ESTHER Database

Home
Search
Tools
Families
Biological
data
Basics on AChE
ESTHER definition
What is up?
Acknowledgments
& disclaimer


MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....790..5....800..5....810..5....820..5....830..5....840..5....850..5....860..5....870..5....880..5....890..5....900..5....910..5....920..5....930..5....940..5....950..5....960..5....970..5....980..5....990..5....1000.5....1010.5....1020.5....1030.5....1040.5....1050.5....1060.5....1070.5....1080.5....1090.5....1100.5....1110.5....1120.5....1130.5....1140.5....1150.5....1160.5....1170.5....1180.5....1190.5....1200.5....1210.5....1220.5....1230.5....1240.5....1250.5....1260.5....1270.5....1280.5....1290.5....1300.5....1310.5....1320.5....1330.5....1340.5....1350.5....1360.5....1370.5....1380.5....1390.5....1400.5....1410.5....1420.5....1430.5....1440.5....1450.5....1460.5....1470.5....1480.5....1490.5....
9hyme-e2a0n6   	-------------------------------------------MA----MRRQH-AFIGRVAVCCYFY----VLLTDIVALA---------QDSMSGSRYYGRDGVY-------VPPRDAFDR--TYIYKDRR--YGYRPSYLDPIYRG------------------PTRAPEDRYLYDE-----TTARLPLPGILGGWREDLQGRERPDSKNF-RDRDVIVN---TNYGQVQGFKVRL-YDDP-------NARHRPW-----NL-AVERVTKSVDVFLGIPYAMPPTKEGRF----------------KPPRP---HRGWQLLQAIDWGPACPQPSEYTGAT----------------------KGVRDVDEDCLYLNIFTPS-----------------IGSGLANKYTVMFYIHGGEFTHGASNLFPAHILAAFYNVVVVSINYRLGALGFLSTGD-----------------ENSPGNYGILDQAMALRWVYDNIAIFNGNPDSITLFGSGAGAASAGLLMVAPRTR----HMVSKVIAQSGSALADWAVTI-DKYRVQNTSRVFAEMLGCSIE-----------------------------------------------SSWKLVQCLKD-GRSFLELGNS--ELKPHVG---MFPWAPVLDINFTIPQDNWYE-DWRASDWRFFAETPEESIKARKYRRDLAYMAGVTTQEAAFII-------------------------KNNITLA-----R---NRYIINSELFDQKVWEL---VLQYNYTLNPQGVHEAIKYMYTYWPDPTNVTHIRDQYINLLSDFHYVAPFDKIAKLLVERH-----------------VPTYLYVLNTSIE------ALHSPEWARVSHD------TELLNPTPSQ------------------------------------------------------------------------ILGLHFDLARHGQLRYLNINTTFNS--------------------SIQINYRQTESAFWSMYLPTVISYL----VPTYPPVTEYWWEPKQPLQIAFWSMSTA-CLLLLVLSVVC---CMLWRNAK------------RQSDHYYSGD-------------------ILMVRE----DEHSEGIENLTR-------ASKENIYEYRDV-PVKSRI--P-R-QNEGRLQE------R---LAH--------NRKFSS-----TPSLRS-----------NSNV---------------------------------------------------------------------SLK--D-----MRSEGFVTSSPNGQPKL---------------------TKTMSQS-----------------------------------------------TLPKAKSKT--------LLVQGVPQTAV-------------------------     =====>
9hyme-e2bc53   	--------------------------------------------M----AARGQ-HAIAESVVICSLC----LLIARSTFAQ---------QPISAGSRYYNRDGVY-------VPQDAYGYK--TIFYKDRRYG------LLDPLDRG------------------PTRAPEDRYLYEH-----STPRIPLPGILAGWRKDLQGKERPDSKTF-RDRDVIVN---TNYGQVQGFKVQL-YDNP-------YSLHRPW-----NP-SVDRVTKDVIVFLGIPYALPPVKEGRF----------------KPPRP---NRGWQLIQAIDWGPACPQPSEYTGKT----------------------KGVEIVDEDCLYLNIFTPS-----------------TDAGVASKYAVMFYIHGGEFTYGASNLFPAHILAAFYNVVVVSINYRLGALGFLSTGD-----------------ENSPGNYGILDQAMALRWVYDNIAFFNGNPESITLFGPGAGAASAGLLMVVPRTR----ELVSKVIAQSGSALADWAVIM-DKYRAQNTSRVYAQMVGCSIE-----------------------------------------------SSWKLVQCLKD-GRNPFELSNP--RFQPHVG---MFPWAPVLDINFTIPQDHWYD-GWRASDWRFFAETPEESIKAGRYRKDLAYMTGVTTQEAAYII-------------------------RNNETLR-----N---NRYVIDSELFDQKVREL---VLQYNYTLNPQGVYEAIKYMYTYWPDPMNVTHIRDQYINLLSDFHYVAPNDKMVKLLVEKY-----------------VPTYLYVLNTSIE------SFNLPQWAKVPHD------TEHLWLTGAPFMDPEFFPERLK----------LNRDMWTDSDRNMSHFFMKAYSNFATYG--------------NPTPS-Q-ILGLHFDVTRYGQLRYLNINTTLNS--------------------SIEINYRQTESAFWSMYLPTVIGYL----VPTYPPVTEYWWEPKQPLQIAFWSMSTA-CLLLLVLSVVC---CMLWRNAK------------RQSDHYYSGD-------------------ILMVRD----DEHSEGIENLTR-------ASKENIYEYRDV-PIKTRV--P-R-QNEAKLQE------R---LAQ--------NRKFSS-----TPSLRS-----------NSNV---------------------------------------------------------------------SLK--D-----MRSEGFVTSSPNGQPKL---------------------TKAMSQS-----------------------------------------------ALPKAKSRT--------LLVQGIPQTAV-------------------------     =====>
acrec-f4w848   	-------------------------------------------MA----NARGG-RAYG--VVRCCLY----LLITGVVTLA---------QDISPGSRYYNRDGVY-------VPQDK------TFVYNGRRYGYGYQPSYLEPGYRG------------------PTRAPEDRFIYGT------TERLPLPGILAGWREDLQGKERPDSKLFIKTRDILVN---TNYGQIQGFKVQL-YDDP-------FARHRPW-----NV-AVERVTKDVNVFLGIPYAMPPTKEGRF----------------KPPRP---PRGWQLLQAIDWGPACPQPSEYTGAT----------------------KGVRDVDEDCLYLNIFTPS-----------------IGYGLANRYPVMFYIHGGEFSHGASNLFPAHILAAFYNVVVVSINYRLGALGFLSTGD-----------------ENSPGNYGILDQAMALRWVYDNIVSFNGDPDSITLFGPGAGAASAGLLMVAPKTR----QMVSKVIAQSGSALADWAVIV-DKYRAQNTSRVYAEMLGCSIE-----------------------------------------------SSWKLVQCLKD-GRSFLELSNS--ELKPHVG---MFPWAPVLDVNFTIPRDDWYE-DWRASDWRFFTETPEESIKAHKYSKDLAYMAGVTTQEAAFII-------------------------KNNATLA-----K---NQYTITPEIFDQRIWEL---VLRYNYTLNPQGIYEAIKYMYTYWPDPMNVTHVRDQYINLLSDFHYVAPYDKIAKLLVERH-----------------VPTYLYVLNTSIE------SLYSPQWARVPHD------TELLWLTGAP------------------------------------------------------------------------FMDVG------------------------------------------------MSFVIYIMYLPTVIGYI----VPTYPPVTEYWWEPKQPLQIAFWSMSTA-CLLLLVLSVVC---CMLWRNAK------------RQSDHYYSGD-------------------ILMVRD----DEHSEGIENITR-------SSKENIYEYRDV-PVKTRI--P-R-QNEMRLQE------R---LAH--------NRKFSS-----TPSLRS-----------NSNV---------------------------------------------------------------------SLK--D-----MRSEGFITSSPNGHPKM---------------------AKTLSQS-----------------------------------------------ALPKTKSKT--------LLVQGVPQTAV-------------------------     =====>
aedae-glita    	MALNTNCGAAKRYQQAKHSAKTTKSSDGGGGCSVRKKCVHLSSS------TTGSEWIHAK--INVLFL--CFAVFISLVDGQYHTT-----RDP----RWYSREGD----FSY-HLPNPGDPDYRTYTYNNRRYGYYQP-NGYGQQYPG------QNLPGQYP---QNTGLGEDRFKYDPT-NP-NNVQTPFPGVLGGWREDLQGKLRRDSIQL--DRDVFVT---TNYGQVQGFKVHL-YDNPD-----PKSFFRPW-----HS-PVDRVMGTCSTFLGIPYALPPTFEGRF----------------KPPRP---HRGWQLLQAVDYGPACPQPVQYTGAT----------------------KGIRDMDEDCLYLNVFSPNT-----------------QSGVAQRFPVMIYIHGGEFVRGASNVFPGHMLAAFYEVVVVTFNYRLGALGFLSTGD-----------------ENSPGNYGILDQIMAVRWVYDNIEAFNGDRNSITLFGPGAGAASAGLLMVAPQTK----DIVTRVIAQSGAAVADWALIV-DKYRAQNTSRVFGQMVGCSIE-----------------------------------------------TSWKLVNCMRQ-GRSFFELGNA--EFAPHVG---LFPWGPVLDINFTFPGDEWYE-GWRERDWHFLAETPEELIRKGHYNRGLHYMSGVTLQEAAFVI-------------------------SQNESLA---------PYFEVDQKFFEQKVWEL---VYRYNYTLNLNGTYEAIKYMYTHWPDPRNTTYIREQYINLLSDFLYRAPADKMTKLLVERR-----------------VPVYSYVMNTTIE------GLKLPEWRKVPHD------IEHYLLTGAPFMDVEFFPRKAR----------LDRLMWTDNDRNMSHFFMKTFSDFARYG--------------NPTPQ-Q-VLGLFFEPARNGELKYLNLNTTYNS--------------------SIRMNYRQTESAFWTQYIPTVVGVM----VPTYPPTTEFWWEPKEPLQIAFWSMSAA-CLLLIVMVVIC---CILWRNAK------------RQSDRFYDDG-------------------VIVVDN-PESER-DVGIDNNVLQ-AQPLRTR-DNIYEYRDSPTKYKS-----P-PTDATSIR------APSSLAMTQTTAK--S-ISGS-----QSSLRSAISM-----KESTNISP--------------------------IPRSE-SNFDRNIKYAERGVDTE--IN--KNGKYPRTDSRGALS--D-----TKSR-EFS-----------------A------S-TPIEPAPRSQQPSSQPAS--------------------------------RGASRAGYDRSNNASRT--------NLIEGIPQTEV-------------------------     =====>
anoda-e3wmw1   	--------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAK---QSPRVNEHHNSWRTN-NP-TLIQTPFPGVLGGWREDLQGKLRRDSMQL--ERDVFVT---TNYGQVQGFITYL-YDDPN-----PRNLYRPW-----HS-TVDRIMGKCSTFLGIPYALPPTHEGRF----------------KPPRQ---HRGWQLVQAVDYGPACPQPVKYTGAT----------------------KGIRDMDEDCLYLNIFSPNT-----------------QAGVAQRYPVMIYIHGGEFVRGASNTFPGHMLAAFYDVVVVTFNYRLGALGFLSTGD-----------------ENSPGNYGILDQVMAVRWVYENIEAFNGDRNSITLFGPGAGGASAGLLMVAPQTR----DIVTRVIGQSGSALADWALIE-DKWRAQNTSRVFGQMVGCSID-----------------------------------------------TSWKLVNCMRN-GRSFYELGNA--EFAPHVG---LFPWGPVLENNFTFPGDNWYE-GWSERDWHFLSETPESLIRRRQYNRGLHYMSGVTLQEAAFVV-------------------------SGNETLA---------PRFEVDERFFDQKVREL---VLRYNYTLNLNGTYEAIKYMYTYWPDPKNTTFIREQYIHLLSDFLYRAPTDKLVKLLVERN-----------------VPVYSYVMNTTIE------GLKLPEWRKVPHD------IEHYLLTGAPFMDVEFFPRRAR----------LDRLMWTDNDRNMSHFFMKTYSDFARHG--------------NPTPS-Q-VLGLYFEKARNGELKYLNLNTTYNS--------------------SIMMNFRQTESAFWTQYIPTVVGVM----IPTYPPTTEFWWEPKEPLQIAFWSLAAA-CLILMVLVVIC---CIMWRNAK------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
anoga-glita    	--------------------------------------MTLSR----------EHHHHASLLLLVVIV--GVASLVGVCDGQYYTT-----RDP----RWYSREGD----FNY-KIPNPGDPEYRTYTFNNRRYGYYQP-NGYGQQYPG------QSLPGQYP---SNTGLGDDRFKYDPT-NP-TLAQTPFPGVLGGWREDLQGKLRRDSMQL--ERDVFVT---TNYGQVQGFMVYL-YDNPD-----PKNLYRPW-----HS-NVDRIMGKCSTFLGIPYALPPTHEGRF----------------KPPRQ---HRGWQLVQAVDYGPACPQPVQYTGAT----------------------KGIRDMDEDCLYLNIFSPNT-----------------QAGVAQRYPVMIYIHGGEFVRGASNTFPGHMLAAFYDVVVVTFNYRLGALGFLSTGD-----------------ENSPGNYGILDQIMAVRWVYENIESFNGDRNSITLFGPGAGGASAGLLMVAPQTK----DIVTRVIGQSGSALADWALIV-DKWRAQNTSRVFAQNVGCSIE-----------------------------------------------TSWKMVNCMRN-GRSSYELGNA--EFPPHVG---LFPWGPVLENNFTFPGDSWYE-GWSERDWHFLAETPESLIRRRHFNRGLHYMSGVTLQEAAFVI-------------------------TGNKSLA---------PYFEVDERFFDQKVREL---VLRYNYTLNLNGTYEAIKYMYTYWPDPKNTTFIREQYINLLSDFLYRAPTDKLIKLLVEQN-----------------VPVYSYVMNTTIE------GLKLAEWCKVPHD------IEHYLLAGAPFMDVEFFPRRER----------FDRLMWTDNDRNMSHFFMKTYSDFARHG--------------NPTPT-Q-VLGLYFEKARNGELKYLNLNTTYNS--------------------TIMMNYRQTESAFWMEYLPTVVGVL----IPTYPPTTEFWWEPKEPLQIAFWSLAAA-CLILMVLVVIC---CMMWRSAK------------RESDRLYDEA-------------------VFGMDN-PESERDTV-MENNMLQ-AQPLRGQSGNIYEYRDSPSKYSK---MPP-DGGGGSIR------SPSSLGMTQVTGK--SGLTGS-----QSSLRSAISM-----KESSSISPP-------------------------PLSKE-SNFDRNIKYAGSDTVPSDTIQ--RNGKFARSDSKNLLA--N-----QMSQ-AELARSQRDLGGATSPMSETS------T-MAGSVLGRSQQITPVP------------------------------------SSRGGGMKSNNASRT--------NLIEGIPQTAV-------------------------     =====>
apime-h9k5b0   	-------------------------------------------MA----AGTPY-SSIG--RICFCLC----LF-AITVICH---------EQISPGSRYYSRDGVY-------VPLNGPDHRTETYVYKDRR--YGYRPSYLDVVYKE------------------HAKAPENRYLYED-----TTSRFPLPGVLSGWREDLQGRERPDSKNL--HRDVTVS---TNYGQVQGFKVYL-YDSP-------QARHRPW-----NL-PVERVTKHVNVFLGIPYAMPPTKEGRF----------------KPPRP---HKGWQLLQAVDWGPACPQPSAYTGAT----------------------KGIRDVDEDCLYLNIFTPS-----------------IDSGLAQPYAVMFYIHGGEFSHGASNLFPAHILAAFYNVVVVSINYRLGVLGFLSTGD-----------------ENSPGNYGILDQAMALRWVYDNIKAFNGNPDAITLFGPGAGAVSAGLLMVAPKTR----EMVSKVIAQSGSALADWGVII-DKYRAQNTSRVYAEMLGCSIE-----------------------------------------------SSWKLVQCLKN-GRSFFELGNS--ELKPHIG---MFPWAPVLDTNFTIP-DNWYE-DWRASDWRFFMETPEESIKNHRFRNNLAYMAGVTTQEAAYLI-------------------------YNNVTLA-----R---NQYIIDIELFEQKIWEF---VLQYNYTLNSQGVYEAIKYMYTYWPDPKNITHIRDQYINLLSDFHYVAPFDKMAKLLIEKH-----------------VPTYLYVLNTTVE------ALRLPQWRSVSHD------TELLWLTGAPFMDVEFFPQKWN----------LKRDMWTDNDRNMSHFFMQTYSNFAKYG--------------NPTPS-Q-ILGLHFDVAKPGQLRYLNINTTFNS--------------------SILLNYRQTESAFWSVYLPTVIGRL----VPTYPPVTEYWWEPKQPLQIAFWSVSTA-CLLLIVLSVVC---CMLWRNAK------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
apime-h9ktv3   	-------------------------------------------MA----AGTPY-SSIG--RICFCLC----LF-AITVICH---------EQISPGSRYYSRDGVY-------VPLNGPDHRTETYVYKDRR--YGYRPSYLDVVYKE------------------HAKAPENRYLYED-----TTSRFPLPGVLSGWREDLQGRERPDSKNL--HRDVTVS---TNYGQVQGFKVYL-YDSP-------QARHRPW-----NL-PVERVTKHVNVFLGIPYAMPPTKEGRF----------------KPPRP---HKGWQLLQAVDWGPACPQPSAYTGAT----------------------KGIRDVDEDCLYLNIFTPS-----------------IDSGLAQPYAVMFYIHGGEFSHGASNLFPAHILAAFYNVVVVSINYRLGVLGFLSTGD-----------------ENSPGNYGILDQAMALRWVYDNIKAFNGNPDAITLFGPGAGAVSAGLLMVAPKTR----EMVSKVIAQSGSALADWGVII-DKYRAQNTSRVYAEMLGCSIE-----------------------------------------------SSWKLVQCLKN-GRSFFELGNS--ELKPHIG---MFPWAPVLDTNFTIP-DNWYE-DWRASDWRFFMETPEESIKNHRFRNNLAYMAGVTTQEAAYLI-------------------------YNNVTLA-----R---NQYIIDIELFEQKIWEF---VLQYNYTLNSQGVYEAIKYMYTYWPDPKNITHIRDQYINLLSDFHYVAPFDKMAKLLIEKH-----------------VPTYLYVLNTTVE------ALRLPQWRSVSHD------TELLWLTGAPFMDVEFFPQKWN----------LKRDMWTDNDRNMSHFFMQTYSNFAKYG--------------NPTPS-Q-ILGLHFDVAKPGQLRYLNINTTFNS--------------------SILLNYRQTESAFWSVYLPTVIGRL----VPTYPPVTEYWWEPKQPLQIAFWSVSTA-CLLLIVLSVVC---CMLWRNAK------------RQSDHYYSGD-------------------ILMVRD----DEPSEGIENITR-------TSKENIHEYRDMPPIKSRI--P-R-QNEIKLQE------R---LAH--------NRKFSS-----TPSLRS-----------NSNT---------------------------------------------------------------------SLK--D-----MRSEGFVTSSPNGQPKL---------------------SKAMSQS-----------------------------------------------SLPKSKSKT--------HLVQGIPQTAV-------------------------     =====>
ascsu-f1kxs8   	------------------------------------------------------------MIVQFCMM------W--------HIVGNKPLAWI-------GFAL------------------YSVF----VRYVDACEQCQQLAS------------------FQEPKRPIDL---WN----PFGTPSTPPP--PG----------------QLRKDEVIVR---LSIGDMVGKKVVV-ENVPWTANRDPLEDIPSDRDRPEPNPVPRRNNVTVFTFLGVPYAEPPVSQRRF----------------KPPQYISELPGEKPYLAFNYPASCAQDIESRPNLLVN------------------DPYRFRVSEDCLYLNIFTPDA-----------------SQISQLIYPVLVFFHGGNFQTGSANEWPGEVLASR-GIVVVTVNYRLGAFGFMSLGD-----------------DV-TGNYGLQDQRTALQFVRDHISSFGGDPQAVTIVGHDAGAVSVGLHMLSPLST----GLFRSASAMSGAEVSYHSTIG-KPALAFNNTIKLGRYLGCTQL-----------------------------------------------IAEDVWNCILT--RSTNDVIRAVQTIPVEYN---RYLFLPTVDGRQIPANPYWMLTV-----------IPA---GTMNYASPVPYLTGLNREDGVE-----------------------V--VLEDRLLGE---FN---DFLLVDQQYVDNFVLEY---AFRHNYTMNREAIAEAIIDRYKYWPDPSDEDAIRAKFIELTTDAYYVAPICLSANLHSAGG-----------------SRVFMYVNNYEFGRGG-D-RRFLPSWIGVCHD------CDLYLLFGFPFMRSDLLPP--H----------LADVQWTDFDRNASQLFTSIYRQFLRNM--------------NPNFP----FDTSWAPLQPRAHWFIDFNYSHWSEMTI--------------PGQLKRDYRWESVAFWTQYIPALVQYM----TTTFSPIEGAMRREV---LVYQIGMGVLSCILMGVMVLACLFAYLVFERNP--RRASKLEHDRRRLIRNTNNSP---------------SKADILK---------------------------VS----SL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
bommo-h9j8g3   	------------------------------------------------------------MFSKVFLFSLSCVSVASQSNKD--------LY-NGQFNAYYN----KQDQNKEYRVPSPGDTDYRTYIYNNRRYGTDPT-R-SNPYNPN------INQPGGFPYNPINTNPLDEQFKYNTNRDP-NNPDALFPGVLGGWREDLQGRERRDSRQL--KRDIFVT---TSYGQVQGFKVYL-YDNPD-----PDSGYRPW-----LT-PVERIQGEVSVFLGIPYARPPVLEGRF----------------KPPRQ---HPGWQLIQAVDWGPACPQPVRFTGAT----------------------KGIRDMDEDCLYLNIFSPNS----------------EAGSTAQRYPVMVYIHGGQFMSGASNLFPAHMMAAFYNVVVVSLNYRLGALGFLSTAD-----------------ENSPGNYGILDQMMALRWVYDNIAAFNGDPGSITLFGPGAGAASAGILAIAPQTR----HMVARVIAQSGSVLADWAMIE-DKFRVQNTSVVFGRMLGCPTD-----------------------------------------------SSWRLLNCLRQ-GRSFYELGNA--EFQPQVG---FIPWGPFLAENVSLPGDEWYE-GWRSRDWALLPAAPAAMLQEGQFNPALRYMTGVTTQEAAYYL-------------------------YNNESLA---------PTYAVSEHWVDERVREL---VRRYNYTLNPRGVYEAVRYMYTHHPAPHCAAAARDQYIHLLSDFLYRAPTDRLVKLLLGRR-----------------VPVYMYVMNTTVE------ALRLDAWRQYPHD------IEWLFLTGAPFMDQEFFPNKYR----------LERQAWTNNDRNMSHFFMKAYTDFARFG--------------NPTRS-R-ILGIHFEMATEGQLRYLNLNTTFNS--------------------SIELNYRQTELAFWTVYLPTVIGRV----LPTYPPITEYWWEPKQPLQIAFWTVSSA-CLLLVALLVVC---CMLWRNAK------------RESDRYYADD-------------------VFVVPE-----AEDVGIDNTN--------RSRDNIYEYRDLPLKRPHT----P-QTISRSLS------QPQ---TMQSSNA--PSVAS-----------TGSAL-----SLRDSVSRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQPRT--------TMVRGIPQTTV-------------------------     =====>
bruma-a8nl88   	------------------------------------------------------------------------------------MDDLKALLWV-------GTVG------------------CL----------------IAERE------------------NGEPTRPINP---WN----EEATWYNGGS--ST----------------QFRKNDVLVR---LSIGNLVGQKVTV-NNVPWIPDHDPMEQIRKDWSYFEPNPIPPLNNVTVVTFLGIPYAEPPVSQRRF----------------KPPQLVTKLPGKQPFLALQHSPSCAQNVEARPTLFIN------------------DPYPFHISEDCLYLNIFTPST-----------------SLVS---RPVIVFFHGGNFQTGSSNEWPGHVLSSR-GIVVVTVNYRLGAFGFLSFGD-----------------AN-TGNYGFQDQRTALQFVQDHIASFGGDPRQVTIVGHDAGAVSVGLHMLSPFSK----NLFRAGAALSGAEISYHSTIG-KPTLAFNNTMKLGRYLGCTQS-----------------------------------------------VAEHVWDCILT--RSTNDIIQAAQTIPVEYN---RYLFLPHVDGRFIPAHPMVLLNS-----------FPT---AITSYPSAVPYLTGFNREDGSE-----------------------V--VLEDRLLGE---FN---DFILVDHEYLKNYVLEY---AFRHNYTTNREAVAEAIIDRYTYWPDASDKRAVMKEFIHMVTDAYYVAPISLSAHLHSAAG-----------------SRVFMYVNNYEFGRGS-S-QQLFPNWMTVCHD------CDLYLLFGFPFMSKDLLPK--H----------FENITWTDADRNASQLLTSIFRQFATYM--------------NPNIP----TDSSWLAFEPRRHWYLNFNYSLFSDFTK--------------PGTLERDYRWDSVSFWNIYIPSLVQYM----TTTFPSLEAKIRKEL---VIYQMSLGIVVCILFVILMLMCLFAYLLFERNP--KRIANE-LNHERLIHNVNQHF---------------LRQSSQE----------------------------S----CL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
caebe-g0m892   	-------------------------------------------------------------------------------------------MYL-------GTIF------------------HGLL----TL-----PLV-ISQF------------------IPPPTRPVNL---WD----PFETTTTPRP--S-G------------LNQGLNRDEVVVR---LPLGDIVGKEVHL-RDLPWTINKDPTEELPRDGTHFDPNPLKPKNNITVFTFLGVPYAEPPTSQRRF----------------KPPQKLTVFPGKQPFLAFNFAASCAQDVEKIPSPFVD------------------HPYPFIVDEDCLYLNIYSPDI-----------------SKNAPTTYPVIVFFHGGNFQTGSANDWPAHGLASR-GMVVVTVNYRLGAFGFMSLGD-----------------SD-TGNYGLQDQRLALEFVRDHIATFGGDPQAVTVIGHDAGAASIGYHMQSPYSR----HLFRSAATMSGADVSYHSYIG-KPALAFNNTVKLGRYVGCTET-----------------------------------------------VPQHMWDCILG--RSTNDIVQATLTIPIEYN---RYLFMPTVDGKELPGNPLWTLVN-----------APS---GETSILSPVPMLIGMNAQDGSE-----------------------V--VLEDRRLGE---YS---QFNDVDHEYLKSYALEY---CYRHNYSMNREATADAILSKYTFWPDRAAVWAIKENFIQFATDAYYTAPMQLSAHLHSASG-----------------SRVFQYVNNYNFSKQHPD-LQFIPDWMGVCRD------CDLYLMFGYPFLPDELRPI--G----------LRGINFTDMDRNASRTFSNIIRRFTYYQ--------------NPNFL----YDGSWAAYEPRRHWYMNFNYSHEEDWKV--------------PGIIGRDYRYQDVAFWNEYIPALVNYM----TTTFSPENVAYRREI---TVYKWITGVNVIIIALLIVLAGAFGYMVFGNRE--EEEAVYKAESHQLVDFRE-----------------------------------------------------------GGHSVSEVTI--S-S-R--TRSPRS-----R----------------VSNI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
caebr-a8xk46   	-------------------------------------------------------------------------------------------MFL-------GTRY------------------YGIF----IL-----PLV-ICQF------------------IPPPTRPVNL---WD----PFETTTTPRP--S-G------------LNQGLNRDEVVVR---LPLGDIVGKEVHL-RNLPWTIHKDPTEELPRDGTHFDPNPLRKNNNITVFTFLGVPYAEPPTSQRRF----------------KPPQQLTVFPGKQPFLAFNYAASCAQDVEKRPSPFVD------------------HPYPFTVDEDCLYLNIFSPDI-----------------SKNAPTTYPVIVFFHGGNFQTGSANEWPAHGLASR-GMVVVTVNYRLGAFGFMSLGD-----------------SD-TGNYGLQDQRLALEFVRDHIATFGGDPQAVTVIGHDAGAASIGLHMQSPKSR----HLFRSAATMSGAEVSYHSYIG-KPALAFNNTIKLGRYVGCSET-----------------------------------------------VPQNVWDCLMT--KATNDIVYATQTIPIEYN---RYLFMPTVDGNEVPANPLWTLMN-----------APS---GEVSIMSPVPLLIGMNAQDGSE-----------------------V--VLEDRRLGE---FS---QFNDVDHEYLKSYALEY---CYRHNYSMNREATADAIVSKYTFWPDRAAVWAIKENFIHFATDAYYTAPMQLSAHLHSASG-----------------SRVFQYVNNYNFSKQHPD-LSFIPDWMGVCRD------CDLYLMFGYPFLPDELRPL--G----------LRGINFTDMDRNASRTFSNIVRRFTYYQ--------------NPNFL----YDGSWVAYEPRRHWYMNFNYSHEEDWKV--------------PGTIARDYRYQDVAFWNEYIPALVNYM----TTTFSPENVAYRREI---IVYRWITGVNAIIIILLVVLAGAFGYMVFGHKE--EEDAVYKGESHQLVDFGI-------------------------------------------------------------RSVSDGTV--S-S-R--TRSPHS-----R----------------I--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
caeel-f55d10.3 	-------------------------------------------------------------------------------------------MFT-------GTIF------------------NSLF----TL-----PLV-ISQF------------------VPPPTRPVDL---WD----PFKTTTTPFP--HGG------------VNQGLNRDEVVVR---LPLGDIVGKEVHL-HNLPWTIHKDPTEELPKDGTHFDPNPLKPKNNITVFTFLGVPYAEPPTSQRRF----------------KPPQQLTVFPGKQPYLAFNYAASCAQDVEKSPSPFVD------------------HPYPFMVDEDCLYLNIFSPDI-----------------SKNAQTTYPVIVFFHGGNFQTGSANEWPAHGLASR-GMVVVTVNYRLGAFGFMSMGD-----------------SE-TGNYGLQDQRLALEFVKNNIVTFGGDPQAVTVVGHDAGAASIGFHMQSPYSR----HLFRSAATMSGAEVSYHSYIG-KTALAFNNTMKLGRYAGCTQA-----------------------------------------------VAQHRWDCILT--RSTGDIIDATRNIPIEYN---RYLFMPTVDGKYLPGNPLWTLVN-----------APS---GETSIMSPVPMLIGMNAQDGSE-----------------------V--VLEDRRLGE---FS---QFNDVDHEYLKSYSLEY---CYRHNYSMNREATADAILSKYTFWPDRAAAWAIKENFIQFATDAYYTAPMQLSSHLHSSSG-----------------SRVFQYVNNYNFSRQHPN-LLFIPDWMGVCRD------CDLYLMFGYPFLPDELRPI--G----------LRGINFTDTDRNASRTFSNIIRRFSYHQ--------------NPNFQ----FDGSWAAYEPRRHWYINFNYTHEEDWKI--------------PGTLARDYRYQDVAFWNEYIPALVNYM----TTTFSPENVAYRREI---MVFKWITGVNVIIIALLIVLAGAFGYMVWGNKE--DEEAAYKAENHQLVEYRD-----------------------------------------------------------TGHSVSDATI--S-S-R--TRSPRS-----R----------------ITNL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
caeja-h2wj36   	-------------------------------------------------------------------------------------------MVI-------NTIN------------------YCVF----LL-----PLAISSQF------------------IPPPTRPVNL---WD----PFETTTTPLP--P-G------------TNQGLNPDEVVVR---LPLGDIVGKEVRI-HNLPWTIHKDPTEELPKDGTHFDPNPLKPNNTVTVFTFLGVPYAEPPTSQRRFKVRLSGKIILIKRAIFQPPQQLTVFPGKQPFLAFNYAASCAQDVEKAPSPFID------------------RPYPFTVDEDCLYLNIFSPDVSFDVISTISKCIPSFQISKNAPTTFPVIVFFHGGNFQTGSANEWPAHGLASR-GMVVVTVNYRLGSFGFMSLGD-----------------SE-SGNYGLQDQRLALEFVKNHIATFGGDPQAITVIGHDAGAASIGFHMQSPYSR----NLFRSAATMSGAEVSYHSYIG-KPALAFNNTMKLGRYLGCTQS-----------------------------------------------VPEHVWDCILT--RSTTDIVYATTTAPVEYN---RYLFMPTVDGKYLPGNPLWTLMN-----------APS---GETSILSPVPMLIGMNAQDGSE-----------------------V--VLEDRRLGE---FS---QFNDVDQEYMKSYTIEY---CFRHNYSMNREATAEAILSKYTFWPDRAAVWAIKENFIQLATDAYYTAPMQLSAHLHSASG-----------------SRVFQYVNNYNFSRQHPD-LQFIPDWMGVCRD------CDLYLMFGYPFLPDELRPL--N----------LRGVNFTDMDRNASRTFSNIVRRFTYYQ--------------NPNFL----YDGSWVAYEPRRHWYNNFNYSHNEDWKV--------------PGTIGRDYRYPDVAFWNEYIPALVNYM----TTTFSPENVAYRREI---TVFKWITGFNVIFIALLIVLAASCGYMVWGNHE--EED-AIKVERHELVGYRD-----------------------------------------------------------NGNPLSDGTM--S-T-RSATRSPRS-----R----------------MMNA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
caere-e3lec6   	-------------------------------------------------------------------------------------------MFL-------GTIF------------------HGLF----TI-----PLV-ISQF------------------IPPPTRPVNL---WD----PFETTTTPRP--S-G------------LNQGLNRDEVVVR---LPLGDIVGKEVHL-HNLPWTIHKDPTEELPRDGTHFDPNPLKPNNTVTVFTFLGVPYAEPPTSQRRF----------------KPPQQLTTFPGKPPFLAFNYAASCAQDVEKAPSPFVD------------------HPYPFMVDEDCLYLNIFSPDI-----------------SKNAPTTYPVIVFFHGGNFQTGSANEWPAHGLASR-GMVVVTVNYRLGAFGFMSFGD-----------------SE-TGNYGLQDQRLALQFVKDHIATFGGDPQAITVVGHDAGAASIGYHMQAPQSR----HLFRSAATMSGADVSYHSYIG-KPALAFNNTMKLGHYVGCTET-----------------------------------------------VPQNMWNCILT--RSTNDIVYATQNVPIEYN---RYLFMPTVDGNHLPGNPLWTLVN-----------APS---GETSIMSPVPMLIGMNAQDGSE-----------------------V--VLEDRRLGE---FS---QFNDVDHEYLKSYSLEY---CYRHNYSMNREATADAILSKYTFWPDRAAVWAIKENFIQFATDAYYTAPMQLSAHLHSASG-----------------SRVFQYVNNYNFSKQHPD-LKFIPDWMGVCRD------CDLYLMFGYPFLPDELRPI--G----------LRGVNFTDMDRNASRTFSNIIRRFTYYQ--------------NPNFL----YDGSWVAYEPRRHWYMNFNYSHEEDWKV--------------PGTIARDYRYQDVAFWNEYIPALVNYM----TTTFSPENVAYRREI---TVFKWITGVNVIIIALLIVLAGAFGYMVFGNNE--EAAAADKVENHQLVGYST------------------------------------------------------------------SDV--S-S-R--TRSPRS-----R----------------ISNV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
closi-h2kvp1   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGTYIGSSVPVNYDYTW-------SE------------WPPQKGRLVNMFLGIPYAAPPTGDRRFRVSLNLFLQLVQ---VPVPAY---LDTRYPWYAKFYRPACVQPSDLLSTFI---------------------TNFTDISEDCLYLNIFTPNR----------------TWEDPKVRYPVVVHIHGGRFVYGSSHMCPGHVLASK-GVVVVTFNYRLGPFGFLATGD-----------------FASIGNFGLWDQLLAMRWVKDNIAWFRGNPDQITLMGDGAGGASVGLHTVSPSSR--GLDLFQRVVLMSGSDLSPWAVSNPDELRTRYYAIELGRQLGCPSVLGADVGASQSAMAGEPWKPASASEVPQGEFGNSSVKLRLTVPYYTRIDSNALVRCLRL-SKSAEEIVRASKLLRPLRG-ATPYIWTPVVDGTA-----------------GFLPRTPLDERRLGRFA-KVPVLAGVVHDEGSSTLLRRISQWE---------------------------------SHVYPVDEFTDAVARRTIGNIVNYENVFRFNATTEELYTRYTWWPNLANNTARWERMVALISDYEINSPLENVVGFHSAYS-----------------NKVYFYEFAYLSP----NDTE-LQPQKGVYHG------ALLPFLFGFPFMNSTFWSTVYGE---SAIPNPANRPFFYPHDTNMSEFLMDLWTNFAKME--------------NPTPYE--IKNTTWRPYKLPEGGYLFIY--LNS--------------------TMRYKFRPLEMAFWRQRFLGLAEIV-----PPSPPL---YYFPLFGSQIATVILGCLVSTVLILLLTLI---GLICRRPK--------------PDQFLHEVRLATPGAALGSAFQTAFKDAFSTRDVPA-------MNNSDV--------------DW-----------------GSGSSMD-----------------------DLEL-----E----SRISH-----SASQH----------------------------------------------------------SRGRLLAP---AGHT--T-----G--------RSRKHPPPPPIPLHGIPKGSA------ISTSRRGQSPAVGYTGGRRFSDY------SYNGPRTFT--MDL------------------------------------------------------------------     =====>
culqu-b0w0b8   	------------------------------------------------------------MQFPSLIY--ADGFVYGLHAGSGFMDDQRALLDPTVLGFWEPFTDK----ANLSHQFELGPTLIETYTYNNRRYGYYQP-SGYGQQYPG------QNLPGQYP---QNTGLGEDRFKYDPA-NP-NNVQTPFPGVLGGWREDLQGKQRRDWQQL--DRDVHVT---TNYGQVQGFKVHL-YDSPD-----PKSFYRPW-----HS-PVDRIMGTCATFLGIPYALPPTFEGRF----------------KPPRQ---HRGWQLLQAVDYGPACPQPVQYTGAT----------------------KGIRDMDEDCLYLNVFSPNT-----------------QSGIAQKYPVMIYIHGGEFVRGASNTFPGQMLAAFYEVVVVTFNYRLGALGFLSTGD-----------------ENSPGNYGILDQIMAVRWVYDNIEAFNGDRNSITLFGPGAGGASAGLLMVAPQTK----DIITRVIAQSGSAVADWALIV-DKYRAQNTSRVFGQMVGCSIE-----------------------------------------------TSWKLVNCMRQ-GRSFYELGNA--EFAPHVG---LFPWGPVLDINFTFPGDEWYE-GWRERDWHFLRETPEELIRRGHYNRGLHYMSGVTLQEAAFVI-------------------------SQNETLA---------PYFEVDQKFFEQKVWEL---VYRYNYTINLNGTYEAIKYMYTYWPDPKNTTFIREQYINLLSDFLYRAPADKMTKLLVERK-----------------VPVYSYVMNTTIE------GLKLPEWRKVPHD------IEHYLLTGAPFMDVEFFPKKAR----------LDRLMWTDNDRNMSHFFMKTYSDFARYG--------------NPTPQ-Q-VLGLHFEKAINGELRYLNLNTTYNS--------------------SIMMNFRQTESAFWTQYIPTVVGVL----VPTYPPTTEFWWEPTEPLQIAFWSMSAA-CLFLIVLVVIC---CILWRNAK------------RQSDRFYDEG-------------------VFVVDN-PESERGDVGIDNNVLQ-AQPLR---QNIYEYRDSPSKYGK---HPP-PTDTGSIR------SPSSLGTMHTTGK--S-ISGS-----QSSLRSAISM-----KEVSVSP---------------------------APRSE-TNFDRNIRYAERGVDTEVQKN--GGGKYQRSDSKGTLN--D-----KARE-FATST----------P---------------IEPVSRSQQPTPQPTT--------------------------------GRGSRAGFDRSNNASRT--------NLIEGIPQTEV-------------------------     =====>
danpl-g6dsv4   	------------------------------------------------------------MFTRVFITVVFCVNVNSQSNKD--------LY-NGQFNNEYY----GAQNKQRSRLPSPGDTDYRTYVYNSRRYGTDPS-R-YNPYNPN------INQPGGFPYNPIDTNPLDEQFKYNTNRDP-NNPDALFPGVLGGWREDLQGKERRDSRQL--KRDIFVN---TNYGQVQGFKVYL-YDNPD-----PNSGYRPW-----LT-PVERIQGEVSVFLGIPYARPPVLEGRF----------------KPPRQ---HPGWQLLQAVDWGPACPQPVRYTGAT----------------------KGIRDMDEDCLYLNIFSPNT----------------EAGATAQRYPVMVYIHGGQFSSGASNLFPAHVLAAFYNVVVVSINYRLGALGFLSTAD-----------------ENSPGNYGILDQVMALRWVRDNIGPFNGDASSITLFGPGAGAASAGLLAVAPQTR----DIVSRVIAQSGSALADWAQIQ-DKFRVQNTSLVFGRLLGCPID-----------------------------------------------SSWKLVNCLKQ-GRSFYELGNA--EFQPQVG---FIPWGPVLEDNFTFPGDEWYE-GWRARDWRFLDSTPETLLKQRRYSPNFRYMTGVTTQEAAYVL-------------------------YKNESLA---------PSYTIDERWFIQKVNEL---VLRYNYTLNPRGVFEAVRYMYTYHPEPHNASAIRDQYIHLLSDFLYRAPTDKMVKLLLENK-----------------VPVYMYVLNTTVE------AFSWPEWRRYSHD------TEHFFLTGAPFMDQEFFPWSQR----------LDRQAWTPNDRNMSHFFMKAFSDFARYG--------------NPTRS-R-ILGLHFEVAEAGQLRYLNLNTTYNS--------------------SIQLNYRQTELAFWTVYLPTVIGRL----VPTYPPITEYWWEPKQPLQIAFWSVSSA-CLVLIVLLVVC---CMLWRNSK------------RESDRFYDGD-------------------IFMVPE-----VEESGIDNNT--------RSRDNIYEYRDTPLKSPAT----P-QTFTRTIS------HPA---TLQSSAT--SEVSS-----------SCLSL-----KEPPKVAPR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PASRT--------QMVRGVPQTTV-------------------------     =====>
dappu-e9h7w9   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGTCRPDYASNVQERDISVT---TPYGRIRGFYVHL-FDGPG-----VPIGDRPG-----VY-HNGKLWRRISTFLGIPYATPPVNEGRF----------------KPPRP---KRAWSIWDAIDFGPACPQPVQYVGAS----------------------KGVRYMNEDCLYLNVFTPTT------------------GAVPEKYPVVFYIHGGDFERGASNTFPGHMLAAVGDVVVVTVNYRLGALGFLSTAN-----------------EYSPGNYGMLDLTMALQWVYDNIYAFNGNKDLITVYGPGAGAAAAGLLAITPGSS----HMVRQVFGQSGSPLADWAAVQ-DLLRVQNTSRVYGERLGCLVD-----------------------------------------------QSHKLIECLR--SR