ESTHER Database

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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....
aspfu-q4wg03   	---MLFTAVTLALLGQ---ALAGPVEL------EERQSSCPNIHVFGARETTAPTGYG-SSSTAVNLILNAYPGSTSE--AINYPACGGQSSCGGVSYANSVVAGINAVVSAVNSFNQRCPNTQLVLVGYSQGGQIMDNALCGGGDPNQ-GYTN-T--AVPLSSSAVNMIKAAIFMGDPRYVAGLPYNVGTCK-AGGFDPRPPGFSCPSA---SKIQSYCDAADPYCCNGN-DANTHQGYGTE-YGQAALTFVKSKLSSSGSGGGSGGGSGGS-----------GGSGGSGGTVAHYGQCGGQGWTGATSCQSPYTCTVIS---------------QWYSQCL----------------------------------------------     =====>
chagb-q2gz03   	---MKV----SAVAVPVLAGLASASPVD-----VEARQSCPGVHIFGARETTAPAGYG-TSQGLVNMVKQAYSGATSE--AINYPACGGQAQCGGVSYDQSASQGTSAVVSAVTSFNQRCPDTKIVLIGYSQGGQIMDNALCGGAG-------------ATLSGNALNAVKAAIFMGDPHNVVGLPYNVGTCQ-AQGFAARPRGFQCSPA-KPAIIQSYCDSTDPYCCNGN-DANSHQQYVNK-YGQQALTFIKGLLG-----------------------------------------------------------------------------------------------------------------------------------     =====>
chagb-q2hid0   	MWPTPKV-ASLLLAAHALLVSGSPVDADAVDAAVLAKRQCPQIHVFGARETTVSPGYG-TAGQVVNLILGAYPGATAE--PISYPA-----------YGDSARQGTSAVASAVNSFNQRCPNAQIVLVGYSQGGQIMDNAVCGGPDSGS-GITS-T--APPISAAALNQIKAVIMMGNPRYVAGLSYNVGTCS-AQGFAPRPRGYVCGSN-SADKMKSYCDSTDPYCCTGN-DANSHQQYGTK-YGQQALTFVKSKLSTSGGGGSQTTPST-PTP------TGGNGGGNTGNCAAKWGQCGGSGWQGPTCCQSGSTCQASN---------------QWYSQCL----------------------------------------------     =====>
gibze-q4hu10   	MWNAAFLASLFLIP----LATGAP-----AIRIEERQAPCQNVHIFLARGTDEP-YPG-RQSSVVSAICSGLPSCDYE--NINYPAGF-NT------YCSSIYAGITGGLSQITTYANRCPNSKIVLSGYSQGAQLFGDILGGGGGQSL-GCTQPSNPALNPANSPGNKIAAALFFGDPRYVANQAYNTGTGASRSGINPRSGAQLTSLNLFSSVLRSWCLAGDNVCAQGT-DPTAHTSYFNV-FSQEAGVWVKTKV------------------------------------------------------------------------------------------------------------------------------------     =====>
gibze-q4hwi8   	MRASLDS-SLLLILAN-------------ALTAKAQAQSCPDVHIFGARETSVAPGFG-STGALIDMIKADHPGATSE--AIDYPACGGQASCGGVEYGVSAKQGTEAVTTAVNELNKRCPNTKIVMIGYSQGGQIMDNNICGGPDSGA-SISA-S--NVPLSASAVEQVKAVIMMGDPRFIHGLAYGVGTCD-AGGFDARPEGFVCPN---AGKIQSYCDSQDPYCCNGN-DAAHHQQYVNI-YGKEALKFVNSKL------------------------------------------------------------------------------------------------------------------------------------     =====>
gibze-q4ifd1   	MRPFVLSTAVLV-T-------GA-------VAQNAWKTCYDGLFMIAARGTNEEKGSG-RIGEIAEAVAKRINGSHVY--GLDYPASFQDP-----AYEDSESDGVKKLKDILSSYFYQCPKNKVAVFGYSQGGQVASDVFCGGSGG---DFPTNK---PLTVNDVEKNVVAIITFGDPSHVANVSYDLGSSI-NDGIFQRNDTKLC-EDKYSGILHAYCDTGDVYCDRGD-DTDVHKSYFEK-YGKKVEDLVVEKYESAMSESTTTPTADATS-------------------SVTSAA-S--EVTSTDAPGNGASGLV------------------------PGLV-------------------------LSMV-PLALGLSQLL--     =====>
gibze-q4ije2   	----MLQKTSLLAF----LANAAA-----AHSIGIRASECKDVHVFLAKGNNEP-YPG-RQGVLAKAICDGYKSCDYE--DIIFNNPLEAP------FCDSVTEGVVNGKKQITAYNKKCPKSKLVVSGYSQGAQVVGDILGGGGGVFFQDCVEDKIPGLSPDSKPGSSIVAAMVFGDTRHTADQPYNVLSGAGKNGLFPRPADQLANLASYGDVFQAYCVATDPICAQGK-NVQTHLNYFDV-YTDQAAKWVKERVEKAGGATEGDGDESSSTA------AASATTKTKVITTVE--------VTTTMASETKATTMVVTKTKASETDDAVSSTTDSLSAVVTSLVDAASSVGPAAAEASSTSTDNAAAPTGAPLVGIIMGVAALLAI     =====>
gibze-q4ips4   	-----------------------------------------------------------------------------------------------------------------MADIVNPGLFVWVFYLNHTGAHIAADVMCGVSSV---GFPATK---PQP-LNITNKVAAIVLMGDPSTTKGQAFHVGSSK-GDGVFSRQKPNG--CRYVSGKTMSFCDAGDPFCEAGGHDLSTHMRYVSA-YGQTATDFAVSMFHLA---------------------------------------------------------------------------------------------------------------------------------     =====>
gibze-q4ips5   	MIAFTLLLSFLVA-----------------LVAAKPTTCAKGAHVIVARGSLEPQGPG-AMGELAEKVLKLVPGSDIE--SLVYPALYNE-------YLESQPVGVRTLTSVIQAYVKNCPKTQLVLMGYSQGAHVIMDTICGASST---GFPATL---PQP-SFVTDKISSVILLGDPSLTEGQTFHVGTSV-GSGMFPRNLPAG--CDSIAKKTVSVCDKGDPFCEAGGKDLSVHLGYIPV-WGDYVVKESVRLAKAFIKKAKAC--------------------------------------------------------------------------------------------------------------------------     =====>
neucr-B19A17.36	MWPSPKA-AYLLLLARSALVGASPVELE-------ERQSCPSIHVFGARETTVSPGFG-TAGVVVNLILQAYPGATSE--AIVYPACGGQSSCGGVQYGDSARQGTNAVATAVNSLNARCPDTQIVLVGYSQGGQIMDNAVCGGPDSGA-GITT-S--TPGINASALNQVKAVIMMGNPRYRAGLSYNVGTCT-AYGFDPRPAGYTCAS---ASKLQNYCDSPDPYCCTGN-DANTHQGYGSK-YGQQALAFVKSKLSSGGGGGGGSTPTT-PSN------PSTPTNPSTGNCAAKWGQCGGQGWTGATCCQSGSTCQAAN---------------QWYSQCI----------------------------------------------     =====>
neucr-q7s259   	---MKLTTTFALLQIPIL---A--SASP-----LQDRQSCPKVHIFGARETTAPAGYG-TSAGLVNSIAAAYPGSTKE--AIVYPACGGQSSCGGVSYDNSASQGTAAVVRAVTNLNSRCPDTKIVLVGYSQGGQIMDNALCGGAG-------------ATLTGNALKAVKAAIFMGDPHNVVGLPYNVGTCR-AKGFAARPSGFQCSPA-SPSIIQSYCDSADPYCCNGN-DANSHQQYVNK-YGQQALAFVKKLVDAA---------------------------------------------------------------------------------------------------------------------------------     =====>
neucr-q7s260   	--MWTIVARFVEAA-------ASV------SHYARDEPCATGLHMIVARGSTEDPGLG-RIGVVARNVSQLIPGSTIS--AIDYPATLEN-------YTTSEEKGAMGFEKMLIEYHEKCPDTKVALLGYSQGAHAMMDSICGGIPGEGSDYQASK---GYL-EVFNESVVAAVAYGDPSHTAGAPWNLGTST-KTGIFPRNNTAS--CLPFASHIASWCDTGDIYCDSGS-SLTVHGSYFAN-YTMDSVKWIVEKYKASGGSSTSTDSTPSSTSTGVAVPTGS-GTVTGGATASASAS---------GKPAEGAAVSV------------------------RGSVVM---------------------VMAGVVGAVGMGLGLF---     =====>
penpu-axylest  	MHSKFFAASLLG-LG----AAAIPLEG------VMEKRSCPAIHVFGARETTASPGYG-SSSTVVNGVLSAYPGSTAE--AINYPACGGQSSCGGASYSSSVAQGIAAVASAVNSFNSQCPSTKIVLVGYSQGGEIMDVALCGGGDPNQ-GYTN-T--AVQLSSSAVNMVKAAIFMGDPMFRAGLSYEVGTCA-AGGFDQRPAGFSCPSA---AKIKSYCDASDPYCCNGS-NAATHQGYGSE-YGSQALAFVKSKLG-----------------------------------------------------------------------------------------------------------------------------------     =====>
trire-axylest  	MPSVKE--TLTLLLSQAFLATGSPVDGE-----TVVKRQCPAIHVFGARETTVSQGYG-SSATVVNLVIQAHPGTTSE--AIVYPACGGQASCGGISYANSVVNGTNAAAAAINNFHNSCPDTQLVLVGYSQGAQIFDNALCGGGDPGE-GITN-T--AVPLTAGAVSAVKAAIFMGDPRNIHGLPYNVGTCT-TQGFDARPAGFVCPSA---SKIKSYCDAADPYCCTGN-DPNVHQGYGQE-YGQQALAFINSQLSSGGSQPPGGGPTSTSRP------TSTRTGSSPGPTQTHWGQCGGQGWTGPTQCESGTTCQVIS---------------QWYSQCL----------------------------------------------     =====>
trire-q7z9m3   	MRALSLSLPLSLSL-------LA-------ASSTAATTCAKGLYMVVARGSEEPAGTG-VTGNLTSQIAAKVPGSEVV--AVDYPASFDD-------YEDSEGDGVKAMRQLLNSYAEACPGNKIAVLGYSQGAQVATDTICGGAGD---PFTSDK---GMS-DDVMDDVVAVAIFGDPTHVANMTYDRGTSI-HNGLFNRSSSSIEVCKSYASRIVSYCDTGDIYCDAGS-NSTVHHMYIQR-YGDEIVDFVVSQFEKSTSSGSGSGTNATTTT-A-PAPTVSPTTTSGGNSTVPTRT-G--GPTTSSTQGSGASALT------------------------SSLM-------------------------LGGLLTVLTAVSQML--     =====>
ustma-q4p8k0   	--------------------------ASLNGSEIARARDCPSIEFITTRGANDSFEQSFWLMEMARQVMSRLPNGTSRRTETNYDSFTGNDM---TSQVSSALNGSWWVANYTTLLAQSCPNTKIIMMAYSLGAAANI--------------VA-----STRPRFPASRISAAVYWGSPLFSPGRPQNRGTAQSALGQFGLLGYRT--PRGMQPKVRDYCKTGDIICTGWG-NLTVHLSYANSSYQDETVEYLVQSVLEA---------------------------------------------------------------------------------------------------------------------------------     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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