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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....
9burk-q3fgz0   	--------------------MARSMRSRVVAGAVACAMSVAPFAG-------TAAMMTLATTHAAMAATAPSDDYATTRYPIILVHGLTGTDKYAGVLEYWYGIQEDLQQHGATVYVANLSGFQNDDGPNGRGEQLLAYVKTVLAATGATKVNLVGHSQGGLTSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQGVLAYDP-----TGLSSSVIAAFVNVFGILTS--SSHNTNQDALAALKTLTTAQAATYNQNYPSA-----GLGAPGSCQT-GAPTESV---------GGNTHLLYSWAGTAIQPTISALGVTGAADTSTIPLVDPANALDLSTLALLGTGTVMINRASGQNDGLVSKCSALYGKVLSTNYKWNHVDEINQLLGVRGAYAEDPVAVIRTHANRLKLAGV     =====>
9rals-q67dx2   	--------------------MSKPSP----------LRAVRGFLRT---HAAAAVVAASTVTIAAFAPAQAASTYAATKYPIVLVHGLSGTDKFLGTVDYWYQIPEDLRANGATVYVANVSAFNDE---TVRGEQLVSQIRSVLATTGAAKVNLIGHSQGGLTSRYAAAVIPDKVASVTTIGTPHKGSEFADFVESAPDPLKAL---LNIGADLAGT---VLSWF----NGNSNPQDGYAALRILSTAGAADFNTAFPSA-----GLA--SGCNT-GSSTDVR---------NGNVQKLYSWTGRSTA----------------------TNILDLFDPALVFTGTVMQARGSGTNDGLVSVCSAKFGQVLSTDYAWNHLDEVNQLLGLIGPFAADPVAVIRTQANRLKTAGL     =====>
burce-lipaa    	--------------------MARTMRSRVVAGAVACAMSIAPFAG-------TTAVMTLATTHAAMAATAPAAGYAATRYPIILVHGLSGTDKYAGVLEYWYGIQEDLQQNGATVYVANLSGFQSDDGPNGRGEQLLAYVKTVLAATGATKVNLVGHSQGGLSSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQDVLAYDP-----TGLSSSVIAAFVNVFGILTS--SSHNTNQDALAALQTLTTARAATYNQNYPSA-----GLGAPGSCQT-GAPTETV---------GGNTHLLYSWAGTAIQPTLSVFGVTGATDTSTLPLVDPANVLDLSTLALFGTGTVMINRGSGQNDGLVSKCSALYGKVLSTSYKWNHLDEINQLLGVRGAYAEDPVAVIRTHANRLKLAGV     =====>
burce-lipad    	--------------------MARSMRSRVVAGAVACAMSVAPFAG-------ATAVMTLATTHAAMAATAPADDYATTRYPIILVHGLTGTDKYAGVLEYWYGIQEDLQQHGATVYVANLSGFQSDDGPNGRGEQLLAYVKTVLAATGATKVNLVGHXQGGLTSRYVAAVAPDLVASVTTIGTPHRAXEFADFVQGVLAYDP-----TGLSSSVIAAFVNVFGILTS--SSHNTNQDALASLKTLTTAQAAAYNQNYPSA-----GLGAPGSCQT-GXPTETV---------RXNTHLLYSWAGTAIQPTLSVFGVTGATDTSTIPLVDPANALDPSTLALFGTGTVMINRGSGPNDGLVSKCSALYGQVLSTSYKWNHIDEINQLLGVRGANAEDPVAVIRTHANRLKLAGV     =====>
burce-q75nt4   	--------------------MARSMRSRVVAGAVACAMSVAPFAG-------TTALMTLATTHAAMAATAPADNYAATRYPIILVHGLTGTDKYAGVLEYWYGIQEDLQQHGATVYVANLSGFQSDDGPNGRGEQLLAYVKTVLAATGAAKVNLVGHSQGGLTSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQSVLAYDP-----TGLSSTVIAAFVNVFGILTS--SSHNTNQDALASLKTLTTSQAATYNQNYPSA-----GLGAPGSCQT-GAPTETV---------GGNTHLLYSWAGTAIQPTLSLFGVTGAQDTSTIPLVDPANALDPSTLALFGTGTVMINRGSGQNDGLVSKCSALYGKVLSTSYKWNHIDEINQLLGVRGAYAEDPVAVIRTHANRLQLAGV     =====>
burch-a0az26   	--------------------MARSMRSRVMAGAVACAMSVAPFAA-------TTALMTLATTHTAMAATAPADNYAATRYPIILVHGLTGTDKYAGVLEYWYGIQENLQQHGATVYVANLSGFQSDDGPNGRGEQLLAYVKTVLAATGATKVNLVGHSQGGLTSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQGVLAYDP-----TGLSSTVIAAFVNVFGILTS--SSHNTNQDALAALKTLTTGQAATYNQNYPSA-----GLGAPGSCQT-GAPTETV---------GGNTHLLYSWAGTAIQPTFSVLGVTGATDTSTIPLVDPANVLDLSTLALLGTGTVMINRASGQNDGLVSKCSALYGKVLSTSYKWNHIDEINQLLGVRGAYAEDPVAVIRTHANRLKLAGV     =====>
burgl-lipas    	--------------------MVRSMRSRVAARAVAWALAVMPLAG-------AAGLTM-----AASPAAVAADTYAATRYPVILVHGLAGTDKFANVVDYWYGIQSDLQSHGAKVYVANLSGFQSDDGPNGRGEQLLAYVKQVLAATGATKVNLIGHSQGGLTSRYVAAVAPQLVASVTTIGTPHRGSEFADFVQDVLKTDP-----TGLSSTVIAAFVNVFGTLVS--SSHNTDQDALAALRTLTTAQTATYNRNFPSA-----GLGAPGSCQT-GAATETV---------GGSQHLLYSWGGTAIQPTSTVLGVTGATDTSTG-TLDVANVTDPSTLALLATGAVMINRASGQNDGLVSRCSSLFGQVISTSYHWNHLDEINQLLGVRGANAEDPVAVIRTHVNRLKLQGV     =====>
burma-q629p4   	------------------------MKSRFASAAAAVRGARKTLAKVWAAVLAAAMCAFAAPAAHADAATGALDDYAATRYPIILVHGLTGTDDYFGVVPYWYGMRPHLQQHGATVFVADLSGFQSDIGPNGRGEQLLAYVQQVLAVTGAQKVNLIGHSQGGLTSRYVAAVAPELVASVTTIATPHRGSPFADFVLGALSLDP-----TGLSTPIFGALLNVFGILTS--HTHNTNQDAIAALNALSTPYATQFDAQFPSA-----GLGAPGACAS-GAPSETV---------GGNVHLLYSWSGSAYQPITLLGLTTGALDKSTIPLVDPANVLDPSTLVFLTAGNIMALKQAGLNDGFTSTCSSLYGTVISTDYKWNHFDEINQLLGIRGAYAADPVAVLRTHANRLKLQGV     =====>
burml-q5mai6   	--------------------MARSMRSRVVAAAVACAMSAAPFAG-------TTALMTLATTRTALAAIAPADDYAATRYPIVLVHGLTGTDKYAGVLEYWYGIQEDLQRHGATVYVANLSGFQSDDGPNGRGEQLLAYVKQVLAATGATKVNLIGHSQGGLTSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQSVLAYDP-----TGLSSSAIAALVNVFGILTS--SSHNTNQDALAALTTLTTAQAATYNRNFPSA-----GLGAPGSCTT-GASTETV---------GGNTHLLYSWAGTAIQPTNAAFGVTGASDTSTIPVVDPANALDAPTLALLGTGTVMINRGSGQNDGLVSKCSALYGQVLGTNFKWNHLDEINQLLGVRGAYAEDPVAMIR-----------     =====>
burps-q63jh5   	--------------------MARTMRSRAVAAAVAFAVSAAPAAG-------IGTFLSLAGTQAAAAATSAVDNYAATQYPIILVHGLTGTDKYANVLEYWYGIREDLQAHGAQVYVANLSGFQSDDGPNGRGEQLLAYVQQVLAATGASKVNLIGHSQGGLTSRYVAAVAPQLVASVTTIGTPHRGSEFADFVQTVLAYDP-----TGLSSTVIAAFVNVFGILTS--STNNTNQDALAALKTLTTSQAATYNQNYPSA-----GLGAPGSCQT-GAQTETV---------GGNTHLLYSWGGTAIQPTLSILGVTGATDTSTIPVVDPANVLDASTLAMLGSGTVMINRGSGANDGLVSRCSSLYGQVLGTSYKWNHLDEINQLLGVRGAYAEDPVAVIRTHANRLKTQGV     =====>
burvi-q4ba73   	--------------------MVRSMRSRVVAAAVACAMSGAQFAG-------TTAVMTLATTHAATAATAATDDYAATRYPVVLVHGLTGTDKYAGVLEYWYGIQEDLQRHGATVYVANLSGFQSDDGPNGRGEQLLAYVKTVLAATGATKVNLIGHSQGGLTSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQSVLAYDP-----TGLSSSVIATFFNVFGILTS--SSNNTNQDALAALKTLTTSQAAAYNQNYPSA-----GLGAPGSCQT-GAPTETV---------GGNTHLLYSWAGTAIQPTVSMFGVTGAKDVSTIPVIDPANALDLSTLALLGTGTVMINRGAGQNDGLVSKCSALYGQVLGTRYKWNHLDEINQLLGVRGAYAEDPVAVIRTHANRLKLAGV     =====>
burvi-q4ba74   	--------------------MTKSMRSRVMAGAAACAMSAAPFAG-------ATAVMALATTRTAVAATAPSDTYAATRYPLVFVHGINGNEKIGGAIDQWYGIRGDLQQHGASVYVANLSAFQSDDGPNGRGEQLLAYVKRVLAASGATRVNLVGHSQGGLTSRYVAAVAPELVASVTTIGTPHRGSEFADFVQRVLAYDP-----TGLSSAVIAKFVNLMAFLTS--TNFNLKQDALAALQTLTTSQAAVYNVNYPSA-----GLGAPGSCET-GASTETI---------GGHTHLLYSWTGTAIRPAFSLSGVMLAKDVSTIPLIDPAYKDDSSTLAMLATGTVMINRGSGRNDGLVSKCSALYGQVLGTHYKWNHVDEINQTLGVHGAFAEDPVAVIRTHANRLKLAGV     =====>
pselu-tglip    	------------------------MRSRVVAGAVACAMSVAPFAG-------SAALMMAATTHVAMAATAPADNYATTRYPIILVHGLTGTDKYAGVLEYWYGIQEDLQQHGATVYVANLSGFQSDDGPKGRDEQLLAYVKTVLAATGATKVNLVGHSQGGLTSRYVPAVAPDLVASVTTIGAADRGSEFADFVQGVLAYDP-----TGLSSSVIAAFVNVFGILTS--SSNNANQDALAGLKTLTTAQAATYNQNYPSA-----GLGRPGSCQT-GRPTETV---------GGNTHLLYSWAGTAIQPTLSVFGVTGATDTSTIPLIDPANVLDPSTLALFGTGTVMINRASGQNDGLVSKCSALYGKVLSTSYKWNHIDEINQLLGVRGANAEDPVAVIRTHANRLKLAGV     =====>
psesp-lipas    	--------------------MARTMRSRVVAGAVACAMSIAPFAG-------TTAVMTLATTHAAMAATAPADGYAATRYPIILVHGLSGTDKYAGVVEYWYGIQEDLQQNGATVYVANLSGFQSDDGANGRGEQLLAYVKTVLAATGATKVNLVGHSQGGLTSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQNVLAYDP-----TGLSSSVIAAFVNVFGILTS--SSHNTNQDALAALQTLTTARAATYNQNYPSA-----GLGAPGSCQT-GAPTETV---------GGNTHLLYSWAGTAIQPTLSVFGITGATDTSTVPLVDLANVLDPSTLALFGTGTVMINRGSGQNDGLVSKCSALYGKVLSTSYKWNHLDEINQLLGVRGAYAEDPVAVIRTHANRLKLAGV     =====>
ralme-q1lgr0   	-----MEHGNRRGPGRACAHQD-TVTLK-----AGTRRSTSAIARTAA---GTAAAIAAAIAMAWPASATASSDYAKTRYPIVLVHGLTGAAKMGGVIDYWYGIPEVLRANGATVYVSTVPSFNSD---EERALALQAYVRAVKLETGADKVNLIGHSQGGPTSRMLAAMSPQDVASVTTIGSPHRGSQLADVVLDVINGISSIPLAGPALVNVIQGVTNLLGWFNGLFNGQALNQDAIASARTLTSQGATEQNARLNATLAPGSQSALGPDCDTPGAVAEQRQGRDASGKLVTYTQAAYSWTGRGGPI-----------------NLLRSNLLDPSTAAMAAAAGVMGMKGAGPNDGMVSVCSAKWGRVLSTDYYWNHLDEINQMLGMYQ--DVDPRTVILNHANRLRNDQL     =====>
ralpj-b2u848   	--------------------MSQTSLLH------AVYGSARSFLRT---HAAAAVLAASALSLGAVAPAQAASTYAATKYPIVLVHGLSGTSKFLGVVDYWYQIPEDLRANGANVYVADVSAFNDE---TVRGEQLVSQIRSVLAATGAAKVNLIGHSQGGLTSRYAAAVVPNLVASVTTIGTPHKGSEFADFVESTPAPFQAL---VNLGADVFGS---VLGWF----NGNSNPQNGFAALHILSTSGAADFNKAFPSA-----GLA--SGCNT-GSATDER---------NGNVQKLYSWTGRSTA----------------------TNLLDLFDPVLVFSGGVMQARGSGTNDGLVSVCSAKFGQVLSTDYAWNHLDEVNQLLGLIGWSAADPVAVIRTQANRLKTAGL     =====>
xylfa-XF1181   	MRIISLEFSDLNFS--GCVELINFISYKLMKKMLACVMSTVFFVNMIA---------LVMLTGMGVASAASKDSYAATKYPIIFEPGFGGVDRLFVLIDYFYRIPEDLRAHGANVYLSTSSAFQRPDGPNGRGEQLLAYVKAVLAITGAEKVNLIGYSQGGLTVRYVAAVAPSLVASVTTMGTPHHGSELADYLDETFNQGL-----TGLLSPVWAGLNNAFASMT----TGNPNQDMLAAFKSLMTSQVALFNKNYPSA-----GLGKRGSCQS-GAEFETV---------GGERQYLYSWGGAAIKEKKSLFGTK-VIDTSVFPFIDAANFIDPTTKILYHLGSVMINHDSGTNDGMVSTCSSMFGKVISSNFNWNHFDEINQVLAIRGAYAEDPLAVIRTHVNRLKMQGL     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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