ESTHER Database

Home
Search
Tools
Families
Biological
data
Basics on AChE
ESTHER definition
What is up?
Acknowledgments
& disclaimer


MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....790..5....800..5....810..5....820..5....830..5....840..5....850..5....860..5....870..5....880..5....890..5....900..5....910..5....920..5....930..5....940..5....950..5....960..5....970..5....980..5....990..5....1000.5....1010.5....1020.5....1030.5....1040.5....1050.5....1060.5....1070.5....1080.5....1090.5....1100.5....1110.5....1120.5....1130.5....1140.5....1150.5....1160.5....1170.5....1180.5....1190.5....1200.5....1210.5....1220.5....1230.5....1240.5....1250.5....1260.5....1270.5....1280.5....1290.5....1300.5....1310.5....1320.5....1330.5....1340.5....1350.5....1360.5....1370.5....1380.5....1390.5....1400.5....1410.5....1420.5....1430.5....1440.5....1450.5....1460.5....1470.5....1480.5....1490.5....1500.5....1510.5....1520.5....1530.5....1540.5....1550.5....1560.5....1570.5....1580.5....1590.5....1600.5....1610.5....1620.5....1630.5....1640.5....1650.5....1660.5....1670.5....1680.5....1690.5....1700.5....1710.5....1720.5....1730.5....1740.5....1750.5....1760.5....1770.5....1780.5....1790.5....1800.5....1810.5....1820.5....1830.5....1840.5....1850.5....1860.5....1870.5....1880.5....1890.5....1900.5....1910.5....1920.5....1930.5....1940.5....1950.5....1960.5....1970.5....1980.5....1990.5....2000.5....2010.5....2020.5....2030.5....2040.5....2050.5....2060.5....2070.5....2080.5....2090.5....2100.5....2110.5....2120.5....2130.5....2140.5....2150.5....2160.5....2170.5....2180.5....2190.5....2200.5....2210.5....2220.5....2230.5....2240.5....2250.5....2260.5....2270.5....2280.5....2290.5....2300.5....2310.5....2320.5....2330.5....2340.5....2350.5....2360.5....2370.5....2380.5....2390.5....2400.5....2410.5....2420.5....2430.5....2440.5....2450.5....2460.5....2470.5....2480.5....2490.5....2500.5....2510.5....2520.5....2530.5....2540.5....2550.5....2560.5....2570.5....2580.5....2590.5....2600.5....2610.5....2620.5....2630.5....2640.5....2650.5....2660.5....2670.5....2680.5....2690.5....2700.5....2710.5....2720.5....2730.5....2740.5....2750.5....2760.5....2770.5....2780.5....2790.5....2800.5....2810.5....2820.5....2830.5....2840.5....2850.5....2860.5....2870.5....2880.5....2890.5....2900.5....2910.5....2920.5....2930.5....2940.5....2950.5....2960.5....
9cucu-a8ikt2   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLR-I-------------------------------------------------------------------------------------------------------RARYPGILWRFGGGFINGSNK-SI-------------V-------------------------------------------------Y-G-PE-YLIT-------E-D-V-VIVAMNYRLGFL----------------------GFLHL----NDQWLDVPGNAGLKDQQLA-----------------------------------LKWVQ-KNIKHFNGDPDN------VTIFGESAGS-ASVHYQVVSPS-S-E--G----------LFHR-------AIMQSGSL-HN-P-W-P-Y----SQ------------D-VGLEFARLV---KED--VA-----------------------------------------D-E---KE-ALE-----VLTSLPANDLFL-Y---QEKFLQS-----R-------------------G--GGLGI-VGPTVE---------------YP-------NDTAFVT-S-PPVELI-TNG----FY-NK-V-PILLGYTDRDGLLFEA----LKK--------------------------------------------------------MRE-----N--SEQK--SES--GSPMS-----LESLVH--PHM-----GLDK------D------DP----K-REIIAKK-YAEFYFQGD-NA---------------------------------------------------------------------------KDKVMILT----D----HI-FFAGI-----FA--------SSIHHAR-T---------------------------S-G--Q-PVHLYRMSIDAG--LNVF-KKFTKL----------------------------------------DEPG----ACHGDDIGYLFTTILG------K--------DS-VEIGPVEEKAMRSFVKLWTDFA------R-----YG--N--PTPEG--------------------------------------------------------SS---LN------------VT-WEPFE--E---I----------------EQNYLDIGE-T----------LT--PLKK--P---------------------------EE----------ER-------------------------------------V-NF-------------------WR----EIFKLSPLTENY--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9cucu-q5wm35   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRVVP------------------L----AILLTSCQ----------------------------------------AES--------IVELPNLGK-VE--G--W----LSTWN-----------G-QRV------------HRFAGIPY-AQP-----------P---VGENRFE--------EPKP-VE---P-WE------G-VWKPS-------T--T--YKCMQF-N-GQP-----TE-----GQ------DYV---TGE-ENC--------LYLTIYTAYLNV-------------------------------------------------------------------------------------------------------------SFDVVVYIHGGAFTSGYGS-F----------------------------------------------------------------Y-Q-PD-YFID-------K-D-I-VFVNLNYRLGPL----------------------GFLST----EDSI--VPGNNGLKDQILA-----------------------------------LKFIK-KYIRYFGGNPDS------ITILGD---G-ASVNFHYLSPQ-S-R--G----------LFHR-------GWSMSGTM-LV-P-W-A-L----MEQ-------P---LARTKKLATLV---GCV--TDE-----------------------------------------------K-MIK-----CLKSRPARQIAL-A---VSHF----------QAWW--------------Y--LPFAQ-FGPVIDSW-----------A---T-Q-------PVLP-T-HPYQLI-KSK----QV-YD-V-PWIASFTKSEGLYRIN-----EI-----------------------Y---------------------------------SD-----P--L------LS--DLDER-----WNRYIP--PIL-----YYNYT---VDP------------NLQDEVSQK-IRKHYLREK--KLSK----KTFRELV-----------------------------------------------------------------AMFS----D----RI-FINDI-----VK--------TAKLMSQ-S------------------------L----K--S-PTYALKFEYRSM--NSWF-EHE-----------------------------------TE-S---GRNFG----AAHDDDVPYIF-NMGP--FD--------------TSRSHRDRAMVKIYVDLLASYS------H-----TS--I--PKVKR--------------------------------------------------------I-------------------H-WPQVPK-NDTD-----------------DLTFLKIVSP-----------TD---VTV--ET--------------------------------------S----------------------------------IQGSA-SF-------------------WD----SLPIKEN----------E-KLP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9cucu-q5zex5   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNPIVTT-EQ--G--K----LLGKI-CTN---ING---EEF------------CSFQGIPY-AQP-----------P---VEHLRFK--------APQP---P-KP-WT------G-IRDAL-------N--E-GNKCYSK-D-LLFN-----------LP-------A----QGS-ENC--------LFLNVYTPKN-----G-------------------------------------------------------------------------------------------------------TNLKPVMVWIHGGGFKTGSSE-TD-------------L-------------------------------------------------H-G-PE-YLMT-------E-D-V-VLVTLNYRLGIL----------------------GFLRF----EDQSLGVPGNAGLKDMVMA-----------------------------------LKWVQ-TNIKYFSGNPNN------VTIFGESAGA-AAVHYLVLSPL-A-K--G----------LFHR-------AIAQSGCA-LN-G-F-A-R----GI------------PDTSKQLAAAL---GMQ--TA-----------------------------------------N-E---KE-IFE-----QLSIVPVDKLLR-I---SEEVANI------WGL----------------K-----------KVYA--------------PV-------VDGEFLT-D-EPIAII-KSG----NY-NH-V-PMIFGYTTREGMIIEM----MRK--------------------------------------------------------NET---------P----------GMPN-----DFEEFV--HPT-----VAKR------G------SI----T-SKNIAKK-IKDFYYEGP-NS--E--ND-------------------------------------------------------------------LDNFYLIHT----D----TY-FLRDI-----IF--------AIRQHTV-T---------------------------A-K--F-PIYLYRMSVETK--LNVF-KRIGNI----------------------------------------RAPG----VCHGDDIGYLFKTKLS------P---------E-LKTGSLEEISMKRFVKFWTTFA------R-----SG--S--PSADG---------------------------------------------------------------------------PE-WKPIN--K---K----------------EINFIDIGE-N----------IT--VGVN--P---------------------------EP----------ER-------------------------------------M-KV-------------------WA----DIYNSNPLFTQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9dipt-aes05    	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSESLESCEISL-PV--G--Q----IRGVKRRSLY------DD-DY------------YSFERLPF-GKP-----------P---VGELRFK--------APVPVE----P-WS------G-VLDCT-------H--F-AEKPVQK-GLL---------------------TGII---EGS-EDC--------LYLNVYAKQLKSA-----------------------------------------------------------------------------------------------------------KPLPVMVYIYGGAFSIGEATRD--------------------------------------------------------------I-Y-S-PD-YFMA-------K-D-V-VLVTLNYRVDCL----------------------GFLSL----KDPSLEVPGNAGLKDQVLA-----------------------------------IKWVN-QYISYFNGDVNN------ITVFGESAGG-CSTHYMMCTEQ-T-R--G----------LFHK-------AIPMSGTL-HN-Y-W-S-N----TP-P----------ADFAYRLAKGN---GYEGEN-N----------------------------------------------DRQVLD-----YLRTVPAEQLVN------HSLLTP------EDRRT-------------G----LIYA-FGPTGEPY-----------V----------MVDCVAP-K-PQLEMV-RNA-----W-SNKL-PAMLGGTSFEGLFMYPALKAN-----------------------------------------------------------PK-----G---------MD--SLPQ-----DLLRLTP--YEV-----RVLN-------------T-E---QQNLESSKK-MKQLYFGDD---T-P------------------------------------------------------------------SS-KLIMNFMDYYS----Y----RI-FWHGF-----HR--------TLQARLA-Y--------------------------A--T---APTYFYRFDFDSP-GFNF-YRKKF-C--------------------------------GD-----DIKQG----VAHADELSYLFRNSE-------SW---------KLDKASAEYRTIQRLVDIWTSFA------A-----TS--N--PNCAE---T---------------------------------------------------------------------AHLD-WQPAK--Q------------------EQPQRVLNIGK-E----------VE--LIDL----------------------------------------------------------------------------PEYDKL-LV-------------------WD----SLYKKEHLF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9euca-f5a5q6   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKLLF--LCVAI--------------------------------A----TWLGVS-----AGEEVPV-VST-EE--G--I----VSGIE-EKA----V-NG-DAF------------YSYYGIPY-ATP-----------P---TGELRFK--------DPTP---LAKG-WE------G-VRNGS-------T--M-PSPCIQV-R-LGAVLMGMNI-----PP-----E-YL---DGK-EDC--------LFLNVFKPKAAT----------------------------------------------------------------------------------------------------------SKGDLPVMVFIHGGGYFAGAA----------------------------------------------------------------DE-Y-L-PH-VLLS-------K-D-V-ILVVIQYRLGFL----------------------GFLST----EDS--VIPGNYGLKDQTLA-----------------------------------LQWVQ-RNIQNFGGDPKR------VTIFGESAGG-ASVHFQVLSPK-A-E--G----------LFSG-------AIMQSGNA-FC-P-W-A-H----AGE-------L---SKVAKEIGDLL---GCS--LE-----------------------------------------EGS---QV-YLK-----CMQSVNANKINA-V---MQDL----------PK---------------FI--AFPLV-AVPRID--------------------------GDFLP-D-HPIRLM-QDG----RY-NK-V-NIMAGVTANEGAIFTH----PM--------------------------------------------------------YARE-----D--L------IP--ALVNN-----FDVNGP--YSL-----QWYS----------------SD-SDHGKLTDL-VYNNYLGGV-H-L-D-RDH-------------------------------------------------------------------ADDLTQMMS----D----RH-FNVGH-----DL--------FSKLHAG-Q----------------------------EG--V-STFRYELVHRGQ--MSVG-DFMAV-------------------------------------D--VGNYW----VSHGDELYYLFRGGPL-----LQPLQKPSE-EPRDLDEEDDLRLRNIILTLWTNFA------A-----TG--H--PTSD-------------------------------------------------------------ES---------L---GFLWSATTP-D--------------------DLLHLALSP-T----------PT--MASD--AR---------------------------K----------EV-------------------------------------R-KF-------------------FS----SLPTKDNRLLNPHLVEEV-NSST-SRANQDEL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9euca-f5a5q7   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK--LLFLH-----AIA--FGFQLIVCA----------------------------------------G----------ELEAPVIST-EE--G--N----VAGVV---EEA-S--NG-KPF------------HSYYGIPY-ATP-----------P---VGELRFK--------DPVP-AN---K-WK------G-VRDGS-------S--M-PSPCPEV-P-YGAAVMGIKL-----TA------KEL---PGK-EDC--------LYLNVFKPKAAQ---------------------------------------------------------------------------------------------------------PSEGDFPVMVYIHGGGYFAGGAE-E----------------------------------------------------------------Y-L-PH-VLMS-------K-D-I-ILVVIQYRLGFL----------------------GFLST----EDSV--MPGNYGLKDQTLA-----------------------------------LQWVQ-KNIQNFGGDPKR------VTIFGESAGS-ASVHYHMLSPK-T-K--G----------LFSG-------AIMQSGSA-FA-S-W-A-S----SKE-------H---KKTAKKVGSLV---GCN--LEE--------------------------------------G----------------------SQPSQVMH-C---DRAR-S--M-----APEL-------------------SSV-ILPSCSPE-----------SN-E-------------T-LPDDQLEY-AVR----RY-NR-G-QTMIGVTANEGAALTQ-----PL-----------------------Y--------------------------------------------------GV--RRNLM-----SELEKG--YPV-----LGP-LS--IEN-----SLND---NDSLRLANH-IYNYYLG-G--VNLD---IEHAEDM-----------------------------------------------------------------TKMIS----D----VH-FNLGF-----DL--------VSQLHSR-A------------------------T------GE-STFRYELGHRGQ--MSFG-DF-----------------------------TTV----DV-----GRHWV-----PHVDDLYYLFRGGPM--LTPVEQPPE----RPTDLEAPEDLAVRNFMVTLWTNFA------A-----HG--H--PTPDK--------------------------------------------------------S-----L--------G---FV-WEATNP-DNLR--------------------HLALT-------------PN--PSMK--GD--------------------------------------AR-------------------------------------K-EV-------------------RR----FLLSLPT---------ET-NLIL------------------------------------------------------------------------------------------------------------N-------PN--L-------ITENTFRTGS----------KRRN---------------QD-----------EL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hemi-a3exl9   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLST----EDEV--IPGNYGLKDTVAV-----------------------------------LRWVQ-EYIDAFGGDKNR------VTVLGGSSGA-ESAGLLLISPL-A-E--G----------LFHR-------VISQSGN-----P-L-T-L----EDRN-----VA---KFRAWKLASLV---GCD--DET--------------------------------------VTNS----EA-LLN-----CLKAIPAKKLVE-N---NLKF----------YTFG-------------HV--LPFVP-LGPVIEN-------------EKVP-G-------AFLV-D-EPRKL---IG----RK-TD-I-PWIVGMNSADGGMITI-----FT-----------------------Y--------------------------------FTP-----ELTV------IE--EFDKN-----YKKYFP--IIF-----QYG-IY--A--------KNS---EEVDRLTEK-IKNYYFGDK--RIKE---NP-------------------------------------------------------------------HGFTKMFT----C----LG-YLPGI-----KE--------MM----K-L------------------------Y----Q--G-PKYVYYYDHRNK--DTFG-HMY--A------------------------EYE-------------GDMG----VIRGDELISMFNWTEV--ITPV--------------TEGVDYVVSKQVIKLWTNFA------A-----KG--D--PNTDG--------------------------------------------------------E------------------EL-WRPVD---------------------SPDINYLHI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hemi-e5fqv0   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAL------------------------------------------------------------------------------------KLAVI------------------NLVW-----SV------VLIF-----------------------------------------PNFSA-----SHNTAPVVHDT-AS--G--D----VTGKW-WTI----APNR-T-I------------EAYLGIPY-AKP-----------P---VGPRRFK--------DPEP---F-GK-WI------GV-YDGT-------K--E-PTRCLQI-N-AFLP-----------EK-------TV---EGS-EDC--------LYLNVYTPSHSS-----------------------------------------------------------------------------------------------------------PAGYPVMVFIHGGGFVDGSAT-SD-------------I-------------------------------------------------Y-G-PE-KLLI-------K-D-I-ILVTLHYRLGFL----------------------GFASL----DDK--DFAGNYGLKDQSLA-----------------------------------LKWVK-NNIAKFGGDANK------ITLVGESAGA-ASAHYQVLSKH-S-Q--D----------LFQQ-------AILMSGTA-DC-P-W-A-V----S--------KPHQNGNLTAKMANFV---NCS--VDD----------------------------------------S-T---TE-LLE-----CLRKVDATEFLK-H---NKKFQ---TVWNGSFV--------------------PIVI-FRPVLES--------------SF-------DNSFMTY-E-A--------H----RA-PAPK-PMMIGVTSAEGALVLE----LLK--------------------------------------------------------SDK-----T--KR-VGEALS--ELDKR-----FLEIIP--VEG-----DFY-------E------EQ----F-PEKKAAS-IREKYFGNL-T-ISN--ET-------------------------------------------------------------------MPQLIKLYS----D----IY-FLNGT-----K-----------ETIKR-H-----------------------------R--G-VKYLYKFGYEGS--FSIS-QLISGD---------------------------------L-T----SKNG----ACHADDLLYLFPMKPF------VAK------RV-GNETDKDKEISAKMVDLVTNYV------I-----EG--N--PNSKS--------------------------------------------------------K--------------P---NI-WTTSTE-D---------------------MDFLSISP-E----------GNFEMKKH-FP---------------------------DA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hemi-e5fqv1   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVG--QRL-L-----VLVVM-----S-----CSATAA------IG-GSEE-------------AIGGTRGGSS-------EDGG-DQQCP----ILNIPEL---G--S----LCGTT-DTS----AWSN-ITL------------YNYQNIPY-ALP-----------P---SGHRRFK--------PPEPAH----P-WN------G-VLDAT------KF----GKKCPQA-NTEKELKDLR------------TRINSG---EDV-GDC--------LTLNVYTPVAPGK-------------------------------------------------------------------------------------------------------CDKHNLLSVMFYIHGGSFRVGSAHD---------------------------------------------------------------F-RPN-Y--LLDE-------G-D-I-VLIVPQYRLGPL----------------------GFLSL----QT--DELPGDMGFMDMVLA-----------------------------------LKWTQ-KYIKYFCGDSSR------VTLFGQSAGG-AAVTLMMASPL-V-TP-D----------MFQR-------VIVQSGSS-LC-D-W-A-L----DR----------DPVEHAKRIAELA---NCT---D--------------------------------------E--N-R---DE-LAL-----CLHRTNTWELLVA---------H------SDFLTEVLV-----TEGQAVK--GNNGG-NHAVIQ-Q----------AGP-----------NSFLI-E-DPHVLF-KEG----RY-RH-V-PMMAGITKHEGSFFLGNIYD----------------------------F-------------------I---------LVRD-----N---------VT-NDTEYL-----KKEFIK--DTL-----QFSG------ID-----------GTTGAITDI-FQDKYFK---------------------------------------------------------------------DDEVGNFTAMIPGLIDICG----V----TL-LKACL-----LQ--------QIRHNWQ-------------------------------L--Q-PSYLYSFNYKGH--LTKF-GYGEE---------------------------------VN-Y---PFGGG----VAHSDDLLYLFPHT-------------------KGELYPHEVEVAKTVVGLWTSFS------K-----DG--Q--PYV---------------------------------------------------------------ND-----------DVE-WLPMSS-A--NG------------------PYLRIEKT-----------SR--LKDH--FM---------------------------------E----EF-NITIT-------------E------------G-------Y-------------------PG----NSENRTSDGQN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQ-----TYKVGLLLSILF---TCLRSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hemi-e5fqv3   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQCSN-F--F--MVIVF-----VF-------IGQIDE---------HEVQ-------------------------VQAYR-----LDKRDCVVQDS-NQ--N--K----YIGLK-KRS----MLNK-VPF------------CSYQGIPY-AEP-----------P---TGNRRFK--------DPIA---V-EP-WG------E-ERDAR-------V--E-GSECMQI-E-PLFS-----------MG-------KV---IGS-EDC--------LYLNVYTQHRSNA-SH------------------------------------------------------------------------------------------------------PPKLKAVMVWIHGGGFVFGSGS-GS-------------I-------------------------------------------------Y-G-PD-FLID-------H-N-I-VLVTFNYRLGAF----------------------GFLNL----RN--KDVPGNAGLKDQVLV-----------------------------------LKWVQ-KNIQSFGGDPNS------VTLFGESAGA-SSIQLHLMSGS-S-T--G----------LFHR-------VIMQSGSV-YC-P-W-T-F----VR-------D---PLARANQLANHL---KLN--ST-----------------------------------------D-P---CK-LVQ-----VLRNVSSYQLTV-T---QSELM---K---TEDM---------------DR--GFYFP-FIPSTEL--------------TG-------TGTNFIT-E-HPDLLL-KSG----RL-MK-V-PTIVGVNSREGIMVLL----GKN--------------------------------------------------------AT----------PEV---LE--TVDKN-----FQRVVP--DIL-----NLTP------N------ST----K-FKEVTDK-IKRFYFRGG-Q-LSW--DS-------------------------------------------------------------------LENYVDLMG----D----IY-FVAPI-----YR--------SMMNMIK-K---------------------------S-P--E-PVYCYEFAFEGS--RGLA-KALTIAALP----------------------------NV--A----NISG----VSHYDDIAYLFPVAIQ------GWEQ------E-IVSSSMDRKTIDRLTMLWTNFA------K-----TG--N--PNGSG--------------------------------------------------------F------------------SL-WDPHHP-S---R-----------------ERYLYIGN-D----------LE--VRHRL-F---------------------------FQ----------HR-------------------------------------M-NF-------------------WK----DIYDNHSNNTEV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hemi-e5fqv4   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---FI------------------------------------------------------------------P---FNIVDILLLFISCGFSEIL----DY----DQT-----S--------LVVKL----------------------------------------NEGS-----------------VR--G--K----LITTW---RG------K-NVR------------A-FLGMPY-AKP-----------P---IGNLRFK--------DPE-DVE---S-WD------G-IRSAL-------A--D-GSLCTQT-K-G--------------EN--------I---IGE-EDC--------LFINVF----VP--------------------------------------------------------------------------------------------------------KTAKTNLPVLFYIHGGFLAFGSSN--S------------------------------------------------------------KD-L-G-PE-ILLD-------YCD-C-ILVTMNYRLSVL----------------------GFLSI----DDAE--ARGNFGFKDQVAA-----------------------------------LRWVN-RNIQHFGGDCNQ------VTLFGHSAGS-TSVGYHLHSDM-S-R--G----------LFHR-------AILASSAM-DS-H-R-A-T-----SAK-----FA---KDNTLKLAGHL---NCP--TSDE----------------------------------------A----SV-IMK-----CLREKSVKDIYD-N------LKH--------FRVF-------------GN--EPLLV-FRPTLEND-----------CG--E-K-------CFIT-E-DSV------K----SR-SS-V-PLLVGYTSED--GYI-VSE--TI-----------------------M--------------------------------KKP-----E--I------IA--AINKK-----FDDIIP--VVL-----RYDQF-------------ED-----KTKMTKA-IKKYYLENS--NIHP--G-------------------------------------------------------------------NFIKFTHMCG----D----VM-YW--R-----AM--------LKELIDH-D------------------------G----P--A-MVY----YY--T--HRGT-LTY-----------------------------------LR-D---KTLEG----VAHGDHQLLIFPYQSQ------------------FGEH--RITSTSA---V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hemi-e5fqv5   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSPH-------FLFVC-----L-----CFSVLL------TAVSSGR-------------AIKEERIFKD-------I----ERNVS----VYVVTTH---G--K----FVGKF-YR-----GHNS-RFY------------LSHADIPY-AKP-----------P---IGKLRFK--------KPEPLD----P-TN------E-TFDATKSIEYESI----VTRCKQY-VRWG--GDDF------------TKDRII---G-T-ENC--------LYLDIIKPVPLELEDV----------------------------------------------------------TYSW-------------------------------AGSETYVIGTAPLAPVLVFLHPGTFMYDIPMNH--------------------------------------------------------------Y-RLA-E--NMCC-------N-Y-I-VFVFVRFRLGPL----------------------GFSNVGYHHGR--AGLTPNLGLWDQVAA-----------------------------------LKWVQ-QHIGAWGGDSSQ------VTFAGVAAGA-ASVNYHLIAGA-S-K--G----------LFSK-------AISIGGSA-LC-T-W-A-F----ARHS-------VE--NTRKMI-REL---NCHGKDQ-------------------------------------EF--P-Y---DN-SSV-----CLKASPVNDIML---------AS------SKLYYFQN---------------IPVNP-LGPTID--------------------------DEFIF-T-EPELAM-RVN----HT-HD-V-PWMVSFSSDYTLYPNYDFIN----------------------------V-------------------I---------HPEG-----E---------SD--M---------FYDLAP--WFL-----GLKGR-----VD-------E---AIMDEVTSD-IREYYLSND-T-GFW--ST-KTPQEV-------------RELKE-------------------------RGEPIVGHDDPQHQWSTLDKINRMVS----D----GM-HTIGI-----VE--------AARLHAWSLQSRQRS-------------VDGKEGSNKTV--P-RVYLYKSNYTLD--R-TS-DFLV-----------------------------------T-S---KQQWG----LVHREEFSVLTGSGIG--TETNKT---------SNETQVTGKWLRKSLLTAWVSFI------K-----YG--Y--VWDAP--------------------------------------------------------ELA-NFRE----------LVK-WPHALQ------------------------NSLGLEVN-----------YQ--ILT------------------------------------DAP----EN-QFSVR-------------S------------DNIGDS-RF-------------------WRTVPLQIYEEFDD-FD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VF-----QDDDIYPYDTLW---NISPIQ------------------K-------KQKDPLS-P------------------FKIPHS------------------------------------------------------------------------------------------------QSTDDDT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e1zye4   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGQ--YK---YI------------------------------------------------------------------A---STI--------CHRLDKRI----WR----YIC-----ILV--LYFILADGL----------------------------------------LDGP-----E-----PIVET-KW--G--I----LQGKW---SRS-I--RD-QRI------------ANFLGIPY-ALP-----------P---VGDLRFR--------SPQRWNY---T-WT------T-IRNAT-------V--D-GNMCSQI-S-G----------------------SKI---SGS-EDC--------LYLNIFIPYIPG--------------------------------------------------------------------------------------------------------IQ-RMKLPVLVFVHSGAYYEGSSN--S------------------------------------------------------------KE-L-S-PD-YLMD-------Q-D-I-ILVTVNYRLNIF----------------------GFFST----MNQV--SPGNYGLKDMKMA-----------------------------------LEWIQ-ENIHSFNGNPES------VTLMGASAGA-ALTHLLALSNK-T-E--G----------LFHR-------YILLSGSA-LS-P-W-A-Y-----NYK-----KY---RQICLKLVKLV---GCQ--SKKDDSIIAINESDIDNSDVENEKKRSNNISVSYKDYNEGYIKDD----EE-IVK-----CMRTVDARQLLK-M------LKH--------FYGG-------------RA--NRKCV-FSPTLEDN-----------SE--D---------AILT-M-HPWKII-KDG----LF-RD-I-PAIMQVVKGE--GLTK---TFEF-----------------------F--------------------------------TDP-----T--L------EK--EMIEN-----FEGYIF--DFL-----ETFKW-------------NF---N-ADAFIPG-IQDFYF-NG--NISL--G-------------------------------------------------------------------LKGNITEMLS----D----GT-VIWPI-----LK--------AARYQSE-I------------------------G----N--S-SVYFSFFAYEGT--FSHT-FIY-----------------------------------AG-S---LAYYG----VCHNDDMNYLFPVLNNMCRNLM------------LNNTESDFMIIKIMTEMWANFM------K-----DG--V--PKAW---------------------------------------------------------------M--------I---PA-WPN-YR-DYHQ--------------------FMRFGNG-----------KS--TDIV--VQ--------------------------------------TD------------FL--------------------CDRM-EF-------------------WE----KLQINGWMKYTNGWMNDT-IIDD------------------------------------------------------------------------------------------------------------S-------PDDTS-------P--------------------------------------VN-----------DDP----IEYK-----L-------------TI---------------------YLVLLIITLLCVLKYY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2a4n5   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISA--------KDSM-L-V-------N-----TMFIRLL-IVLLCLN--------------------------------------LAILA-----NSNETAPRVKT-PL--G--A----LKGYY-KIS----Q-NS-RKY------------EAYEGIPY-ALP-----------P---IGKLRFK--------PPRQ---I-PA-WM------G-ELSAT-------K--F-GSPCIQY-S-HFPY-----D-----PT-----E-KV---EGA-EDC--------LYLNIYVPIRKKS-------------------------------------------------------------------------------------------------------E-NKTSMPVLFWIHGGGFQFGSGR----------------------------------------------------------------L-Y-K-AT-YLMD-------S-D-V-ILVTINYRLGPM----------------------GFLST----EDE--VVPGNMGLKDQNMA-----------------------------------LRWVS-ENIEWFGGDPNR------ITLIGLSAGG-ASVHYHYLSPM-S-T--G----------LFQG-------GISFSGTA-FD-C-W-T-Q----TEN-------A---LEKTKKLSALM---GCP--TT-----------------------------------------T-S---RD-MIR-----CLRYRPAQAIVQ-A---TSEF----------MP-F-------------FF--NPFTP-FGPVPEKV-----------GDD----------TPFID-K-TPVEIV-NNG----DV-QD-I-PWITGVTSEEGLYPVA----DL--------------------------------------------------------IAN------E--N------LK--QLNDN-----WDLLGP--HFL-----DFNY------T------IP-K-EK-QVEIARL-IKKHYFDTK-P-I--DQTT-------------------------------------------------------------------TKQLIQMAS----D----RF-FVVDS-----QK--------AARMQAK-V----------------------------NQ--N-PVWYYYFTYRGN--QSLS-DSM-----------------------------------SG--T--TNNYG----VCHGDDILYVLDTA-W-----VNP-----------VTTQQDRDMQKLLIDFCVSFA------T-----NG--I--VNMA------------------------------------------------------------------------G---VE-WPKLDP-S---------K---------KELHYLHIASPT---------KIN--MDSN--AN--------------------------L-----------GE-------------------------------------K-EF-------------------WN----SIKFKENVLTSKN-------------RK--EEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2a4n6   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVRLL-IVLLCLN--------------------------------------LAIIA-----NSDETAPRVKT-LS--G--A----LKGYY-RIS----Q-YG-RKY------------EAYEGIPY-ALP-----------P---VGKLRFK--------PPQP---I-PA-WT------G-ELPAT-------K--F-CSPCIQY-V-QTPI-----D-----PT-----N-KV---EGA-ENC--------LCLNIYVAVQKMS-------------------------------------------------------------------------------------------------------K-NKTSMPVLFWIHGGAFQFGSGS----------------------------------------------------------------N-Y-G-AT-YLMD-------S-D-I-ILVTINYRLGPM----------------------GFLST----EDE--VVPGNMGLKDQNMA-----------------------------------LRWVF-QNIESFGGDPNG------ITLFGQSAGG-ASVQYHYLSPL-S-T--G----------LFQG-------GISFSGTA-FD-C-W-A-Q----TEG-------S---LEKTKKLSALM---RCP--TT-----------------------------------------T-S---RD-MID-----CLRRRPARNIVQ-A---TSKF----------MT-F-------------YF--NPFTP-FGPVIEKI-----------GDD----------TPFID-R-TPIEIV-NNG----DV-QD-L-PWVTSVVSEEGLFPVA----EF--------------------------------------------------------IADN-----E--N------LK--QLNDN-----WDLLGP--HFL-----DFNY------T------IP-K-EK-QDETGRL-IKKHYFDKK-P-I--NQTT-------------------------------------------------------------------TKQLIQMAS----D----RF-FMVDS-----EK--------AARMQAK-V----------------------------NW--N-PVWYYYFSYRGN--HSLS-DFI-----------------------------------SG--T--TNDYG----VSHGDDIFYILDSP-I-----VNT-----------NTTQRDRDMQKVLIDFCVSFA------T-----NG--I--PNVA------------------------------------------------------------------------G---VK-WSKLDP-E---------K---------EDFEYLHIASPTNN-------KIK--MDSN--AN--------------------------F-----------GD-------------------------------------K-KF-------------------WN----SIKFNENVLTTQR-------------NW--EEVLN-----DFTRKFD---F---LSIF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2acx6   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRAT-W-LLFASVL-------L-----LVQRIHVIR-----------------------AQRTHARQGS--------NRE-TT------TTVTIPGQ---G--T----VLGKE-VTIG----NSI--KV------------TQYLGIPY-AQP-----------P---KGELRFA--------RPVTDPL---PSWN------E-VRNAT------QF----APSCQQV-EGPL-KKHEKLYKELL-SNI-----PDP---GFS-EDC--------LFLNIFVPDG-R-T---------------------------------------------------------------------------------------------------------NERWPVMVWFHGGDFNTGTPAI---------------------------------------------------------------W--DA-SI-FVMKQK---------V-LVVTVAYRLNIL----------------------GFFTT----TD--SEAPGNYGIFDQIAA-----------------------------------LDWVK-RKIKHFNGSPSN------IVIYGHSSGA-ISVGLHMLSPL-S-R--G----------KFNK-------AIAMSGDA-IN-S-V-R---------------SPEMEVPVVNFVADKF---GCNRQP--------------------------------------------T---SA-LME-----CLRRLDADHIVK----------H------TSS----------------------IES-WGPIVD-A----------ETN-N------GT-DPFLP-Q-HPKDIL-DSG----NFNA--V-PLIVGYTKNEQVLAIIESTR----------------------------E-------------------Y-----------GG-----D---------LENGLSPER-----FETMIL--DEF-----SSAVP-----F-MDENSTCT---SKPEMVTNA-VLFFYKPYP-S-TRN--TT-VFRDRY-------------LDLQT-------------------------------------------------------E----RT-F---------GA--------GLTMLAG------------------------QVAKR-----A-TTFVYRFDYRAK--TQ----SVT----------------------------------KE-I---PEWAG----VPHMFELPFVWGLPFQ--MSSPQ-----------MQWLPNDRKTSDTMMTMMATFA------K-----TG--D--PSITG--------------------------------------------------------GT---GP-----------SVK-WESFTQ-DD--------------------PKILIIDKN--------------------------------------------------------------------------------I-E------MGEPNAVDHKAL-AF-------------------WN----DYYPQVVE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---AT-TCC------------------N-------VT--------------------------------------------------------------------------------------------------------------------------------NTARRL--FSYS---I---YLSGMTT-------TMA----LYL--FWF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw2   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKVEVCV-TE--G--K----LIGIV-EES---IH--G-DHF------------IAFRGIPY-AKP-----------P---VGELRFK--------DPVP---P-EP-WS------G-NRDAS-------K--Y-GKIAVQV-D-I-FT-----------QE--------V---IGD-EDC--------LYLNVFTTDTKP---L--------------------------------------------------------------------------------------------------------KKRAVMVWIHGGGFFMGSGN-A-S------------F-------------------------------------------------Y-G-PD-HIIR-------K-D-V-VLVTLNYRLGVL----------------------GFLNL----YHR--MATGNQGLKDVVMA-----------------------------------LQWIK-RNISQFSGDPDN------VTIFGESAGG-DIVHCLTISPL-A-K--G----------LFHK-------AISQSGVM-TN-P-W-G-I----TE-R-----DTC-I-NNGLRIAEKL---GKA--TS-----------------------------------------D-T---KV-AYK-----FLKEIDARKLRK-A---EIELFLT------KAR---------------RLN-L-SIA-FTPTVDS--------------ES--------SNPFFP-I-EPLKLL-HNG-------IK-M-PVIFGYNSSEGNFFLR----GKF-------------------------------------------------F----GDISE-----E--T------LK--EIDSD-----FKKVIH--PKI-------LR------Q------LP----E-IPITISE-LRALYFGDK-A-VSE--ET-------------------------------------------------------------------IMNYSDFLG----D----QC-FYKGI-----IE--------AIDIQMS-S------------------------G---AN--E-PIYLYKFSYESK--TSPM-KNIL-----------------------------------N-I---Q-LPG----TAHFEELGYLFYPYLM------KD-LGL---SP-AAPDSKDYKIINCLTQMWTDFA------K-----TG--N--PTPAN--------------------------------------------------------KDS---I--------S---VK-WTPLI---N--G-----N----------AYDYLNINI-K----------PQ--METL--YK--------------------------TE----------QR---------------------------------------WD-------------------WQ----MRRKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw3   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGNRVVINV-RE--G--K----LIGII-EEN---FL--D-GKY------------IAFRGIPY-AKP-----------P---IGKLRFK--------DPAP---P-EP-WS------G-ARDAS-------K--Y-GNVAVQT-D-I-IT-----------GE--------M---IGD-EDC--------LYLNVYTADVES---W--------------------------------------------------------------------------------------------------------RKRPVMVWIHGGAFSLGSGD-A-S------------V-------------------------------------------------Y-G-PD-YIVR-------K-D-V-VLVTLNYRLGVL----------------------GFLNL----NDE--VAAGNQGIKDTIMA-----------------------------------LRWVQ-KNISKFSGDPGN------VTIFGESAGG-VIVHYLTLSPL-S-E--G----------LFHK-------AISQSGVV-TN-P-W-A-F----IE-L-----TNK-ATNKGFQLAEYF---GKA--TS-----------------------------------------D-P---KV-AYE-----LLKIIDARKLRK-A----EHKLQT------KTE---------------RLQ-K-IIP-FPPSLDH--------------KS--------LNPVIT-E-DPSILI-HRR-------AK-V-PYIVGYNSCEGSYLV-----NST-------------------------------------------------F----GYLNE-----E--T------FK--EINSN-----FKKTII--PRI-------LP------T------LS----Q-IPITIEE-LRFLYFGNK-T-VSE--ET-------------------------------------------------------------------LINYADFMG----D----IY-FYRGI-----ME--------VVDAQMS-S------------------------D---AN--E-PTYLYKFSYENE--ASFL-RKIL-----------------------------------N-V---T-LPG----VTHSEELFYLFYSHMM------KD-LGL---PP-FAPDSKDYKIMNRLTQMWTDFA------K-----TG--N--PTPAI--------------------------------------------------------TNL---T--------P---IK-WTPLKI--A--G-----N----------VYDYLDIDI-E----------PR--MKIL--RK--------------------------EE----------QR---------------------------------------CN-------------------WK----NMKHKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw4   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERVEVCV-RD--G--K----LIGIV-EEG---IY--G-DRY------------VAFRGIPY-AKP-----------P---VGELRFK--------DPVP---P-EP-WS------G-SRDAS-------K--Y-GNIAIQI-D-I-IK-----------SK--------I---TGD-EDC--------LYLNVFTTNIKS---S--------------------------------------------------------------------------------------------------------EKRPVMVWIHGGGFYVGSGD-S-T------------F-------------------------------------------------Y-G-PD-YIVE-------K-D-V-VLVTLNYRLGVL----------------------GFLNL----YDE--VATGNQGLKDVILA-----------------------------------LQWVQ-KNISEFGGDSEN------VTIFGQSAGG-VIVHYLTLSPL-S-E--G----------LFHK-------AISQSGTV-LC-P-W-A-F----TE-P-----KSC-STNKGFLLAKKL---GKV--TE-----------------------------------------D-P---KV-VYE-----FFKTIDAKKLIE-V---EQKFLRT------EKE---------------RLQ-S-LLS-FTPSLDH--------------ES--------SNPVFP-E-DLTTLI-HRG-------VK-V-PYLLGFTNCEGLFFLR-----NN-------------------------------------------------Y----ECINK-----K--A------LS--QIDSD-----FELAIY--PTV----------------------LP----K-LPITLCQ-LRSLYFGDK-N-ISE--ET-------------------------------------------------------------------LANYINLLT----D----MF-ILRGI-----MQ--------VVDIQMN-N------------------------D---NC--G-KTYLYQFSYESE--TSLM-KKIF-----------------------------------N-I---D-FPG----VSHSEELSYLFYPDII------KV-LGL---SV-PASDSEDYKMINRLTQMWTDFA------K-----TG--N--PTPVI--------------------------------------------------------TDL---T--------P---IK-WTPLKS-----G-----N----------VYDYLDIDV-E----------PR--MKVF--RK--------------------------GE----------QR---------------------------------------WA-------------------WE----NMNNISYDYSVYKI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw5   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKRVEVCI-HD--G--K----LVGIV-EKG---IY--G-GRY------------IAFRGIPY-AKP-----------P---IGELRFK--------DPVP---P-EP-WS------G-SRDAS-------K--Y-GNVAVQI-----HN-----------GK--------I---IGN-EDC--------LYLNVFSTDIKS---L--------------------------------------------------------------------------------------------------------EKRSVMVWIHGGSFVTGSGD-S-S------------F-------------------------------------------------H-G-PD-YIVE-------K-N-I-VLVTLNYRLGVL----------------------GFLNL----FDE--VATGNQGLKDVILA-----------------------------------LQWVQ-KNISKFGGDSEN------VTIFGQSAGG-VIVHCLTLSPL-S-E--G----------LFHK-------AISQSGTV-MC-P-S-A-F----TE-P-----KSC-STNKGFLLAKKL---GKV--TE-----------------------------------------D-P---KV-VYE-----FFKTIDAKKLIE-V---EQKFLRT------EKE---------------RLQ-S-LLS-FTPSLDH--------------ES--------SNPVFP-E-DLTTLI-HRG-------VK-V-PYLLGFTNCEGLFFLR-----NN-------------------------------------------------Y----ECINK-----K--A------LS--QIDSD-----FELAIY--PTV----------------------LP----K-LPITLCQ-LRSLYFGDK-N-ISE--ET-------------------------------------------------------------------LANYINLLT----D----MF-ILRGI-----MQ--------VVDIQMN-N------------------------D---NC--G-KTYLYQFSYESE--NSLM-KQNF-----------------------------------N-I---D-FPG----VSHSEELCYLFYPDII------KE-LGL---SV-PASYSEDYKMINRLTQMWTDFA------K-----TG--N--PTPAI--------------------------------------------------------TFL---I--------P---NK-WTPLKH--A--E-----N----------VYDYLDIDI-E----------PR--MKTL--RK--------------------------GK----------QR---------------------------------------WD-------------------WE----NMKNISYDHSFYKI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw6   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---ERV-EVC--------VR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------G-K-L-VGIVKKG---IY----------------------GGRYV----AF--RGIPY---AKPPIGE-----------------------------------LRFKL-RNIFYDNKLRVP------------------K---VLDTI----LFRG----------LFHK-------AISQSGTV-TF-P-W-A-L----TELE-------SCSTNKGFLLAKKL---G-KVT----------------------------------------E--Y-P---KD-VYE-----FLKMIDAKKLIET---------Q------KFLATEEER----------QQ--F-LLI-FTPTLD-H----------ESS-----------NPVFP-G----DLT-TLI----HR-GVKV-PYLLGFTNCEGSVLLKSNFYGYI-------------------------T-------------------K---------EALS-----Q---------VD-SD---------FKLAIY--PRV------LTTL------------------PKIPITLCQ-LRSLYFGDE-N-I---------------------------------------------------------------S------EKTVPNYINLLS----D----IF-FFRGI-----MQ--------AADIQMN----------------------------NDNS--G-KTYLYQFSYGSE--TSLM-KKIL----------------------------------NT-D-----FPG----VSHSEELCYLFYPDII--KELGLS---------VPAPDSEDYKMISRLTQMWTDFA------K-----TG--N--PTPAI--------------------------------------------------------TD---LT-----------PIK-WTPLKP-AGDVY------------------DYLDIDVK-----------PR--MKTF--RK---------------------------------G----EQ-RWEWE-------------K------------A-------L-------------------GV----EEYMKYSY--D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HS-----VCKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw7   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERAEVCV-RD--G--K----LVGVV-EKG---IY--G-GRY------------IAFRGIPY-AKP-----------P---IGELRFK--------DPVP---P-EP-WS------G-SRDAS-------K--Y-GNVAVQI-N-VDKK-----------SQ--------I---IGD-EDC--------LFLNVFTTDIKS---S--------------------------------------------------------------------------------------------------------EKRPVMVWIHGGGFFFGSGD-S-S------------F-------------------------------------------------Y-S-PD-YIVE-------K-D-V-LLITLNYRLGVL----------------------GFLNL----YNE--VATGNQGLKDVILA-----------------------------------LQWVQ-KNISEFGGDSEN------VTIFGESAGG-AIVHYLTLSPL-S-E--G----------LFHK-------AISQSGTI-TC-P-W-A-F----TD-P-----ESC-STNKGFLLAKKL---GKM--TE-----------------------------------------D-P---KD-VYE-----FLKMIDAKKLVE-T---E-KFLAT------EEE---------------RRQ-F-LLI-FTPTLDH--------------ES--------SNPVFS-E-DLMTFI-HRG-------VK-V-PYLLGFTSCEGSYLLK----SND-------------------------------------------------Y----GCISK-----E--S------LS--QVDSD-----FKLGIY--PRV-------LA------I------LP----K-IPITLYQ-LRSLYFGDK-N-ISE--ES-------------------------------------------------------------------VANYINLLS----D----IF-FFRGI-----MQ--------TADIQMN-N------------------------D---NS--G-KTYLYQFSYESE--TSLM-KKIL-----------------------------------N-I---D-FPG----VSHGEELCYLFYPDII------KE-LGL---SV-PAPDSEDYKMISRLTQMWTDFA------K-----TG--N--PTPAI--------------------------------------------------------TDL---T--------P---IK-WTPLKP--A--G-----D----------VYDYLDIDV-K----------PR--MKTF--RK--------------------------GE----------QR---------------------------------------WE-------------------WK----NT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw8   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP--------I-------------------------------------EYYEI-INMLYECLAPVH------AKHYSEAH---FV---YHASR----AVKS----------LFHK-------AISQSGTV-TC-P-W-A-F----TDPE-------SYSTNKGFLLAKKL---G-KVT----------------------------------------E--D-P---KD-VYE-----FLKTIDAKKLVET---------E------KFLVTEEER----------RQ--F-LVI-FTPTLD-H----------ESS-----------NPVFP-E----DLT-TLI----HR-SIKV-PYLLGFTSCEGSFLLKSNFIGCI-------------------------S-------------------K---------EALN-----R---------VD-SD---------FKLAIH--PRV------LNTL------------------PKISTTLCQ-LRSLYFGDK-N-I---------------------------------------------------------------S------EETLANYINLIS----D----TY-FLRGI-----MQ--------AVDIQMN----------------------------NDNS--G-KTYLYQFSYESE--TSFM-KKIS----------------------------------NV-D-----FPG----VSHGEELGYLFYPDII--KELGLS---------VPVPDSEDYKMINRLTQMWTDFA------K-----TG--N--PTPAI--------------------------------------------------------TD---LT-----------PIK-WIPLKR--EAVY------------------DYLDIHIE-----------PR--MKTL--HK---------------------------------G----KQ-RWDWE-------------N------------M-------N-------------------NI----S------Y--D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YS-----VYKI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adw9   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERVKVYV-RD--G--K----LIGIV-EKG---IY--G-GHY------------IAFRGIPY-AKP-----------P---IGELRFK--------DPVP---P-EP-WS------G-SRDAS-------K--Y-GNVAVQI-----NK-----------NK--------I---IGD-EDC--------LYLNIFTTDIKS---L--------------------------------------------------------------------------------------------------------EKRPVMIWIHGGGFTNGSGG-S-S------------M-------------------------------------------------H-G-PD-YIVD-------K-N-I-VLVTLNYRLGVL----------------------GFLNL----YDE--VATGNQGLKDVIMA-----------------------------------LKWIQ-KNITEFGGDSGN------VTIFGGSAGA-AIVHYLTLSPL-S-E--G----------LFHK-------AISQSGTA-IC-P-W-A-F----TE-P-----ESC-STNKGFLLAKKL---GKV--TA-----------------------------------------D-P---KV-AYE-----FLKTIDAKKLIE-S---E-QFLKT------EAE---------------RLQ-I-LLI-FTPSLDH--------------ES--------SNPFFP-E-DLTTLI-HRG-------VK-V-PYLLGFTSCEGIFFLR-----SS-------------------------------------------------Y----RHITK-----E--T------LS--QVDSD-----FKLAIY--PRV-------LT------T------LP----K-IPITLCQ-LRSLYFGDK-N-ISE--ET-------------------------------------------------------------------LANYINLVG----D----TM-LLRDI-----MQ--------AADIQMN-N------------------------D---NS--G-NTYLYQFSYDSE--TSLM-RKIL-----------------------------------N-V---D-FPG----VSHGEEIGYLFYPDII------KE-LGL---SV-PAPDSEDYKMINRLTQMWTDFA------K-----TG--N--PTPAI--------------------------------------------------------TDL---T--------P---IK-WTPLKH--A--G-----N----------VYDYLDINT-E----------PR--MKTL--HR--------------------------GE----------QR---------------------------------------WD-------------------WE----NMKYNL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2adx0   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRVEVCI-RD--G--K----LIGIV-EKG---IY--G-GHY------------IAFRGIPY-AKP-----------P---IGELRFK--------DPVP---P-EP-WS------G-SRDAS-------K--Y-GNVAVQI-N-D-IK-----------NK--------I---IGD-EDC--------LYLNVFTTDIMS---L--------------------------------------------------------------------------------------------------------EKRPVMVWIHGGKFSIGSGD-S-S------------F-------------------------------------------------H-G-PD-YIVE-------K-D-V-VLVTLNYRLGVL----------------------GFLNL----YNK--VATGNQGLKDVILA-----------------------------------LQWVQ-KNISEFGGDSGN------VTIFGESAGG-VIVHYLTLFSL-S-E--G----------LFHK-------AISQSGTV-TC-P-W-A-L----TE-P-----ESY-STNRGLLLAKKL---GKV--TE-----------------------------------------D-P---KD-VYE-----FLKTIDAKKLIE-T---E-KFLVT------KKE---------------RRQ-Y-FLI-FTPTLDH--------------ES--------SNPVFP-E-DLATLI-HRS-------VK-V-PYLLGFTSCEGSIFL------ND-------------------------------------------------Y----ELINK-----E--A------LS--DIDCD-----FKLAIY--PTV-------LA------T------LP----K-IPITLYQ-LRSLYFGDK-N-ISE--ET-------------------------------------------------------------------LANYINLIS----D----IF-IMRGI-----MQ--------TVDIQIN-N------------------------D---NS--G-KTYLYQFSYESE--SSLM-KKIL-----------------------------------N-I---D-FPG----ACHCEELCYLFYPDII------KE-LGL---SV-PAPDSEDYKMINRLTQMWTDFA------K-----TG--N--PTPVI--------------------------------------------------------TDL---T--------P---IK-RTPVKR--A--E-----D----------VYDYLDIDV-E----------PR--MKTF--RK--------------------------GE----------QR---------------------------------------WD-------------------WK----KREK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2ai90   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISA--------KNST-I-L-------N-----TMFIRLL-IVLLCLN--------------------------------------LTILA-----NSEEIAPKVKT-LS--G--A----LKGYY-KIS----Q-YG-RKY------------EAYEGIPY-ALP-----------P---IGELRFK--------PPRP---I-TP-WI------S-ELPAT-------K--F-GSPCIQY-V-QFSS-----D-----SA-----D-KV---EGA-EDC--------LYLNIYVPVRNKT-------------------------------------------------------------------------------------------------------E-NKTFMPVLFWIQGGAFQFDSGM----------------------------------------------------------------N-Y-G-AT-YLMD-------S-D-V-ILVTINYRLGPM----------------------GFLST----EDE--VVPGNMGLKDQNMA-----------------------------------LRWVF-QNIESFGGDPNG------ITLFGQSAGS-ASVHYHYLSPM-S-A--G----------LFRG-------GISYSGTA-FD-C-W-A-Q----TEN-------S---LEKTKKLSALM---GCP--TT-----------------------------------------N-S---RD-MID-----CLRHRPARDIVQ-CQYSTNEF----------MY-F-------------LY--NLVTP-FGPVVEKV-----------DSD----------TPFID-K-TPVEIV-NNG----DV-QD-L-PWVTSVVSQDGLYPVA----EF--------------------------------------------------------IADN-----E--T------LK--QLNNN-----WDHLAP--RCL-----DFHD------T------IP-K-EK-YVEISRI-IKKHYFGTK-P-I--DQTT-------------------------------------------------------------------TSQLIQMTS----D----RF-FYVDS-----EK--------AALMQAK-V----------------------------NK--S-PVRYSYFSYRGN--HSLS-EYY-----------------------------------SG--T--TNNYG----VCHGDDITYILDTP-W-----VDP-----------TTTQRDRDMQKVLIDNCVSFA------T-----NG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9hyme-e2ajl7   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVST--------KDST-M-L-------N-----IMMVKLL-IVLLCLN--------------------------------------LAISV-----NSNETAPTVKT-PS--G--A----LKGYY-KLS----Q-NG-RKY------------EAYEGIPY-ALP-----------P---IEKLRFK--------PPQP---I-PA-WI------G-ELSAT-------K--F-GSPCIQY-A-QFPY-----D-----ST-----E-KV---EGA-EDC--------LYLNIYVPVQNKT-------------------------------------------------------------------------------------------------------E-NNISMPVLFWIHGGAFQYGSGM----------------------------------------------------------------I-Y-R-AT-YLMN-------S-D-V-ILVTINYRLGPM----------------------GFLST----EDE--VVPGNMGLKDQNMA-----------------------------------LRWVF-QNIESFGGDPNG------ITLFGQSAGG-ASVHYHYLSPM-S-A--G----------LFQG-------GMSYSGTA-FD-C-W-A-Q----TE