPQAMIIPMEYFLMGYGL---------------YRPTQ-SVSPRSP---LSPTR-------------ISPELLSPENMGLKL--KPIKTRLAL-----------------------------------------     =====>
arath-at5g56750	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDSYGAVSVDVGTIYLGGKEHRVKTA-SGVVSVI--VYGDRE----KPALITYPDLALNH------------------------------------------MSCFQGLFFCPEAASLLLHNFCIYHISPPGHELG-------------------AAPICP---------------------------------------------NDSVPSAENLADQILEVLNFFGLGVVMCMGVTAGAYILTLFAM--------------------------KHRERVLGLILVSPLCKAPSWSEWFYNKVITNLLYYYG------------------------------------------------------------------------------------------MCGVVKEFLLQRYFSKEVRGNVEIPESDIAQACRRLLD-ERQGINVLRFLDAIDRRPDISSGL----------------KKLKCR-TLIFIGDQSPFYSEA---------------VHMAATL---------DRGYCALVE------------------------VQACGSMVTEEQPHAMLIPMEYFLMGYGL---------------YRPSLFSESPRSP---LSPSC-------------ISPELLSPESMGLKL--KPIKTRISAA----------------------------------------     =====>
bovin-ndr1     	------------------------------------------------------------------------------------------MSRELQ-------D-----VDLAEVKPLV-----------------------------------------------EKG----ETITGLLQEFDVQEQDIETL-HGSIHVT--LCGTPK--GNRPVILTYHDIGMNH------------------------------------------KTCYNPLFNSEDMQ-EITQHFAVCHVDAPGQQDG-------------------AASFPT---------------------------------------------GYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFAL--------------------------NNPEMVEGLVLINVNPCAEGWMDWAASKISGWT-------------------------------------------------------------------------------------------------QALPDMVVSHLFGKEEMQNNV----EVVHAYRHHVMNDMNPGNLQLFINAYNGRRDLEIERPMPGAHT---------VTLQCP-ALLVVGDSSPAVDAV---------------VECNSKL---------DPTKTTLLK------------------------MADCGGLPQISQPAKLAEAFKYFVQGMGY---------------MPSASMTRLMRSRTASGS-------SVTSLEGAR-SRSHTSEGT----------RSRSHTSEGTRLDIIPNS-GGPGSSAGPNSTEVSC------------     =====>
bovin-ndrg2    	-------------------------------------------------------------------------------------------MAELR-------E-----VQITEEKPLLPGQTPEVAK----------------------------------------------------------THSVETP-YGSVTFT--VYGTPK--PKRPAILTYHDVGLNY------------------------------------------KSCFQPLFQFADMQ-EIIQNFVRVHVDAPGMEEG-------------------APVFPL---------------------------------------------GYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYAL--------------------------THPDTVEGLVLINIDPNAKGWMDWAAHKLTGLT-------------------------------------------------------------------------------------------------SSISEMILGHLFSQEELSGNS----ELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGD-------------TTLKCP-VMLVVGDQAPHEDAV---------------VECNSKL---------DPTQTSFLK------------------------MADSGGQPQLTQPGKLTEAFKYFLQGMGY---------------MASSCMTRLSRSRTASLT-------SAASIDGNR-SRSRTLSQSSESGT--------------------------LSSGPPGHTMEVSC------------     =====>
bovin-ndrg3    	-------------------------------------------------------------------------------------------MDELQ-------D-----VQLTEIKPLLNDKNGTRNF----QDFDCQ------------------------------------------------EHDIETA-HGMVHVT--IRGLPK--GNRPVILTYHDIGLNH------------------------------------------KSCFNAFFNFEDMQ-EITQHFAVCHVDAPGQQEG-------------------APSFPT---------------------------------------------GYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFAL--------------------------NHPELVEGLVLINVDPCAKGWIDWAASKLSGLT-------------------------------------------------------------------------------------------------TNVVDIILSHHFGQEELQANL----DLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKS------KTLKCS-TLLVVGDSSPAVEAV---------------VECNSRL---------NPVNTTLLK------------------------MADCGGLPQVVQPGKLTEAFKYFLQGMGY---------------IPSASMTRLARSRTHSTSS------SIGSGESAF-SRSVASNQSDGTQE-SS---------------------ESPDVLDRHQTMEVSC------------     =====>
caebr-q5wng1   	-------------------------------------------------------------------------------------------------------------------------------------------------------------MASIE----MHSFTRDMQPLMEEAANNFAEEKVNTA-FGQVKVS--IYGDRKD-PKKVPMITFHDLGLDS------------------------------------------ESNFQNFFQFVSIA-EFADKFCIYNINAPGQEMD-------------------AQPLPE---------------------------------------------NYQYPTMDGVAKTIENVADHFKINQFIGFGVGVGANVLLRYAA--------------------------QNQNRVIALILVNCCSGKSGWVEWGYEKWNASYLRKVG------------------------------------------------------------------------------------------MTKFTVDYLMWHHFGRNYDRCSP----DIVRQYRVFFQHLPNPNSLAAFIESYIQRSPLPISRDG-----------TTGVQLKVP-VLQLVGAGSAHVEDT---------------VEVNTKL---------DPAHADWIK------------------------ISDSCGLVLDDRPDAVTESMMLFLQGLGY---------------FPTLNVMKMTKKMQETQNGGGFSAITSQSNEC---------------------------------------------------------------------     =====>
caebr-q613g6   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSDDNLQMVVVQAANCGVLHVY--VQGNLEERGGKTIILTVHDIGTNH-------------------------------------------KSFVRFVNHPSMA-AVKEKAIFLHVCVPGQEDN-------------------SADYFG-----------------------------------------------DFPTLDGIGDDLNAVLDKFEVKSAIAFGEGVGANIICRFAM--------------------------GHPNRIMGIILVHCTSTTAGIIEYCKEKVMNMRLENSI------------------------------------------------------------------------------------------MSDGAWDYLLAHKFGG---------ESKSRAEYLEELKQTLNAKNLSKYLVAFTKRTDLSSTIGT--------------KLETVD-ALLVTGSKASHLHTV---------------YTTHKSM---------NKKKTTLLV------------------------VDN-VADVMQEAPDKLARSLILLCKGCGV---------------LSGVAIPGMERQR-------TLSSSMEE----ADRPRRM-------------------SVT-QPHL-----------------------PPVPSA------     =====>
caeel-Y48G10A.3	-------------------------------------------------------------------------------------------------------------------------------------------------------------MASIE----MHSFTRDMQPLMEESANNFTEEKVNTA-FGAIKVS--IYGDRND-PKKVPMVTFHDLGLDS------------------------------------------ESNFQNFFQFVSIA-EFADKFCIYNVNAPGQEMD-------------------AQPLPE---------------------------------------------NFTYPTMDGIAKTIESVADHFKLNQFIGFGVGVGANVLLRYAA--------------------------QNQNRVIALVLVNCCSGKSGWVEWGYEKWNTSYLRKVG------------------------------------------------------------------------------------------MTKFTVDYLMWHHFGRNYDRCSP----DIVRQYRVFFQHLPNPNSLAEFIESYIQRTPLPISRDG-----------TTGVQLKVP-VLQLVGAGSAHVEDT---------------VEVNTKL---------DPAHADWIK------------------------ISDSCGLVLDDRPDAVTESMMLFLQGLGY---------------FPTLNVMKMTKKMQETQNG-GFAAVASSANEC---------------------------------------------------------------------     =====>
caeel-ydj1     	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEDNLQMVVVQAQNCGVLHVY--VQGNLEERGGKTIILTVHDIGTNH-------------------------------------------KSFVRFVNHPSMA-TVKEKAIFLHVCVPGQEDN-------------------SADFFG-----------------------------------------------DFPTLDGIGDDLSAVLDKFEVKSAIAFGEGVGANIICRFAM--------------------------GHPNRIMGIVLVHCTSTTAGIIEYCKEKVMNMRLENSI------------------------------------------------------------------------------------------MSDGAWDYLLAHKFGG---------ESKSRQEYLEELKATLNPKNLSKYLVAFTKRTDLSSTIGT--------------KLETVD-ALLVTGSKASHLHTV---------------YTTHKSM---------NKKKTTLLV------------------------VDN-VADVMQEAPDKLARSLILLCKGCGV---------------LSGVAIPGMERQR-------TLSSSMEE----ADRPRRM-------------------SVT-QPHL-----------------------PPVPSA------     =====>
danre-ndr3     	------------------------------------------------------------------------------------------MMDELQ-------D-----VQLTEIKPLLTDKNG-QNF----QDFDCQ------------------------------------------------EHDIETP-RGVLHVT--LRGTPK--GNRPVILTYHDIGLNH------------------------------------------KSCFNTLFNFEDMQ-EITQHFAVVHVDAPGQQES-------------------APPFPT---------------------------------------------GFLYPTMDELAEMLPSVLTHLKINSVIGIGVGAGAYILTRFAL--------------------------NEPALVEGLVLINVDPCAKGWIDWAASKLSGWT-------------------------------------------------------------------------------------------------SNLIDIVMAHHFSTDELTENQ----EIIQTYRLHIAQDINQDNLALFCQSYNSRRDLEIERPVLGMNENAV------KTLKCP-ALLIVGDTSPAVEAG---------------VECNSRL---------NPTKTTLLK------------------------MADCGGLPQVVQPGKLAEAFKYFVQGMGY---------------MPTASMTRLARSRTHSAS-------SMGSGDGSR-SRTQTSSQMEGATG-GP---------------------ALDNQ---NRTMEVSC------------     =====>
danre-ndrg2    	------------------------------------------------------------------------------------------MTTEMQ-------E-----IAITEEKPLLPGQSD-AVK--------------------------------------DAE------IAARILLDQGQEHTVETP-HGVLHVT--VHGSGN--ARRPAILTIHDVGMDS------------------------------------------KSCFSTLFRFEEMQ-EIVKNFTVVHIDAPGQEEG-------------------AAVYPA---------------------------------------------GYQYASMDQVSEMLPAVLQFFNFRTIIGVGVGAGAYILSRFTL--------------------------NNPEAVEGLVLVNVDPNARGWMDWAAHKLSNLT-------------------------------------------------------------------------------------------------SSLSDQIISHLFSQQELSANT----ELIQTHRERITKAPNLLNIELFWKSYLGRRDLSLDRNN---------------TFKCP-VMLVVGDQAPYEEAA---------------VECNSKL---------DPTTTSFLK------------------------MADAGGMPQLTQPSKLTEAFKYFIQGMGY---------------MASSCMTRLSRSRTTSLS-------SSYSMEGSR-SRSRTLSQGSQGGQ--------------------------LPPS-PSNTMEVSC------------     =====>
danre-q1mti5   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPECWDGEHDIETP-YGMLHVV--IRGAPK--GNKPAILTYHDVGLNH------------------------------------------KLCFNSFFQNEDML-EITKHFVVCHVDAPGQHIG-------------------APQMPQ---------------------------------------------GYQYPTMDQLAGMLPSVVQHFGFKSIVGIGVGAGAYILAKFAL--------------------------IFPDLVEGLVLLNIDPNGKGWIDWAATKLSGLT-------------------------------------------------------------------------------------------------STLPDTVLTHLFSQEELMSNT----EVVQNYRQQINNTINQFNLQLFWNMYNSRRDLEMNRSGSVI---NA------KTLRCP-VMLVVGDNAPAEEGV---------------VECNSKL---------DPTNTTFLK------------------------MADSGGMPQITQPGKLTEAFKYFLQGMGYIAYMKDRRMS--GGPVPSASMTRLARSRTASLT-------SAGSVDGSR-NRACTHSDS------------------------------SEGVGQVSHTMEVSC------------     =====>
danre-q6a3p5   	----------------------------------------------------------------------------------------------MD-------D-----IQV-ESKPLI-------------------------------------V--------DKDL----QGLREAVQKLELKEHDVETP-YGKIHCT--MKGVPK--ADRPVILTFHDIGLNH------------------------------------------KSCFDTLFSHEDMQ-EIMQHFAVCHVDAPGQQEG-------------------ANTFST---------------------------------------------GYEYPSMDQLSETLPSILKHFGLKSVIGMAIGAGAYILSKFAL--------------------------DYPAMVEGLVLININPCAEGWMDWAAHKISGWT-------------------------------------------------------------------------------------------------HAMPDMIISHLFGKEEIQQNH----DLIGRYRHHIVNEMNQYNLQLFVKSYTSRRDLEIERPVAGSHI-NA------RTLKCP-ALLVVGDSSPAVDAV---------------VECNTKL---------DPTKTTLLK------------------------MADCGGLPQVDQPGKLTEAFKYFIQGMGY---------------MPSASMTRLVRSRTASGS-------SITSFDGNR-SRSHTNEGNRSRSHTNEG-RARAHTSENQRGRSHTDNMD-SSVDQTPKSTEVSC------------     =====>
danre-q6pc94   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MVL----EDSESSVFELDITEDDVETS-FGRVHCT--MKGVPK--GNRPTILTFHDIGLNH------------------------------------------KSCFESMFHHKDMH-EILQHFAVCHVDAPGQQEG-------------------ASTLST---------------------------------------------DYTYPSMDQLSESLPMVLNHFGLKSVIGMGVGAGANILARFAL--------------------------KHPDMVESLVLINMSTQAEGFMDWAAQKITSWT-------------------------------------------------------------------------------------------------HALPDTVISHLFGKEEIHNNH----ELIATFRQLITNNINQSNLQQFVKSYKSRKDLEIERPVQGGNV-NT------KTLQCP-ALLIVGDNSPAVDAV---------------VDSNSRM---------NPTTTTFLK------------------------MADCGGLPQVDQPGKLIEAFKYFIQGMGY---------------MPSASMTRLARSRTASNS-------SNRTR-------SGTTDEQRGRSHTDVS-MESACVEHSS--------------SGHSVSVELTC------------     =====>
danre-q6tgx0   	-------------------------------------------------------------------------------------------MDELQ-------D-----VQLTEIKPLLTYKNS-QNF----QDFDCQ------------------------------------------------EHDIETP-HGVLHVT--MRGSPK--GNRPVILTYHDIGLNH------------------------------------------KSCFNTLFNFEDMM-EITQHFAVVHVDAPGQQEG-------------------GPPFPT---------------------------------------------GYLYPTMDELAEMLPSVLTQLKVNSVIGIGVGAGAYILTRFAL--------------------------IHPSLVEGLVLINVDPCAEGWIDWAASKLTGWT-------------------------------------------------------------------------------------------------SNLVDIVMAHHFSTEELTDNQ----ELIQTYRLHIAQDINQDNLALFCGSYNARQDLGIERPIAGLNENIV------KTLTCP-ALLVVGDTSPAVEAV---------------VECNSRL---------NPTKTTLLK------------------------MADCGGLPQVVQPGKLAEAFKYFVQGMGY---------------IPAAGMTRLSRSRSSSS--------SITSTDGSR-NRNLNSP-----LD-GP---------------------QFWTTNHGGVLLKLKCPPATAV------     =====>
dicdi-q55bx3   	-------------------------------------------------------------------------------------------MSSLN-------K----------------------------------------SIGS-------V---------TESPINVVV-HNYDNNDPTETRHEVQTK-HGKLVCFQKIGSNQS--PNMPTIISYHDLGLNH------------------------------------------TTCFSPFFNHPNMN-HILPYLNIIHIEAPGHEFN-------------------AETIPS----------------------------------------------SQYPSITEMAEDIQYVLDYFKVKVFIGLGAGAGGCILTQYSI--------------------------FYPRSVVGLVLVGSVIKSFSWLDWVKSW-VELTTLPSLK-----------------------------------------------------------------------------------------NPTGVRKYLIDHYYADNLEETNP----DLLEIIKK-EMVLINPDNLYHYVHSFVKRDDIKEEQI---------------KALGCK-ILLVVGKDSTYKEDI---------------IDLFSQF---------NPRNSTILQ------------------------VPDCGILVTAEKPGDIVEPFKLFMQGIGFLLDYYQSHDDAQK-------------------------------------------------------------------------------------------------------     =====>
drome-GH02439  	----------------------------------------------------------------------------------------------------------------------------------M--------------------SKPGTPKHGAG----SSSA--------AAAPEKISKYNISTEKCGDLTVI--VQGDLSQQEKRAVFITVHDLGCNH-------------------------------------------NSFQEFVSSPCMT-EIKERSCFIHVDVPGHADN-------------------AEALAD---------------------------------------------GFPFPSLQSLGEDLVTVLDYLHVKYVIGLGEGAGANVLARFGL--------------------------AHPSRVLGLILINATGSAASVVQSFKNKFISWKSDEVAQSAESFLMYHKFGHVM-----------------------------------------------------------------------------------------EQIVGENP-DKEKIVAEYQKRLHRSLNSKNIGLYVKAFMNRKDLTL------------------KGCKVD-VILITGMLSPYASMV---------------EKLHRDV---------EKERVTILK------------------------IER-AGDVLADAPGKVAQSILLFCKGQGL---------------LTSVVMPGVDRGR-------AFSTASSGSLEGANGSRRLSRGISMEDYD--KPNIRRLSIMNSE-L-----------------------PKKE--------     =====>
drome-MESK2    	----------------------------MPQSEGGYVSLPAVNGNGGAIYQSTTEPTA-PPSVFASVKRAIGQAIKSSPTDSEELLRSDRLPVIVGGSRISFRDRDKSGKTLTTKMPSAPTHTAEEAHLLG--------------------TMPVDPMDDIE----LRSVQLQFPNARGSILEACEQRRVPTD-KGDVHVA--IQGDTA----KPAIITYHDLGLNY------------------------------------------ATSFAGFFNFPVMR-GLLENFCVYHVTAPGQEEG-------------------APTLPE---------------------------------------------DYVYPTMDDLAAQLLFVLSHFGLKSVIGFGVGAGANILARFAH--------------------------AHPDKVGALCLINCVSTQSGWIEWGYQSFNARFLRTKG------------------------------------------------------------------------------------------MTQGVIDYLMWHHFGRNPEERNH----DLVQMYKQHFERGVNPTNLAMLINAYIHRNDLHLARTPPGTPG----SETAATTLKMP-VINITGSLSPHVDDT---------------VTFNGRL---------DPTNSSWMK------------------------ISD-CALVLEEQPAKLAEAFRLFLQGEGY---------------VSEKPQ-----------------------------------------------------------------------------------------------     =====>
drops-q297k9   	-------------------------------------------------------------------------------------------------------------------------------------------------------------MRGRM----NEYR--------HVVKCYQQKYNISTEKCGDLTVI--VQGDLSQQEKRAVFITVHDLGCNH-------------------------------------------NSFQEFVSSPCMT-EIKERSCFIHVDVPGHADN-------------------AEALAD---------------------------------------------GFPFPSLQSLGEDLVTVLDYLHVKYVIGLGEGAGANVLARFGL--------------------------AHPGRALGLILINATGSAASVLQSFKSKFISWKSDEVAQSAESFLMYHKFGH--------------------------------------------------------------------------------------------QIVGENP-DKDKIVAEYQKRLHRSLNSKNVGLYVKAFMNRKDLTL------------------KGCKVD-VILITGMLSPYASMV---------------EKLHRDV---------EKERVTILK------------------------IER-AGDVLVDAPGKVAQSILLFCKGQGL---------------LTSVVMPGVDRGR-------AFSTASSGSFESANGSRRLSRGISMEDYD--KPNIRRLSIMNSE-L-----------------------AKKE--------     =====>
helan-SF21-x   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MADSGRFVAADLPPIHLGGKEHIIQTG-CGSVSVT--VYGDQQ----KPPLITYPDLGLNH------------------------------------------TSCFEGLFISPESASLLLNNFCIYHITPPGHESG-------------------AATISK---------------------------------------------DEPVLSVVDLCDQILVILNHFRLGSVMCMGAMAGAYILTLFSI--------------------------KYSERVSGLILVSPICRAASWNEWFYNKFMSKLLQYCG------------------------------------------------------------------------------------------MCDMFKELLNPRYFSKAGC---EVPESEIVRACRKFLN-ERDSINVRRYLQALDRRHDMSKEL----------------ETLECK-SIIFVGDKSPFLDDA---------------LHMKTIL---------GKRCSAFVE------------------------VHPCGSMVTEEQPHAMLIPLELFLKGFGF---------------YRPCQFNDSPRSP---LDSCC-------------VDPSLLYPKQMGLKL--RPIKTRVSPPQPRAKHS---------------------------------     =====>
helan-q2xp02   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCPEAASLLLHNFCIYHISPPGHELG-------------------AAAICS---------------------------------------------DDPILSVDDLCDQILEVLNYFRLGSVMCMGAMAGAYILTLFAI--------------------------KYRDRVTGLILVSPLYKAPSWTEWLYNKFMSNLLYYYG------------------------------------------------------------------------------------------MCGLLKECLLQRYFSKEVRGNPEIPESDIVQCCRKLLD-ERQSVNVWRYLQAIDKRPDITEGL----------------KKLKCR-TLIFVGDSSPFHSEA---------------LHMTGKL---------DRRYSALVE------------------------VQVCGSLVTEEQPRAMLIPMEYFLMGYGL---------------YRPSPITGSPRSP---LSPSC-------------IAPKLLSPESMGLKL--KPIKTRGSPPDSSTLMW---------------------------------     =====>
helan-q2xp03   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCPEAASLLLHNFCIYHISPPGHELG-------------------AAAICP---------------------------------------------DDPILSVEDLCDQILEVLNYFRLGAVMCMGAMAGAYILTLFAT--------------------------KYRDRVTGLILVSPLCKAPSWTEWFYNKLMSNLLYYYG------------------------------------------------------------------------------------------MCGLLKECLLQRYFSKEVRGNPEIPESDIVQSCRKLLD-ERQSVNVWRYLQAIDKRPDITEGL----------------KKLKCR-TLIFVGDSSPFHSEA---------------LHMMGKL---------DRRYSALVE------------------------VQACGSMVTEEQPHAMLIPMEYFLMGYGL---------------YRPSPFTGSPRSP---LSPSC-------------ISPELLSPESMGLKL--KPIKTRVSSPDSNNIERLS--------------------MICLFV-----     =====>
helan-q6pwu0   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDSTDSIAVDMETIYLGGKEHVIRTG-HGCVSVI--LYGDEE----KPPLITYPDVALNH------------------------------------------MSCFQGLFFSPEAASLLLHNFCIYHITPPGHELG-------------------AASICP---------------------------------------------DVPVPSVDDLCDQILEVLNHFRLGAVMCMGAMAGAYLLTLFAI--------------------------RYRDRVTGLILISPLCKAPSWTEWLYNKLMSNLLYYYG------------------------------------------------------------------------------------------TCSLSKECLLQRYFSKEVRGTPEIPESDIVQACRKLLD-EWQSITVLRFLQAIHRRPDITQEL----------------EKLKCR-TLIFVGDNSLFHSEA---------------LHMSEKL---------DRRFSALVE------------------------VQGCGSMVTEEQPHAMLVSLEYFLIGFGL---------------YRPSESDGSPRSP---LSPFS-------------ISPELLSPESLGLKL--KPIKTRVLSRGGDSTCYSS-------------------------------     =====>
helan-sf21     	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MADSGHSISVTFPSFHSGGKEHIIRTG-CGSVSVT--VCGDQE----KPPLITYPDLALNH------------------------------------------MSCFQGLFVSPESASLLLHNFCIYHINPPGHELG-------------------AASIGI---------------------------------------------DDPVPSIEDLCDQILVVLNYFRLGSVMCMGAMAGAYILTLFSI--------------------------KYSERVTGLILISPICKAPSWTERFYNKLTSKTLYYYG------------------------------------------------------------------------------------------MCDLVKELLIHRYFSKEVCGNPEIPESDMVLACRKLLD-ERDSVNVWRYLQAIDSRRDITEEL----------------KSLECK-TIIFVGDSSPFHDEA---------------LQIAEKL---------GTNCSALVE------------------------VHACGSMVTQEQPHAMLIPLENFLKGFGL---------------YRPCRYSNSPRSP---LGPSS-------------IDPELLYPEKMGLKL--RPIKLRVSPQPRAHKN----------------------------------     =====>
human-NDR2     	-------------------------------------------------------------------------------------------MAELQ-------E-----VQITEEKPLLPGQTPEAAK--------------------------------------EAE------LAARILLDQGQTHSVETP-YGSVTFT--AYGTPK--PKRPAILTYHDVGLNY------------------------------------------KSCFQPLFQFEDMQ-EIIQNFVRVHVDAPGMEEG-------------------APVFPL---------------------------------------------GYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYAL--------------------------NHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLT-------------------------------------------------------------------------------------------------SSIPEMILGHLFSQEELSGNS----ELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGN-------------ITLRCP-VMLVVGDQAPHEDAV---------------VECNSKL---------DPTQTSFLK------------------------MADSGGQPQLTQPGKLTEVFKYFLQGMGY---------------MASSCMTRLSRSRTASLT-------SAASVDGNR-SRSRTLSQSSESGT--------------------------LSSGPPGHTMEVSC------------     =====>
human-ndr1     	------------------------------------------------------------------------------------------MSREMQ-------D-----VDLAEVKPLV-----------------------------------------------EKG----ETITGLLQEFDVQEQDIETL-HGSVHVT--LCGTPK--GNRPVILTYHDIGMNH------------------------------------------KTCYNPLFNYEDMQ-EITQHFAVCHVDAPGQQDG-------------------AASFPA---------------------------------------------GYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFAL--------------------------NNPEMVEGLVLINVNPCAEGWMDWAASKISGWT-------------------------------------------------------------------------------------------------QALPDMVVSHLFGKEEMQSNV----EVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHT---------VTLQCP-ALLVVGDSSPAVDAV---------------VECNSKL---------DPTKTTLLK------------------------MADCGGLPQISQPAKLAEAFKYFVQGMGY---------------MPSASMTRLMRSRTASGS-------SVTSLDGTR-SRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNS-GAAGNSAGPKSMEVSC------------     =====>
human-ndr3     	-------------------------------------------------------------------------------------------MDELQ-------D-----VQLTEIKPLLNDKNGTRNF----QDFDCQ------------------------------------------------GHDIETT-HGVVHVT--IRGLPK--GNRPVILTYHDIGLNH------------------------------------------KSCFNAFFNFEDMQ-EITQHFAVCHVDAPGQQEG-------------------APSFPT---------------------------------------------GYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFAL--------------------------NHPELVEGLVLINVDPCAKGWIDWAASKLSGLT-------------------------------------------------------------------------------------------------TNVVDIILAHHFGQEELQANL----DLIQTYRMHIAQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKS------KTLKCS-TLLVVGDNSPAVEAV---------------VECNSRL---------NPINTTLLK------------------------MADCGGLPQVVQPGKLTEAFKYFLQGMGY---------------IPSASMTRLARSRTHSTSS------SLGSGESPF-SRSVTSNQSDGTQE-SC---------------------ESPDVLDRHQTMEVSC------------     =====>
human-ndr4     	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPECWDGEHDIETP-YGLLHVV--IRGSPK--GNRPAILTYHDVGLNH------------------------------------------KLCFNTFFNFEDMQ-EITKHFVVCHVDAPGQQVG-------------------ASQFPQ---------------------------------------------GYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFAL--------------------------IFPDLVEGLVLVNIDPNGKGWIDWAATKLSGLT-------------------------------------------------------------------------------------------------STLPDTVLSHLFSQEELVNNT----ELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTVP---NA------KTLRCP-VMLVVGDNAPAEDGV---------------VECNSKL---------DPTTTTFLK------------------------MADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLS--GGAVPSASMTRLARSRTASLT-------SASSVDGSR-PQACTHSES------------------------------SEGLGQVNHTMEVSC------------     =====>
macfa-ndrg2    	-------------------------------------------------------------------------------------------MAELQ-------E-----VQITEEKPLLPGQTPEAAK----------------------------------------------------------IHSVETP-YGSVTFT--VYGTPK--PKRPAILTYHDVGLNY------------------------------------------KSCFQPLFQFGDMQ-EIIQNFVRVHVDAPGMEEG-------------------APVFPL---------------------------------------------GYQYPSLDQLADMIPCVLQYLNFSTVIGVGVGAGAYILSRYAL--------------------------NHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLT-------------------------------------------------------------------------------------------------SSIPEMILGHLFSQEELSGNS----ELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGD-------------ITLKCP-VMLVVGDQAPHEDAV---------------VECNSKL---------DPTQTSSLK------------------------MADSGGQPQLTQPGKLTEAFKYFLQGMGY---------------MASSCMTRLSRSRTASLT-------SAASIDGNR-SRSRTLSQSSESGT--------------------------LSSGPPGHTMEVSC------------     =====>
macfa-q4r4q3   	------------------------------------------------------------------------------------------MSREMQ-------D-----VDLAEVKPLV-----------------------------------------------EKG----ETITSLLQEFDVQEQDIETL-HGSVHVT--LCGTPK--GNRPVILTYHDIGMNH------------------------------------------KTCYNPLFNYEDMQ-EITQHFAVCHVDAPGQQDG-------------------AASFPA---------------------------------------------GYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFAL--------------------------NNPEMVEGLVLINVNPCAEGWMDWAASKISGWT-------------------------------------------------------------------------------------------------QALPDMVVSHLFGKEEMHSNV----EVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHT---------VTLQCP-ALLVVGDSSPAVDAV---------------VECNSKL---------DPTKTTLLK------------------------MADCGGLPQISQPAKLAEAFKYFVQGMGY---------------MPSASMTRLMRSRTASGS-------SVTSLDGTR-SRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNS-GAAGNNAGPKSMEVSC------------     =====>
mouse-Q923D7   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPECWDGEHDIETP-YGLLHVV--IRGSPK--GNRPAILTYHDVGLNH------------------------------------------KLCFNTFFNFEDMQ-EITKHFVVCHVDAPGQQVG-------------------ASQFPQ---------------------------------------------GYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFAL--------------------------IFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLT-------------------------------------------------------------------------------------------------STLPDTVLSHLFSQEELVNNT----ELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDINRPGTVP---NA------KTLRCP-VMLVVGDNAPAEEGV---------------VECNSKL---------DPTTTTFLK------------------------MADSGGLPQVTQPGKLTEAFKYFLQGMGYM---------------PSASMTRLARSRTASLT-------SASSVDGSR-PQPCAHSDS------------------------------SEGMGQVNHTMEVSC------------     =====>
mouse-ndr1     	------------------------------------------------------------------------------------------MSRELH-------D-----VDLAEVKPLV-----------------------------------------------EKG----ESITGLLQEFDVQEQDIETL-HGSLHVT--LCGTPK--GNRPVILTYHDIGMNH------------------------------------------KTCYNPLFNSEDMQ-EITQHFAVCHVDAPGQQDG-------------------APSFPV---------------------------------------------GYMYPSMDQLAEMLPGVLHQFGLKSVIGMGTGAGAYILTRFAL--------------------------NNPEMVEGLVLMNVNPCAEGWMDWAASKISGWT-------------------------------------------------------------------------------------------------QALPDMVVSHLFGKEEIHNNV----EVVHTYRQHILNDMNPSNLHLFISAYNSRRDLEIERPMPGTHT---------VTLQCP-ALLVVGDNSPAVDAV---------------VECNSKL---------DPTKTTLLK------------------------MADCGGLPQISQPAKLAEAFKYFVQGMGY---------------MPSASMTRLMRSRTASGS-------SVTSLEGTR-SRSHTSEGPRSRSHTSEGSRSRSHTSEDARLNITPNS-GATGNNAGPKSMEVSC------------     =====>
mouse-ndr2     	-------------------------------------------------------------------------------------------MAELQ-------E-----VQITEEKPLLPGQTPETAK--------------------------------------EAE------LAARILLDQGQTHSVETP-YGSVTFT--VYGTPK--PKRPAIFTYHDVGLNY------------------------------------------KSCFQPLFRFGDMQ-EIIQNFVRVHVDAPGMEEG-------------------APVFPL---------------------------------------------GYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYAL--------------------------NHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLT-------------------------------------------------------------------------------------------------SSIPDMILGHLFSQEELSGNS----ELIQKYRGIIQHAPNLENIELYWNSYNNRRDLNFERGGE-------------TTLKCP-VMLVVGDQAPHEDAV---------------VECNSKL---------DPTQTSFLK------------------------MADSGGQPQLTQPGKLTEAFKYFLQGMGY---------------MASSCMTRLSRSRTASLT-------SAASIDGSR-SRSRTLSQSSESGT--------------------------LPSGPPGHTMEVSC------------     =====>
mouse-ndr3     	-------------------------------------------------------------------------------------------MDELQ-------D-----VQLTEIKPLLNDKNGTRNF----QDFDCQ------------------------------------------------EHDIETP-HGMVHVT--IRGLPK--GNRPVILTYHDIGLNH------------------------------------------KSCFNTFFNFEDMQ-EITQHFAVCHVDAPGQQEA-------------------APSFPT---------------------------------------------GYQYPTMDELAEMLPPVLTHLSMKSIIGIGVGAGAYILSRFAL--------------------------NHPELVEGLVLINIDPCAKGWIDWAASKLSGFT-------------------------------------------------------------------------------------------------TNIVDIILAHHFGQEELQANL----DLIQTYRLHIAQDINQENLQLFLGSYNGRRDLEIERPILGQNDNRL------KTLKCS-TLLVVGDNSPAVEAV---------------VECNSRL---------DPINTTLLK------------------------MADCGGLPQVVQPGKLTEAFKYFLQGMGY---------------IPSASMTRLARSRTHSTSS------SIGSGESPF-SRSVTSNQSDGTQE-SC---------------------ESPDVLDRHQTMEVSC------------     =====>
mouse-ndr4     	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPECWDGEHDIETP-YGLLHVV--IRGSPK--GNRPAILTYHDVGLNH------------------------------------------KLCFNTFFNFEDMQ-EITKHFVVCHVDAPGQQVG-------------------ASQFPQ---------------------------------------------GYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFAL--------------------------IFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLT-------------------------------------------------------------------------------------------------STLPDTVLSHLFSQEELVNNT----ELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDINRPGTVP---NA------KTLRCP-VMLVVGDNAPAEEGV---------------VECNSKL---------DPTTTTFLK------------------------MADSGGLPQVTQPGKLTEAFKYFLQGMGYIAHLKDRRLS--GGAVPSASMTRLARSRTASLT-------SASSVDGSR-PQPCAHSDS------------------------------SEGMGQVNHTMEVSC------------     =====>
orysa-P0671B11.	----------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDSSRSVSIDVERISFGGKEHRVRTR-YGSVSVS--VFGDED----KPALITYPDVALNY------------------------------------------MSCFQGLFFCPEAASLLLHNFCIYHITPQGHELG-------------------AAPISS---------------------------------------------DVPVPSVDELVDQVADVLDFFGLGSVMCLGVTAGAYILTLFAT--------------------------KYRDRVIGLMLVSPLCKAPSWSEWLYNKVLLNLLYYYG------------------------------------------------------------------------------------------SRGLVKECLLQRYFSTEVRGNGQDPESEIVQACRSLLH-ERQGSNVWRFLQAINERHDLTEAL----------------KKLQCR-TLIFVGENSQFHDDA---------------VHMTTKL---------DRRYCALVE------------------------VQACGSLVTEEQPHAMLIPMEYFLMGYGL---------------YRPSQLDSSPRST---LNPFC-------------ISPELLSPESMGVKL--KPIKTRISLKV---------------------------------------     =====>
orysa-q53wj4   	------------------------------------------------------------------------------------------------------------------------------------------------------------MGDSSG----SGSGSGSVSVDVERISFGGKEHQVRTR-CGSLSVA--IYGDED----KPALITYPDIALNH------------------------------------------MSCFQGLLFCPEVASLLLHNFCIYHINPQGHELG-------------------AAPIPS---------------------------------------------DVPVPSVEDLADQVADVLDFFGLGSVMCLGVTAGAYVLTLFAT--------------------------KYRERVIGLMLVSPLCRAPSWSEWLYNKVLLNLIYYYG------------------------------------------------------------------------------------------TRGLVKECLLQRYFSKKVCGSGHYLESDIVQACRNLLD-ERQGENIWRFLHSINERHDLTDAL----------------RKLQCR-TLIFVGENSQFHEDA---------------IHMTTKL---------DKRYCALVE------------------------VQGCGSLVTEEQPHAMLMPMEYFLMGYGL---------------YRPYQMNSSPRSP---LSPCC-------------ISPELLSPESMGVKL--KPIKTRIAVDY---------------------------------------     =====>
orysa-q5z901   	------------------------------------------------------------------------------------------------------------------------------------------------------------MGDS---------GGSVVSVDVERISFGGKEHHIQTN-HGSVSVA--VYGDHD----KPALVTYPDIALNH------------------------------------------MSCFQGLLFCPEASSLLLHNFCIYHISPPGHELG-------------------AAPVSP---------------------------------------------SSPVASVDELADQVSDVLDFFGLGPVMCLGVTAGAYILTLFAT--------------------------KYRERVLGLILVSPLCRTPSWTEWFHNKVMSNLLYYYG------------------------------------------------------------------------------------------MCNMVKDCLLQRYFSKGVQGCSAVPESDIVQASRSFLD-QRQSMNVWRFIHTINERHDLTESL----------------KELQCR-TLIFVGQNSQFHAEA---------------VHMTSKL---------DERYSALVE------------------------VQGCGSVVTEEQPHAMLMPLEYFLMGYGL---------------YRPSQISCSPRSP---LNPFC-------------ISPELLSPESMGVKL--KPIKTRANLEV---------------------------------------     =====>
orysa-q6z8b1   	------------------------------------------------------------------------------------------------------------------------------------------------------------MGDS---------GGSVVSIDVERISFGGKEHHIHTN-HGPVSVA--VYGDHD----KPALVTYPDIALNH------------------------------------------MSCFQGLLFCPEAASLLLHNFCIYHISPPGHELG-------------------AAPISP---------------------------------------------NAPIPSVDDLADQVADVLDFFGLGSVMCLGVSAGAYILTLFAA--------------------------KYRDRVLGLILVSPLCKPPTWTEWFYNKVASNLLYYYG------------------------------------------------------------------------------------------MCGLVKEGLLQRYFSKEVRGCSDLPESDIVQACRSLLD-QRQSMNVWRFVQTMNMRYDLTEDL----------------KQLQCR-TLIFVGEYSQFHTEA---------------VHMTSKL---------DRRYCALVE------------------------VQACGSLITEEQPHAMLIPMEYFFMGYGL---------------YRPSQLDCSPRSP---LSPFC-------------ISPDLLSPESMGVKL--KPIKTRVRLEV---------------------------------------     =====>
pantr-ndrg2    	-------------------------------------------------------------------------------------------MAELQ-------E-----VQITEEKPLLPGQTPEAAK----------------------------------------------------------THSVETP-YGSVTFT--VYGTPK--PKRPAILTYHDVGLNY------------------------------------------KSCFQPLFQFEDMQ-EIIQNFVRVHVDAPGMEEG-------------------APVFPL---------------------------------------------GYQYPSLDQLADMIPCVLQYLNFST